Module
- Number
- 17
- Regulatory Genes
- 5
- Module Genes
- 66
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
nhr-167 | C49F5.4 | WBGene00008208 | 573 | View | |
T22E7.2 | T22E7.2 | WBGene00020694 | 328 | View | |
ZK177.3 | ZK177.3 | WBGene00022671 | 187 | View | |
nhr-158 | C17E7.6 | WBGene00015901 | 159 | View | |
ztf-8 | ZC395.8 | WBGene00022598 | 107 | View |
CLR Predictions
23 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
---|---|---|---|---|
acr-11 | D2092.3 | WBGene00000050 |
A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions.
|
View |
acr-14 | T05C12.2 | WBGene00000053 |
acr-14 encodes a protein that contains neurotransmitter-gated ion-channel ligand-binding and transmembrane domains.
|
View |
asic-2 | T28F4.2 | WBGene00012137 | View | |
B0331.2 | B0331.2 | WBGene00007141 | View | |
bbs-8 | T25F10.5 | WBGene00000244 |
bbs-8 encodes a tetratricopeptide repeat (TPR)-containing protein that is orthologous to the human Bardet-Biedl syndrome protein, BBS8; in C. elegans, bbs-8 activity is required for cilia biogenesis and function; accordingly, bbs-8 mutant animals display odorant chemotaxis defects and exhibit both aberrant motility and abnormal localization of at least two intraflagellar transport (IFT) protein markers; a BBS-8::GFP translational fusion is expressed exclusively in ciliated head and tail neurons, where it localizes predominantly to the base of cilia, known as the ciliary transition zone; BBS-8::GFP is also observed moving bidirectionally (anterograde and retrograde) along the ciliary axoneme; DNA sequences upstream of bbs-8 contain X box DNA binding sites, suggesting that bbs-8 expression may be regulated by the DAF-19 RFX-type transcription factor.
|
View |
C07A4.1 | C07A4.1 | WBGene00007396 | View | |
C07A4.2 | C07A4.2 | WBGene00007397 | View | |
C09G9.3 | C09G9.3 | WBGene00007494 | View | |
C12D5.5 | C12D5.5 | WBGene00015708 | View | |
C13F10.1 | C13F10.1 | WBGene00015741 | View | |
C29F4.3 | C29F4.3 | WBGene00007809 | View | |
C30B5.7 | C30B5.7 | WBGene00016248 | View | |
C48C5.3 | C48C5.3 | WBGene00016748 | View | |
cha-1 | ZC416.8 | WBGene00000481 |
cha-1 is part of a gene complex, in which it shares a common promoter and first (noncoding) exon with unc-17 (and is thus coexpressed with unc-17), but in which the two genes encode mutationally separable functions; cha-1 encodes a choline acetyltransferase that synthesizes acetylcholine, is expressed in neurons, and is required for viability, normal growth, locomotion, and sensitivity to acetylcholinesterase inhibitors.
|
View |
clec-71 | Y46C8AL.4 | WBGene00021582 | View | |
clh-4 | T06F4.2 | WBGene00000531 |
A homolog of a mammalian CIC-type chloride channel that is uniquely expressed in adult worms.
|
View |
dod-20 | B0554.6 | WBGene00015259 | View | |
dop-1 | F15A8.5 | WBGene00001052 |
dop-1 encodes a D1-like dopamine receptor; dop-1 is required cell autonomously in the touch neurons for modulation of mechanosensory behaviors such as tap habituation; in addition, dop-1 is required for regulation of locomotion via antagonism of the DOP-3 D2-like dopamine receptor in cholinergic neurons; when expressed in tissue culture cells, DOP-1 activity is stimulated by dopamine and to a lesser extent, by norepinephrine and epinephrine; when coexpressed with bovine or C. elegans GalphaS, DOP-1 stimulates potassium channel activity; DOP-1 is expressed in several different types of cells including mechanosensory neurons, cholinergic motor neurons, interneurons, excretory gland cells, head muscles, and neuronal support cells; DOP-1 localizes to the plasma membrane; dop-1 expression in the RIS interneuron is regulated by the LIM-6 homeodomain protein.
|
View |
dop-2 | K09G1.4 | WBGene00001053 |
dop-2 is orthologous to the human gene DOPAMINE RECEPTOR D2 (DRD2; OMIM:126450), which when mutated leads to myoclonus-dystonia syndrome.
|
View |
dyf-5 | M04C9.5 | WBGene00001121 |
dyf-5 encodes a putative MAP kinase orthologous to human MAK/ICK (OMIM:154235), Chlamydomonas reinhardtii LF4, and Leishmania mexicana MPK9; DYF-5 negatively regulates cilial length, restricts KAP-1 to middle ciliary segments, is required for normal localization of six IFT components, and is required for OSM-3 to comigrate normally with IFT particles; DYF-5 is also required for dye-filling of amphid and phasmid neurons and for normal chemotaxis, dauer formation, and male mating; DYF-5 is expressed in head neurons (including amphid neurons), tail neurons (including phasmid neurons), CAN cells, excretory canal neurons, posterior lateral ganglion neurons and in many male tail cells; dyf-5 mutant cilia are abnormally elongated, either failing to enter the amphid channel or accumulating IFT proteins at their distal ends, whereas DYF-5 overexpression results in truncated cilia; the dyf-5 promoter region contains an X-box, predicted to be bound and transcriptionally activated by DAF-19, and dyf-5 is regulated by DAF-19 in vivo; dyf-5 animals are slightly shorter than normal.
|
View |
E04A4.6 | E04A4.6 | WBGene00017120 | View | |
F02E8.2 | F02E8.2 | WBGene00017176 | View | |
F12D9.1 | F12D9.1 | WBGene00017400 | View | |
F14F4.1 | F14F4.1 | WBGene00008808 | View | |
F19H6.6 | F19H6.6 | WBGene00008961 | View | |
F25B3.2 | F25B3.2 | WBGene00009099 | View | |
F35D2.4 | F35D2.4 | WBGene00018042 | View | |
F38B6.3 | F38B6.3 | WBGene00018173 | View | |
F40A3.7 | F40A3.7 | WBGene00018222 | View | |
F41E7.3 | F41E7.3 | WBGene00009619 | View | |
F53B7.4 | F53B7.4 | WBGene00009967 | View | |
F59G1.4 | F59G1.4 | WBGene00019128 | View | |
fbxb-14 | W08F4.9 | WBGene00021098 | View | |
gcy-18 | ZK896.8 | WBGene00001543 |
gcy-18 encodes a receptor-type guanylyl cyclase that, along with gcy-8 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-18 functions redundantly with gcy-8 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; in addition, microarray experiments indicate that gcy-18 expression is induced in daf-16(RNAi); daf-2(RNAi) double mutants and repressed in daf-2(RNAi) mutants, suggesting that GCY-18 activity may contribute to a shortened lifespan; consistent with this, loss of gcy-18 activity via RNAi does result in lifespan extension; GCY-18 is expressed exclusively in the AFD thermosensory neurons, where it localizes to sensory endings.
|
View |
gcy-22 | T03D8.5 | WBGene00001547 |
gcy-22 is predicted to encode a guanylate cyclase.
|
View |
ggr-3 | F09C12.1 | WBGene00001588 |
ggr-3 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels; expressed in the AVA, AVB, SMDD, DVA, SIAD, and in some other neurons of the nerve ring.
|
View |
gnrr-1 | F54D7.3 | WBGene00018798 |
F54D7.3 is orthologous to the human gene GONADOTROPIN RELEASING HORMONE RECEPTOR (GNRHR; OMIM:138850), which when mutated leads to disease.
|
View |
gpa-7 | R10H10.5 | WBGene00001669 |
gpa-7 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects egg laying and response to water- soluble odorants; it is expressed in excitable cells.
|
View |
grl-12 | F28A12.2 | WBGene00001721 |
grl-12 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
|
View |
H14N18.4 | H14N18.4 | WBGene00019204 | View | |
H23L24.1 | H23L24.1 | WBGene00019228 | View | |
hlh-4 | T05G5.2 | WBGene00001951 | View | |
K06A4.2 | K06A4.2 | WBGene00010592 | View | |
K09H11.6 | K09H11.6 | WBGene00019603 | View | |
K11E4.3 | K11E4.3 | WBGene00010775 |
The K11E4.3 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease.
|
View |
lgc-46 | Y71D11A.5 | WBGene00022106 | View | |
M01H9.2 | M01H9.2 | WBGene00019718 | View | |
nhr-104 | R11E3.5 | WBGene00003694 |
nhr-104 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain.
|
View |
nhr-116 | F09C6.9 | WBGene00003706 | View | |
osm-6 | R31.3 | WBGene00003886 |
osm-6 encodes a novel protein that is orthologous to the IFT52 component of the intraflagellar transport particle; osm-6 activity is required cell autonomously for proper sensory cilium structure and thus for normal ciliated sensory neuron function; OSM-6 is a component of the intraflagellar transport particle subcomplex B, and OSM-6::GFP reporter fusions are expressed exclusively in ciliated sensory neurons.
|
View |
otpl-8 | H19J13.1 | WBGene00010403 |
otpl-8 encodes an ortholog of otopetrins such as human OTOP1 (OMIM:607806), OTOP2 (OMIM:607827), and OTOP3 (OMIM:607828), along with other homologs in fish and insects (such as crustacean OTOPLb); otopetrins are predicted to have 12 transmembrane helices; by homology with OTOP1 and OTOPLb, OTPL-8 might regulate intracellular calcium fluxes during extracellular stimuli, promote extracellular calcium carbonate biomineralization, or both; OTPL-8's paralogs include OTPL-1 through OTPL-7; OTPL-8 has no function in mass RNAi assays.
|
View |
R04E5.8 | R04E5.8 | WBGene00019871 | View | |
srd-23 | Y40H7A.5 | WBGene00005101 | View | |
srd-53 | F13G3.2 | WBGene00005131 | View | |
srh-70 | T21B4.9 | WBGene00005291 | View | |
srx-56 | C03G6.2 | WBGene00005947 | View | |
str-253 | F41B5.8 | WBGene00006279 | View | |
str-7 | F22B8.5 | WBGene00006075 | View | |
str-78 | Y40H7A.1 | WBGene00006138 | View | |
sulp-1 | C55B7.6 | WBGene00016945 |
sulp-1 encodes one of eight C. elegans members of the sulfate permease family of anion transporters; by homology, SULP-1 is predicted to function as an anion transporter that regulates cellular pH and volume via transmembrane movement of electrolytes and fluids; a sulp-1::GFP transcriptional fusion is expressed strongly in several neurons, weakly in hypodermal cells and the intestine, and very faintly in the excretory cell and body wall muscle.
|
View |
T06D8.2 | T06D8.2 | WBGene00011523 | View | |
W07E6.3 | W07E6.3 | WBGene00021075 | View | |
Y45F3A.8 | Y45F3A.8 | WBGene00012863 | View | |
Y62H9A.13 | Y62H9A.13 | WBGene00013401 | View | |
ZC487.1 | ZC487.1 | WBGene00022623 | View | |
ZK177.3 | ZK177.3 | WBGene00022671 | View |