Module
- Number
- 126
- Regulatory Genes
- 5
- Module Genes
- 15
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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atf-5 | T04C10.4 | WBGene00000221 | 385 |
atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4 and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4, atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorly translated in unstressed cells but well-translated during ER stress, amino acid starvation, or arsenite treatment; possibly atf-5 is also translationally regulated in a way similar to ATF4.
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rab-1 | C39F7.4 | WBGene00004266 | 332 |
rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.
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nhr-64 | C45E1.1 | WBGene00003654 | 132 |
nhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis.
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F08G12.3 | F08G12.3 | WBGene00008587 | 118 | View | |
srg-14 | F26B1.6 | WBGene00005171 | 106 | View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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alh-8 | F13D12.4 | WBGene00000114 |
alh-8 is orthologous to the human gene METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ALDH6A1; OMIM:603178), which when mutated leads to MMSDH deficiency.
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C44B7.10 | C44B7.10 | WBGene00016630 | View | |
eft-4 | R03G5.1 | WBGene00001169 |
eft-4 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and a normal postembryonic growth rate; eft-4 encodes at least one alternatively spliced coding sequence identical to that of eft-3.
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F07H5.5 | F07H5.5 | WBGene00014309 | View | |
F46E10.10 | F46E10.10 | WBGene00018491 | View | |
F46H5.3 | F46H5.3 | WBGene00018519 | View | |
gpd-3 | K10B3.7 | WBGene00001685 |
gpd-3 encodes a predicted glyceraldehyde 3-phosphate dehydrogenase that affects embryonic viability; GPD-3 interacts with LIN-2 in two-hybrid assays.
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iff-2 | F54C9.1 | WBGene00002065 | View | |
inf-1 | F57B9.6 | WBGene00002083 |
inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A.
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K02F2.2 | K02F2.2 | WBGene00019322 |
K02F2.2 encodes the C. elegans S-adenosylhomocysteine hydrolase (SAHH) ortholog; by homology, the product of K02F2.2 is predicted to catalyze the hydrolysis of S-adenosyl-L-homocysteine to adenosine and L-homocysteine; loss of K02F2.2 activity via RNAi results in embryonic and larval lethality, abnormal body morphology, sick animals, and uncoordinated locomotion; Northern blot analyses indicate the K02F2.2 mRNA is expressed in very high abundance.
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rpl-11.1 | T22F3.4 | WBGene00004422 |
rpl-11.1 encodes a large ribosomal subunit L11 protein.
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rpl-26 | F28C6.7 | WBGene00004440 |
rpl-26 encodes a large ribosomal subunit L26 protein; by homology, RPL-26 is predicted to function in protein biosynthesis; in C. elegans, RPL-26 activity is required for embryonic and germline development and normal rates of postembryonic growth.
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rpl-28 | R11D1.8 | WBGene00004442 |
rpl-28 encodes a large ribosomal subunit L28 protein.
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rps-18 | Y57G11C.16 | WBGene00004487 |
rps-18 encodes a small ribosomal subunit S18 protein.
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rps-30 | C26F1.4 | WBGene00004499 |
rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
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