Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

aqp-4  

Sequence Name

F40F9.9  

WB ID

WBGene00000172  

Description

aqp-4 encodes an aquaporin whose expression in Xenopus oocytes increases water permeability 5- to 10-fold; loss of AQP-4 activity via mutation or RNAi results in no obvious defects; however, AQP-4, in conjunction with AQP-2, AQP-3, and AQP-8, is weakly required for recovery from hypotonic stress; AQP-4 is expressed in the apical membrane of intestine; AQP-4 is paralogous to AQP-5 and AQP-6, and orthologous to human AQP8 (OMIM:603750).