Module
- Number
- 101
- Regulatory Genes
- 4
- Module Genes
- 39
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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moe-3 | F32A11.6 | WBGene00003388 | 248 |
moe-3 encodes a CCCH tandem zinc finger (TZF) protein; while loss of moe-3 activity via RNAi alone results in no obvious abnormalities, animals triply mutant for moe-3, oma-1, and oma-2 demonstrate oocyte maturation defects, indicating that these genes likely function redundantly during germline development; in situ hybridization experiments indicate that moe-3 mRNA expression is relatively weak and restricted to the distal region of the gonad; based upon its sequence similarity to other TZF proteins, such as MEX-5 and POS-1, the product of MOE-3 is predicted to function as an RNA-binding protein.
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B0336.7 | B0336.7 | WBGene00015147 | 242 |
B0336.7 encodes, by alternative splicing, two isoforms of a protein with a THAP or THAP-like domain; other proteins with such domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1; B0336.7 is expressed in intestine and amphid neurons.
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eea-1 | T10G3.5 | WBGene00011696 | 195 |
eea-1 encodes a coiled-coil protein that is the C. elegans ortholog of early endosome antigen 1 (EEA1); eea-1 activity is required for wild-type levels of endocytosis; a fusion protein between EEA-1 FYVE domains and GFP binds endosomal/vacuolar membranes in wild-type worms but not in those lacking vps-34 activity, suggesting that, like its human ortholog, C. elegans EEA-1 binds phosphatidylinositol 3-phosphate (PtdIns 3-P) in vivo; EEA-1 reporter fusion proteins localize to endocytic vesicles.
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nhr-84 | T06C12.7 | WBGene00003674 | 125 | View |
CLR Predictions
28 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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aco-1 | ZK455.1 | WBGene00000040 |
aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; ACO-1 is predicted to be mitochondrial, and its mRNA levels appear to decrease in response to iron treatment.
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aps-1 | F29G9.3 | WBGene00000159 |
aps-1 encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1).
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ard-1 | F01G4.2 | WBGene00000181 |
ard-1 encodes a homolog of mammalian 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD) that is predicted to be mitochondrial.
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B0491.5 | B0491.5 | WBGene00007192 | View | |
C07D8.6 | C07D8.6 | WBGene00015565 | View | |
C35C5.3 | C35C5.3 | WBGene00007955 | View | |
C40H1.6 | C40H1.6 | WBGene00008041 | View | |
C46C2.2 | C46C2.2 | WBGene00008110 | View | |
calu-1 | M03F4.7 | WBGene00019760 | View | |
D2030.4 | D2030.4 | WBGene00008414 |
D2030.4 encodes the C. elegans ortholog of the NDUFB7/B18 subunit of the mitochondrial NADH dehydrogenase (ubiquinone) complex (complex I).
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ddp-1 | Y39A3CR.4 | WBGene00000941 |
ddp-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Tim8p and human deafness/dystonia peptide (DDP; OMIM:300356, mutated in Mohr-Tranebjaerg syndrome); by homology, DDP-1 is predicted to be part of a heterooligomeric complex that localizes to the mitochondrial intermembrane space and facilitates translocation of proteins from the cytosol to the inner mitochondrial membrane; loss of ddp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, indicating that ddp-1 is not essential for C. elegans development or may function redundantly with its paralogs, TIN-9, -10, and -13.
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dpm-3 | F28D1.11 | WBGene00009219 |
dpm-3 encodes a putative regulatory subunit of dolichol phosphate mannosyltransferase, orthologous to human DPM3 (OMIM:605951); in mass RNAi assays, DPM-3 is required for normal body size, fertility, and health.
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dss-1 | Y119D3B.15 | WBGene00022492 |
dss-1 encodes the C. elegans ortholog of human DSS1 (deleted in split hand/split foot 1) and Saccharomyces cerevisiae SEM1, subunits of the 26S proteasome regulatory particle; in C. elegans, DSS-1 is an essential protein, required for oogenesis and for embryonic and larval development; in addition, dss-1 appears to be required for proper development and/or function of the intestine and dss-1 may play a role in vulval development and regulation of adult lifespan; although loss of dss-1 activity in C. elegans results in no obvious defects in proteasomal function, dss-1 expression in Saccharomyces cerevisiae can efficiently rescue Sem1 growth defects and partially rescue Sem1 protein degradation defects; a DSS-1::GFP fusion protein is expressed in the intestinal epithelium and head neurons during larval and adult stages; DSS-1::GFP expression is strongest in the nucleus, with more diffuse staining seen in the cytoplasm.
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eif-3.D | R08D7.3 | WBGene00001227 |
eif-3.D encodes the C. elegans ortholog of the translation initiation factor 3 subunit d (eIF3d/Moe1); by homology, EIF-3.D is predicted to function as part of the eIF3 translation initiation complex but also as part of a Ras-mediated pathway that regulates mitotic spindle formation; in C. elegans, large-scale RNAi screens indicate that eif-3.D is required for embryonic and germline development, locomotion, and normal rates of post-embryonic growth; in the early embryo, eif-3.D is specifically required for the fidelity of meiotic divisions and normal pseudocleavage; eif-3.D function is likely conserved, as expression of eif-3.D in Schizosaccharomyces pombe can rescue the mitotic spindle and growth defects associated with moe1 mutant cells; to date, eif-3.D expression has been reported in anterior neurons and the pharynx, beginning at late stages of embryogenesis.
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erd-2 | F09B9.3 | WBGene00001331 |
erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1.
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F13E6.1 | F13E6.1 | WBGene00008745 | View | |
F35G12.2 | F35G12.2 | WBGene00009440 | View | |
F37C12.3 | F37C12.3 | WBGene00018151 | View | |
F45H10.3 | F45H10.3 | WBGene00009740 | View | |
F49C12.12 | F49C12.12 | WBGene00009881 | View | |
gpdh-2 | K11H3.1 | WBGene00010778 |
gpdh-2 encodes one of two C. elegans glycerol 3-phosphate dehydrogenases; although loss of gpdh-2 activity via large-scale RNAi screens results in no obvious defects, expression of a gpdh-2 cDNA in Saccharomyces cerevisiae hog1 mutants is able to rescue the high osmolarity-sensitive growth phenotype of these mutants, suggesting that gpdh-2 encodes a functional glycerol 3-phosphate dehydrogenase.
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K10C2.4 | K10C2.4 | WBGene00019620 |
K10C2.4 encodes a putative fumarylacetoacetate hydrolase, orthologous to human FAH (OMIM:276700, mutated in type I tyrosinemia), that is required for tyrosine metabolism, resistance to oxidative and protein-folding stresses, and more generally for normally rapid growth, normal locomotion, fertility, and viability; K10C2.4 is expressed in hypodermis and intestine; the intestines of K10C2.4(RNAi) animals atrophy rapidly, and show an abnormally active oxidative stress response (seen via gst-4::GFP) and ER stress response (seen via hsp-4::GFP); while RNAi against enzymes upstream of K10C2.4 suppresses the K10C2.4(RNAi) phenotype, excess dietary tyrosine or homogentisic acid enhances it, and exogenous succinylacetone (SA) mimics it, consistent with the hypothesis that blocked SA metabolism is toxic in K10C2.4(RNAi) animals.
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K12H4.3 | K12H4.3 | WBGene00019678 | View | |
K12H4.5 | K12H4.5 | WBGene00019680 | View | |
lpd-5 | ZK973.10 | WBGene00003061 |
lpd-5 is orthologous to the human gene NADH DEHYDROGENASE (UBIQUINONE) FE-S PROTEIN 4 (18KD) (NADH-COENZYME Q REDUCTASE) (NDUFS4; OMIM:602694), which when mutated leads to NADH:ubiquinone oxidoreductase (complex I) deficiency.
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lpd-9 | T21C9.5 | WBGene00003065 |
lpd-9 encodes a novel protein conserved amongst C. elegans, C. briggsae, and C. remanei; loss of lpd-9 activity via RNAi indicates that LPD-9 is required for fat storage and for larval growth and development.
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nuo-2 | T10E9.7 | WBGene00020417 | View | |
pfd-5 | R151.9 | WBGene00020112 |
pfd-5 encodes a putative prefoldin 5 subunit, orthologous to human PFDN5 (OMIM:604899), that is required for normal microtubule growth, embryonic and larval viability, fertility, vulval development, and locomotion; PFD-5 is expressed in most, if not all, tissues; pfd-5(RNAi) animals show sterile progeny, larval arrest or lethality, uncoordination, and abnormal body shapes, and pfd-5(RNAi) embryos show a reduced microtubule growth rate.
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rpb-7 | Y54E10BR.6 | WBGene00021845 | View | |
T07A9.9 | T07A9.9 | WBGene00020297 | View | |
T28D9.1 | T28D9.1 | WBGene00020894 | View | |
tag-242 | C14A4.1 | WBGene00007555 | View | |
W01A8.4 | W01A8.4 | WBGene00012166 |
W01A8.4 encodes the C. elegans ortholog of the NDUFB4/B15 subunit of the mitochondrial NADH dehydrogenase (ubiquinone) complex (complex I).
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W10D9.5 | W10D9.5 | WBGene00021133 | View | |
Y37D8A.10 | Y37D8A.10 | WBGene00012550 | View | |
Y60A3A.19 | Y60A3A.19 | WBGene00013365 | View | |
Y63D3A.7 | Y63D3A.7 | WBGene00013406 |
Y63D3A.7 encodes the C. elegans ortholog of the NDUFA2/B8 subunit of the mitochondrial NADH dehydrogenase (ubiquinone) complex (complex I).
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Y94H6A.8 | Y94H6A.8 | WBGene00022380 | View | |
ZK686.3 | ZK686.3 | WBGene00022793 |
ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
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