Module
- Number
- 97
- Regulatory Genes
- 3
- Module Genes
- 21
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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ZK1320.3 | ZK1320.3 | WBGene00014253 | 970 | View | |
ras-1 | C44C11.1 | WBGene00004310 | 187 |
ras-1 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:21928) (RRAS2; OMIM:600098), which when mutated leads to disease.
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ceh-21 | T26C11.6 | WBGene00000444 | 148 |
ceh-21 encodes a a ONECUT class CUT homeobox protein with a single N-terminal cut domain and an OCAM domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-21 is one of three nematode-specific ONECUT genes in a cluster with ceh-39 and ceh-41; CEH-21 may be required for muscle formation and differentiation, and is expressed in muscle precursor cells and differentiated gut cells; ceh-21 has no obvious function in mass RNAi assays.
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CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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asp-2 | T18H9.2 | WBGene00000215 |
asp-2 encodes aspartic protease.
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asp-5 | F21F8.3 | WBGene00000218 | View | |
asp-6 | F21F8.7 | WBGene00000219 |
aspartic protease.
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C17F4.7 | C17F4.7 | WBGene00015913 | View | |
cpr-1 | C52E4.1 | WBGene00000781 |
cpr-1 encodes a cysteine protease of the cathepsin B-like cysteine protease family; cpr-1 appears to be required for embryogenesis; cpr-1 is specifically expressed in the gut of all stages except the embryo and around developing embryos in the gonad; expression of cpr-1 is regulated by three promoter GATA motifs.
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cpr-4 | F44C4.3 | WBGene00000784 |
cpr-4 encodes a cathepsin B-like cysteine protease expressed at all life stages.
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cpr-6 | C25B8.3 | WBGene00000786 | View | |
dpy-4 | Y41E3.2 | WBGene00001066 |
dpy-4 encodes a cuticle collagen; dpy-4 activity is required for normal body morphology, locomotion, and larval development.
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F08B12.4 | F08B12.4 | WBGene00008572 | View | |
F41C3.5 | F41C3.5 | WBGene00018271 | View | |
F57F5.1 | F57F5.1 | WBGene00010204 | View | |
fat-2 | W02A2.1 | WBGene00001394 |
fat-2 encodes a delta-12 fatty acyl desaturase that increases membrane fluidity when expressed in yeast, and that may protect against cold stress; FAT-2's substrate is unknown, but may be acyl-CoA; FAT-2 is required in vivo for normal levels of C18 or C20 polyunsaturated fatty acids (PUFAs); FAT-2 is fully required for a sperm-attracting cue (perhaps an eicosanoid) secreted by oocytes, and partially required for the polarizing activity of PAR-3, PAR-6, and other proteins; FAT-2 is also required for a normally fast growth rate and movement rate, and for normal body shape, defecation rhythm, and brood size.
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lbp-6 | W02D3.5 | WBGene00002258 | View | |
lec-6 | Y55B1AR.1 | WBGene00002269 |
lec-6 encodes a 'proto' type galectin (beta-galactosyl-binding lectin) containing a single carbohydrate recognition domain; by homology, LEC-6 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-6 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-6 in C. elegans development and/or behavior is not yet known; in vitro, LEC-6 can interact with several types of blood group precursor oligosaccharides and gangliosides.
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mlc-3 | F09F7.2 | WBGene00003371 |
mlc-3 encodes an essential myosin light chain; large-scale RNAi screens indicate that mlc-3 activity is required for both embryonic and postembryonic development, as well as for normal locomotion and egg laying.
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pat-10 | F54C1.7 | WBGene00003934 |
pat-10 encodes body wall muscle troponin C, the calcium-binding component of the troponin complex of actin thin filaments; PAT-10 is essential for muscle contraction and thus for completion of embryonic morphogenesis and elongation; by homology, PAT-10 likely functions to regulate body wall muscle contraction in response to changes in intracellular calcium; PAT-10 is expressed in body wall muscle but is also detected in vulval and anal muscles; expression in body wall muscle begins during early embryonic morphogenesis, concurrent with expression of other body wall muscle structural components.
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T21H3.1 | T21H3.1 | WBGene00020662 | View | |
T25F10.6 | T25F10.6 | WBGene00020808 | View | |
ttr-15 | T07C4.5 | WBGene00011561 | View | |
ttr-16 | Y5F2A.1 | WBGene00012382 | View | |
unc-27 | ZK721.2 | WBGene00006764 |
unc-27 encodes a troponin I isoform; unc-27 is required for coordinated motility and normal muscle morphology; structural analyses indicate that unc-27 is required for proper sarcomeric organization; unc-27/troponin I interacts with the body wall and pharynx types of troponin C; expression studies show that unc-27 is expressed in body wall, vulval and anal muscles.
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