Genes
Page 1 of 264, showing 20 records out of 5271 total, starting on record 1, ending on 20
Public Gene Name | Sequence Name | WB ID | Description | Module | Actions |
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ZK994.6 | ZK994.6 | WBGene00022842 |
lemone_173_gene |
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ceh-45 | ZK993.1 | WBGene00022837 |
ceh-45 encodes a homeodomain-containing protein; loss of ceh-45 activity via large-scale RNAi results in variable embryonic lethality.
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lemone_35_gene lemone_77_regulator lemone_199_regulator lemone_260_regulator |
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ZK973.3 | ZK973.3 | WBGene00022832 |
lemone_26_gene |
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ZK973.11 | ZK973.11 | WBGene00022836 |
lemone_62_gene |
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lpd-5 | ZK973.10 | WBGene00003061 |
lpd-5 is orthologous to the human gene NADH DEHYDROGENASE (UBIQUINONE) FE-S PROTEIN 4 (18KD) (NADH-COENZYME Q REDUCTASE) (NDUFS4; OMIM:602694), which when mutated leads to NADH:ubiquinone oxidoreductase (complex I) deficiency.
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lemone_101_gene |
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vha-9 | ZK970.4 | WBGene00006918 |
vha-9 encodes an ortholog of subunit F of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-9 is a predicted cytosolic rotor (stalk) component.
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lemone_203_gene |
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mdt-22 | ZK970.3 | WBGene00007022 |
lemone_41_gene |
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ZK970.1 | ZK970.1 | WBGene00014171 |
ZK970.1 encodes, by alternative splicing, two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK970.1 has no clear orthologs in other organisms.
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lemone_13_gene |
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lov-1 | ZK945.9 | WBGene00003058 |
lov-1 encodes an ortholog of human PKD1 (OMIM:601313; mutated in autosomal dominant polycystic kidney disease) that is expressed in the ciliated sensory endings of three types of male-specific neurons and that is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location; LOV-1 acts with PKD-2; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron; in vitro, LOV-1 interacts, via its conserved PLAT domain, with the N-terminus of ATP-2, the beta subunit of ATP synthase that also localizes to cilia, suggesting that ATP synthase may play a role in C. elegans polycystin signaling.
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lemone_2_gene |
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ZK945.7 | ZK945.7 | WBGene00014169 |
lemone_32_gene |
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puf-12 | ZK945.3 | WBGene00014165 |
lemone_22_gene |
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lact-2 | ZK945.1 | WBGene00014164 |
lact-2 encodes a beta-lactamase domain-containing protein that contains a predicted transmembrane domain in its N terminus.
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lemone_23_gene |
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ZK938.4 | ZK938.4 | WBGene00014161 |
lemone_115_gene |
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ZK938.3 | ZK938.3 | WBGene00014160 |
lemone_4_gene |
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ZK938.2 | ZK938.2 | WBGene00014159 |
lemone_74_gene |
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ZK930.3 | ZK930.3 | WBGene00014153 |
lemone_318_gene |
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fbxb-70 | ZK909.5 | WBGene00014149 |
lemone_85_gene |
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ces-2 | ZK909.4 | WBGene00000469 |
ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor, most similar in sequence and binding specificity to the PAR (proline- and acid-rich) subfamily of bZIP proteins; ces-2 is required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons, and is transcriptionally inhibited by activated LET-60(G12V).
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lemone_265_regulator lemone_265_gene |
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gap-2 | ZK899.8 | WBGene00001516 |
gap-2 encodes a Ras GTPase-activating protein (RasGAP) that is orthologous to mammalian nGAP and synGAP (OMIM:606136, OMIM:603384, synGAP is essential for postnatal survival and neuronal development); by homology, GAP-2 is predicted to function as a negative regulator of Ras signaling by enhancing the intrinsically weak Ras GTPase activity; gap-2 loss-of-function mutations partially suppress the larval lethality of let-23 and let-60 loss-of-function mutations, supporting a role for gap-2 in negative regulation of Ras signaling in vivo; gap-2 can encode at least eight different isoforms that appear to be expressed in a wide variety of tissues including the vulva, gonad, pharynx, neurons, and blast/rectal cells of the tail.
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lemone_31_gene |
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tba-8 | ZK899.4 | WBGene00006534 |
tba-8 encodes a member of the alpha tubulin family with high similarity to the human tubulin alpha-6 chain; expressed in some neurons with occasional expression in the hypodermis.
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lemone_27_gene |
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