Module
- Number
- 67
- Regulatory Genes
- 3
- Module Genes
- 19
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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cid-1 | K10D2.3 | WBGene00019629 | 681 |
cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases.
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cey-3 | M01E11.5 | WBGene00000474 | 173 |
cey-3 encodes a protein with a cold-shock/Y-box domain; CEY-3 associates with CGH-1, CEY-2, and CEY-4 in cytoplasmic particles of the gonad and early embryo.
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pde-2 | R08D7.6 | WBGene00011146 | 162 | View |
CLR Predictions
2 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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asg-1 | K07A12.3 | WBGene00000209 |
asg-1 encodes a homolog of the proton-translocating F0 ATP synthase complex subunit g; by homology, ASG-1 is predicted to function in ATP synthesis, although its precise role in ATP anabolism is not yet known; in C. elegans, asg-1 activity is required for transposon silencing in the germline, suggesting that healthy energy metabolism is necessary for this process; in addition, large-scale RNAi screens indicate that asg-1 activity is required for embryonic and germline development, normal post-embryonic growth rates, and normal body morphology.
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C25H3.9 | C25H3.9 | WBGene00016118 |
C25H3.9 encodes the C. elegans ortholog of the NDUFB5/SGDH subunit of the mitochondrial NADH dehydrogenase (ubiquinone) complex (complex I).
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C34B2.8 | C34B2.8 | WBGene00016393 | View | |
C46F11.2 | C46F11.2 | WBGene00008117 |
C46F11.2 is orthologous to human MITOCHONDRIAL GLUTATHIONE REDUCTASE (GSR; OMIM:138300); GSR deficiency has been associated with hemolytic anemia.
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cct-1 | T05C12.7 | WBGene00000377 |
cct-1 encodes a putative alpha subunit of the eukaryotic cytosolic ('T complex') chaperonin, orthologous to human TCP1 (OMIM:186980), and required for normal pronuclear-centrosome rotation, positioning of the mitotic spindle, meiosis, and distal tip cell migration; CCT-1 is also required to repress SKN-1-dependent transcription of gst-4, and for fertility and viability; CCT-1 is expressed in larval and adult pharynx, intestine, body wall muscle, and neurons, as well as adult rectal epithelium; cct-1 mRNA is enriched in cultured touch receptor neurons.
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cct-5 | C07G2.3 | WBGene00000380 |
cct-5 encodes, by alternative splicing, two isoforms of a putative epsilon subunit of the eukaryotic cytosolic ('T complex') chaperonin, orthologous to human CCT5 (OMIM:610150, mutated in sensory neuropathy with spastic paraplegia); CCT-5 represses SKN-1-dependent transcription of gst-4; in mass RNAi assays, cct-5 is required for normal embryonic osmotic integrity, transgene subcellular localization, viability (throughout the life cycle), fertility, vulval development, and locomotion.
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F31D4.9 | F31D4.9 | WBGene00009294 | View | |
F42G8.10 | F42G8.10 | WBGene00018361 | View | |
F44G4.2 | F44G4.2 | WBGene00009712 | View | |
K07H8.10 | K07H8.10 | WBGene00019510 | View | |
M01A10.3 | M01A10.3 | WBGene00019693 | View | |
pbs-1 | K08D12.1 | WBGene00003947 |
pbs-1 encodes a protease subunit with highest similarity to vertebrate proteasome subunit beta type 6 that affects fertility, embryonic viability, locomotion, and larval viability
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R07G3.5 | R07G3.5 | WBGene00019941 | View | |
rpt-3 | F23F12.6 | WBGene00004503 |
rpt-3 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-3 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
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rpt-4 | F23F1.8 | WBGene00004504 |
rpt-4 encodes a predicted ATPase subunit of the 19S regulatory complex of the proteasome that affects body morphology, embryonic viability, growth, movement, and fertility; interacts with itself in yeast two-hybrid assays.
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sod-1 | C15F1.7 | WBGene00004930 |
sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).
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T09A5.11 | T09A5.11 | WBGene00011638 | View | |
trap-4 | Y56A3A.21 | WBGene00013238 | View | |
ZK809.3 | ZK809.3 | WBGene00014086 | View |