Module
- Number
- 52
- Regulatory Genes
- 4
- Module Genes
- 28
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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eya-1 | C49A1.4 | WBGene00001377 | 927 |
eya-1 encodes a protein orthologous to the Eyes absent/Eya Drosophila protein which is involved in eye development and has protein tyrosine phosphatase ; RNA interference and mutant studies indicate that eya-1 is involved in embryonic and larval tissue morphogenesis as well as larval viability; eya-1 mutants show increased embryonic cell deaths due to activation of the cell death pathway; eya-1 functions redundantly with vab-3/eyeless to control larval viability and anterior body morphogenesis; GFP studies show that eya-1 is expressed in a subset of nuclei during embryonic morphogenesis; the human genes EYA1 and EYA4, when mutated, lead to disease syndromes.
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alr-1 | R08B4.2 | WBGene00044330 | 206 | View | |
tag-347 | C25G4.4 | WBGene00007732 | 172 | View | |
ast-1 | T08H4.3 | WBGene00020368 | 169 |
ast-1 encodes a novel ETS-box transcription factor; AST-1 is required for the proper navigation of some interneuron axons to their targets, for differentiation of the ventral cord pioneer neuron AVG, and for pharyngeal morphogenesis; AST-1 is transiently expressed in many head neurons late in their differentiation and axon outgrowth, and in a few pharyngeal cells; AST-1 is at first nuclear, but then relocates to spots in cell bodies and even neuronal processes; hypomorphic ast-1 mutants have axons extending laterally, and crossing over from the right axon tract to the left axon bundle; null ast-1(hd92) mutants are inviable, failing to attach a working pharynx to their cuticle during development and then starving as L1 larvae; behaviorally, hypomorphic ast-1 animals are at least superficially normal, indicating that the ventral nerve cord can tolerate at least some miswiring; AST-1 regulates odr-2 expression, while ast-1 expression is itself regulated by lin-11.
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CLR Predictions
92 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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ags-3 | F32A6.4 | WBGene00000092 |
ags-3 encodes an ortholog of mammalian AGS3, a receptor independent activator of G protein signalling, and of Drosophila RAPSYNOID; AGS-3 proteins have four GoLoco motifs; AGS-3 is involved in polarity and spindle orientation during early embryogenesis; a region of AGS-3 encompassing three GoLoco motifs specifically binds GOA-1 in yeast two-hybrid assays; AGS-3 is expressed in all muscles, intestine, and weakly in some head and ventral nerve cord neurons, with subcellular localization in strong dots.
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atf-6 | F45E6.2 | WBGene00000222 |
atf-6 is an ortholog of mammalian ATF6alpha, a proximal sensor required for the unfolded protein response (UPR) in the endoplasmic reticulum (ER); ATF6alpha is a transmembrane protein, with a bZIP transcription factor domain in its cytosolic amino terminus that is released and activated by proteolytic cleavage upon ER stress; either ire-1 or xbp-1 deletions are synthetically lethal with atf-6 or pek-1 deletions, producing arrest in L2 larvae; RNAi of Y56A3A.2 (a S2P protease homolog) is synthetically lethal with ire-1(RNAi), consistent with the hypothesis that Y56A3A.2 cleaves ATF-6; atf-6 regulates few genes that are transcriptionally induced by UPR, but regulates roughly one-quarter of genes that require UPR constitutively; pdr-1 transcripts are strongly upregulated in a atf-6(ok551) mutant background, but atf-6(ok551);pdr-1(lg103) double mutants have a grossly normal phenotype ; atf-6 is dispensable for proper localization of GLR-1 glutamate receptors.
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C17G1.4 | C17G1.4 | WBGene00007651 | View | |
C26B9.1 | C26B9.1 | WBGene00016131 | View | |
C34F6.9 | C34F6.9 | WBGene00007943 | View | |
C56G2.4 | C56G2.4 | WBGene00016979 | View | |
cbp-1 | R10E11.1 | WBGene00000366 |
cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates.
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dpy-22 | F47A4.2 | WBGene00001081 |
dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression.
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dsh-1 | C34F11.9 | WBGene00001101 |
dsh-1 encodes a homolog of Drosophila DISHEVELED and a paralog of MIG-5 (and DSH-2); DSH-1 appears to be required for Wnt-induced endoderm specification in the EMS blastomere, and may influence HSN migration as well.
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F17H10.3 | F17H10.3 | WBGene00008927 | View | |
F34D10.3 | F34D10.3 | WBGene00009373 | View | |
F59F4.3 | F59F4.3 | WBGene00010338 | View | |
gei-8 | C14B9.6 | WBGene00001565 |
gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains; interacts with GEX-3 in yeast two-hybrid assays.
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H01A20.2 | H01A20.2 | WBGene00010347 | View | |
ksr-1 | F13B9.5 | WBGene00002239 | View | |
lin-17 | Y71F9B.5 | WBGene00003006 |
lin-17 encodes one of four C. elegans Frizzled homologs, integral membrane proteins that contain an external cysteine rich domain (CRD) and seven transmembrane domains and that function in a wide variety of species as receptors for Wnt glycoprotein signaling molecules; LIN-17 activity is required for specifying the polarity of a number of asymmetric cell divisions that, in C. elegans, are essential for development of such structures as the vulva, somatic gonad, and tail; LIN-17 is also required for the proper polarity of neuronal migrations along the anterior-posterior axis; genetic interactions indicate that LIN-17 likely functions as a receptor for several different Wnt molecules, including LIN-44 and EGL-20, and that in specifying cell fates, the LIN-17-mediated signaling pathway often functions redundantly with other signaling pathways, including the RTK/Ras pathway; a LIN-17 translational reporter fusion shows membrane-associated expression in all of the Pn.pxx vulval precursor cells, in the descendants of V6 and T in males, in the P11.p and B cells, as well as their daughters, and granddaughters, and weakly in P10.p and its daughters; the reporter fusion does not reveal expression in P7.p, Z1, Z4, and T
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lsy-12 | R07B5.9 | WBGene00045419 |
lsy-12 is maternally required for developmental differentiation of ASEL neurons from ASERs, with lsy-12 mutants having double ASERs and no ASELs; lsy-12 is also zygotically required for normal vulval development, locomotion, egg-laying, fecundity, health, and viability of gravid hermaphrodites; lsy-12(ot171) hermaphrodites bag prematurely, are sickly, and have mildly protruding vulvae, while other lsy-12 mutants display egg-laying defects, protruding vulvae, or low brood sizes; on the basis of its phenotype, lsy-12 is expected to act in concert with CEH-36, DIE-1, LIN-49, LSY-2, and lsy-6 during the lateral specification of ASER/ASEL.
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mml-1 | T20B12.6 | WBGene00003378 |
mml-1 encodes, by alternative splicing, two isoforms of a bHLH-ZIP protein orthologous to human MLX (OMIM:602976), MLXIP (OMIM:608090), and MLXIPL (OMIM:605678, deleted in Williams-Beuren syndrome); MML-1 has five N-terminal Mondo Conserved Regions, an N-terminal nuclear localization sequence, and a C-terminal bHLHZip domain; with MXL-2, MML-1 is probably required for normal migration of ray 1 precursor cells in the male tail and for proper epidermal expression of extracellular matrix component genes; MML-1 is expressed in epidermal cells from 50-100 cell embryos onward, and in intestinal cells at the 4E stage, until adulthood; MML-1 requires MXL-2 for protein stability; MML-1 binds MXL-2 but not MXL-1 in two-hybrid assays; either coexpressed MML-1/MXL-2 or MML-1 alone can activate transcription via CACGTG E-boxes.
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R08B4.3 | R08B4.3 | WBGene00011139 | View | |
sym-4 | R03E1.1 | WBGene00006369 |
sym-4 encodes a large (1,043-residue) protein that is required for viability in a mec-8 mutant background, and is also required by itself for normally rapid growth and locomotion; SYM-4 is orthologous to human WDR44, and has a nondescript N-terminal domain, with a C-terminal domain containing seven WD repeats; SYM-4 is broadly expressed, in larval and adult pharynx, digestive tract, neurons, vulva, body wall muscle, and coelomocytes; sym-4 is synthetically lethal with mec-8, with double mutants showing an abnormally buccal cavity between the anterior end of the embryo and the internal anterior end of the pharyngeal primordium; mec-8;sym-4 embryos arrest development at hatching, are unable to eat, and thus die; SYM-4 may function in concert with SYM-3, since sym-3 mutants have the same synthetic lethal phenotype as sym-4.
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T22C8.3 | T22C8.3 | WBGene00011924 | View | |
tag-172 | E02H4.3 | WBGene00006517 | View | |
tbc-11 | F35H12.2 | WBGene00018075 |
F35H12.2 encodes, by alternative splicing, two isoforms of a putative Rab GTPase activator containing a TBC domain; F35H12.2 is orthologous to human RABGAP1 and RABGAP1L (OMIM:609238), and to budding yeast GYP5; F35H12.2 is paralogous to human TBC1D1 (OMIM:609850; variant in obesity) and TBC1D4/AS160; F35H12.2 is expressed very widely (in both larval and adult digestive, reproductive, and nervous systems, along with larval renal gland cells and distal tip cell); despite its wide expression and evolutionary conservation, F35H12.2 has no obvious function in either mass or targeted RNAi assays.
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vav-1 | C35B8.2 | WBGene00006887 |
vav-1 encodes an ortholog of the Vav proto-oncogene, a complex protein with several domains, from N- to C-terminus: a calponin-like actin-binding domain; a RhoGEF/DH domain; a pleckstrin-like domain; a SH2 motif domain; and an SH3 domain.
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Y105C5A.14 | Y105C5A.14 | WBGene00013638 | View | |
Y105E8B.7 | Y105E8B.7 | WBGene00013692 | View | |
Y113G7B.11 | Y113G7B.11 | WBGene00013761 | View | |
ztf-13 | F52E4.8 | WBGene00018704 | View |