Module
- Number
- 39
- Regulatory Genes
- 6
- Module Genes
- 71
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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ZK1320.3 | ZK1320.3 | WBGene00014253 | 384 | View | |
nhr-78 | F36A4.14 | WBGene00003668 | 308 | View | |
Y43C5A.2 | Y43C5A.2 | WBGene00012782 | 247 | View | |
C12D12.5 | C12D12.5 | WBGene00015716 | 199 | View | |
ceh-21 | T26C11.6 | WBGene00000444 | 193 |
ceh-21 encodes a a ONECUT class CUT homeobox protein with a single N-terminal cut domain and an OCAM domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-21 is one of three nematode-specific ONECUT genes in a cluster with ceh-39 and ceh-41; CEH-21 may be required for muscle formation and differentiation, and is expressed in muscle precursor cells and differentiated gut cells; ceh-21 has no obvious function in mass RNAi assays.
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C49C8.5 | C49C8.5 | WBGene00016769 | 131 | View |
CLR Predictions
2 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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asm-2 | ZK455.4 | WBGene00000212 |
asm-2 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase 1; the ASM-2 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-2 shows phosphodiesterase activity when expressed in COS-7 cells; like mammalian ASM, asm-2 is probably both intracellular and secreted; northern blot analysis indicates that asm-2 is expressed during post-embryonic development as compared to asm-1 which is expressed at higher levels in the embryo; human ASM is implicated in Niemann-Pick disease type B (OMIM:607608).
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B0035.13 | B0035.13 | WBGene00007112 | View | |
B0513.5 | B0513.5 | WBGene00007197 | View | |
C04F12.8 | C04F12.8 | WBGene00007302 | View | |
C10B5.3 | C10B5.3 | WBGene00015671 | View | |
C18A11.3 | C18A11.3 | WBGene00015949 | View | |
C18E9.5 | C18E9.5 | WBGene00007685 | View | |
C18H9.6 | C18H9.6 | WBGene00016004 | View | |
C25H3.10 | C25H3.10 | WBGene00016119 | View | |
C28G1.5 | C28G1.5 | WBGene00016190 | View | |
C34F11.8 | C34F11.8 | WBGene00016417 | View | |
C34H4.2 | C34H4.2 | WBGene00016425 | View | |
C44C1.5 | C44C1.5 | WBGene00016644 | View | |
C53C11.2 | C53C11.2 | WBGene00016900 | View | |
clec-10 | C03H5.1 | WBGene00015403 | View | |
col-141 | T15B7.5 | WBGene00000714 | View | |
col-182 | R09A8.4 | WBGene00000755 | View | |
cpg-9 | Y67D8C.8 | WBGene00022072 |
cpg-9 encodes a small (69-residue), putatively secreted protein with 4 potential chondroitin attachment sites, 2 of them verified by mass spectrometry; CPG-9 has no obvious function in mass RNAi assays.
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dlc-2 | M18.2 | WBGene00010888 |
dlc-2 encodes a putative dynein light chain 1; DLC-2 is orthologous to human DYNLL1 (OMIM:601562) and DYNLL2 (OMIM:608942), but much more divergent from them than its paralog DLC-1; its other paralogs are DLC-3/-5 and DLC-6.
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dsc-4 | K02D7.4 | WBGene00001099 |
dsc-4 encodes the C. elegans ortholog of the large subunit of the microsomal triglyceride transfer protein; dsc-4 affects the length of the defecation cycle and genetically interacts with clk-1 with respect to defecation cycle length, and also with respect to the clk-1- dependent adjustment of defecation cycle length to temperature; a DSC-4::GFP fusion protein is expressed in the intestine beginning during embryonic elongation and continuing on through adulthood.
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F07C6.3 | F07C6.3 | WBGene00008554 | View | |
F09G8.7 | F09G8.7 | WBGene00017321 | View | |
F14B8.4 | F14B8.4 | WBGene00017446 | View | |
F14B8.6 | F14B8.6 | WBGene00017448 | View | |
F16F9.4 | F16F9.4 | WBGene00017515 | View | |
F18E2.1 | F18E2.1 | WBGene00008936 | View | |
F21D5.3 | F21D5.3 | WBGene00009008 | View | |
F23F1.7 | F23F1.7 | WBGene00017748 | View | |
F26E4.2 | F26E4.2 | WBGene00009157 | View | |
F29C6.1 | F29C6.1 | WBGene00009243 | View | |
F32A5.2 | F32A5.2 | WBGene00017968 | View | |
F32H5.1 | F32H5.1 | WBGene00009347 | View | |
F35A5.1 | F35A5.1 | WBGene00018024 |
The F35A5.1 gene encodes a homolog of human FMR2, which when mutated leads to fragile site mental retardation, type 2 (OMIM:309548).
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F37H8.3 | F37H8.3 | WBGene00009512 | View | |
F38B6.4 | F38B6.4 | WBGene00018174 | View | |
F40A3.1 | F40A3.1 | WBGene00018216 | View | |
F41B4.1 | F41B4.1 | WBGene00018257 | View | |
F42G10.1 | F42G10.1 | WBGene00009645 |
F42G10.1 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F42G10.1 has no clear orthologs in other organisms.
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F53B3.6 | F53B3.6 | WBGene00018744 | View | |
F58B4.5 | F58B4.5 | WBGene00010238 | View | |
fbxa-156 | C06H5.1 | WBGene00007392 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
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fmo-1 | K08C7.2 | WBGene00001476 |
fmo-1 encodes a flavin-containing monoxygenase homologous to human FMO1, FMO2, and FMO3 (OMIM:602079, mutated in trimethylaminuria).
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glc-1 | F11A5.10 | WBGene00001591 |
glc-1 encodes the alpha subunit of a glutamate-gated chloride channel and forms a functional channel in Xenopus oocytes; mutations genetically interact with avr-14 and avr-15 mutations such that triple mutants exhibit high level resistance to ivermectin.
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gsto-1 | C29E4.7 | WBGene00016204 |
gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site.
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haf-9 | ZK484.2 | WBGene00001819 |
haf-9 is orthologous to the human gene ATP-BINDING CASSETTE, SUB-FAMILY B (MDR/TAP), MEMBER 3 (TAP2; OMIM:170261), which when mutated leads to disease.
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K06A4.5 | K06A4.5 | WBGene00010595 | View | |
K11E4.2 | K11E4.2 | WBGene00010774 | View | |
lips-17 | R07G3.2 | WBGene00019939 | View | |
nhx-2 | B0495.4 | WBGene00003730 |
nhx-2 encodes a sodium/proton exchanger expressed in the apical membranes of intestinal cells; NHX-2 is required for normally high growth rates, and for propagation or maintenance of the germline, NHX-2 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton.
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nlp-26 | Y43F8C.2 | WBGene00003764 |
nlp-26 encodes a predicted neuropeptide not found in multigene families within C. elegans and is not clearly related to other well-characterized neuropeptides.
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pcp-2 | F23B2.12 | WBGene00003957 | View | |
pgp-1 | K08E7.9 | WBGene00003995 |
pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.
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pmp-1 | C44B7.8 | WBGene00004058 |
pmp-1 encodes an ATP-binding cassette (ABC) transporter most closely related to the peroxisomal membrane proteins; pmp-1 activity is required for efficient RNA interference (RNAi) of a germline-expressed target, pop-1.
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R01B10.3 | R01B10.3 | WBGene00019805 | View | |
R03G5.5 | R03G5.5 | WBGene00019846 | View | |
spp-23 | Y34D9A.11 | WBGene00021335 | View | |
T05E12.6 | T05E12.6 | WBGene00011487 | View | |
T15B7.1 | T15B7.1 | WBGene00020516 | View | |
T20G5.8 | T20G5.8 | WBGene00011870 | View | |
T25B6.2 | T25B6.2 | WBGene00020788 |
T25B6.2 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T25B6.2 is orthologous to Ac-mep-1, a gut luminal neprilysin which is specifically expressed in the adult life stage of Ancylostoma caninum hookworms, and whose protein product is localized to the microvilli of the gastrointestinal tract, suggesting a role in digestion.
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T25G12.3 | T25G12.3 | WBGene00020811 | View | |
T28H10.2 | T28H10.2 | WBGene00012143 | View | |
ttr-8 | R13A5.6 | WBGene00020049 |
R13A5.6 encodes a protein containing a predicted signal sequence followed by a transthyretin-like domain; the product of R13A5.6 belongs to a family of apparently nematode-specific proteins whose function is not yet known; an R13A5.6::GFP promoter fusion directs expression outside of the nervous system.
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ugt-17 | C08B6.1 | WBGene00007422 | View | |
unc-23 | H14N18.1 | WBGene00006760 | View | |
VC5.2 | VC5.2 | WBGene00020908 | View | |
W01B11.6 | W01B11.6 | WBGene00020917 | View | |
W02B12.1 | W02B12.1 | WBGene00012201 | View | |
Y45F10B.13 | Y45F10B.13 | WBGene00012875 | View | |
Y59C2A.1 | Y59C2A.1 | WBGene00021984 | View | |
Y71H2AL.1 | Y71H2AL.1 | WBGene00022164 | View |