Module
- Number
- 27
- Regulatory Genes
- 7
- Module Genes
- 38
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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zbed-6 | F25H8.6 | WBGene00009133 | 678 |
zbed-6 encodes a protein that contains a BED-type zinc finger domain; loss of zbed-6 activity in large-scale RNAi screens indicates that zbed-6 is required for larval development.
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F17A9.3 | F17A9.3 | WBGene00017535 | 312 | View | |
K02D7.2 | K02D7.2 | WBGene00019299 | 176 |
K02D7.2 encodes an ortholog of human SNAI2/SLUG (OMIM:602150, mutated in Waardenburg syndrome type IID) and Drosophila ESCARGOT; based on its orthology to SNAI2, K02D7.2 is predicted to be a transcriptional inhibitor.
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lin-54 | JC8.6 | WBGene00003037 | 165 | View | |
syd-1 | F35D2.5 | WBGene00006363 | 165 | View | |
nhr-97 | H27C11.1 | WBGene00003687 | 164 | View | |
ztf-2 | F13G3.1 | WBGene00008762 | 118 | View |
CLR Predictions
30 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0395.2 | B0395.2 | WBGene00007174 | View | |
C27A2.5 | C27A2.5 | WBGene00016153 | View | |
C30G12.1 | C30G12.1 | WBGene00016273 | View | |
cdh-5 | F08B4.2 | WBGene00000397 |
a homolog of cadherin.
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cdh-7 | R05H10.6 | WBGene00000399 |
cdh-7 encodes a protein that contains a cadherin domain.
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cutl-10 | Y53H1B.1 | WBGene00013180 | View | |
dpy-6 | F16F9.2 | WBGene00001068 |
dpy-6 encodes a novel, conserved protein; dpy-6 activity is required for normal body morphology.
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F01D5.6 | F01D5.6 | WBGene00008496 | View | |
F10G2.2 | F10G2.2 | WBGene00017363 | View | |
F26F12.4 | F26F12.4 | WBGene00017835 | View | |
F32D8.7 | F32D8.7 | WBGene00009331 | View | |
F46G11.2 | F46G11.2 | WBGene00018515 | View | |
F52F10.2 | F52F10.2 | WBGene00018706 | View | |
F54B11.10 | F54B11.10 | WBGene00010033 | View | |
F59D12.2 | F59D12.2 | WBGene00010330 | View | |
grd-2 | F46B3.5 | WBGene00001691 |
grd-2 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, four Ground domains, an short region of low-complexity sequence, and a Hint/Hog domain; the Hint/Hog domain is predicted to cut GRD-2 into two halves and then covalently link cholesterol to the C-terminus of the Ground domain; the four N-terminal Ground domains are predicted to form one or more cysteine-crosslinked proteins involved in intercellular signalling; Ground domains have subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-2 is weakly required for normal molting; GRD-2 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
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H19M22.3 | H19M22.3 | WBGene00019212 | View | |
K02D3.2 | K02D3.2 | WBGene00010505 | View | |
lpr-1 | Y65B4BR.2 | WBGene00002393 | View | |
M02G9.3 | M02G9.3 | WBGene00010832 | View | |
M03B6.3 | M03B6.3 | WBGene00010835 | View | |
mab-7 | ZC13.4 | WBGene00003104 |
mab-7 encodes a protein with a hydrophobic type II transmembrane region at the N-terminus, an EGF-like motif, a ShKT motif and a long C-terminus; mab-7 is involved in morphogenesis of the male tail, specifically affecting the structural cells, neuronal processes and the hypodermal sheath of the sensory rays, as such, it affects mating in males; a mab-7 promoter-gfp construct is expressed in hypodermis, body seam, ray structural cells, and several neurons in the head and tail region.
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nas-27 | T23F4.4 | WBGene00003545 |
nas-27 encodes an astacin-like metalloprotease; large-scale expression studies reveal that a nas-27::GFP promoter fusion is expressed in the reproductive system, the vulva, and the hypodermis.
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ncx-2 | C10G8.5 | WBGene00003567 |
ncx-2 encodes, by alternative splicing, three full-length isoforms of a putative 3Na[+]/1Ca[2+] exchanger, orthologous to human SLC8A1-3 and paralogous to NCX-1 and NCX-3; NCX-2 is predicted to export free cytoplasmic Ca[2+] with low affinity but high capacity, being complemented by low-capacity/high-affinity Ca[2+] ATPase pumps such as MCA-1/-3; NCX-3 has tandem Calx-alpha and Calx-beta domains predicted to carry out ion transport and regulation; NCX-1 is required for normally rapid growth in mass RNAi assays.
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osr-1 | C32E12.3 | WBGene00016329 | View | |
ptr-15 | T07H8.6 | WBGene00004229 |
ptr-15 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-15 has no known function in vivo.
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R05G6.9 | R05G6.9 | WBGene00019901 |
R05G9.6 encodes a protein with a predicted signal sequence and EGF-like repeats that are related to those of Notch family members.
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scl-14 | F09E8.5 | WBGene00008625 | View | |
T05C1.3 | T05C1.3 | WBGene00020250 | View | |
T06A4.1 | T06A4.1 | WBGene00020281 | View | |
T06A4.3 | T06A4.3 | WBGene00020283 | View | |
T06E4.8 | T06E4.8 | WBGene00011535 | View | |
tba-8 | ZK899.4 | WBGene00006534 |
tba-8 encodes a member of the alpha tubulin family with high similarity to the human tubulin alpha-6 chain; expressed in some neurons with occasional expression in the hypodermis.
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W08E12.6 | W08E12.6 | WBGene00021087 | View | |
wrt-8 | C29F3.2 | WBGene00006954 |
wrt-8 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-8 is strongly expressed in hypodermal syncytia hyp6-hyp10 throughout life, and in in 12 subventral P cells and their descendants from 3-fold embryo to L2 larva stages; the Hint/Hog domain is predicted to cut WRT-8 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-8 has no obvious function in RNAi assays.
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Y46G5A.29 | Y46G5A.29 | WBGene00012917 | View | |
ZC21.3 | ZC21.3 | WBGene00022505 |
ZC21.3 encodes a protein predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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ZC513.1 | ZC513.1 | WBGene00022626 | View |