Module
- Number
- 137
- Regulatory Genes
- 3
- Module Genes
- 14
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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tlp-1 | T23G4.1 | WBGene00006580 | 410 |
The tlp-1 gene encodes a C2H2-type zinc finger of the Sp-1-like protein family, which is required for normal asymmetry in the divisions of the T.p and T.ap cells; such asymmetry, in turn, is required for normal, rounded tail morphology in adult males.
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eea-1 | T10G3.5 | WBGene00011696 | 304 |
eea-1 encodes a coiled-coil protein that is the C. elegans ortholog of early endosome antigen 1 (EEA1); eea-1 activity is required for wild-type levels of endocytosis; a fusion protein between EEA-1 FYVE domains and GFP binds endosomal/vacuolar membranes in wild-type worms but not in those lacking vps-34 activity, suggesting that, like its human ortholog, C. elegans EEA-1 binds phosphatidylinositol 3-phosphate (PtdIns 3-P) in vivo; EEA-1 reporter fusion proteins localize to endocytic vesicles.
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Y17G7B.20 | Y17G7B.20 | WBGene00012471 | 167 | View |
CLR Predictions
7 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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asg-2 | C53B7.4 | WBGene00000210 |
asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
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atp-3 | F27C1.7 | WBGene00000230 |
atp-3 encodes a mitochondrial ATP synthase and is part of a regulatory system that controls and establishes rates of respiration, behavior and aging during development that persist during adulthood.
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C23G10.2 | C23G10.2 | WBGene00016011 | View | |
C48B6.10 | C48B6.10 | WBGene00016746 | View | |
F45H10.2 | F45H10.2 | WBGene00009739 | View | |
fat-1 | Y67H2A.8 | WBGene00001393 |
fat-1 encodes an omega-3 fatty acyl desaturase that acts on substrates of 16-20 carbons with a preference for omega-6 fatty acids; FAT-1 dehydrogenates its substrates 3 carbons from the methyl terminus; FAT-1 is required in vivo for n3 polyunsaturated fatty acid (PUFA) synthesis; the fatty acids of fat-1(wa9) mutants consist of 20% arachidonic acid (20:4n6), instead of the 20% eicosapentaenoic acid (20:5n3) seen in wild-type worms; fat-1(wa9) mutants are generally normal, with normal chemotaxis; fat-4(wa14) fat-1(wa9) double mutants are superficially normal but have deficient chemotaxis to AWA-sensed odorants (though not to AWC-sensed ones), and mildly defective OSM-9/OCR-2-dependent nociception by ASH neurons; fat-1 mutants are abnormally sensitive to excess dihommogamma-linolenic acid (DGLA, 20:3n-6), which induces degeneration of larval germ cells, excess apoptosis in adult germline, and sterility; while this sensitivity is enhanced by fat-4 mutations, it requires excess DGLA (or its precursor, gamma-linolenic acid/18:3n-6) in the food media; fat-1 or fat-1;fat-4 mutants grown on normal food are fertile, despite their having excess DGLA in vivo; transgenic FAT-1 can lower apoptosis in cultured mammalian neurons, suggesting that it may be required for an evolutionarily conserved signalling pathway regulating apoptosis.
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fkb-1 | F36H1.1 | WBGene00001426 |
fkb-1 encodes a homolog of mouse FK506-binding protein 2.
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pgk-1 | T03F1.3 | WBGene00020185 |
T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances.
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R07H5.8 | R07H5.8 | WBGene00011128 | View | |
sdhb-1 | F42A8.2 | WBGene00006433 |
sdhb-1 encodes the C. elegans ortholog of human succinate dehydrogenase subunit B (SDHB; OMIM:185470, mutations lead to extraadrenal pheochromocytoma) which contains several iron-sulfur (Fe-S) clusters and functions to transfer electrons from the A (SDHA) subunit to the membrane-associated C (SDHC) subunit; RNAi screens indicate that sdhb-1 activity is essential for embryonic and larval development, as well as for normal brood sizes, body morphology, osmoregulation, and growth rate; sdhb-1 is widely expressed in larvae and adults and is predicted to localize to mitochondria.
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T02H6.11 | T02H6.11 | WBGene00020181 | View | |
ucr-1 | F56D2.1 | WBGene00018963 | View | |
Y113G7B.17 | Y113G7B.17 | WBGene00013766 | View | |
ZK484.1 | ZK484.1 | WBGene00022748 | View |