Module
- Number
- 115
- Regulatory Genes
- 4
- Module Genes
- 11
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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unc-42 | F58E6.10 | WBGene00006778 | 576 |
unc-42 encodes a paired-like homeodomain protein of the Q50 class; UNC-42 is required to specify the fate of ASH sensory neurons, AVA, AVD, and AVE interneurons, and a subset of motor neurons; unc-42 mutants fail to express cell-surface receptors required for differentiated neuronal function (sra-6, srb-6, glr-1, glr-5, and glr-6); UNC-42 is also required for AVKR and HSNL growth cones to follow the PVPR and PVQL pioneer axons, for axonal outgrowth in the backward command interneurons AVA, AVD, and AVE, and for inhibition of ectopic FMRFamide-positive and GABAergic axons; unc-42 mutants are defective in mechanosensation, backward motion, and regulation of egg-laying.
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ceh-33 | C10G8.7 | WBGene00000454 | 182 |
ceh-33 encodes a Six/sine oculis class homeodomain transcription factor; preliminary RNAi experiments suggest that CEH-33 activity may be required for gonad development; a ceh-33::gfp reporter shows very weak pharyngeal expression in late embryos and early larvae.
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nhr-167 | C49F5.4 | WBGene00008208 | 135 | View | |
ceh-8 | ZK265.4 | WBGene00000433 | 130 |
ceh-8 encodes a paired-like homeodomain protein of the Q50 class orthologous to the Rx homeobox protein of humans (RAX; OMIM:601881) and Drosophila (CG10052-PA); CEH-8 and RX belong to one of at least 18 distinct families of paired-like homeodomain proteins, including 12 families in the Q50 class.
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CLR Predictions
16 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C14A11.5 | C14A11.5 | WBGene00015750 | View | |
C25G6.4 | C25G6.4 | WBGene00016109 | View | |
ceh-31 | C33D12.1 | WBGene00000452 |
ceh-31 encodes a protein containing a homeobox domain.
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F18E9.1 | F18E9.1 | WBGene00017568 | View | |
F32B5.2 | F32B5.2 | WBGene00017976 | View | |
osm-12 | Y75B8A.12 | WBGene00003892 | View | |
R02E12.4 | R02E12.4 | WBGene00019828 | View | |
ser-7 | C09B7.1 | WBGene00004780 |
ser-7 encodes an ortholog of mammalian 5-HT7 metabotropic serotonin receptors; SER-7 is required for stimulation of egg-laying or pharyngeal pumping by serotonin (5-HT), for regular pumping in response to bacteria, and probably also for 5-HT to activate MC neurons; SER-7 and SER-1 are redundantly required for normal egg-laying; SER-7 is expressed in head and tail neurons, pharyngeal neurons (M4, MCs, I2s, I3, M5, M3s, I4, I6, and M2s), vulval muscles, and intestine; heterologously expressed SER-7, when challenged with 5-HT, stimulates intracellular adenylate cyclase activity; SER-7 has high affinity for 5-HT and tryptamine, but not for 5-CT, and is unaffected by at least some agonists of mammalian 5-HT7 receptors.
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Y44A6D.6 | Y44A6D.6 | WBGene00012856 | View | |
Y54E2A.1 | Y54E2A.1 | WBGene00013187 | View | |
ZK938.4 | ZK938.4 | WBGene00014161 | View |