Module
- Number
- 26
- Regulatory Genes
- 5
- Module Genes
- 145
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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Y62E10A.14 | Y62E10A.14 | WBGene00013380 | 835 | View | |
tag-233 | D2021.2 | WBGene00044071 | 222 | View | |
cey-2 | F46F11.2 | WBGene00000473 | 214 |
cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; CEY-2 associates with CGH-1 and CEY-3/4 in cytoplasmic particles of the gonad and early embryo; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
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ZK546.5 | ZK546.5 | WBGene00022762 | 133 | View | |
C04F5.9 | C04F5.9 | WBGene00015451 | 131 | View |
CLR Predictions
114 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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acl-9 | ZK40.1 | WBGene00022646 | View | |
atf-7 | C07G2.2 | WBGene00000223 | View | |
B0001.4 | B0001.4 | WBGene00007089 | View | |
B0024.13 | B0024.13 | WBGene00007102 | View | |
B0035.12 | B0035.12 | WBGene00007111 | View | |
B0035.5 | B0035.5 | WBGene00007108 |
B0035.5 is orthologous to the human gene GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD; OMIM:305900), which when mutated leads to disease.
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B0280.3 | B0280.3 | WBGene00015101 | View | |
B0303.15 | B0303.15 | WBGene00015133 | View | |
B0334.4 | B0334.4 | WBGene00007144 | View | |
bre-3 | B0464.4 | WBGene00000268 |
bre-3 encodes a protein similar to beta-glycosyltransferases from bacteria that is required for the toxicity of Bacillus thuringiensis Cry5B; BRE-3 may act in a pathway with bre-5 and is expressed and functions in the gut epithelium.
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C05D11.10 | C05D11.10 | WBGene00015487 | View | |
C08B11.8 | C08B11.8 | WBGene00007435 | View | |
C08B6.8 | C08B6.8 | WBGene00007429 | View | |
C16C2.4 | C16C2.4 | WBGene00007621 | View | |
C18A3.3 | C18A3.3 | WBGene00015941 | View | |
C18E3.9 | C18E3.9 | WBGene00015976 | View | |
C23H3.5 | C23H3.5 | WBGene00016021 | View | |
C24D10.4 | C24D10.4 | WBGene00016055 | View | |
C24F3.4 | C24F3.4 | WBGene00007698 | View | |
C25A1.5 | C25A1.5 | WBGene00007707 | View | |
C30H6.9 | C30H6.9 | WBGene00007826 | View | |
C32D5.11 | C32D5.11 | WBGene00016318 | View | |
C32D5.3 | C32D5.3 | WBGene00016311 |
C32D5.3 encodes an ortholog of ROLLING BLACKOUT (RBO; also called CMP44E or STAMPHA), a eukaryotic protein required for sustained phospholipase C activity during Drosophila phototransduction; RBO homologs have two predicted transmembrane helices, are significantly similar to several acylglycerol lipases, and share motifs characteristic of carboxyesterases and lipases.
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C33H5.18 | C33H5.18 | WBGene00016384 |
C33H5.18 encodes a CDP-diglyceride synthetase ortholog required for locomotion and osmoregulation; given its biochemical function in other organisms, C33H5.18 is expected to catalyse synthesis of cytidine diphosphate-diacylglycerol (CDP-DAG), an activated precursor for anionic and zwitterionic phospholipids, and is likely to regulate phosphatidylinositol lipid signalling; one might expect loss of C33H5.18 function to be lethal, but its deficiency may be supplemented by lipids in food.
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C34B7.2 | C34B7.2 | WBGene00007912 | View | |
C34D4.4 | C34D4.4 | WBGene00016400 | View | |
C42C1.11 | C42C1.11 | WBGene00016589 | View | |
C42C1.12 | C42C1.12 | WBGene00016590 | View | |
C43G2.1 | C43G2.1 | WBGene00016610 | View | |
C47E12.2 | C47E12.2 | WBGene00008147 | View | |
C48A7.2 | C48A7.2 | WBGene00016739 | View | |
C48E7.2 | C48E7.2 | WBGene00016750 | View | |
C50F4.14 | C50F4.14 | WBGene00008237 |
The C50F4.14 gene encodes a putative GDP-fucose transporter orthologous to the human GDP-FUCOSE TRANSPORTER 1 gene (LAD II; OMIM:605881), which when mutated leads to congenital disorder of glycosylation, type IIc.
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C50F4.16 | C50F4.16 | WBGene00008238 |
The C50F4.16 gene encodes a NUDIX hydrolase.
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cchl-1 | T06D8.6 | WBGene00011527 | View | |
cdc-42 | R07G3.1 | WBGene00000390 |
cdc-42 encodes a RHO GTPase which controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins; CDC-42 is expressed at hypodermal cell boundaries; cdc-42 expression levels are unusually stable, with relatively little variation between adults, dauers, and L3 larvae, or between wild-type and daf-2(e1370ts) or daf-16(m26) mutant adults.
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clp-1 | C06G4.2 | WBGene00000542 |
clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
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crml-1 | K07G5.1 | WBGene00010641 | View | |
cutc-1 | ZK353.7 | WBGene00022702 | View | |
dhs-1 | C01G8.3 | WBGene00000965 | View | |
ebp-2 | VW02B12L.3 | WBGene00012156 |
ebp-2 encodes an RP/EB-type microtubule-binding protein orthologous to human MAPRE1 (OMIM:603108), MAPRE2 (OMIM:605789), MAPRE3 (OMIM:605788), and paralogous to EBP-1/-3; EBP-2 binds the plus ends of growing microtubules, but is dispensable for embryonic viability and for any obvious function in mass RNAi assays; by orthology, the N-terminal calponin homology domain of EBP-2 is predicted to bind microtubules (MTs), while the C-terminal region of EBP-2 is predicted to contain a dimerization domain and a site for binding protein ligands that activate EBP-2's MT-binding; ebp-2(RNAi) animals have no obvious phenotypes, perhaps because of genetic redundancy with ebp-1 and ebp-3.
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edc-3 | R05D11.8 | WBGene00011036 | View | |
EEED8.10 | EEED8.10 | WBGene00017138 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
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efa-6 | Y55D9A.1 | WBGene00013223 |
efa-6 encodes a putative guanine nucleotide exchange factor that inhibits DHC-1 in vivo; EFA-6's human orthologs are the pleckstrin and Sec7 domain proteins PSD/TYL/cytohesin-1 (OMIM:602327), PSD2, PSD3, and PSD4; efa-6(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that EFA-6 negatively regulates dynein; EFA-6 is localized to nonpolarized cell cortex in oocytes and early one-cell zygotes, to anterior cell cortex in one-cell embryos after pseudocleavage, and to the interface of AB and P1 blastomeres, subsequently disappearing in four-cell embryos; EFA-6 has a central Sec7 domain predicted to activate guanine-nucleotide exchange in ARF1, and a C-terminal pleckstrin-homology domain predicted to activate the Sec7 domain when binding phosphatidylinositol.
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exos-3 | F59C6.4 | WBGene00010325 | View | |
F08F8.7 | F08F8.7 | WBGene00017272 | View | |
F09E5.7 | F09E5.7 | WBGene00017285 | View | |
F11A10.5 | F11A10.5 | WBGene00008686 | View | |
F13H10.4 | F13H10.4 | WBGene00008775 |
F13H10.4 is orthologous to the human gene A-GLUCOSIDASE I (GCS1; OMIM:601336), which when mutated leads to disease.
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F14B4.3 | F14B4.3 | WBGene00008781 | View | |
F30A10.3 | F30A10.3 | WBGene00009262 | View | |
F33A8.4 | F33A8.4 | WBGene00009352 | View | |
F33D4.4 | F33D4.4 | WBGene00017996 | View | |
F35G2.1 | F35G2.1 | WBGene00009435 | View | |
F36D4.2 | F36D4.2 | WBGene00018088 | View | |
F46B6.5 | F46B6.5 | WBGene00009770 | View | |
F46F11.6 | F46F11.6 | WBGene00018509 | View | |
F56A11.5 | F56A11.5 | WBGene00018925 | View | |
frm-4 | C24A11.8 | WBGene00001491 |
frm-4 encodes a predicted transmembrane protein that contains an N-terminal FERM (Band 4.1-ezrin-radixin-moesin) domain; by homology, FRM-4 is predicted to function as a membrane-cytoskeleton linker protein that plays a role in cell adhesion, migration, or organization of cell surface structures; however, as loss of frm-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of FRM-4 in C. elegans development and/or behavior is not yet known.
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fut-3 | F59E12.13 | WBGene00006402 | View | |
fzo-1 | ZK1248.14 | WBGene00001509 | View | |
gfi-2 | K02A11.1 | WBGene00001582 | View | |
gly-10 | Y45F10D.3 | WBGene00001635 | View | |
gsy-1 | Y46G5A.31 | WBGene00001793 |
gsy-1 is orthologous to the human gene GLYCOGEN SYNTHASE 1 (GYS1; OMIM:138570); deficiencies of GYS1 may be associated with susceptibility to type 2 diabetes.
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H14A12.3 | H14A12.3 | WBGene00019196 |
H14A12.3 encodes an ortholog of S. cerevisiae RAV2; like RAV2, H14A12.3 may be required for the reassociation of vacuolar proton-translocating ATPase (V-ATPase) after temporary glucose starvation.
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H19N07.4 | H19N07.4 | WBGene00010408 |
H19N07.4 encodes an integral membrane protein with acyl-CoA:diacylglycerol o-acyltransferase activity when expressed in yeast; H19N07.4 belongs to the MBOAT protein family, whose biochemically characterized members transfer fatty acids or acetate to membrane-associated hydroxyl-bearing substrates such as cholesterol, diacylglycerol, long-chain alcohols, or alginate; MBOAT proteins include MOM-1 and its Drosophila homolog PORCUPINE, involved in Wnt signalling; H19N07.4 has no obvious function in mass RNAi assays.
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H27A22.1 | H27A22.1 | WBGene00010418 | View | |
haf-3 | F57A10.3 | WBGene00001813 |
haf-3 encodes a member of the ABC transporter family with highest similarity to human ABCB10.
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him-17 | T09E8.2 | WBGene00001874 |
him-17 encodes a protein with no obvious non-nematode homologs that localizes to chromatin in germline nuclei, and that is required for double-stranded break (DSB) formation, chiasmata, crossovers, and genetic recombination during meiosis, but is dispensable for homolog pairing and synapsis, spo-11 germline transcription, or the conversion of DSBs into chiasmata; HIM-17 is also required for normal organization of meiotic stages in the germline, and to promote its orderly transistion from (potentially tumorous) mitosis to meiosis; moreover, HIM-17 is required for normal dimethylation of lysine 9 residues on H3 histones in meiotic prophase chromosomes from early pachytene onward, with null him-17(ok424) mutants showing greatly reduced or delayed dimethylation in both hermaphrodite and male germlines; HIM-17 cooperates with GLP-1 to promote meiotic entry, and with EGO-1 to promote germline viability; HIM-17 has six THAP and THAP-like domains, a domain type also found in CDC-14B, CTB-1, GON-14, LIN-15A, LIN-15B, and LIN-36, along with ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1; missense or truncating mutations of HIM-17's THAP and THAP-like domains cause partial loss of function, implying that the domains collectively and partially contribute to HIM-17 activity; of the C. elegans genes encoding THAP or THAP-like domains, at least four (lin-15A, lin-15B, lin-36, and him-17) interact genetically with lin-35/Rb.
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hipr-1 | ZK370.3 | WBGene00022717 | View | |
hrdl-1 | F26E4.11 | WBGene00009164 | View | |
ire-1 | C41C4.4 | WBGene00002147 |
ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis.
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K02B2.3 | K02B2.3 | WBGene00019296 | View | |
K02F3.10 | K02F3.10 | WBGene00019333 | View | |
K04G2.6 | K04G2.6 | WBGene00010565 | View | |
K07C5.2 | K07C5.2 | WBGene00010625 | View | |
K07H8.2 | K07H8.2 | WBGene00019504 |
K07H8.2 encodes, by alternative splicing, three isoforms of an ortholog of human SLC41A1 (OMIM:610801) and bacterial MgtE; like its orthologs, K07H8.2 is predicted to transport Mg(2+) into cells; K07H8.2 is paralogous to ZK185.2 and ZK1053.6; K07H8.2 is expressed in intestine, but has no obvious function in mass RNAi assays.
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K11H12.8 | K11H12.8 | WBGene00019664 | View | |
lap-1 | ZK353.6 | WBGene00002249 |
The lap-1 gene encodes a homolog of the zinc metalloprotease leucine aminopeptidase LAP that is predicted to be mitochondrial.
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lat-1 | B0457.1 | WBGene00002251 |
lat-1 encodes a predicted latrophilin that affects embryonic elongation, pharyngeal development, and reproductive organ formation; apically localized in developing epithelia and localized to presynaptic surfaces in neurons.
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lir-1 | F18A1.3 | WBGene00003044 |
lir-1 encodes a LIN-26-like zinc-finger protein that shares a unique C2H2 motif together with LIR-2, LIR-3, and LIN-26; lir-1 is part of two distinct operons: it is the downstream gene in an operon with lir-2 and the upstream gene in a second, overlapping operon with lin-26; the precise role of lir-1 in C. elegans development and/or behavior is not yet known as neither loss nor gain of lir-1 function appears to result in clear abnormalities and RNAi experiments targeting lir-1 result in embryonic and larval lethality due to loss of lin-26 expression; lir-1 transcripts appear ubiquitous in early embryos, disappear, and then re-appear in later embryonic hypodermal and support cells; during larval development, a lir-1::lacZ fusion that should reflect expression of all transcripts is seen in nearly all cells with the exception of germ cells and post-L1 intestinal cells.
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M05D6.2 | M05D6.2 | WBGene00010875 | View | |
M176.2 | M176.2 | WBGene00010941 |
M176.2 is orthologous to the human gene GLUTATHIONE SYNTHETASE (GSS; OMIM:601002), which when mutated leads to 5-oxoprolinuria, or to GSS deficiency restricted to erythrocytes and associated only with hemolytic anemia.
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mmab-1 | C26E6.11 | WBGene00016144 |
mmab-1 encodes an ortholog of human co(I)balamin adenosyltransferase (MMAB; mutated in methylmalonic aciduria, OMIM:607568); mmab-1 deletion mutants incorporate abnormally low levels of 1-[(14)C]-propionate into proteins; mmab-1 mutants and mmab-1(RNAi) animals excrete abnormally high levels of methylmalonic acid into their culture medium when challenged with propionic acid; these data are consistent with the hypothesis that MMAB-1 participates in the conversion of propionyl-CoA to succinyl-CoA.
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ndx-9 | F13H10.2 | WBGene00003586 |
The ndx-9 gene encodes a member of the NADH pyrophosphatase subfamily of the NUDIX hydrolases.
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nft-1 | Y56A3A.13 | WBGene00003594 |
The nft-1 gene encodes an ortholog of human FHIT, which when mutated is associated with head and neck cancers (OMIM:601153).
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npp-12 | T23H2.1 | WBGene00003798 |
npp-12 encodes Gp210, an evolutionarily conserved membrane protein of the nuclear pore complex (NPC); NPP-12 is required for embryonic viability and normal nuclear membrane structures.
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num-1 | T03D8.1 | WBGene00003830 |
num-1 encodes two isoforms of an ortholog of Drosophila NUMB that inhibits endocytotic recycling and antagonizes RME-1 in vivo; NUM-1 is required for recycling (but not internalization) of a transmembrane endocytosis marker (RME-1??); num-1(bc365) null mutants, while mostly normal, no longer require RME-1 in endocytotic recycling; NUM-1A is localized to the basolateral surfaces of most polarized epithelial cells, such as those in hypodermis and intestine; NUM-1A and -1C isoforms are expressed in many somatic cells in all stages of development, with notable expression in the embryonic intestinal primordium and differentiating epithelia, and (later, through larval to adult stages) in intestine, pharynx, hypodermis, seam cells, coelomocytes, spermatheca, uterus, and head neurons; NUM-1A and -1C are expressed in nuclei, cytoplasmic granules, and cell membranes, being notably concentrated at cell peripheries at lateral cell-cell junctions in early embryos; NUM-1A and -1C are localized to the cell periphery by highly basic N-terminal domains with predicted phosphorylation sites; NUM-1A and -1C isoforms bind PKC-3 via their PTB domains in two-hybrid assays, and may serve as PKC-3 adaptors in vivo.
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pct-1 | C07G1.3 | WBGene00003961 | View | |
pdhk-2 | ZK370.5 | WBGene00022719 | View | |
pisy-1 | Y46G5A.5 | WBGene00012897 | View | |
pps-1 | T14G10.1 | WBGene00004091 |
pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia).
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prx-14 | R07H5.1 | WBGene00004199 | View | |
R08C7.2 | R08C7.2 | WBGene00019946 | View | |
R11A8.5 | R11A8.5 | WBGene00011239 | View | |
R12C12.6 | R12C12.6 | WBGene00020026 | View | |
R12C12.7 | R12C12.7 | WBGene00020027 | View | |
R12E2.2 | R12E2.2 | WBGene00020031 | View | |
rad-51 | Y43C5A.6 | WBGene00004297 |
rad-51 encodes two isoforms of a protein orthologous to S. cerevisiae Rad51p and Dmc1p, and to E. coli RecA, and paralogous to C30A5.2; RAD-51 proteins are probably required for meiotic recombination; while dispensable for viability and meiotic synapsis, RAD-51A/B are required for normal chromosomal morphology, univalent formation, dissociation of chiasmata, hyperresistance of meiotic pachytene nuclei to X-irradiation, and the progress of oocytes through diakinesis; RAD-51A/B require CHK-2, MRE-11, and SPO-11 to localize to foci in late zygotene/early pachytene nuclei, and genetically acts downstream of CHK-2 and SPO-11; RAD-51A/B foci later disappear from homologously synapsed chromosomes.
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rnp-1 | ZK863.7 | WBGene00004384 | View | |
sel-13 | T04A8.10 | WBGene00011411 | View | |
sms-1 | H21P03.3 | WBGene00004892 | View | |
spd-5 | F56A3.4 | WBGene00004955 | View | |
sqv-5 | T24D1.1 | WBGene00005023 |
sqv-5 encodes a chondroitin synthase that both initiates and elongates chondroitin chains (unlike human chondroitin synthase, which only elongates them); SQV-5 is required for cytokinesis (e.g., at the one-cell embryo stage), gonad migration, and vulval morphogenesis (by expanding the extracellular space of the vulva in L4 larvae); the common requirement for SQV-5 in both processes may be to promote filling an extracellular space with fluid (either in the eggshell, or underneath the L4 cuticle); SQV-5 colocalizes with SQV-1 at punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes; SQV-5 is most similar to human chondroitin synthase (KIAA0990) and Drosophila CG9220.
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sqv-7 | C52E12.3 | WBGene00005025 |
The sqv-7 gene encodes a nucleotide-sugar transporter of the Golgi membrane, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-7 promotes glycosaminoglycan biosynthesis by translocating UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose into the lumen of the Golgi apparatus; SQV-7 is biochemically active when transgenically expressed in yeast or mammalian Golgi membranes; the common requirement for SQV-7 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
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srgp-1 | F12F6.5 | WBGene00006406 | View | |
stam-1 | C34G6.7 | WBGene00004109 |
pqn-19 encodes, by alternative splicing, two isoforms of a putative Janus kinase substrate ('signal-transducing adaptor molecule') that is required for maintaining meiotic arrest and for acetylcholine neurotransmission; PQN-19 is located in puncta of the DA motor neurons; PQN-19 is required in the germline for arrested oocytes to continue responding to an inhibitory signal from somatic gonadal sheath cells, before the oocytes have been induced by major sperm protein (MSP) to exit meiotic prophase; PQN-19 has an N-terminal VSH domain, a central ubiquitin-interacting motif and SH3 domain, and a C-terminal glutamine/asparagine (Q/N)-rich domain; PQN-19 is orthologous to human STAM (OMIM:601899) and STAM2 (OMIM:606244).
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T03F1.1 | T03F1.1 | WBGene00020184 | View | |
T03F1.8 | T03F1.8 | WBGene00020190 | View | |
T05G5.5 | T05G5.5 | WBGene00011500 | View | |
T05H10.7 | T05H10.7 | WBGene00011511 | View | |
T06D8.5 | T06D8.5 | WBGene00011526 | View | |
T09F3.2 | T09F3.2 | WBGene00011662 | View | |
T12G3.4 | T12G3.4 | WBGene00011739 | View | |
T22D1.3 | T22D1.3 | WBGene00020682 | View | |
T23B12.4 | T23B12.4 | WBGene00020719 | View | |
T25G3.3 | T25G3.3 | WBGene00012030 |
T25G3.3 encodes an ortholog of S. cerevisiae NMD3; by orthology, T25G3.3 is predicted to help export large ribosomal subunits from the nucleus to IMB-4; T25G3.3 transcripts are enriched during oogenesis, and T25G3.3 is predicted to be coexpressed in an operon with chs-1; however, there is no obvious connection between T25G3.3 and CHS-1 function, so their coexpression may simply reflect their both being required for oogenesis; T25G3.3 is required for viability, growth, and fertility in mass RNAi assays.
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T26A5.4 | T26A5.4 | WBGene00020820 | View | |
T26C12.1 | T26C12.1 | WBGene00020831 | View | |
T28D6.6 | T28D6.6 | WBGene00012126 | View | |
tag-114 | F23B12.6 | WBGene00006465 | View | |
tag-131 | H38K22.3 | WBGene00006478 | View | |
tag-165 | C01G6.6 | WBGene00006510 |
C01G6.6 encodes an ortholog of the human gene METHIONINE SYNTHASE REDUCTASE (MTRR), which when mutated leads to homocystinuria (OMIM:236270)
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uaf-1 | Y92C3B.2 | WBGene00006697 |
uaf-1 encodes the large subunit of U2AF, the U2 small nuclear ribonucleoparticle (snRNP) auxiliary factor and is a homolog of mammalian and fly U2AF65; UAF-1 has been shown to bind RNA and this binding is enhanced by UAF-2; the abundance of one alternative transcript appears to be increased during starvation and this transcript is retained in the nucleus; uaf-1 affects embryonic viability, based on RNAi analysis.
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unc-76 | C01G10.11 | WBGene00006808 |
unc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies.
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vpr-1 | F33D11.11 | WBGene00018008 |
vpr-1 encodes the C. elegans VAP (VAMP-associated protein) ortholog, a transmembrane protein containing an N-terminal extracellular major sperm protein (MSP) domain; loss of vpr-1 function during development indicates that vpr-1 is required, both in vab-1-dependent and vab-1-independent pathways, for proper distal tip cell migration during somatic gonad development, ventral hypodermal cell migrations during embryonic enclosure, and anteriorly directed amphid neuron migration; like C. elegans MSPs, injection of the VPR-1 MSP domain into fog-2 females induces oocyte maturation and gonadal sheath cell contraction; the VPR-1 MSP domain directly binds the VAB-1/Ephrin receptor extracellular domain in vitro and in vivo, binds the oocyte and gonadal sheath cell plasma membranes.
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W01D2.5 | W01D2.5 | WBGene00012182 | View | |
W02D3.4 | W02D3.4 | WBGene00020933 | View | |
xpo-3 | C49H3.10 | WBGene00002080 |
imb-6 encodes an importin-beta-like protein orthologous to vertebrate Exportin-t, a specific mediator of tRNA export from the nucleus; IMB-6 is predicted to function by binding tRNAs directly in the presence of the RAN-1 GTPase and facilitating their nucleocytoplasmic transport; in C. elegans, loss of imb-6 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
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Y106G6H.5 | Y106G6H.5 | WBGene00013718 |
The Y106G6H.5 gene encodes a homolog of the human gene SARDH, which when mutated leads to sarcosinemia, (OMIM:268900).
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Y106G6H.8 | Y106G6H.8 | WBGene00013720 | View | |
Y111B2A.20 | Y111B2A.20 | WBGene00013740 | View | |
Y17G9B.5 | Y17G9B.5 | WBGene00021202 | View | |
Y18D10A.16 | Y18D10A.16 | WBGene00012483 | View | |
Y32H12A.4 | Y32H12A.4 | WBGene00021312 |
Y32H12A.4 encodes an ortholog of various protein phosphatase 1 (PP1) regulatory (inhibitor) subunit 2 proteins; the phosphatase inhibitory activity of recombinant Y32H12A.4 protein has been validated in vitro, with an IC50 of 5 nM versus purified PP1 catalytic subunit; Y32H12A.4 has anomalously low mobility in SDS-PAGE, consistent with the hypothesis that it (like its orthologs) is a naturally disordered protein that uses native flexibility to bind its substrates; Y32H12A.4 is efficiently phosphorylated in vitro by casein kinase II or CDC2/cyclinB, but not by glycogen synthase kinase-3; Y32H12A.4 is required for embryonic development in mass RNAi assays.
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Y39E4A.3 | Y39E4A.3 | WBGene00012713 |
Y39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial.
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Y47G6A.22 | Y47G6A.22 | WBGene00021647 | View | |
Y48B6A.12 | Y48B6A.12 | WBGene00012983 | View | |
Y48G10A.1 | Y48G10A.1 | WBGene00013018 | View | |
Y56A3A.22 | Y56A3A.22 | WBGene00013239 | View | |
Y57A10A.16 | Y57A10A.16 | WBGene00013259 | View | |
Y71F9B.2 | Y71F9B.2 | WBGene00022126 | View | |
ZK1098.7 | ZK1098.7 | WBGene00014224 | View | |
ZK673.2 | ZK673.2 | WBGene00014058 | View | |
ZK973.3 | ZK973.3 | WBGene00022832 | View |