Module
- Number
- 23
- Regulatory Genes
- 4
- Module Genes
- 58
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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F53H10.2 | F53H10.2 | WBGene00010012 | 857 | View | |
ztf-18 | T24C4.7 | WBGene00020763 | 236 | View | |
F45C12.15 | F45C12.15 | WBGene00018446 | 129 | View | |
jun-1 | T24H10.7 | WBGene00012005 | 109 | View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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aex-5 | F32A7.6 | WBGene00000088 |
an ortholog of calcium-dependent serine endoproteinases, the kex2/subtilisin-like proprotein convertase that affects defecation cycle and anterior body contractions; and is expressed in all muscle cells except pharyngeal muscles.
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alp-1 | T11B7.4 | WBGene00001132 | View | |
C01B10.3 | C01B10.3 | WBGene00015278 |
C01B10.3 encodes a paralog of IPP-5, and thus may functionally overlap with ipp-5 in vivo.
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C12D12.1 | C12D12.1 | WBGene00015713 | View | |
C13C4.5 | C13C4.5 | WBGene00007549 | View | |
C26D10.6 | C26D10.6 | WBGene00007746 | View | |
C33C12.3 | C33C12.3 | WBGene00016335 | View | |
C34C12.7 | C34C12.7 | WBGene00007926 | View | |
C49C3.9 | C49C3.9 | WBGene00008199 | View | |
cah-5 | R173.1 | WBGene00000283 |
cah-5 encodes a member of the carbonic anhydrase family.
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cgr-1 | T27A10.7 | WBGene00020847 | View | |
col-111 | F29B9.9 | WBGene00000685 | View | |
F26E4.3 | F26E4.3 | WBGene00009158 | View | |
F40A3.6 | F40A3.6 | WBGene00018221 | View | |
F41B4.2 | F41B4.2 | WBGene00018258 | View | |
F41C3.2 | F41C3.2 | WBGene00018268 | View | |
F44A6.4 | F44A6.4 | WBGene00009676 | View | |
F46H5.7 | F46H5.7 | WBGene00018522 | View | |
F53A9.9 | F53A9.9 | WBGene00018732 | View | |
F59B10.5 | F59B10.5 | WBGene00010321 | View | |
F59C6.14 | F59C6.14 | WBGene00044792 | View | |
flp-7 | F49E10.3 | WBGene00001450 |
flp-7 encodes an MVRFamide-containing peptide that, upon injection into A. suum, produces paralysis and loss of locomotory waveforms, increased body length, and decreased cAMP production.
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gst-28 | Y53F4B.31 | WBGene00001776 | View | |
gtl-1 | C05C12.3 | WBGene00001795 |
gtl-1 encodes a TRPM subfamily member of the TRP channel family that affects the periodicity of the defecation cycle in combination with gon-2; expression includes the intestine.
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hmit-1.3 | M01F1.5 | WBGene00010811 |
hmit-1.3 encodes one of three C. elegans proton (H+)-dependent myo-inositol transporters; loss of hmit-1.3 activity via large-scale RNAi result in no obvious abnormalities but by homology, HMIT-1.3 is predicted to function as a plasma membrane protein required for the regulated uptake of myo-inositol and thus potentially for regulation of cell signaling and intracellular osmolarity.
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hum-4 | F46C3.3 | WBGene00002037 |
hum-4 encodes a class XII myosin, an unconventional myosin.
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hum-8 | Y66H1A.6 | WBGene00002041 | View | |
ifd-2 | F25E2.4 | WBGene00002058 |
ifd-2 encodes a nonessential intermediate filament protein; IFD-2 is predicted to function as a structural component of the cytoskeleton; IFD-2 has no obvious function in RNAi assays.
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ins-17 | F56F3.6 | WBGene00002100 |
ins-17 encodes an insulin-like peptide.
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K05F1.10 | K05F1.10 | WBGene00019411 |
K05F1.10 encodes a putative secreted TIL-domain protease inhibitor paralogous to SWM-1, ISL-1, and the products of 11 other C. elegans genes; K05F1.10 and its relatives are collectively similar to other TIL-domain protease inhibitors from nematodes, insects, and vertebrates; although it has no obvious function in mass RNAi assays, K05F1.10 transcription is reproducibly induced by infection, suggesting that it may participate in innate immunity.
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K08D8.6 | K08D8.6 | WBGene00010660 | View | |
K09E2.3 | K09E2.3 | WBGene00019572 | View | |
lact-2 | ZK945.1 | WBGene00014164 |
lact-2 encodes a beta-lactamase domain-containing protein that contains a predicted transmembrane domain in its N terminus.
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mec-5 | E03G2.3 | WBGene00003169 |
mec-5 encodes a collagen unique in the number of Gly-X-Y repeats and in the composition of amino acids surrounding these repeats; MEC-5 is required for normal mechanosensory response to gentle touch and for the proper functioning of the touch receptor neurons; mec-5 interacts genetically with mec-4 and mec-10 which encode degenerins (ion channels) expressed in the touch neurons, mec-9, which encodes a protein containing EGF-like and Kunitz/protease inhibitor domains secreted by the touch neurons, and mec-12, which encodes an alpha-tubulin expressed in the touch neurons; these genetic interactions suggest that MEC-5 may play a role in anchoring the degenerin complex to the extracellular matrix; MEC-5 is produced and secreted by hypodermal cells.
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nas-37 | C17G1.6 | WBGene00003553 |
nas-37 encodes a Astacin-class metalloprotease required for full ecdysis that is expressed in hypodermal cells 4 hours before each ecdysis; NAS-37 protein has an N-terminal signal sequence followed by an Astacin protease domain and three protein-binding domains (EGF-like, CUB, and thrombospondin); NAS-37 accumulates in anterior cuticle, being shed with it after ecdysis; nas-37 mutants fail to complete anterior ecdysis at each molt; nas-37(ox196) mutations alter an evolutionarily invariant histidine residue yet are phenotypically indistinguishable from null mutations, consistent with the hypothesis that NAS-37 encodes a functional protease; NAS-37 orthologs are found in other nematodes such as Brugia malayi.
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nlp-9 | E03D2.2 | WBGene00003747 | View | |
pbo-4 | K09C8.1 | WBGene00003943 |
pbo-4 encodes a Na+/H+ ion exchanger (NHE) most closely related to mammalian NHE1 that promotes extracellular acidification (and intracellular alkalinization) by catalyzing the electroneutral exchange of one extracellular Na+ ion for one intracellular H+ ion; in C. elegans, PBO-4 functions cell autonomously in the intestine to regulate normal posterior body wall muscle contractions (pBoc) during the defecation cycle; expressed in the basolateral membrane of posterior intestinal cells, PBO-4 regulates the pBoc step of the defecation cycle by promoting H+ secretion from intestinal cells that, in turn, activates a PBO-5/PBO-6 proton-gated, cys-loop cation channel expressed in adjacent posterior body wall muscle cells; based on sequence similarity to mammalian NHE1, the carboxy-terminal region of PBO-4 contains a number of potential regulatory sites, including predicted PIP2- and CaM-binding sites, as well as potential CamKII and PKC phosphorylation sites.
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R02D5.3 | R02D5.3 | WBGene00010977 | View | |
snb-2 | F23H12.1 | WBGene00004898 | View | |
T01D1.3 | T01D1.3 | WBGene00020148 | View | |
T06E6.10 | T06E6.10 | WBGene00011540 | View | |
T07C12.9 | T07C12.9 | WBGene00011573 | View | |
T14A8.2 | T14A8.2 | WBGene00020497 | View | |
T19D12.1 | T19D12.1 | WBGene00020576 | View | |
T23E7.2 | T23E7.2 | WBGene00020732 | View | |
tag-60 | C01F6.6 | WBGene00006438 |
tag-60/C01F6.6 encodes, by alternative splicing, five isoforms of an ortholog of Drosophila SIP1 and of human PDZK1 (OMIM:603831) and PDZD3 (OMIM:607146); TAG-60 is required for normally short lifespan and for normal acetylcholine neurotransmission; TAG-60 is expressed in larval and adult pharynx, intestine, excretory cell, and tail cells.
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tax-6 | C02F4.2 | WBGene00006527 |
tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling.
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tre-3 | W05E10.4 | WBGene00006609 |
tre-3 encodes one of four putative trehalases in C. elegans of unknown function, as RNAi analysis has not produced an obvious phenotype; expressed throughout development.
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ttr-32 | R13A5.3 | WBGene00020047 |
R13A5.3 encodes a protein containing a predicted signal sequence followed by a transthyretin-like domain; although the product of R13A5.3 belongs to a family of apparently nematode-specific proteins whose function is not yet known, loss of R13A5.3 activity via RNAi has been reported to result in hyperactive locomotion.
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unc-52 | ZC101.2 | WBGene00006787 |
The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle.
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vha-5 | F35H10.4 | WBGene00006914 |
vha-5 encodes an ortholog of subunit a of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-5 is orthologous to human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutated in distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated in osteopetrosis); VHA-5 is expressed broadly in embryos (in dot- or cup-like perinuclear compartments in each cell), and in the postembryonic pharynx, excretory cell, and epidermal syncytium; VHA-5 is required for survival past the L2 larval stage; VHA-5 is required for osmoregulation, since vha-5(mc38) die as fluid-filled L1 larvae; VHA-5 is also required for apical secretion of the hedgehog-like proteins WRT-2 and -8, and this requirement is genetically separable from V-ATPase activity (i.e., WRT secretion may require only the V0 domain, acting separately from the V1 domain); VHA-5 is required for alae formation, like the V0 subunits VHA-1 and VHA-4, but not like the V1 subunits VHA-8 or VHA-13; in S. cerevisiae, different V0 a-subunits (Stv1p and Vph1p) direct the assembly of V-ATPases to different membranes and organelles, suggesting that the profusion of such subunits in C. elegans (VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have a similar function; VHA-5 is predicted to capture protons from V-ATPase transmembrane rotor components and export the protons across the membrane.
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W05B5.1 | W05B5.1 | WBGene00012274 | View | |
Y105C5A.8 | Y105C5A.8 | WBGene00013633 | View | |
Y12A6A.1 | Y12A6A.1 | WBGene00012439 | View | |
Y37D8A.3 | Y37D8A.3 | WBGene00012545 | View | |
Y40C5A.1 | Y40C5A.1 | WBGene00021495 | View | |
Y48C3A.3 | Y48C3A.3 | WBGene00012987 | View | |
Y57G11A.4 | Y57G11A.4 | WBGene00013292 | View |