Module
- Number
- 57
- Regulatory Genes
- 6
- Module Genes
- 26
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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K02E10.1 | K02E10.1 | WBGene00019317 | 535 | View | |
ceh-20 | F31E3.1 | WBGene00000443 | 237 |
ceh-20 encodes the C. elegans ortholog of the homeodomain co-factor Extradenticle (Exd/Pbx); together with ceh-40 and unc-62, ceh-20 activity is required for embryonic viability; ceh-20 is also required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; in addition, ceh-20 is required for regulating post-embryonic migrations of the Q neuroblast descendants and for regulating vulval development; a CEH-20::GFP fusion protein is expressed in embryos and postembryonically in many cell types including the Q, P, and V cells and their descendants; CEH-20 localizes to the nucleus.
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cey-1 | F33A8.3 | WBGene00000472 | 225 |
cey-1 encodes a protein with a cold-shock/Y-box domain that is expressed in early embryonic blastomeres (at the 15-cell stage, i.e., pre-gastrulation), but is normally repressed in early germline blastomeres by PIE-1; it is predicted to be mitochondrial by phylogenetic profiling.
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ast-1 | T08H4.3 | WBGene00020368 | 205 |
ast-1 encodes a novel ETS-box transcription factor; AST-1 is required for the proper navigation of some interneuron axons to their targets, for differentiation of the ventral cord pioneer neuron AVG, and for pharyngeal morphogenesis; AST-1 is transiently expressed in many head neurons late in their differentiation and axon outgrowth, and in a few pharyngeal cells; AST-1 is at first nuclear, but then relocates to spots in cell bodies and even neuronal processes; hypomorphic ast-1 mutants have axons extending laterally, and crossing over from the right axon tract to the left axon bundle; null ast-1(hd92) mutants are inviable, failing to attach a working pharynx to their cuticle during development and then starving as L1 larvae; behaviorally, hypomorphic ast-1 animals are at least superficially normal, indicating that the ventral nerve cord can tolerate at least some miswiring; AST-1 regulates odr-2 expression, while ast-1 expression is itself regulated by lin-11.
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alr-1 | R08B4.2 | WBGene00044330 | 175 | View | |
W02D9.3 | W02D9.3 | WBGene00012209 | 120 | View |
CLR Predictions
119 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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abl-1 | M79.1 | WBGene00000018 |
abl-1 encodes, by alternative splicing, three isoforms of a Src homology (SH) 2 and 3 domain-containing non-receptor tyrosine kinase orthologous to human ABL1 (OMIM:189980, mutated in chronic myeloid leukemia) and ABL2 (OMIM:164690); ABL-1 inhibits germline apoptosis induced by radiation or by natural aging, but it has no effect on apoptosis induced by starvation or by chemical mutagens (ethylnitrosourea, ethylmethanesulfonate, cisplatin, etoposide), or on constitutive ('physiological') germline apoptosis; at the same time, ABL-1 is required for germline apoptosis induced by oxidative, osmotic or heat-shock stress, and is also required for pathogenesis by Shigella flexneri infecting the intestine; ABL-1-inhibited apoptosis is confined to a single gonad arm undergoing radiation, having no nonautonomous effect on the unirradiated arm; abl-1 is expressed in the germline, in most or all cells of early embryos, and in postembryonic pharynx, tail ganglia and ventral nerve cord; abl-1(ok171) mutants are hypersensitive to germline apoptosis and resistant to S. flexneri infection; both abl-1(ok171) phenotypes are phenocopied by c-ABL inhibitors such as STI-571 (Gleevec); ABL-1-inhibited apoptosis requires active CED-3 and EGL-1, inactive CED-9, and active AKT-1, CEP-1, CLK-1, HUS-1, and MRT-2; abl-1(ok171) has no effect on somatic apoptosis, and abl-1(ok171) mutants are generally normal; abl-1 transcripts are enriched in cultured unc-4::GFP neurons.
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C10A4.3 | C10A4.3 | WBGene00015664 | View | |
C53D5.2 | C53D5.2 | WBGene00016903 | View | |
ddr-2 | F11D5.3 | WBGene00017381 |
F11D5.3 encodes a putative tyrosine kinase homologous to human RS1 (OMIM:312700, mutated in juvenile X-linked retinoschisis).
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egl-46 | K11G9.4 | WBGene00001210 |
egl-46 encodes a predicted transcription factor and conserved member of a TFIIA-like zinc finger protein family that affects coordinated locomotion, morphology and process formation of the touch cells, male mating efficiency, HSN cell migration, differentiation, and axonal outgrowth, serotonin production and also affects terminal divisions of the Q neuroblasts; acts to inhibit touch cell fate in FLP cells together with egl-44 and is expressed dynamically in neurons, specifically in touch cells, FLP, and HSN neurons.
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F14B4.1 | F14B4.1 | WBGene00008779 | View | |
F20D6.10 | F20D6.10 | WBGene00017639 | View | |
F21A9.2 | F21A9.2 | WBGene00017651 | View | |
F26E4.7 | F26E4.7 | WBGene00009162 |
The F26E4.7 gene encodes a homolog of human BIGH3, which when mutated leads to Groenouw granular dystrophy, type 1 (OMIM:122200).
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F27D4.6 | F27D4.6 | WBGene00009190 | View | |
fkh-7 | F26D12.1 | WBGene00001439 |
fkh-7 encodes one of 15 forkhead transcriptional regulators encoded by the C. elegans genome; by homology, FKH-7 is predicted to function as a transcription factor that regulates gene expression during development; however, as loss of fkh-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of FKH-7 in C. elegans development and/or behavior is not yet known; however, reporter gene studies indicate that fkh-7 expression is detected only in neurons of the head and tail ganglia, the nerve cord, and the male tail, suggesting that FKH-7 likely functions in nervous system differentiation.
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K02E10.1 | K02E10.1 | WBGene00019317 | View | |
lam-3 | T22A3.8 | WBGene00002248 |
lam-3 is orthologous to human LAMININ ALPHA-2 (LAMA2; OMIM:156225), which when mutated leads to merosin-deficient congenital muscular dystrophy.
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nhr-152 | C12D5.2 | WBGene00015705 | View | |
nhr-190 | F48G7.11 | WBGene00018622 | View | |
R03E9.2 | R03E9.2 | WBGene00019843 | View | |
R03G5.7 | R03G5.7 | WBGene00019848 | View | |
rig-5 | C36F7.4 | WBGene00004372 | View | |
ser-3 | K02F2.6 | WBGene00004778 |
ser-3 encodes a putative homolog of mammalian 5-HT4 metabotropic serotonin receptors; SER-3 is required for normal inhibition of movement by 5-HT, with ser-3 mutants being hyperactive and excessively curling their male tails (but this phenotype is reversed by exogenous 5-HT, with ser-3 mutants then becoming sluggish); SER-3 activity is required for normally high brood sizes and for embryonic development, and weakly required for pharyngeal pumping; SER-3 is expressed in pharynx, head and tail neurons, nerve ring, and intestine.
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syd-2 | F59F5.6 | WBGene00006364 |
syd-2 encodes alpha-liprin, a member of the liprin family of proteins that interact with LAR (leukocyte common antigen related)-type receptor tyrosine phosphatases (RPTPs) to facilitate clustering of RPTPs to focal adhesions; SYD-2 is required for establishing normal presynaptic density, and is expressed in all neurons and muscles; SYD-2 is required cell autonomously in neurons for differentiation of presynaptic active zones, where SYD-2 is localized.
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tbx-2 | F21H11.3 | WBGene00006543 |
tbx-2 encodes one of 21 C. elegans T-box transcription factors; during development, tbx-2 activity is required for normal adaptation, but not chemotaxis, to attractive odorants sensed by the AWC amphid neurons; tbx-2 is required redundantly with unc-3 and unc-31 for negative regulation of dauer formation, and large-scale RNAi screens reveal an essential role for tbx-2 in early larval development, normal rates of postembryonic growth, and locomotory behavior; tbx-2 is also required along with pha-4 for embryonic precursor cells to adopt a pharyngeal muscle fate; TBX-2 and PHA-4 are mutually dependant on each other to maintain expression implicating them in a regulatory loop that controls commitment to the pharyngeal muscle fate; yeast two-hybrid assays have identified that TBX-2 interacts with UBC-9 (E2 SUMO conjugating enzyme) and GEI-17 (E3 SUMO ligase); based on the two-hybrid interaction and the similar pharyngeal muscle phenotype of ubc-9, it is likely that protein sumoylation is required for precursor-cell derived pharyngeal muscle development; antibodies to TBX-2 detect expression in the cytoplasm of amphid and pharyngeal neurons in larvae and adults, suggesting that TBX-2 function may be controlled, in part, by regulation of its subcellular localization; in addition, in situ hybridization studies indicate that tbx-2 mRNA is expressed during mid-embryogenesis; tbx-2 expression in the AWC amphid neurons is sufficient to rescue the olfactory adaptation defects seen in tbx-2 mutant animals.
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vab-8 | K12F2.2 | WBGene00006874 |
The vab-8 gene encodes a novel protein containing an atypical kinesin-like motor domain that is required for many posteriorly-directed cell migrations, as well as axonal outgrowth and pathfinding; vab-8 encodes two protein isoforms: VAB-8S, a novel protein expressed in migrating cells, and VAB-8L, which contains a kinesin-related domain, is expressed in neurons and functions in growth cone migrations; VAB-8 interacts with UNC-51, a serine-threonine kinase also required for axon outgrowth.
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W03F8.10 | W03F8.10 | WBGene00020998 | View | |
Y38H6C.17 | Y38H6C.17 | WBGene00012629 |
Y38H6C.17 encodes a putative amino acid transporter that inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51; Y38H6C.17 has 11 predicted transmembrane alpha-helices; Y38H6C.17 has multiple C. elegans paralogs and non-nematode orthologs, including budding yeast AVT3 and AVT4 and human SLC36A1 (OMIM:606561).
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Y44E3A.1 | Y44E3A.1 | WBGene00021547 | View | |
Y54G11B.1 | Y54G11B.1 | WBGene00013222 | View |