Module
- Number
- 62
- Regulatory Genes
- 7
- Module Genes
- 26
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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gei-11 | F32H2.1 | WBGene00001568 | 585 |
gei-11 encodes a protein that contains Myb DNA-binding domains and is homologous to mammalian SNAPC4, required for RNA polymerase II and III transcription of snRNA genes; GEI-11 is required for ventral enclosure during embryonic development, as well as for normal rates of postembryonic growth; GEI-11 interacts with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1 that is also essential for embryonic morphogenesis.
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T11G6.8 | T11G6.8 | WBGene00011722 | 373 | View | |
efl-1 | Y102A5C.18 | WBGene00001161 | 294 |
efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition.
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ceh-49 | F17A9.6 | WBGene00017538 | 260 |
ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
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srg-33 | F21F8.1 | WBGene00005190 | 239 | View | |
hmg-5 | F45E4.9 | WBGene00001975 | 229 | View | |
nhr-225 | T27B7.2 | WBGene00020849 | 116 | View |
CLR Predictions
66 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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atg-3 | Y55F3AM.4 | WBGene00021922 |
atg-3 encodes an ortholog of the autophagic budding yeast protein Atg3p, and of human ATG3 (OMIM:609606); ATG-3 is expressed in larval and adult pharynx and body wall muscle, and in adult reproductive system, vulval muscle, spermetheca, and seam cells; ATG-3 has no obvious phenotype in mass RNAi assays.
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B0464.6 | B0464.6 | WBGene00007186 | View | |
B0495.6 | B0495.6 | WBGene00015205 | View | |
C01G5.6 | C01G5.6 | WBGene00015308 | View | |
C07A9.2 | C07A9.2 | WBGene00007400 | View | |
C13F10.7 | C13F10.7 | WBGene00015746 | View | |
C37A2.8 | C37A2.8 | WBGene00016494 | View | |
csn-5 | B0547.1 | WBGene00000817 |
csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4.
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csn-6 | Y67H2A.6 | WBGene00000818 |
csn-6 encodes a homolog of COP9 signalosome complex subunit 2 that affects embryonic viability and fertility.
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D1054.3 | D1054.3 | WBGene00008371 | View | |
F17A9.2 | F17A9.2 | WBGene00017534 | View | |
F23C8.6 | F23C8.6 | WBGene00017735 | View | |
F49C12.9 | F49C12.9 | WBGene00009878 | View | |
gfi-4 | F45E4.10 | WBGene00001584 |
gfi-4 encodes a novel protein that was identified in screens for proteins that interact with GEI-4, a coiled-coil domain protein required for embryonic viability, fertility, and vulval morphogenesis that also interacts with GEX-2, a putative Rac-binding protein, and intermediate filaments; based on its interaction with GEI-4, GFI-4 may be predicted to play a role in intermediate filament rearrangements during germline development or embryonic or vulval morphogenesis; however, as loss of gfi-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GFI-4 in C. elegans development and/or behavior is not yet known.
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R05D11.9 | R05D11.9 | WBGene00011037 | View | |
rfc-1 | C54G10.2 | WBGene00004337 | View | |
rnp-3 | K08D10.3 | WBGene00004386 |
rnp-3 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-3/U2B''; genetically, rnp-3 appears to function redundantly with rnp-2/U1A: loss of rnp-3 activity alone results in low levels of embryonic and total lethality, while animals doubly mutant for rnp-3 and rnp-2/U1A show much higher levels of embryonic and total lethality; in addition, animals doubly mutant for SAP-1/U2A' and RNP-3/U2B'', display a much more severe phenotype than either single mutation, indicating that in vivo, these proteins have some independent functions; immunoprecipitation experiments indicate that RNP-3 associates with U2 RNA in vivo and that this association does not require the presence of SAP-1/U2A'.
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rpa-1 | F18A1.5 | WBGene00017546 |
rpa-1 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, RPA-1 is predicted to function as a DNA-binding and oligonucleotide oligosaccharide-binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that rpa-1 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that rpa-1 transcripts are expressed in germ cells.
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T11G6.8 | T11G6.8 | WBGene00011722 | View | |
taf-10 | K03B4.3 | WBGene00006392 | View | |
tag-125 | C14B1.4 | WBGene00006474 |
tag-125/C14B1.4 encodes an ortholog of the histone methyltransferase subunit WDR5 (OMIM:609012) that antagonizes SynMuv transcriptional repressors.
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tag-65 | F58G11.5 | WBGene00006442 | View | |
Y57G11C.9 | Y57G11C.9 | WBGene00013307 | View | |
Y71H2AM.20 | Y71H2AM.20 | WBGene00022185 | View | |
Y92H12BR.2 | Y92H12BR.2 | WBGene00022368 | View | |
ZK973.11 | ZK973.11 | WBGene00022836 | View |