Module
- Number
- 2
- Regulatory Genes
- 6
- Module Genes
- 83
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
srg-44 | F31E9.2 | WBGene00005201 | 613 | View | |
trf-1 | F45G2.6 | WBGene00006612 | 418 |
The trf-1 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
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srg-7 | C18F10.8 | WBGene00005165 | 364 | View | |
rab-1 | C39F7.4 | WBGene00004266 | 204 |
rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.
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srg-20 | ZC204.4 | WBGene00005177 | 199 | View | |
srg-62 | C24B9.12 | WBGene00005219 | 128 | View |
CLR Predictions
2 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0564.4 | B0564.4 | WBGene00007204 | View | |
C15C7.6 | C15C7.6 | WBGene00015792 | View | |
C25H3.11 | C25H3.11 | WBGene00016120 | View | |
C30G4.6 | C30G4.6 | WBGene00016271 | View | |
C31B8.1 | C31B8.1 | WBGene00016279 | View | |
C32C4.3 | C32C4.3 | WBGene00007863 | View | |
C50E3.7 | C50E3.7 | WBGene00016818 | View | |
C55A1.1 | C55A1.1 | WBGene00008321 | View | |
clec-177 | E03H12.2 | WBGene00017109 | View | |
col-64 | F52F12.2 | WBGene00000640 | View | |
cutl-7 | F53B6.6 | WBGene00009961 | View | |
F07C4.10 | F07C4.10 | WBGene00017203 | View | |
F15A8.7 | F15A8.7 | WBGene00017479 | View | |
F16G10.2 | F16G10.2 | WBGene00017517 | View | |
F40G12.3 | F40G12.3 | WBGene00009598 | View | |
F54D12.8 | F54D12.8 | WBGene00018821 | View | |
F59A6.3 | F59A6.3 | WBGene00019085 | View | |
fbxb-58 | H11E01.1 | WBGene00019186 | View | |
fbxc-55 | Y27F2A.5 | WBGene00021297 | View | |
gcy-37 | C54E4.3 | WBGene00001557 |
gcy-37 encodes a predicted soluble guanylyl cyclase that is expressed in four candidate sensory neurons connected to the pseudocoelom, URXL, URXR, AQR, and PQR; as loss of gcy-37 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-37 in C. elegans development and/or behavior is not yet known; GCY-37 expression in neurons connected to the pseudocoelom suggests, however, that GCY-37 may play a role in fluid homeostasis.
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gnrr-7 | F13D2.3 | WBGene00008737 | View | |
K03D7.9 | K03D7.9 | WBGene00010536 | View | |
K03H9.3 | K03H9.3 | WBGene00019372 | View | |
K05C4.10 | K05C4.10 | WBGene00010586 | View | |
K10C9.4 | K10C9.4 | WBGene00019625 | View | |
K10H10.6 | K10H10.6 | WBGene00010762 | View | |
lov-1 | ZK945.9 | WBGene00003058 |
lov-1 encodes an ortholog of human PKD1 (OMIM:601313; mutated in autosomal dominant polycystic kidney disease) that is expressed in the ciliated sensory endings of three types of male-specific neurons and that is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location; LOV-1 acts with PKD-2; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB neuron; in vitro, LOV-1 interacts, via its conserved PLAT domain, with the N-terminus of ATP-2, the beta subunit of ATP synthase that also localizes to cilia, suggesting that ATP synthase may play a role in C. elegans polycystin signaling.
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mod-5 | Y54E10BR.7 | WBGene00003387 |
mod-5 encodes a Na[+],Cl[-]-dependent serotonin transporter that is required for serotonin uptake by neurosecretory motor neurons and for the experience-dependent enhanced slowing response to food; MOD-5 has serotonin transport activity in cell culture, and is a target of the serotonin uptake inhibitor fluoxetine (Prozac) in vivo; MOD-5 is orthologous to the human serotonin transporter (SLC6A4, OMIM:182138, associated with varying levels of neuroticism, introversion, and anxiety).
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nhr-209 | R07B7.16 | WBGene00011100 | View | |
rom-3 | Y116A8C.14 | WBGene00004402 | View | |
snf-6 | M01G5.5 | WBGene00004905 |
snf-6 encodes a member of the sodium:neurotransmitter symporter family.
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srbc-50 | F54B8.8 | WBGene00010022 | View | |
srd-33 | T19H12.4 | WBGene00005111 | View | |
srd-70 | F48F5.4 | WBGene00005147 | View | |
sre-27 | Y57A10C.3 | WBGene00013281 | View | |
sre-29 | F57G9.4 | WBGene00010220 | View | |
sre-40 | T05A7.8 | WBGene00020225 | View | |
sre-44 | W07G1.2 | WBGene00012329 | View | |
sre-52 | C50E10.5 | WBGene00016828 | View | |
srg-20 | ZC204.4 | WBGene00005177 | View | |
srg-30 | W02F12.7 | WBGene00005187 | View | |
srh-105 | T27A1.7 | WBGene00005512 | View | |
srh-133 | Y59A8B.3 | WBGene00005350 | View | |
srh-142 | T08G3.3 | WBGene00005359 | View | |
srh-190 | C17E7.2 | WBGene00005404 | View | |
srh-214 | T20B3.4 | WBGene00005424 | View | |
srh-251 | R08H2.4 | WBGene00005457 | View | |
srh-265 | T06E6.9 | WBGene00005471 | View | |
srh-3 | K04F1.5 | WBGene00005229 | View | |
srh-79 | C04F2.1 | WBGene00005300 | View | |
srh-90 | F53C3.10 | WBGene00005311 | View | |
srj-42 | Y73F8A.3 | WBGene00005625 | View | |
srj-6 | F31F4.8 | WBGene00005594 | View | |
srsx-14 | C39H7.5 | WBGene00016543 | View | |
srt-21 | M01G12.3 | WBGene00010818 | View | |
srt-23 | Y55F3C.2 | WBGene00021947 | View | |
srt-47 | Y41E3.12 | WBGene00012770 | View | |
sru-19 | T04A11.8 | WBGene00005682 | View | |
sru-36 | R07B5.6 | WBGene00005699 | View | |
sru-47 | F36D1.3 | WBGene00005710 | View | |
srw-117 | C44C3.6 | WBGene00005864 | View | |
srw-33 | T26H5.5 | WBGene00005780 | View | |
srw-48 | F26D2.9 | WBGene00005795 | View | |
srx-120 | F49C5.2 | WBGene00006011 | View | |
srx-137 | F09F3.13 | WBGene00006028 | View | |
srx-4 | Y49C4A.5 | WBGene00005895 | View | |
srx-64 | K07C6.7 | WBGene00005955 | View | |
srxa-14 | Y44A6B.1 | WBGene00012846 | View | |
str-131 | C09H5.6 | WBGene00006180 | View | |
str-168 | Y9C9A.6 | WBGene00006212 | View | |
str-208 | F26G5.2 | WBGene00006241 | View | |
str-224 | K10C9.8 | WBGene00006255 | View | |
str-248 | C55A1.3 | WBGene00006275 | View | |
str-61 | F14F8.1 | WBGene00006125 | View | |
str-89 | F59A1.4 | WBGene00006148 | View | |
T24D5.1 | T24D5.1 | WBGene00011989 | View | |
tph-1 | ZK1290.2 | WBGene00006600 |
tph-1 encodes tryptophan hydroxylase, the enzyme that catalyzes the rate-limiting first step in serotonin biosynthesis; in vivo, tph-1 activity is required for serotonin biosynthesis, and well-fed animals mutant for tph-1 exhibit changes in behavioral and metabolic processes similar to those caused by starvation: slower rates of egg laying and pharyngeal pumping, dauer larval arrest, increased fat storage, and an extended reproductive lifespan; genetic studies indicate that, in regulating feeding and metabolism, tph-1 interacts with the daf-7/TGF-beta and daf-2/insulin-like signaling pathways; a TPH-1::GFP reporter is expressed in the serotonergic neurons: NSM, ADF, HSN (hermaphrodite-specific), CP (male-specific), and also rarely in the AIM and RIH neurons.
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trf-1 | F45G2.6 | WBGene00006612 |
The trf-1 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
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twk-34 | K06B4.12 | WBGene00006686 | View | |
Y19D10B.5 | Y19D10B.5 | WBGene00021234 | View | |
Y67D8C.4 | Y67D8C.4 | WBGene00022068 | View | |
Y7A5A.7 | Y7A5A.7 | WBGene00012413 | View | |
ZC477.10 | ZC477.10 | WBGene00022622 | View |