Module
- Number
- 22
- Regulatory Genes
- 7
- Module Genes
- 38
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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hda-2 | C08B11.2 | WBGene00001835 | 375 |
hda-2 encodes a Class I histone deacetylase; by homology, HDA-2 is predicted to function in deacetylation of histone residues and transcriptional regulation; loss of hda-2 activity via RNAi results in an increased spontaneous mutation rate, suggesting that hda-2 also plays a role in regulating genome stability.
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nfyb-1 | W10D9.4 | WBGene00021132 | 338 | View | |
pptr-1 | W08G11.4 | WBGene00012348 | 203 | View | |
ztf-8 | ZC395.8 | WBGene00022598 | 149 | View | |
ekl-4 | Y105E8A.17 | WBGene00013676 | 143 | View | |
unc-120 | D1081.2 | WBGene00006844 | 120 |
unc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles.
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C02F5.12 | C02F5.12 | WBGene00015352 | 117 |
C02F5.12 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8 and ZIM-1/-3; while its specific biological function and expression pattern are unknown, C02F5.12 is required for normal meiosis in mass RNAi assays, and thus might share a function in meiotic chromosomal segregation with its better-characterized paralogs.
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CLR Predictions
20 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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arl-8 | Y57G11C.13 | WBGene00000192 | View | |
arx-2 | K07C5.1 | WBGene00000200 |
arx-2 encodes the C. elegans ortholog of the Arp2 subunit of the actin-related protein (Arp)2/3 complex.
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B0205.11 | B0205.11 | WBGene00015025 | View | |
B0414.8 | B0414.8 | WBGene00015176 | View | |
byn-1 | F57B9.5 | WBGene00000276 |
byn-1 encodes a homolog of mammalian BYSTIN-LIKE (BYSL; OMIM:603871).
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C24D10.6 | C24D10.6 | WBGene00016057 | View | |
C26E6.6 | C26E6.6 | WBGene00016142 | View | |
C35D10.10 | C35D10.10 | WBGene00016446 | View | |
C53H9.2 | C53H9.2 | WBGene00016907 |
C53H9.2 encodes at least three protein isoforms orthologous to the GTP-binding proteins human GNL1 (HSR1; OMIM:143024) and murine MMR1, as well as LSG1 in S. cerevisiae and many other eukaryotic and bacterial proteins; one alternative transcription unit of the C53H9.2 locus, C53H9.2a, has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that C53H9.2 is a natural substrate for SMG-mediated nonsense suppresssion; C53H9.2 is required in mass RNAi assays for embryonic viability, normally rapid growth, and early embryonic nuclear positioning; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, C53H9.2's protein products may function in translation as well, an inference supported by the observed role of LSG1 in cytoplasmic 60S ribosomal subunit biogenesis.
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cup-2 | F25D7.1 | WBGene00000843 |
The primary phenotype of cup-2 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes.
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dylt-1 | F13G3.4 | WBGene00008764 |
dylt-1 encodes a putative dynein light chain subunit that inhibits DHC-1 in vivo, but is otherwise dispensable for viability; DYLT-1 is paralogous to DYLT-3, and orthologous to human DYNLT1 and DYNLT3 (OMIM: 300302); dylt-1(RNAi) and dylt-1(ok417) both suppress the lethality of conditional dhc-1 mutations, and dylt-1(RNAi) suppresses dhc-1(or195) spindle length and cytokinesis defects as well, indicating that DYLT-1 negatively regulates dynein; in oocytes and early embryos, DYLT-1 is associated with nuclear envelopes and centrosomes, and with meiotic and mitotic spindle poles; like DHC-1 itself, DYLT-1 is strongly mislocalized to centrosomes in dhc-1(or195) animals shifted to nonpermissive temperature.
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elpc-4 | C26B2.6 | WBGene00016128 | View | |
F15C11.2 | F15C11.2 | WBGene00008852 | View | |
F30A10.6 | F30A10.6 | WBGene00009264 | View | |
F45G2.4 | F45G2.4 | WBGene00009732 |
F45G2.4 encodes an epsilon subunit of the coatomer (COPI) complex; in mass RNAi assays, F45G2.4 is required for larval viability, proper locomotion, and properly rapid growth.
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F56D2.6 | F56D2.6 | WBGene00018967 |
The F56D2.6 gene encodes a DEAH helicase orthologous to the Drosophila CG11107, the human DDX15, and the S. cerevisiae PRP43 proteins.
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farl-11 | F10E7.8 | WBGene00017349 |
F10E7.8 encodes a FAR11-like protein that inhibits DHC-1 in vivo; F10E7.8 is orthologous to human FAM40A and FAM40B, and to budding yeast FAR11; F10E7.8(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that F10E7.8 negatively regulates dynein; in early embryos, F10E7.8 is a pronuclear and nuclear protein; F10E7.8 has no obvious function in mass RNAi assays.
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fkb-6 | F31D4.3 | WBGene00001431 |
fkb-6 encodes a peptidyl-prolyl cis-trans isomerase that is most closely related to mammalian FK506-binding protein 4; loss of fkb-6 activity via large-scale RNAi screens indicates that fkb-6 is required fro embryonic and vulval development.
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frs-1 | T08B2.9 | WBGene00001497 |
frs-1 encodes a predicted phenylalanyl-t-RNA synthetase.
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H43I07.2 | H43I07.2 | WBGene00019275 | View | |
K02B12.3 | K02B12.3 | WBGene00010496 | View | |
K10C8.3 | K10C8.3 | WBGene00010736 | View | |
klp-12 | T01G1.1 | WBGene00002223 | View | |
M01F1.3 | M01F1.3 | WBGene00010809 | View | |
puf-12 | ZK945.3 | WBGene00014165 | View | |
R05D11.5 | R05D11.5 | WBGene00011033 | View | |
R186.3 | R186.3 | WBGene00011306 | View | |
rnf-5 | C16C10.7 | WBGene00004381 |
This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein.
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stc-1 | F54C9.2 | WBGene00006059 | View | |
tsfm-1 | F55C5.5 | WBGene00010094 |
F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline.
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ubc-14 | Y87G2A.9 | WBGene00006709 |
ubc-14 encodes an E2 ubiquitin-conjugating enzyme; by homology, UBC-14 is predicted to function in the covalent attachment of ubiquitin molecules to protein substrates, via its association with an E3 ubiquitin-protein ligase; loss of ubc-14 activity via RNAi results in embryonic lethality at a stage after gastrulation but prior to muscle twitching, and in abnormal larval tail morphology.
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ubh-4 | C08B11.7 | WBGene00006724 | View | |
xbx-6 | F40F9.1 | WBGene00009580 | View | |
Y54H5A.1 | Y54H5A.1 | WBGene00021899 | View | |
Y71H2AR.1 | Y71H2AR.1 | WBGene00022188 | View | |
Y74C10AL.2 | Y74C10AL.2 | WBGene00022280 | View | |
Y97E10AL.3 | Y97E10AL.3 | WBGene00022394 | View | |
ZK265.9 | ZK265.9 | WBGene00044094 |
ZK265.9 encodes an ortholog of FIT1 and FIT2, membrane proteins of the endoplasmic reticulum that both induce, and are require for, lipid droplet accumulation; more distantly, ZK265.9 is orthologous to budding yeast Scs3p and Yft2p; ZK265.9 has no obvious function in mass RNAi assays.
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