Genes
Page 4 of 264, showing 20 records out of 5271 total, starting on record 61, ending on 80
| Public Gene Name | Sequence Name | WB ID | Description | Module | Actions |
|---|---|---|---|---|---|
| asp-5 | F21F8.3 | WBGene00000218 |
lemone_97_gene |
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| asp-6 | F21F8.7 | WBGene00000219 |
aspartic protease.
|
lemone_97_gene |
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| atf-5 | T04C10.4 | WBGene00000221 |
atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4 and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4, atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorly translated in unstressed cells but well-translated during ER stress, amino acid starvation, or arsenite treatment; possibly atf-5 is also translationally regulated in a way similar to ATF4.
|
lemone_28_regulator lemone_86_regulator lemone_126_regulator |
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| atf-6 | F45E6.2 | WBGene00000222 |
atf-6 is an ortholog of mammalian ATF6alpha, a proximal sensor required for the unfolded protein response (UPR) in the endoplasmic reticulum (ER); ATF6alpha is a transmembrane protein, with a bZIP transcription factor domain in its cytosolic amino terminus that is released and activated by proteolytic cleavage upon ER stress; either ire-1 or xbp-1 deletions are synthetically lethal with atf-6 or pek-1 deletions, producing arrest in L2 larvae; RNAi of Y56A3A.2 (a S2P protease homolog) is synthetically lethal with ire-1(RNAi), consistent with the hypothesis that Y56A3A.2 cleaves ATF-6; atf-6 regulates few genes that are transcriptionally induced by UPR, but regulates roughly one-quarter of genes that require UPR constitutively; pdr-1 transcripts are strongly upregulated in a atf-6(ok551) mutant background, but atf-6(ok551);pdr-1(lg103) double mutants have a grossly normal phenotype ; atf-6 is dispensable for proper localization of GLR-1 glutamate receptors.
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lemone_31_regulator lemone_52_gene |
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| atf-7 | C07G2.2 | WBGene00000223 |
lemone_26_gene lemone_109_regulator |
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| atp-3 | F27C1.7 | WBGene00000230 |
atp-3 encodes a mitochondrial ATP synthase and is part of a regulatory system that controls and establishes rates of respiration, behavior and aging during development that persist during adulthood.
|
lemone_137_gene |
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| bar-1 | C54D1.6 | WBGene00000238 |
bar-1 encodes a beta-catenin; during C. elegans development, BAR-1 likely functions as a transcriptional coactivator whose activity is required for Q neuroblast migration, P12 cell fate specification, and P3.p through P8.p vulval cell fate specification at two different stages of development; in specifying vulval cell fates, bar-1 interacts with Wnt and MAPK signaling pathways to regulate proper expression of the LIN-39 homeodomain transcription factor, overexpresion of which can partially rescue the bar-1 mutant phenotype; in yeast two-hybrid assays, BAR-1 interacts strongly with the POP-1/TCF transcription factor, and when fused to the Gal4 DNA binding domain, BAR-1 can function in yeast as a transcriptional coactivator; during larval development, BAR-1 expression begins in P3.p through P8.p at the late L1 stage and then disappears from these cells by the mid-L3 stage; BAR-1 is also expressed in P12, in the seam cells, and in cells of the somatic gonad; BAR-1 subcellular localization, assessed using an integrated transgene, reveals localization to the cytoplasm, nucleus, and cell junctions; genetic mosaic analyses indicate that, in P4.p and in P12, bar-1 acts cell autonomously to specify cell fates.
|
lemone_299_regulator |
View |
| bas-1 | C05D2.4 | WBGene00000239 |
bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development.
|
lemone_70_gene |
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| pah-1 | K08F8.4 | WBGene00000240 |
pah-1 encodes a biochemically active phenylalanine-4-hydroxylase orthologous to human PAH (OMIM:261600, mutated in phenylketonuria); recombinant PAH-1 has hydroxylase activity on phenylalanine and tryptophan substrates in vitro; pah-1 is expressed in seam cells, tail hypodermal cells, and ventral hypodermis, with stronger posterior than anterior expression; PAH-1 might help provide tyrosine for cross-linking in the cuticle, and is partially required for the tyrosinemic phenotype of K10C2.4(RNAi) animals.
|
lemone_88_gene |
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| bbs-8 | T25F10.5 | WBGene00000244 |
bbs-8 encodes a tetratricopeptide repeat (TPR)-containing protein that is orthologous to the human Bardet-Biedl syndrome protein, BBS8; in C. elegans, bbs-8 activity is required for cilia biogenesis and function; accordingly, bbs-8 mutant animals display odorant chemotaxis defects and exhibit both aberrant motility and abnormal localization of at least two intraflagellar transport (IFT) protein markers; a BBS-8::GFP translational fusion is expressed exclusively in ciliated head and tail neurons, where it localizes predominantly to the base of cilia, known as the ciliary transition zone; BBS-8::GFP is also observed moving bidirectionally (anterograde and retrograde) along the ciliary axoneme; DNA sequences upstream of bbs-8 contain X box DNA binding sites, suggesting that bbs-8 expression may be regulated by the DAF-19 RFX-type transcription factor.
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lemone_17_gene |
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| bir-2 | C50B8.2 | WBGene00000250 |
The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis.
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lemone_29_gene |
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| bli-1 | C09G5.6 | WBGene00000251 |
The bli-1 gene encodes an unusual cuticular collagen that is required for proper strut formation within the unique medial layer of the adult cuticle; bli-1 interacts genetically with other cuticular collagens such as bli-2 and rol-1, and may be processed for secretion by BLI-4, a Kex2/subtilisin serine endoproteinase; consistent with its role in adult cuticle formation, bli-1 mRNA is highly expressed only during the L4 larval stage.
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lemone_98_gene |
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| bli-2 | F59E12.12 | WBGene00000252 |
A cuticle collagen involved in strut assembly in the adult cuticle.
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lemone_221_gene |
View |
| bra-1 | F54B11.6 | WBGene00000262 |
The bra-1 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1) that negatively regulates the DAF-1/DAF-7/DAF-14 TGF-beta signalling pathway.
|
lemone_136_gene |
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| bre-1 | C53B4.7 | WBGene00000266 |
bre-1 is required for Cry5B toxicity.
|
lemone_70_gene |
View |
| bre-3 | B0464.4 | WBGene00000268 |
bre-3 encodes a protein similar to beta-glycosyltransferases from bacteria that is required for the toxicity of Bacillus thuringiensis Cry5B; BRE-3 may act in a pathway with bre-5 and is expressed and functions in the gut epithelium.
|
lemone_26_gene |
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| brp-1 | Y79H2A.1 | WBGene00000273 |
brp-1 encodes a glutamine-rich protein that is conserved in nematodes, but that has no known homologies or sequence motifs; BRP-1 is able to bypass the need for the S. cerevisiae mating pheromone MAP kinase cascade to activate the mating pheromone-responsive gene FUSl.
|
lemone_130_gene |
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| btf-1 | F15D4.1 | WBGene00000274 |
btf-1 encodes a member of the TBP-associated family (TAF), with weak similarity to human TBP-associated factor 172.
|
lemone_10_gene |
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| byn-1 | F57B9.5 | WBGene00000276 |
byn-1 encodes a homolog of mammalian BYSTIN-LIKE (BYSL; OMIM:603871).
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lemone_22_gene |
View |
| cah-5 | R173.1 | WBGene00000283 |
cah-5 encodes a member of the carbonic anhydrase family.
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lemone_23_gene |
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