Module
- Number
- 10
- Regulatory Genes
- 6
- Module Genes
- 64
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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D2030.7 | D2030.7 | WBGene00008417 | 458 | View | |
R02D3.7 | R02D3.7 | WBGene00019824 | 277 | View | |
ztf-8 | ZC395.8 | WBGene00022598 | 249 | View | |
oma-1 | C09G9.6 | WBGene00003864 | 170 |
The oma-1 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-2; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation.
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F56D1.1 | F56D1.1 | WBGene00018959 | 161 | View | |
W04D2.4 | W04D2.4 | WBGene00012243 | 122 | View |
CLR Predictions
92 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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acbp-5 | T12D8.3 | WBGene00011731 | View | |
B0001.8 | B0001.8 | WBGene00007093 | View | |
B0205.9 | B0205.9 | WBGene00015023 | View | |
B0546.2 | B0546.2 | WBGene00015249 | View | |
btf-1 | F15D4.1 | WBGene00000274 |
btf-1 encodes a member of the TBP-associated family (TAF), with weak similarity to human TBP-associated factor 172.
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C01G5.5 | C01G5.5 | WBGene00015307 | View | |
C03H5.3 | C03H5.3 | WBGene00015405 | View | |
C05C8.5 | C05C8.5 | WBGene00015462 | View | |
C14B1.6 | C14B1.6 | WBGene00007577 | View | |
C16A3.1 | C16A3.1 | WBGene00015806 |
C16A3.1 is orthologous to the human gene SMARCAL1 (SMARCAL1; OMIM:606622), which when mutated leads to disease
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C33H5.6 | C33H5.6 | WBGene00016373 | View | |
C35D10.7 | C35D10.7 | WBGene00016444 | View | |
C44E4.5 | C44E4.5 | WBGene00016654 | View | |
C56C10.9 | C56C10.9 | WBGene00016965 | View | |
D1007.16 | D1007.16 | WBGene00017011 | View | |
D1007.5 | D1007.5 | WBGene00017003 | View | |
dcap-1 | Y55F3AM.12 | WBGene00021929 |
dcap-1 encodes an ortholog of budding yeast Dcp1p and human DCP1A (OMIM:607010) and DCP1B (OMIM:609843); DCAP-1 is expressed in diverse tissues, including muscle, intestine, neurons, and the reproductive system; DCAP-1 is colocalized with CAR-1 to P granules, and with AIN-1 and CAR-1 to discrete cytoplasmic foci that resemble P bodies; although it is orthologous to mRNA decapping complex subunits, DCAP-1 itself shows no decapping activity in vitro on either m7GpppG- or m2,2,7GpppG-capped RNAs; however, dcap-1(RNAi) shows weak synthetic lethality with dcap-2(RNAi), suggesting that DCAP-1 and DCAP-2 are partially redundant in vivo.
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dnj-17 | T03F6.2 | WBGene00001035 |
This gene encodes a protein containing a DnaJ ('J') domain.
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dpf-7 | R11E3.7 | WBGene00001060 | View | |
F25H8.1 | F25H8.1 | WBGene00009131 | View | |
F26F4.5 | F26F4.5 | WBGene00017827 | View | |
F32D1.9 | F32D1.9 | WBGene00017988 | View | |
F37D6.2 | F37D6.2 | WBGene00009508 | View | |
F44E2.7 | F44E2.7 | WBGene00018420 | View | |
F48A11.4 | F48A11.4 | WBGene00018585 | View | |
F49E8.1 | F49E8.1 | WBGene00018635 | View | |
F52B5.2 | F52B5.2 | WBGene00009921 | View | |
F55F8.6 | F55F8.6 | WBGene00018894 | View | |
grp-1 | K06H7.4 | WBGene00001743 | View | |
K02B12.5 | K02B12.5 | WBGene00010498 | View | |
K08E7.1 | K08E7.1 | WBGene00010671 | View | |
M01E5.4 | M01E5.4 | WBGene00010807 | View | |
M106.2 | M106.2 | WBGene00010910 | View | |
M106.7 | M106.7 | WBGene00044924 | View | |
M18.3 | M18.3 | WBGene00010889 | View | |
mau-2 | C09H6.3 | WBGene00003136 |
mau-2 encodes an ortholog of budding yeast Scc4p, Drosophila CG4203, and human KIAA0892; MAU-2 is required (with PQN-85 and SCC-3) for normal mitotic chromosome segregation, and for cellular (e.g., neuronal) or axonal migration; MAU-2 is required for migration both embryonically and postembryonically, along both dorsoventral and longitudinal body axes; MAU-2 guides the axonal projection of AVM (and probably other neurons) by some cell-autonomous mechanism independent of SLT-1; MAU-2 is also required for normal larval development, locomotion, excretory canals and osmoregulation, phasmid morphology, and egg-laying; the primary sequences of MAU-2 and its Scc4-like orthologs are composed of tetratricopeptide repeats, and are highly divergent between yeast and metazoa; MAU-2 is expressed ubiquitously in embryos during late gastrulation, subsequently becoming restricted to neurons; mau-2 transcripts are abundant in oocytes, and maternal transcripts alone can support normal MAU-2 protein synthesis through the L3 larval stage (but not in L4 larvae or adults); MAU-2's N-terminal 371 residues of MAU-2 are its most conserved domain, and are sufficient to transgenically rescue mau-2 mutants; despite its behavioral phenotype, MAU-2 is thought to act early in development, since the uncoordinated phenotype of mau-2 mutants is maternal; while the uncoordinated phenotype of mau-2 mutants can be rescued either maternally or zygotically, the egg-laying phenotype of mau-2 mutants is purely zygotic; partially penetrant mau-2 dye-filling phenotypes occur on one side of the body, suggesting that MAU-2 acts on a whole side of an embryo at a time; while mau-2(RNAi) has no obvious early embryonic phenotype, joint mau-2/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos, and mau-2(RNAi) enhances the lagging of anaphase chromosomes induced by pqn-85(RNAi).
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mlh-1 | T28A8.7 | WBGene00003373 |
The mlh-1 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MLH1.
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pash-1 | T22A3.5 | WBGene00011908 |
pash-1 encodes an RNA-binding protein that is orthologous to Drosophila Pasha and mammalian DGCR8; pash-1 activity is required for processing of primary miRNA transripts (pri-miRNAs), such as that of let-7, to generate pre-miRNAs that will then be processed by DCR-1 to generate mature miRNAs; accordingly, pash-1 mutants show defects in let-7-mediated developmental processes, namely the transition from late larval to adult cell fates.
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R02F11.4 | R02F11.4 | WBGene00019842 | View | |
R10D12.13 | R10D12.13 | WBGene00011194 | View | |
R10E11.3 | R10E11.3 | WBGene00011216 | View | |
rbg-3 | B0393.2 | WBGene00007167 | View | |
rnf-113 | K01G5.1 | WBGene00010476 | View | |
rsd-2 | F52G2.2 | WBGene00004681 | View | |
set-31 | C15H11.5 | WBGene00007615 |
set-31 encodes a protein with an N-terminal Chromo domain, and a C-terminal SET domain; SET-31 has no obvious non-nematode orthologs; set-31(ok1482) has no obvious mutant phenotype, and SET-31 has no obvious function in mass RNAi assays.
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strd-1 | Y52D3.1 | WBGene00013132 | View | |
T01H3.3 | T01H3.3 | WBGene00011349 | View | |
T05G5.8 | T05G5.8 | WBGene00011502 | View | |
T21C9.1 | T21C9.1 | WBGene00011890 | View | |
T23B5.1 | T23B5.1 | WBGene00011939 | View | |
ttb-1 | W03F9.5 | WBGene00006648 | View | |
ucp-4 | K07B1.3 | WBGene00006729 | View | |
W07A8.2 | W07A8.2 | WBGene00012319 | View | |
Y37H2A.1 | Y37H2A.1 | WBGene00012562 | View | |
Y47H9C.8 | Y47H9C.8 | WBGene00012951 | View | |
Y51H1A.1 | Y51H1A.1 | WBGene00013092 | View | |
Y55F3BR.1 | Y55F3BR.1 | WBGene00021938 |
Y55F3BR.1 encodes a DEAD-box helicase; loss of Y55F3BR.1 activity via RNAi indicates that Y55F3BR.1 activity is required for positive regulation of growth rate, reproduction, locomotion, and embryonic development.
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Y5F2A.4 | Y5F2A.4 | WBGene00012385 | View | |
Y66D12A.15 | Y66D12A.15 | WBGene00013441 |
Y66D12A.15 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 3 (XERODERMA PIGMENTOSUM GROUP B COMPLEMENTING) (ERCC3; OMIM:133510), which when mutated leads to disease.
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Y69A2AR.1 | Y69A2AR.1 | WBGene00022074 | View | |
Y71H2B.2 | Y71H2B.2 | WBGene00022192 | View | |
ZK1248.13 | ZK1248.13 | WBGene00022882 | View | |
ZK632.11 | ZK632.11 | WBGene00014018 | View | |
ZK652.6 | ZK652.6 | WBGene00022785 | View |