Module
- Number
- 86
- Regulatory Genes
- 4
- Module Genes
- 18
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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Y52B11A.9 | Y52B11A.9 | WBGene00013128 | 482 | View | |
atf-5 | T04C10.4 | WBGene00000221 | 414 |
atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4 and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4, atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorly translated in unstressed cells but well-translated during ER stress, amino acid starvation, or arsenite treatment; possibly atf-5 is also translationally regulated in a way similar to ATF4.
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hmg-1.1 | Y48B6A.14 | WBGene00001971 | 128 |
hmg-1.1 encodes a member of the high mobility group (HMG) family of proteins.
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zfp-2 | F35H8.3 | WBGene00009448 | 111 |
zfp-2 encodes a zinc-finger transcription factor; loss of zfp-2 and lin-35/Rb results in almost complete sterility accompanied by defects in somatic gonad development and vulval morphology, as well as polyploidization of somatic cell nuclei; loss of zfp-2 activity by itself reveals that zfp-2 is also required for cosuppression, inhibition of RNAi of some genes, and wild-type levels of expression of a rol-6 extrachromosomal array; a zfp-2::GFP promoter fusion construct is expressed in vulval cells and all somatic gonad structures, such as the spermatheca, sheath cells, uterine cells and distal tip cells (DTCs).
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CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C37A2.7 | C37A2.7 | WBGene00016493 | View | |
cyc-2.1 | E04A4.7 | WBGene00017121 |
E04A4.7 encodes, along with ZC116.2, one of two C. elegans cytochrome c proteins; the product of E04A4.7 is predicted to function in the electron transport chain by transferring electrons from respiratory chain Complex III to Complex IV; large-scale RNAi screens indicate the E04A4.7 activity is required for embryonic and larval development as well as for normal brood sizes and growth rates.
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rpl-1 | Y71F9AL.13 | WBGene00004412 |
rpl-1 encodes a large ribosomal subunit L10a protein; by homology, RPL-1 is predicted to function in protein biosynthesis; in C. elegans, RPL-1 activity is essential for embryonic development.
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rpl-14 | C04F12.4 | WBGene00004426 |
rpl-14 encodes a large ribosomal subunit L14 protein.
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rpl-19 | C09D4.5 | WBGene00004431 |
rpl-19 encodes a large ribosomal subunit L19 protein.
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rpl-21 | C14B9.7 | WBGene00004433 |
rpl-21 encodes a large ribosomal subunit L21 protein; by homology, RPL-21 is predicted to function in protein biosynthesis; in C. elegans, RPL-21 activity is required for embryonic and germline development.
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rpl-34 | C42C1.14 | WBGene00004448 |
rpl-34 encodes a putative large ribosomal subunit L34 protein that inhibits DHC-1 in vivo; RPL-34 is expressed in most somatic tissues of larvae and adults; in mass RNAi assays, RPL-34 is required for embryonic and larval development, normally rapid growth, and normal body coloration.
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rpl-38 | C06B8.8 | WBGene00004452 |
rpl-38 encodes a large ribosomal subunit L38 protein.
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rpl-41 | C09H10.2 | WBGene00004454 |
rpl-41 encodes a large ribosomal subunit L41 protein; by homology, RPL-41 is predicted to function in protein biosynthesis.
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rpl-6 | R151.3 | WBGene00004417 |
rpl-6 encodes a large ribosomal subunit L6 protein.
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rpl-9 | R13A5.8 | WBGene00004420 |
rpl-9 encodes a large ribosomal subunit L9 protein that affects fertility and embryonic viability.
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rps-11 | F40F11.1 | WBGene00004480 |
rps-11 encodes a small ribosomal subunit S11 protein; by homology, RPS-11 is predicted to function in protein biosynthesis; in C. elegans, RPS-11 activity is required for embryonic and germline development, as well as the overall health of the animal; loss of rps-11 activity in adult animals extends lifespan.
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rps-20 | Y105E8A.16 | WBGene00004489 |
rps-20 encodes a small ribosomal subunit S20 protein.
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rps-21 | F37C12.11 | WBGene00004490 |
rps-21 encodes a small ribosomal subunit S21 protein; by homology, RPS-21 is predicted to function in protein biosynthesis; in C. elegans, RPS-21 activity is required for embryonic and germline development, as well as the overall health of the animal.
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rps-22 | F53A3.3 | WBGene00004491 |
rps-22 encodes a small ribosomal subunit S15a protein.
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rps-7 | ZC434.2 | WBGene00004476 |
rps-7 encodes a small ribosomal subunit S7 protein.
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rps-8 | F42C5.8 | WBGene00004477 |
rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal.
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ubq-2 | ZK1010.1 | WBGene00006728 |
ubq-2 encodes a bifunctional protein that contains two domains; an N-terminal ubiquitin peptide, and a C-terminal large ribosomal subunit protein L40 peptide.
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