Module
- Number
- 109
- Regulatory Genes
- 3
- Module Genes
- 14
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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rap-2 | C25D7.7 | WBGene00004308 | 492 |
rap-2 encodes a Ras-related GTPase that is most similar to the RAP2 members of the Ras GTPase superfamily; by homology, RAP-2 is predicted to function as a membrane-localized GTPase that likely plays a role in signal transduction; as animals homozygous for a rap-2 deletion mutation show no obvious abnormalities, the precise role of RAP-2 in C. elegans development and/or behavior is not yet known.
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let-607 | F57B10.1 | WBGene00002783 | 154 | View | |
atf-7 | C07G2.2 | WBGene00000223 | 113 | View |
CLR Predictions
16 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C32E8.11 | C32E8.11 | WBGene00016326 | View | |
cdk-9 | H25P06.2 | WBGene00000410 |
cdk-9 encodes an ortholog of the metazoan transcription elongation factor kinase CDK-9; it is required for general expression of early embryonic genes, and thought (in conjunction with partners such as cyclin T) to form a transcription factor (P-TEFb) that which prevents transcription from stalling in vitro.
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H13N06.4 | H13N06.4 | WBGene00010397 |
H13N06.4 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:12715) (SUOX; OMIM:602216), which when mutated leads to disease.
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lin-23 | K10B2.1 | WBGene00003009 |
lin-23 encodes an F-box- and WD-repeat-containing protein orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 also functions cell autonomously in some neurons to regulate neurite outgrowth; LIN-23 expression is first detected broadly during gastrulation, with expression continuing postembryonically in body wall and enteric muscle, hypodermal cells, and many but not all neurons; LIN-23 localizes to the cytoplasm.
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mrck-1 | K08B12.5 | WBGene00006437 |
tag-59/K08B12.5 encodes a serine/threonine-protein kinase that is homologous to human DMK (OMIM:160900l; mutated in dystrophia myotonica I).
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sem-5 | C14F5.5 | WBGene00004774 |
sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355), that functions in multiple signaling pathways during development; these pathways include those regulating sex myoblast migration, muscle membrane extension, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-, MAP-, as well as IP-3-, mediated signal transduction.
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smk-1 | F41E6.4 | WBGene00018285 |
smk-1 encodes a novel, evolutionarily conserved protein that is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) proteins; smk-1 activity is essential for several aspects of DAF-16-mediated longevity namely, the defense response to pathogenic bacteria and increased resistance to oxidative and UV-induced damage; in regulating DAF-16 activity, SMK-1 appears to act by affecting the transcription of DAF-16 target genes, such as sod-3, ctl-1, and lys-8; SMK-1 is present in the nucleus of intestinal cells, many head and tail neurons, and some hypodermal cells throughout development.
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W08E3.2 | W08E3.2 | WBGene00012343 | View | |
Y32H12A.5 | Y32H12A.5 | WBGene00021313 | View | |
Y48E1A.1 | Y48E1A.1 | WBGene00012999 | View | |
Y54F10AL.1 | Y54F10AL.1 | WBGene00021847 | View | |
Y71G12B.8 | Y71G12B.8 | WBGene00022148 |
Y71G12B.8 encodes a putative DEAD-box helicase, orthologous to human DDX27 and Drosophila Rs1, that is required for larval development and normally rapid growth.
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ZK154.4 | ZK154.4 | WBGene00022666 | View | |
ZK757.4 | ZK757.4 | WBGene00014075 | View |