Module
- Number
- 77
- Regulatory Genes
- 5
- Module Genes
- 20
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
C46E10.8 | C46E10.8 | WBGene00016712 | 267 | View | |
ceh-45 | ZK993.1 | WBGene00022837 | 168 |
ceh-45 encodes a homeodomain-containing protein; loss of ceh-45 activity via large-scale RNAi results in variable embryonic lethality.
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dmd-4 | C27C12.6 | WBGene00007776 | 149 | View | |
nhr-15 | F33E11.1 | WBGene00003614 | 110 |
nhr-15 is predicted to encode a member of the nuclear hormone receptor family.
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T15B7.1 | T15B7.1 | WBGene00020516 | 103 | View |
CLR Predictions
5 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C03B1.14 | C03B1.14 | WBGene00015382 | View | |
C04G2.10 | C04G2.10 | WBGene00007309 | View | |
C55C3.3 | C55C3.3 | WBGene00016953 | View | |
cyp-34A2 | T10H4.11 | WBGene00011699 | View | |
dhs-26 | ZK816.5 | WBGene00000989 |
dhs-26 encodes a short-chain dehydrogenase predicted to be mitochondrial.
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F09A5.1 | F09A5.1 | WBGene00008598 | View | |
F21F3.3 | F21F3.3 | WBGene00017673 | View | |
F23F1.2 | F23F1.2 | WBGene00017743 | View | |
F23F1.6 | F23F1.6 | WBGene00017747 | View | |
H25K10.1 | H25K10.1 | WBGene00010411 | View | |
M02D8.5 | M02D8.5 | WBGene00019731 | View | |
nspd-7 | Y43C5A.1 | WBGene00012781 | View | |
pes-8 | F18G5.2 | WBGene00003981 |
pes-8 encodes a novel protein that contains a proline-rich region and a predicted transmembrane domain, but no otherwise recognizably conserved domains; pes-8 was identified in promoter trapping screens and based on large-scale RNA-mediated interference (RNAi) screens, appears to be required for egg laying, germline development, locomotion, and regulation of adult lifespan; a pes-8 reporter is expressed at the cell surfaces of the spermathecal valve cell, the uterine wall, the vulva, and the rectal epithelium; strong expression is also detected in the uterus during its development; PES-8 may be required for normal morphology of the openings of the spermathecal valve, the vulva, and the rectum, a hypothesis consistent with its expression pattern and RNAi phenotype.
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R11H6.4 | R11H6.4 | WBGene00011252 | View | |
scl-20 | ZK384.2 | WBGene00013972 |
scl-20 encodes a predicted extracellular protein that is a member of the C. elegans family of SCP/TAPS domain-containing proteins; SCL-20 is homologous to mammalian GliPR1, a p53 target with proapoptotic activity mediated by an increase in production of reactive oxygen species; loss of scl-20 activity via RNAi in daf-2 mutants and in gld-1;daf-2 doubly mutant animals indicates that, in C. elegans, scl-20 can function to regulate both lifespan and tumor cell proliferation; scl-20 contains five DAF-16 consensus binding sites within 5kb of its promoter.
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sod-3 | C08A9.1 | WBGene00004932 |
sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter; heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress.
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W02D7.4 | W02D7.4 | WBGene00020940 | View | |
Y39B6A.24 | Y39B6A.24 | WBGene00012683 | View | |
Y73F8A.11 | Y73F8A.11 | WBGene00013520 | View | |
Y75B8A.28 | Y75B8A.28 | WBGene00013559 | View |