Genes
Page 5 of 264, showing 20 records out of 5271 total, starting on record 81, ending on 100
Public Gene Name | Sequence Name | WB ID | Description | Module | Actions |
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aqp-4 | F40F9.9 | WBGene00000172 |
aqp-4 encodes an aquaporin whose expression in Xenopus oocytes increases water permeability 5- to 10-fold; loss of AQP-4 activity via mutation or RNAi results in no obvious defects; however, AQP-4, in conjunction with AQP-2, AQP-3, and AQP-8, is weakly required for recovery from hypotonic stress; AQP-4 is expressed in the apical membrane of intestine; AQP-4 is paralogous to AQP-5 and AQP-6, and orthologous to human AQP8 (OMIM:603750).
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lemone_36_gene |
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aqp-7 | M02F4.8 | WBGene00000175 |
aqp-7 encodes an aquaglyceroporin whose expression in Xenopus oocytes increases either water or glycerol permeability five- to seven-fold; AQP-7 has no function in mass RNAi assays, perhaps reflecting genetic redundancy with its several paralogs; AQP-7 is expressed in muscle punctae (perhaps focal adhesions).
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lemone_130_gene |
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arc-1 | ZK1320.6 | WBGene00000180 |
arc-1 encodes a member of the ARL (ADP-ribosylation factor(ARF)-like) family of proteins which are very similar to ARF proteins but lack the ability to stimulate ADP ribosylation by cholera toxin; arc-1 has a human homolog, MID1, which when mutated leads to Opitz syndrome (OMIM:300000).
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lemone_167_gene |
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ard-1 | F01G4.2 | WBGene00000181 |
ard-1 encodes a homolog of mammalian 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD) that is predicted to be mitochondrial.
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lemone_101_gene |
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arg-1 | F31A9.3 | WBGene00000185 |
arg-1 encodes a member of the Delta/Serrate/LAG-2 family of transmembrane signaling ligands; arg-1 mediates cell fate decisions during early embryogenesis and in addition, is a downstream target of HLH-8/CeTwist, which binds E box sequences in the arg-1 promoter and is required for fate specification of a subset of mesodermal cells; arg-1 is closely related to apx-1 and lag-2 and is functionally interchangeable with them; an arg-1::gfp reporter is expressed in the vm1 vulval muscles, the intestinal, anal depressor, and anal sphincter muscles, and the head mesoderm cell.
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lemone_1_gene |
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arl-8 | Y57G11C.13 | WBGene00000192 |
lemone_22_gene |
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ars-2 | F28H1.3 | WBGene00000197 |
ars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; ARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; ARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development.
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lemone_73_gene |
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arx-2 | K07C5.1 | WBGene00000200 |
arx-2 encodes the C. elegans ortholog of the Arp2 subunit of the actin-related protein (Arp)2/3 complex.
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lemone_22_gene |
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asg-1 | K07A12.3 | WBGene00000209 |
asg-1 encodes a homolog of the proton-translocating F0 ATP synthase complex subunit g; by homology, ASG-1 is predicted to function in ATP synthesis, although its precise role in ATP anabolism is not yet known; in C. elegans, asg-1 activity is required for transposon silencing in the germline, suggesting that healthy energy metabolism is necessary for this process; in addition, large-scale RNAi screens indicate that asg-1 activity is required for embryonic and germline development, normal post-embryonic growth rates, and normal body morphology.
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lemone_67_gene |
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asg-2 | C53B7.4 | WBGene00000210 |
asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
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lemone_137_gene |
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asic-2 | T28F4.2 | WBGene00012137 |
lemone_17_gene |
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asm-1 | B0252.2 | WBGene00000211 |
asm-1 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase; the ASM-1 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-1 shows phosphodiesterase activity when expressed in COS-7 cells; while mammalian ASM is detected as both intracellular and secreted forms, asm-1 was detected exclusively in the secreted form; northern blot analysis indicates that asm-1 is expressed at higher levels in the embryo compared with other stages.
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lemone_106_gene |
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asm-2 | ZK455.4 | WBGene00000212 |
asm-2 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase 1; the ASM-2 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-2 shows phosphodiesterase activity when expressed in COS-7 cells; like mammalian ASM, asm-2 is probably both intracellular and secreted; northern blot analysis indicates that asm-2 is expressed during post-embryonic development as compared to asm-1 which is expressed at higher levels in the embryo; human ASM is implicated in Niemann-Pick disease type B (OMIM:607608).
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lemone_39_gene |
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asp-1 | Y39B6A.20 | WBGene00000214 |
asp-1 encodes a homolog of cathepsin D aspartic protease; it is transcribed exclusively in intestinal cells of the late embryo and early larvae and is not observed in older larvae or adults; ASP-1 is dispensable for neuronal degeneration.
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lemone_215_gene |
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asp-2 | T18H9.2 | WBGene00000215 |
asp-2 encodes aspartic protease.
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lemone_97_gene |
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asp-3 | H22K11.1 | WBGene00000216 |
asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
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lemone_215_gene |
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asp-4 | R12H7.2 | WBGene00000217 |
asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
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lemone_135_gene |
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asp-5 | F21F8.3 | WBGene00000218 |
lemone_97_gene |
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asp-6 | F21F8.7 | WBGene00000219 |
aspartic protease.
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lemone_97_gene |
View |
ast-1 | T08H4.3 | WBGene00020368 |
ast-1 encodes a novel ETS-box transcription factor; AST-1 is required for the proper navigation of some interneuron axons to their targets, for differentiation of the ventral cord pioneer neuron AVG, and for pharyngeal morphogenesis; AST-1 is transiently expressed in many head neurons late in their differentiation and axon outgrowth, and in a few pharyngeal cells; AST-1 is at first nuclear, but then relocates to spots in cell bodies and even neuronal processes; hypomorphic ast-1 mutants have axons extending laterally, and crossing over from the right axon tract to the left axon bundle; null ast-1(hd92) mutants are inviable, failing to attach a working pharynx to their cuticle during development and then starving as L1 larvae; behaviorally, hypomorphic ast-1 animals are at least superficially normal, indicating that the ventral nerve cord can tolerate at least some miswiring; AST-1 regulates odr-2 expression, while ast-1 expression is itself regulated by lin-11.
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lemone_52_regulator lemone_57_regulator lemone_89_regulator lemone_315_regulator |
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