Module
- Number
- 70
- Regulatory Genes
- 6
- Module Genes
- 21
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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F45C12.15 | F45C12.15 | WBGene00018446 | 883 | View | |
gpa-17 | Y71H2B.7 | WBGene00022196 | 225 |
gpa-17 encodes a divergent Gq alpha subunit paralogous to EGL-30; gpa-17 is reported to be expressed in intestine, but has no known function in vivo.
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ZC204.12 | ZC204.12 | WBGene00022562 | 176 | View | |
nhr-107 | C33G8.11 | WBGene00003697 | 171 |
nhr-107 encodes a member of the nuclear hormone receptor family.
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zip-3 | W07G1.3 | WBGene00012330 | 155 |
zip-3 encodes a bZip transcription factor.
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Y43C5A.2 | Y43C5A.2 | WBGene00012782 | 133 | View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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bas-1 | C05D2.4 | WBGene00000239 |
bas-1 encodes a serotonin- and dopamine-synthetic aromatic amino acid decarboxylase (AAADC) that is required for the synthesis of serotonin from 5-hydroxytryptophan in vivo; mutations of bas-1 impair the turning step in male mating, the migration of AVM, SDQR, ALM, and BDU neurons during development.
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bre-1 | C53B4.7 | WBGene00000266 |
bre-1 is required for Cry5B toxicity.
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C12C8.2 | C12C8.2 | WBGene00007533 |
C12C8.2 encodes a putative cystathionine gamma-lyase orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), and paralogous to F22B8.6 and ZK1127.10; C12C8.2 has no obvious function in mass RNAi assays, and (unlike its paralog ZK1127.10) does not inhibit DHC-1 in vivo.
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C25E10.12 | C25E10.12 | WBGene00016101 | View | |
C54E4.5 | C54E4.5 | WBGene00016920 | View | |
F17C11.12 | F17C11.12 | WBGene00008923 | View | |
F36G3.1 | F36G3.1 | WBGene00009482 | View | |
F40F9.5 | F40F9.5 | WBGene00009582 | View | |
hex-2 | C14C11.3 | WBGene00015767 |
hex-2 encodes a beta-N-acetylhexosaminidase.
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ilys-4 | C55F2.2 | WBGene00016958 | View | |
inx-17 | R12E2.4 | WBGene00002139 | View | |
K02A11.3 | K02A11.3 | WBGene00010488 | View | |
K02E2.6 | K02E2.6 | WBGene00010507 | View | |
K04A8.1 | K04A8.1 | WBGene00019373 | View | |
nlp-12 | M01D7.5 | WBGene00003750 |
nlp-12 encodes two predicted neuropeptide-like proteins; nlp-12 is part of a LQFamide neuropeptide family that has members in at least one other nematode species; nlp-12 is expressed in one tail neuron; as loss of nlp-12 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of nlp-12-encoded peptides in development and/or behavior is not yet known.
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phy-2 | F35G2.4 | WBGene00004025 | View | |
R07B7.5 | R07B7.5 | WBGene00011089 | View | |
T28D9.3 | T28D9.3 | WBGene00020895 | View | |
unc-64 | F56A8.7 | WBGene00006798 |
unc-64 encodes syntaxin, an plasma membrane receptor for intracellular vesicles that is orthologous to vertebrate syntaxin 1A (OMIM:186590) and Drosophila Syx1A; UNC-64 is required for normal locomotion and possibly also for insulin secretion; as an essential component of the core synaptic vesicle fusion machinery, UNC-64 interacts with UNC-13, a diacylglycerol-binding protein, and SNB-1/synaptobrevin; UNC-64 protein levels are reduced in an unc-18 mutant background; unc-64 mutations can be suppressed by mutations in slo-1, a calcium-activated potassium channel; UNC-64 is expressed ubiquitously in the nervous system and in secretory cells such as the uv1 cell in the vulva and excretory gland cells.
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unc-95 | Y105E8A.6 | WBGene00006824 |
unc-95 encodes a LIM domain-containing protein related to Drosophila and vertebrate paxillins; UNC-95 is required for locomotion and organization of thick and thin filaments in body wall muscle; by homology, UNC-95 may function as an anchor protein that links signaling and cytoskeletal proteins at focal adhesions; in vitro, UNC-95 interacts with RNF-5, a RING finger protein that may function as an E3 ligase to regulate UNC-95 levels via ubiquitin-mediated degradation; UNC-95 is expressed in body-wall and vulval muscles, and co-localizes with RNF-5 to muscle dense bodies (focal adhesion-like attachment sites).
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W01F3.1 | W01F3.1 | WBGene00012184 | View |