Module
- Number
- 13
- Regulatory Genes
- 4
- Module Genes
- 41
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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rab-3 | C18A3.6 | WBGene00004267 | 718 |
rab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons.
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egl-13 | T22B7.1 | WBGene00001182 | 274 |
egl-13 encodes a SOX domain transcription factor; egl-13 is required for maintenance of the uterine pi cell fate; mutations in egl-13 affect the cell fusion process that makes the vulval-uterine connection and consequently egg laying; egl-13 is expressed in the pi cells, transiently expressed in the rho lineage, in the anchor cell following fusion, and in neurons, body wall muscles, and intestinal cells; egl-13 expression during pi cell fate specification is dually controlled by LAG-1 and FOS-1/JUN-1.
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nhr-40 | T03G6.2 | WBGene00003630 | 234 |
nhr-40 encodes, by alternative splicing and promoters, three isoforms of a nuclear hormone receptor specific to nematodes; NHR-40 is required for normal development of bodywall muscles, and hence for normal movement; both nhr-40 promoters are active in body wall and pharygeal muscle cells, as well as in some (perhaps non-overlapping) neurons of the head and ventral nerve cord; NHR-40 is a divergent ortholog of HNF4, with 17 closely related paralogs in C. elegans belonging to the class 1, subgroup 8 of C. elegans NHRs with the P box sequence CNGCKT; nhr-40 is most strongly transcribed in L2 larvae; nhr-40(RNAi), overexpression of nhr-40 by heat shock, or the nhr-40(ok667) mutation all result in developmentally arrested embryos or larvae, with surviving larvae being smaller, abnormally bulging, and sluggish; nhr-40(RNAi) animals have disorganized epithelial cells and missing body wall muscle cells; nhr-40(ok667) mutants are slow-moving and uncoordinated, frequently reversing direction or going in circles; transgenic expression of nhr-40 cDNA in muscles rescues larval but not embryonic arrest.
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sem-4 | F15C11.1 | WBGene00004773 | 112 |
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
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CLR Predictions
63 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0310.3 | B0310.3 | WBGene00015139 | View | |
C01C4.3 | C01C4.3 | WBGene00015293 |
C01C4.3 encodes a serine/threonine protein kinase.
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C02C2.5 | C02C2.5 | WBGene00015334 | View | |
C11D9.1 | C11D9.1 | WBGene00015704 | View | |
C27A2.4 | C27A2.4 | WBGene00016152 | View | |
C54D2.2 | C54D2.2 | WBGene00016916 | View | |
ceh-48 | C17H12.9 | WBGene00015934 |
ceh-48 encodes a ONECUT class CUT homeobox protein with a single N-terminal cut domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; CEH-48 is strongly affiliated with, and may be orthologous to, Drosophila ONECUT and mammalian HNF6 proteins; ceh-48 has no obvious function in mass RNAi assays.
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cka-2 | C52B9.1 | WBGene00000510 |
cka-2 encodes an isoform of choline kinase whose activity has been verified in vitro; CKA-1 and CKA-2 comprise a related group ('A') of choline kinases; purified CKA-2 is dimeric, requires 1 mM Mg(2+) for optimal activity, and has a strong preference for choline over ethanolamine; CKA-2 has a pH optimum of 10 and a k(cat) of 74/s, close to the maximum rate observed for yeast and rat enzymes.
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F10E9.1 | F10E9.1 | WBGene00017353 | View | |
F18E9.4 | F18E9.4 | WBGene00017570 | View | |
F21A10.1 | F21A10.1 | WBGene00008998 | View | |
F22E12.1 | F22E12.1 | WBGene00009058 | View | |
F25E5.2 | F25E5.2 | WBGene00017783 | View | |
F29A7.4 | F29A7.4 | WBGene00017914 | View | |
F49E10.4 | F49E10.4 | WBGene00018641 | View | |
hot-7 | Y48B6A.9 | WBGene00001992 |
hot-7 encodes a predicted membrane-associated protein that is a member of the Ly-6 superfamily of glycosylphosphatidylinositol (GPI)-linked signaling proteins and is homologous to ODR-2, a neuronally expressed protein required for olfaction; as loss of hot-7 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HOT-7 in C. elegans development and/or behavior is not yet known.
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ins-26 | ZC334.1 | WBGene00002109 |
ins-26 encodes an insulin-like peptide.
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mab-9 | T27A1.6 | WBGene00003106 |
mab-9 encodes a member of the T-box family of transcriptional regulators containing a 200-amino acid T-box DNA-binding domain most similar to mouse Brachyury; mab-9 is involved in hindgut and male tail development, specifically affecting the fate of two posterior blast cells in the hindgut, B and F; in the male this results in a grossly abnormal tail lacking spicules, and renders them incapable of mating; in the hermaphrodite this results in hindgut defects; mab-9 may also be part of a network of T-box genes that includes tbx-8, tbx-9 and vab-7 and is important for the correct patterning of posterior cells in the developing embryo; mab-9 affects movement to some extent though the basis for this defect is unknown; MAB-9 localizes to the nucleus of B and F and their descendents during development.
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nhr-59 | T27B7.1 | WBGene00003649 | View | |
ptl-1 | F42G9.9 | WBGene00004212 |
ptl-1 encodes a microtubule-binding protein that is homologous to members of the tau/MAP2/MAP4 subfamily of microtubule-associated proteins (OMIM:157140, abnormal aggregates of hyperphosphorylated tau are associated with several neurodegenerative disorders, including Alzheimer's disease, Pick's disease, and corticobasal degeneration); by homology, PTL-1 is predicted to promote microtubule assembly and stability, and to play a role in maintaining neuronal integrity and axonal transport; in vitro, bacterially expressed PTL-1 can bind microtubules; ptl-1 mRNA is expressed at highest levels in the embryo and early larval stages, while PTL-1 is detected in embryonic hypodermis and head neurons and then in the mechanosensory neurons, ALML, ALMR, AVM, PLML, and PLMR, in larvae and adults; as loss of ptl-1 function via mutation or large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PTL-1 in C. elegans development and/or behavior is not yet known.
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R02F11.2 | R02F11.2 | WBGene00019840 | View | |
R10H10.4 | R10H10.4 | WBGene00011223 | View | |
R12C12.3 | R12C12.3 | WBGene00020023 | View | |
rbf-1 | F37A4.7 | WBGene00004316 |
rbf-1 encodes the sole C. elegans rabphilin homolog; rbf-1 activity is required for normal basal rates of locomotion (in the absence of stimulation) and, in combination with SNARE components ric-4, snb-1, and unc-64, for normal rates of both basal and stimulated locomotion; RBF-1 is expressed in the nerve ring and in the dorsal and ventral nerve cords and colocalizes with synaptic vesicle markers.
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ric-3 | T14A8.1 | WBGene00004363 |
The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
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sue-1 | F07A5.5 | WBGene00006306 | View | |
T06F4.1 | T06F4.1 | WBGene00020294 | View | |
T19D7.4 | T19D7.4 | WBGene00020572 | View | |
tag-168 | Y39A3CL.2 | WBGene00006513 | View | |
tag-341 | ZK669.1 | WBGene00014051 | View | |
tag-343 | F43B10.2 | WBGene00018374 | View | |
trpa-1 | C29E6.2 | WBGene00007801 |
trpa-1 encodes a transient receptor potential (TRP) ion channel orthologous to the vertebrate and Drosophila TRPA1 channels; in C. elegans, trpa-1 activity is required for specific mechanosensory behaviors such as nose-touch avoidance and touch-mediated foraging; when expressed in mammalian cells, TRPA-1 exhibits channel activity in response to mechanical stimulation; TRPA-1::GFP reporters are expressed in a number of different cell types including sensory neurons, muscle, and epithelial cells.
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tsp-16 | F01E11.4 | WBGene00006642 | View | |
twk-13 | R04F11.4 | WBGene00006668 |
twk-13 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-13 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-13 in C. elegans development and/or behavior is not yet known; however, TWK-13 likely functions redundantly with other TWK channels; the TWK-13 expression pattern has not been determined.
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W07B8.3 | W07B8.3 | WBGene00021071 | View | |
Y12A6A.2 | Y12A6A.2 | WBGene00012440 | View | |
Y49E10.23 | Y49E10.23 | WBGene00013042 | View | |
Y67A10A.7 | Y67A10A.7 | WBGene00013456 | View | |
ZK20.1 | ZK20.1 | WBGene00013923 | View | |
ZK682.7 | ZK682.7 | WBGene00022790 | View | |
ZK970.1 | ZK970.1 | WBGene00014171 |
ZK970.1 encodes, by alternative splicing, two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK970.1 has no clear orthologs in other organisms.
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