Module
- Number
- 74
- Regulatory Genes
- 6
- Module Genes
- 51
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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K10B3.5 | K10B3.5 | WBGene00019611 | 332 | View | |
zfp-3 | W05H7.4 | WBGene00021047 | 328 | View | |
ZK1320.3 | ZK1320.3 | WBGene00014253 | 305 | View | |
K04C1.3 | K04C1.3 | WBGene00010553 | 227 | View | |
Y82E9BR.17 | Y82E9BR.17 | WBGene00022349 | 196 | View | |
hlh-2 | M05B5.5 | WBGene00001949 | 149 |
hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates.
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CLR Predictions
46 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C02F5.12 | C02F5.12 | WBGene00015352 |
C02F5.12 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8 and ZIM-1/-3; while its specific biological function and expression pattern are unknown, C02F5.12 is required for normal meiosis in mass RNAi assays, and thus might share a function in meiotic chromosomal segregation with its better-characterized paralogs.
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C13C4.4 | C13C4.4 | WBGene00007548 | View | |
C15F1.5 | C15F1.5 | WBGene00015796 | View | |
C16E9.2 | C16E9.2 | WBGene00015866 | View | |
C18B12.6 | C18B12.6 | WBGene00007668 | View | |
C43H6.7 | C43H6.7 | WBGene00016620 | View | |
C46H3.2 | C46H3.2 | WBGene00016725 | View | |
C52B9.8 | C52B9.8 | WBGene00016868 | View | |
cdc-25.2 | F16B4.8 | WBGene00000387 |
cdc-25.2 encodes a putative homolog of Cdc25 phosphatase protein family that affects germline proliferation.
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ced-9 | T07C4.8 | WBGene00000423 |
ced-9 encodes the sole C. elegans homolog of the mammalian cell-death inhibitor Bcl-2; during development, CED-9 activity is essential for preventing cells from undergoing programmed cell death and CED-9 functions by binding and repressing the activity of CED-4, a protein similar to human APAF-1 that positively regulates CED-3 caspase activity; CED-9 localizes to mitochondria.
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E04F6.2 | E04F6.2 | WBGene00017122 | View | |
F13E9.13 | F13E9.13 | WBGene00044797 | View | |
F19C6.5 | F19C6.5 | WBGene00008954 | View | |
F21D9.6 | F21D9.6 | WBGene00009020 | View | |
F28C10.3 | F28C10.3 | WBGene00017898 | View | |
F47G4.2 | F47G4.2 | WBGene00009823 | View | |
fbxa-153 | B0391.5 | WBGene00007162 |
fbxa-153 encodes a protein with an N-terminal F-box domain and a C-terminal FTH domain; FBXA-153 has no obvious non-nematode orthologs; FBXA-153 shares N-terminal UNC-13 binding, and thus may share at least some functions, with ERI-1, W04D2.6, and Y55F3AM.13; FBXA-153 has no obvious function in mass RNAi assays.
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gst-16 | F37B1.5 | WBGene00001764 | View | |
hst-2 | C34F6.4 | WBGene00002029 |
hst-2 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme 2O-sulfotransferase; by homology, HST-2 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying sulfation of the C2 hydroxyl group of hexuronic acid; during development, hst-2 activity is required for normal body size, cell migration, and nervous system development; an hst-2::gfp reporter fusion is first expressed in embryos, continuing on through adulthood; expression is detected in many tissues, including the pharynx, hypodermis, muscles, vulva, and distal tip cells (DTCs) of the somatic gonad.
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ife-4 | C05D9.5 | WBGene00002062 |
The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family.
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K04C1.3 | K04C1.3 | WBGene00010553 | View | |
K05F1.5 | K05F1.5 | WBGene00019407 | View | |
K09A11.1 | K09A11.1 | WBGene00010704 | View | |
K09E9.3 | K09E9.3 | WBGene00010726 | View | |
kin-32 | C30F8.4 | WBGene00002213 |
kin-32 encodes, by alternative splicing, two isoforms of a focal adhesion kinase, orthologous to human PTK2 (OMIM:600758) and PTK2B (OMIM:601212); KIN-32 is expressed in both nuclei and cytoplasms of larval and adult bodywall muscle cells; KIN-32 is also expressed in head neurons, a head mesodermal cell, adult vulval muscle, and the reproductive system; KIN-32 has an N-terminal FERM domain, a central tyrosine kinase domain, and a divergent C-terminal focal adhesion targeting domain; KIN-32 has no obvious function, and both kin-32(RNAi) animals and kin-32(ok166) homozygotes are phenotypically normal; kin-32(ok166) probably leaves protein-kinase activity intact, and thus is likely to be only a partial loss-of-function allele.
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lin-25 | F56H9.5 | WBGene00003011 |
lin-25 encodes a novel transcription factor that is conserved in C. briggsae and C. remanei; during development, lin-25 functions downstream of let-60 ras to regulate fate specification and differentiation of a number of cell types such as the vulval precursor cells; targets of LIN-25 activity include the lin-39 Hox gene, whose transcriptional upregulation during vulval cell fate specification is dependent upon lin-25; LIN-25 is expressed in vulval precursor cells, hypodermal seam cells, and cells in the somatic gonad; LIN-25 is detected in nuclei, but also seen in the cytoplasm.
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mom-1 | T07H6.2 | WBGene00003394 |
mom-1 encodes a predicted O-acyltransferase that is orthologous to Porcupine proteins conserved across a wide range of species; MOM-1 functions as part of a Wnt/MAPK signaling pathway that is required maternally for endoderm induction in the early embryo; by homology, MOM-1 is predicted to be a membrane-spanning endoplasmic reticulum protein that stimulates post-translational processing of Wnt signaling molecules such as MOM-2; embryonic mosaic analysis indicates that MOM-1 activity is required in the signaling cell, P2, for proper specification of endoderm, consistent with its predicted role in processing MOM-2/Wnt.
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mom-5 | T23D8.1 | WBGene00003397 |
mom-5 encodes one of four C. elegans members of the Frizzled (Fz) family of seven transmembrane receptors; during development, MOM-5 activity is required for asymmetric cell division in the early embryo as well as for asymmetric cell division during neuronal development; MOM-5::GFP is enriched at the posterior pole of cells prior to division and during later stages of embryogenesis, is found at the leading edges of epidermal cells during ventral enclosure; in neuroblasts, MOM-5 is required for proper subcellular distribution of DSH-2 to the cortex.
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nhr-122 | Y41D4B.9 | WBGene00003712 | View | |
nhr-78 | F36A4.14 | WBGene00003668 | View | |
R03A10.1 | R03A10.1 | WBGene00010981 | View | |
R12E2.8 | R12E2.8 | WBGene00020034 | View | |
sdc-2 | C35C5.1 | WBGene00004746 |
The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation.
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T20G5.4 | T20G5.4 | WBGene00011868 | View | |
unc-50 | T07A5.2 | WBGene00006785 |
unc-50 encodes an integral membrane protein orthologous to the Saccharomyces cerevisiae Golgi component Gmh1p; UNC-50 is required for regulating subtype-specific nicotinic receptor trafficking to the cell surface and thus, for normal synaptic transmission at the neuromuscular junction; UNC-50 is ubiquitously expressed from early embryogenesis to adulthood and localizes to the Golgi.
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W09D10.5 | W09D10.5 | WBGene00012363 | View | |
Y111B2A.12 | Y111B2A.12 | WBGene00013735 | View | |
Y45F10A.3 | Y45F10A.3 | WBGene00012866 | View | |
Y46G5A.8 | Y46G5A.8 | WBGene00012900 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
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Y50D4B.2 | Y50D4B.2 | WBGene00021741 | View | |
Y53F4B.10 | Y53F4B.10 | WBGene00013157 |
Y53F4B.10 is orthologous to the human gene INSULIN (IRF4; OMIM:176730), which when mutated leads to disease.
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Y59C2A.3 | Y59C2A.3 | WBGene00021986 | View | |
Y71D11A.3 | Y71D11A.3 | WBGene00022104 | View | |
ZC13.1 | ZC13.1 | WBGene00022502 | View | |
ZC376.1 | ZC376.1 | WBGene00013873 | View | |
ZC504.3 | ZC504.3 | WBGene00013917 | View | |
ZK154.5 | ZK154.5 | WBGene00022667 | View | |
ZK512.1 | ZK512.1 | WBGene00013982 | View | |
ZK742.3 | ZK742.3 | WBGene00022813 | View | |
ZK792.1 | ZK792.1 | WBGene00014076 | View | |
ZK938.2 | ZK938.2 | WBGene00014159 | View |