Module
- Number
- 150
- Regulatory Genes
- 3
- Module Genes
- 22
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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nhr-64 | C45E1.1 | WBGene00003654 | 300 |
nhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis.
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nhr-68 | H12C20.3 | WBGene00003658 | 235 | View | |
elt-2 | C33D3.1 | WBGene00001250 | 222 |
elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, and the stress-induced mtl-2; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation
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CLR Predictions
49 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0222.9 | B0222.9 | WBGene00015057 | View | |
C01G6.7 | C01G6.7 | WBGene00007228 | View | |
D1025.2 | D1025.2 | WBGene00008354 | View | |
dhs-2 | F55A12.4 | WBGene00000966 |
dhs-2 encodes a short-chain dehydrogenase predicted to be mitochondrial.
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dhs-4 | T05F1.10 | WBGene00000968 |
dhs-4 encodes a short-chain dehydrogenase predicted to be mitochondrial.
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dnj-7 | C55B6.2 | WBGene00001025 |
This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial.
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E01A2.7 | E01A2.7 | WBGene00017089 |
The E01A2.7 gene encodes one of five paraoxonase-like proteins; it is homologous to the human genes PARAOXONASE 1 gene (PON1, OMIM:168820) and PARAOXONASE 2 (OMIM:602447), which in some allelic forms are associated with susceptibility to coronary artery disease or to variations in fasting plasma glucose.
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F10D7.3 | F10D7.3 | WBGene00017340 | View | |
F25B4.8 | F25B4.8 | WBGene00017771 | View | |
F41E6.5 | F41E6.5 | WBGene00018286 | View | |
F54F3.4 | F54F3.4 | WBGene00010063 | View | |
F59F5.8 | F59F5.8 | WBGene00010346 | View | |
K09H11.1 | K09H11.1 | WBGene00019599 | View | |
M79.3 | M79.3 | WBGene00010903 | View | |
nhr-69 | T23H4.2 | WBGene00003659 |
nhr-69 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-69 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-69 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-69 in C. elegans development and/or behavior is not yet known; nhr-69 is expressed strongly in the gut and hypodermis at all stages and is detected in the uterus during the late L4 and adult stages; nhr-69 expression is also occasionally detected in the rectal epithelia and posterior pharynx.
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nnt-1 | C15H9.1 | WBGene00003778 |
nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial.
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pgp-2 | C34G6.4 | WBGene00003996 |
pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family and that is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); during development, pgp-2 activity is required, in parallel with that of the AP-3 adaptor complex, for the proper formation of gut granules, lysosome-related fat storage organelles found in the C. elegans intestine; pgp-2 is expressed in the intestine, from the E2 stage of embryonic development through adulthood; PGP-2 localizes to the gut granule membrane.
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pmp-2 | C44B7.9 | WBGene00004059 | View | |
prx-3 | C15H9.8 | WBGene00004193 |
prx-3 is orthologous to the human gene PEROXISOMAL BIOGENESIS FACTOR 3 (PEX3; OMIM:603164), which when mutated leads to Zellweger syndrome of complementation group G.
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R04B5.5 | R04B5.5 | WBGene00011003 | View | |
ttr-20 | F36A4.8 | WBGene00018085 | View | |
ugt-1 | AC3.7 | WBGene00007072 | View |