Genes
Page 9 of 264, showing 20 records out of 5271 total, starting on record 161, ending on 180
| Public Gene Name | Sequence Name | WB ID | Description | Module | Actions |
|---|---|---|---|---|---|
| clc-2 | C01C10.1 | WBGene00000523 |
clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes; clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein.
|
lemone_89_gene |
View |
| C01C4.3 | C01C4.3 | WBGene00015293 |
C01C4.3 encodes a serine/threonine protein kinase.
|
lemone_13_gene |
View |
| C01F4.2 | C01F4.2 | WBGene00015303 |
lemone_19_regulator |
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| aly-1 | C01F6.5 | WBGene00000120 |
aly-1 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-1 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-2 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-2, ALY-1 and its paralog ALY-2 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; ALY-1 and NXF-2 bind the TRE element in vitro; ALY-1 is also bound competitively by either NXF-2 or TRA-1 in vitro; aly-1(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-1 is thought to promote recruitment of mRNA export factor to mRNAs; other than these sex-determination phenotypes, ALY-1 has no grossly obvious function in four-way RNAi assays of ALY-1/-3 and W04D2.6.
|
lemone_141_gene |
View |
| tag-60 | C01F6.6 | WBGene00006438 |
tag-60/C01F6.6 encodes, by alternative splicing, five isoforms of an ortholog of Drosophila SIP1 and of human PDZK1 (OMIM:603831) and PDZD3 (OMIM:607146); TAG-60 is required for normally short lifespan and for normal acetylcholine neurotransmission; TAG-60 is expressed in larval and adult pharynx, intestine, excretory cell, and tail cells.
|
lemone_23_gene |
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| C01F6.9 | C01F6.9 | WBGene00007223 |
The C01F6.9 gene resides in an operon that also contains the genes icl-1 and lpl-1.
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lemone_41_gene lemone_83_regulator |
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| unc-76 | C01G10.11 | WBGene00006808 |
unc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies.
|
lemone_26_gene |
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| C01G10.13 | C01G10.13 | WBGene00007238 |
lemone_3_gene |
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| srx-79 | C01G10.2 | WBGene00005970 |
lemone_3_gene |
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| C01G10.5 | C01G10.5 | WBGene00007232 |
lemone_192_gene |
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| C01G10.9 | C01G10.9 | WBGene00007236 |
lemone_106_gene |
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| C01G12.7 | C01G12.7 | WBGene00007247 |
lemone_108_gene |
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| C01G12.8 | C01G12.8 | WBGene00007248 |
lemone_53_gene |
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| C01G5.5 | C01G5.5 | WBGene00015307 |
lemone_10_gene |
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| C01G5.6 | C01G5.6 | WBGene00015308 |
lemone_62_gene |
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| aqp-2 | C01G6.1 | WBGene00000170 |
aqp-2 encodes, by alternative splicing, two isoforms of an biochemically atypical aquaglyceroporin; when expressed in Xenopus oocytes, AQP-2 increases water permeability 5- to 11-fold, and urea permeability 4.5-fold, but has no effect on glycerol permeability; AQP-2::GFP fusion proteins are expressed predominantly in the excretory cell and more weakly in muscle, motor neurons, and hypodermis; AQP-2 expression is also enriched in dauer larvae; loss of AQP-2 activity via mutation or RNAi results in no obvious defects; however, AQP-2, in conjunction with AQP-3, AQP-4, and AQP-8, is weakly required for recovery from hypotonic stress.
|
lemone_254_gene |
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| C01G6.3 | C01G6.3 | WBGene00007225 |
lemone_231_gene |
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| tag-165 | C01G6.6 | WBGene00006510 |
C01G6.6 encodes an ortholog of the human gene METHIONINE SYNTHASE REDUCTASE (MTRR), which when mutated leads to homocystinuria (OMIM:236270)
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lemone_26_gene |
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| C01G6.7 | C01G6.7 | WBGene00007228 |
lemone_150_gene |
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| C01G6.9 | C01G6.9 | WBGene00007229 |
lemone_127_gene |
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