Child MapMan terms

Original MapMan term
19
Description
Protein homeostasis
Type
mapman

MapMan description genes species aco aof ash ath atr bdi calsi cam cre egu hvu lpe mac mco mpo msi obr osa osaindica oth pab ped peq ppa ptr sbi sit sly smo spo ssp tae ttu vvi zjn zma zma-b104 zma-ph207 zosmarina
19.2 Protein homeostasis.ubiquitin-proteasome system 21869 37 460 432 382 599 334 558 809 459 156 627 563 595 824 123 253 0 474 569 506 428 600 672 439 509 767 553 565 593 563 364 1378 1934 1129 430 480 690 0 656 396
19.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation 14838 37 311 273 263 433 215 384 555 295 71 422 392 411 604 50 152 0 315 395 341 275 433 450 306 296 524 389 392 440 350 234 899 1390 781 287 333 482 0 436 259
19.4 Protein homeostasis.proteolysis 13729 37 315 242 201 348 293 366 439 342 91 237 405 381 348 80 158 0 309 377 345 250 474 356 262 266 456 360 386 372 364 223 1001 1359 765 318 211 404 0 403 222
19.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation) 8556 37 168 147 152 258 116 227 281 163 30 237 240 246 356 23 81 0 168 230 202 156 265 263 166 157 290 241 243 229 206 126 515 824 464 161 207 303 0 267 148
19.2.2.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities 7114 37 142 118 127 217 98 190 240 138 17 198 193 200 305 11 63 0 140 201 172 130 204 211 136 116 244 203 203 195 162 103 427 696 390 133 183 257 0 224 127
19.4.2 Protein homeostasis.proteolysis.serine-type peptidase activities 5920 37 114 122 92 178 116 169 207 142 50 121 171 157 146 39 64 0 131 146 140 101 197 153 127 129 207 153 156 168 155 101 443 495 299 171 118 177 0 176 89
19.2.2.1.5.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities 5179 37 104 86 94 152 66 139 193 92 7 146 143 143 245 5 36 0 100 146 122 91 143 149 98 77 180 148 147 143 112 75 279 507 282 95 153 206 0 173 102
19.1 Protein homeostasis.protein quality control 4848 37 108 110 95 116 81 112 187 111 36 146 127 122 172 36 57 0 106 119 109 86 111 158 92 131 162 118 123 113 149 103 351 378 213 88 106 170 0 165 81
19.2.2.8 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes 4300 37 94 78 73 125 70 106 204 80 11 135 104 115 172 12 46 0 98 113 95 79 127 131 93 89 173 95 101 154 92 75 258 389 223 85 80 129 0 122 74
19.4.3 Protein homeostasis.proteolysis.aspartic-type peptidase activities 3535 37 109 41 41 70 73 90 101 105 3 15 128 90 80 2 44 0 87 130 100 70 175 87 52 40 93 102 117 97 72 52 262 439 250 52 5 110 0 105 46
19.4.3.1 Protein homeostasis.proteolysis.aspartic-type peptidase activities.A1-class protease (Pepsin) 3535 37 109 41 41 70 73 90 101 105 3 15 128 90 80 2 44 0 87 130 100 70 175 87 52 40 93 102 117 97 72 52 262 439 250 52 5 110 0 105 46
19.2.2.8.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes 3411 37 72 63 59 103 50 79 178 70 6 103 84 85 137 8 36 0 82 95 76 64 105 107 74 60 144 77 83 126 70 62 198 297 162 68 71 102 0 97 58
19.2.2.1.5.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-H2-class E3 ligase 2676 37 46 27 47 87 32 73 87 37 1 79 78 76 134 1 18 0 45 85 63 36 90 64 53 32 88 85 84 73 56 35 111 303 148 41 93 119 0 89 60
19.4.5 Protein homeostasis.proteolysis.metallopeptidase activities 2601 37 54 47 43 58 49 68 72 55 31 57 63 79 63 31 34 0 59 61 64 52 72 71 47 71 89 58 64 57 102 43 181 252 134 56 59 72 0 75 58
19.2.2.8.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components 2520 37 51 46 47 76 44 60 116 49 2 81 49 58 109 4 31 0 55 63 51 54 70 89 63 41 121 60 61 98 59 53 151 181 108 55 60 82 0 73 49
19.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation 2477 37 59 58 44 57 43 69 78 57 26 75 63 61 80 22 33 0 61 65 60 51 61 82 48 64 90 62 63 60 72 50 156 193 122 58 40 69 0 75 50
19.2.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome 2460 37 47 50 39 57 43 59 99 61 35 69 61 61 72 34 36 0 53 59 58 54 50 79 51 78 82 54 60 48 77 41 192 178 108 43 66 77 0 79 50
19.4.2.2 Protein homeostasis.proteolysis.serine-type peptidase activities.S10-class serine carboxypeptidase (SCPL) 2153 37 34 45 24 54 44 72 81 62 8 49 68 66 44 3 11 0 53 56 53 37 92 56 56 20 62 58 57 60 30 25 169 211 129 58 57 57 0 66 26
19.2.2.8.1.4.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component FBX 1942 37 41 33 36 62 32 46 81 38 2 63 36 41 87 4 24 0 43 49 40 39 55 69 49 34 103 45 46 82 46 39 113 139 84 45 42 61 0 54 39
19.3 Protein homeostasis.autophagy 1832 37 44 49 30 50 35 44 74 43 15 46 37 43 60 14 30 0 41 43 36 37 48 52 36 48 73 41 41 55 63 32 132 120 72 39 41 68 0 69 31
19.2.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation 1678 37 42 40 29 37 29 47 54 40 15 50 35 40 56 11 21 0 42 47 41 37 42 60 32 38 60 40 44 39 46 34 113 131 84 41 27 47 0 55 32
19.4.1 Protein homeostasis.proteolysis.cysteine-type peptidase activities 1546 37 36 30 23 38 34 37 53 38 6 42 41 51 56 6 15 0 30 37 38 24 28 40 34 24 62 45 46 47 31 24 109 165 78 37 25 43 0 45 28
19.2.2.1.5.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-HC-class E3 ligase 1471 37 33 29 28 32 20 37 69 34 4 43 35 37 61 3 12 0 32 35 34 30 30 50 29 31 57 40 39 39 38 24 93 115 77 29 37 56 0 55 24
19.2.6.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle 1445 37 27 29 20 32 25 37 57 37 19 40 36 37 43 19 20 0 30 35 35 35 28 45 31 43 52 30 37 28 46 24 114 113 65 26 37 43 0 44 26
19.2.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD) 1260 37 22 33 23 30 22 27 47 27 16 33 31 36 40 14 20 0 26 26 26 27 29 35 20 37 47 29 29 29 40 25 86 106 66 25 24 42 0 44 21
19.1.5 Protein homeostasis.protein quality control.cytosolic Hsp70 chaperone system 1237 37 27 28 24 32 15 32 41 30 4 31 31 33 48 5 9 0 31 32 34 26 28 46 21 31 45 31 33 31 31 24 93 95 54 14 26 50 0 45 26
19.2.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways 1120 37 27 25 18 30 17 24 39 26 13 38 24 33 39 7 17 0 26 30 26 26 31 34 18 43 33 26 28 24 33 19 66 85 64 23 23 31 0 32 22
19.2.3.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities 1103 37 27 27 18 25 17 32 37 27 6 34 21 25 37 4 13 0 29 32 28 24 33 42 20 22 37 26 30 26 33 22 74 87 56 28 15 32 0 37 20
19.4.5.6 Protein homeostasis.proteolysis.metallopeptidase activities.aminopeptidase activities 981 37 20 20 17 21 18 23 30 23 10 23 24 30 25 14 10 0 24 24 26 17 25 27 18 22 26 25 29 19 39 15 82 88 50 20 24 26 0 31 16
19.2.6.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle 960 37 18 20 18 23 17 21 40 23 15 28 23 23 28 14 15 0 22 23 22 18 21 32 19 34 29 23 22 19 29 16 72 60 40 16 27 33 0 34 23
19.4.2.1 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families 941 37 22 10 20 52 25 28 36 15 2 4 27 20 32 1 9 0 14 25 23 5 18 13 15 15 55 27 33 45 22 26 70 75 40 50 3 29 0 21 14
19.1.1 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery 922 37 21 22 20 19 18 20 37 21 10 31 21 20 30 11 15 0 20 22 20 18 18 32 20 25 29 23 23 19 37 18 69 60 36 19 19 29 0 30 20
19.2.6.2.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components 900 37 14 17 14 19 15 21 41 22 12 25 23 23 25 12 13 0 19 22 22 24 22 26 22 26 34 17 22 17 26 14 67 69 39 15 23 33 0 33 12
19.2.2.1.5.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities 815 37 12 13 9 38 12 22 11 22 6 12 22 32 16 2 9 0 18 26 24 18 16 19 8 11 20 27 26 18 15 7 74 116 63 11 11 19 0 22 8
19.4.2.6 Protein homeostasis.proteolysis.serine-type peptidase activities.S54-class protease (RBL)) 778 37 17 18 14 20 13 22 19 20 8 23 19 24 21 9 11 0 19 19 19 18 18 24 15 21 21 21 20 18 21 12 57 59 39 15 17 24 0 28 15
19.2.2.1.5.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities 759 37 17 9 17 20 14 19 26 14 1 27 20 17 34 1 12 0 14 21 20 15 33 28 23 15 31 19 19 20 25 13 52 50 29 19 15 21 0 17 12
19.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation) 707 37 16 18 13 18 8 21 23 26 15 14 15 25 19 7 9 0 17 18 13 14 14 17 18 21 19 20 18 21 15 11 42 72 36 15 15 19 0 14 11
19.2.2.1.5.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.E3 ubiquitin ligase (PUB) 676 35 16 7 16 19 12 17 23 12 0 25 17 15 32 0 10 0 12 19 18 12 28 27 20 13 30 17 17 19 23 12 46 44 25 15 14 19 0 15 10
19.1.8 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities 662 35 14 11 13 19 15 15 37 10 0 29 16 21 25 0 10 0 10 15 10 13 16 14 12 4 28 16 16 17 11 18 38 80 30 15 20 22 0 21 1
19.4.2.9 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex 652 37 16 16 12 15 11 17 21 16 7 15 25 16 19 7 12 0 14 18 15 12 12 16 14 29 21 14 16 15 23 13 45 48 31 13 11 16 0 17 14
19.2.2.8.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.target protein binding component SKP1/ASK1 630 37 14 12 7 21 2 13 49 15 1 14 29 21 18 1 2 0 22 26 18 3 30 9 8 11 14 11 16 18 5 4 30 93 42 8 7 14 0 19 3
19.2.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation) 623 37 10 11 11 14 9 17 20 16 10 15 19 15 16 7 8 0 16 19 17 13 13 17 10 19 19 19 17 16 21 10 46 58 31 12 9 16 0 16 11
19.1.7 Protein homeostasis.protein quality control.Hsp60 chaperone system 612 37 13 14 13 14 10 14 13 17 8 13 17 14 19 5 6 0 14 15 13 11 13 21 10 21 18 16 15 14 28 15 50 45 28 13 9 21 0 20 12
19.4.1.1 Protein homeostasis.proteolysis.cysteine-type peptidase activities.C1-class protease (Papain) 584 36 16 10 6 15 12 17 18 16 0 14 21 23 17 1 4 0 10 12 14 4 8 9 11 6 32 21 19 15 9 7 39 84 33 14 6 14 0 19 8
19.2.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway 579 37 15 13 9 11 8 13 23 16 5 21 10 14 23 4 6 0 17 19 16 17 16 16 9 21 17 17 18 12 14 9 40 36 27 12 13 15 0 15 12
19.2.3.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities 575 37 15 13 11 12 12 15 17 13 9 16 14 15 19 7 8 0 13 15 13 13 9 18 12 16 23 14 14 13 13 12 39 44 28 13 12 15 0 18 12
19.2.2.8.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes 563 36 14 9 9 13 14 18 20 8 1 20 15 22 23 0 4 0 10 12 12 10 15 16 10 8 16 11 11 17 10 6 42 71 45 9 7 14 0 14 7
19.1.6 Protein homeostasis.protein quality control.Hsp90 chaperone system 557 37 14 12 9 11 7 12 37 14 5 15 9 13 20 6 7 0 12 14 13 11 16 16 11 19 19 12 15 13 15 12 43 30 18 13 18 18 0 19 9
19.1.5.2 Protein homeostasis.protein quality control.cytosolic Hsp70 chaperone system.co-chaperone (Hsp40) 552 37 10 12 9 15 8 15 15 13 2 13 14 14 20 3 3 0 14 15 16 15 17 20 10 17 19 14 16 13 14 10 43 36 20 7 14 24 0 26 6
19.2.2.1.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination 537 37 14 12 9 13 9 11 29 11 3 19 12 14 22 2 4 0 13 13 13 10 21 17 11 11 19 14 13 11 11 9 35 40 24 12 13 17 0 18 8
19.2.4.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction 528 37 8 10 8 12 9 11 14 12 5 14 17 18 15 5 8 0 11 11 11 11 10 14 8 12 17 13 14 10 16 10 40 58 36 10 9 16 0 18 7
19.1.1.2 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system 527 37 12 13 11 10 10 11 25 12 7 16 13 11 16 7 9 0 11 12 12 10 10 15 9 15 15 14 14 10 20 12 41 33 17 10 13 20 0 20 11
19.2.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation 524 37 17 14 11 14 9 10 21 8 3 18 9 11 35 3 4 0 11 12 11 9 14 17 13 10 18 11 10 17 9 9 36 36 23 12 16 16 0 16 11
19.3.3 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system 522 37 17 18 7 17 10 11 19 15 6 13 9 11 18 5 8 0 11 14 11 9 10 13 13 14 21 11 11 14 18 10 43 31 13 12 12 19 0 16 12
19.2.2.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-conjugating E2 protein (UBC) 520 37 12 14 10 12 8 14 21 10 7 20 16 13 23 6 7 0 8 8 7 9 13 20 10 11 16 11 13 16 16 11 29 38 26 12 7 19 0 18 9
19.4.2.3 Protein homeostasis.proteolysis.serine-type peptidase activities.S1-class protease (Deg) 490 37 9 10 9 16 10 11 14 9 14 11 11 11 10 10 8 0 10 9 10 10 19 16 11 18 15 11 10 11 22 10 38 31 20 12 10 14 0 13 7
19.3.2 Protein homeostasis.autophagy.ATG9-2-18 membrane shuttling complex 486 37 9 14 8 11 11 13 24 11 3 11 10 14 16 4 7 0 11 11 10 11 10 13 8 13 16 11 10 12 18 10 36 36 24 11 11 13 0 16 9
19.3.4 Protein homeostasis.autophagy.autophagic cargo receptor activities 483 37 8 10 8 14 7 12 19 9 3 14 10 10 17 2 11 0 12 10 7 10 21 17 8 12 22 11 11 21 16 7 32 30 20 8 9 20 0 19 6
19.2.6.1.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components 482 37 7 10 10 12 9 11 22 10 7 14 13 12 15 7 8 0 11 13 12 7 8 17 9 20 15 12 10 10 13 8 35 33 22 7 12 16 0 17 8
19.4.5.8 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities 481 37 10 7 6 12 8 11 11 9 6 13 7 16 14 7 7 0 10 10 11 9 4 16 8 17 15 11 11 13 17 8 38 60 29 6 15 10 0 10 9
19.2.6.1.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components 478 37 11 10 8 11 8 10 18 13 8 14 10 11 13 7 7 0 11 10 10 11 13 15 10 14 14 11 12 9 16 8 37 27 18 9 15 17 0 17 15
19.2.2.8.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components 473 35 13 7 8 11 13 15 18 6 0 18 13 19 18 0 3 0 7 9 9 8 14 11 9 6 14 9 9 15 6 4 35 65 41 8 5 11 0 11 5
19.2.2.1.5.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-v-class E3 ligase 461 36 9 11 10 13 5 12 15 10 1 14 13 12 24 0 1 0 11 14 14 10 12 18 8 3 17 11 12 15 10 7 32 33 25 12 8 15 0 13 11
19.2.6.2.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components 459 37 12 10 5 11 8 14 13 12 6 13 10 11 16 6 6 0 9 11 11 9 6 15 8 16 16 10 12 10 18 9 36 38 22 10 12 7 0 8 13
19.2.1.2.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification 453 37 13 8 7 9 6 11 18 14 3 16 8 11 20 2 4 0 13 16 14 15 13 13 7 6 13 15 16 9 10 7 33 27 20 10 10 13 0 13 10
19.3.2.1 Protein homeostasis.autophagy.ATG9-2-18 membrane shuttling complex.components 441 37 8 13 7 10 10 12 22 10 3 10 9 13 15 4 6 0 10 10 9 10 9 12 7 11 15 10 9 11 16 8 32 33 22 10 10 12 0 15 8
19.2.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin 426 37 11 9 8 10 8 9 16 8 8 14 17 8 14 8 8 0 8 8 8 7 12 13 9 13 18 8 8 11 14 9 23 26 18 11 10 14 0 13 9
19.2.3.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex 426 37 11 9 8 10 8 9 16 8 8 14 17 8 14 8 8 0 8 8 8 7 12 13 9 13 18 8 8 11 14 9 23 26 18 11 10 14 0 13 9
19.1.2 Protein homeostasis.protein quality control.ribosome-associated chaperone activities 421 37 7 7 5 10 5 8 13 10 4 13 22 9 15 5 4 0 8 10 8 4 13 12 8 15 11 9 9 9 10 6 34 36 26 5 10 17 0 18 6
19.4.1.7 Protein homeostasis.proteolysis.cysteine-type peptidase activities.C97-class peptidase (PPPDE) 406 37 8 9 7 10 7 10 12 10 3 16 9 12 19 4 4 0 9 10 9 8 6 10 12 7 16 11 11 10 9 7 37 28 16 8 9 13 0 13 7
19.1.1.1 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.calnexin/calreticulin chaperone system 395 37 9 9 9 9 8 9 12 9 3 15 8 9 14 4 6 0 9 10 8 8 8 17 11 10 14 9 9 9 17 6 28 27 19 9 6 9 0 10 9
19.2.2.1.5.3.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (SINA) 379 35 12 11 6 15 5 12 14 8 0 4 11 13 15 0 2 0 7 7 8 11 7 10 5 4 14 8 8 13 4 5 30 45 25 10 8 9 0 9 4
19.4.5.7 Protein homeostasis.proteolysis.metallopeptidase activities.carboxypeptidase activities 376 37 9 6 8 7 7 10 16 7 5 8 17 10 7 4 5 0 9 8 8 9 20 10 9 11 10 7 8 8 20 6 16 27 21 10 7 10 0 10 6
19.4.2.4 Protein homeostasis.proteolysis.serine-type peptidase activities.S16-class protease (LON) 363 37 7 8 6 9 5 8 13 8 3 7 9 8 7 5 5 0 9 8 9 9 13 11 5 14 11 9 9 6 11 8 29 29 16 5 8 15 0 14 7
19.2.2.1.5.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities 361 37 9 10 7 7 6 10 10 10 3 13 8 8 10 3 6 0 8 8 6 6 12 15 7 13 13 9 11 14 10 8 22 23 16 8 4 11 0 12 5
19.2.2.1.5.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities.monomeric E3 ubiquitin ligase (HECT) 361 37 9 10 7 7 6 10 10 10 3 13 8 8 10 3 6 0 8 8 6 6 12 15 7 13 13 9 11 14 10 8 22 23 16 8 4 11 0 12 5
19.1.6.1 Protein homeostasis.protein quality control.Hsp90 chaperone system.chaperone (Hsp90) 354 37 8 7 6 7 4 8 27 9 3 5 6 9 11 4 5 0 9 9 9 8 11 10 6 14 11 7 9 7 9 6 30 18 12 8 11 12 0 13 6
19.2.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway 346 37 7 8 6 14 6 7 11 7 6 12 8 11 10 1 8 0 6 7 7 7 10 13 6 15 11 6 6 8 13 6 16 27 17 7 6 11 0 12 7
19.2.1.3.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex 346 37 7 8 6 14 6 7 11 7 6 12 8 11 10 1 8 0 6 7 7 7 10 13 6 15 11 6 6 8 13 6 16 27 17 7 6 11 0 12 7
19.2.2.5.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.conjugation E2 protein 345 37 11 10 8 8 6 7 14 5 2 11 6 8 23 2 3 0 7 8 7 6 7 12 8 7 11 7 6 12 7 6 23 27 17 7 11 9 0 9 7
19.2.4.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex 341 37 7 12 6 9 6 7 15 7 5 10 6 7 12 5 6 0 6 6 6 7 8 8 6 12 14 7 7 9 10 6 22 23 13 7 9 14 0 15 6
19.3.1 Protein homeostasis.autophagy.ATG1-13 autophagosome assembly control complex 341 37 10 7 7 8 7 8 12 8 3 8 8 8 9 3 4 0 7 8 8 7 7 9 7 9 14 8 9 8 11 5 21 23 15 8 9 16 0 18 4
19.1.7.1 Protein homeostasis.protein quality control.Hsp60 chaperone system.chaperone (Hsp60) 337 37 8 8 8 9 6 9 7 9 4 8 9 8 10 3 3 0 8 8 7 5 4 13 3 10 10 9 9 9 14 9 26 30 20 7 1 10 0 9 7
19.4.2.1.1 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families.protease (SBT1) 337 31 6 0 8 9 10 12 11 5 0 0 14 7 15 0 1 0 7 12 9 0 8 4 7 3 18 10 13 26 4 10 27 38 15 6 0 11 0 6 5
19.2.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation 336 37 5 8 6 9 5 12 8 8 2 10 11 12 9 3 3 0 10 9 10 6 6 8 6 12 11 13 10 9 10 6 19 33 18 5 2 8 0 6 8
19.2.2.1.5.4.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.plant-specific E3 ubiquitin ligase (RSL/RFA) 330 36 5 4 4 20 7 9 4 11 3 4 4 12 7 0 2 0 6 10 9 7 8 7 3 4 10 10 11 9 7 1 34 48 23 5 4 7 0 7 4
19.2.2.8.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes 326 37 8 6 5 9 6 9 6 2 4 12 5 8 12 4 6 0 6 6 7 5 7 8 9 21 13 7 7 11 12 7 18 21 16 8 2 13 0 11 9
19.2.1.2.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.cysteine oxidase (PCO) 324 37 9 5 4 5 3 8 15 11 1 13 6 7 17 1 1 0 10 13 11 11 9 10 5 4 9 11 13 6 4 4 24 18 13 7 10 10 0 10 6
19.3.2.1.3 Protein homeostasis.autophagy.ATG9-2-18 membrane shuttling complex.components.component ATG18 314 37 6 11 5 8 7 9 18 6 2 6 6 9 10 2 4 0 7 7 6 7 6 8 5 8 11 7 6 9 12 6 18 24 15 8 9 9 0 12 5
19.1.4 Protein homeostasis.protein quality control.plastidial Hsp70 chaperone system 310 37 8 11 8 8 6 6 9 6 4 9 6 7 11 2 5 0 7 7 8 3 6 11 6 14 9 7 7 7 15 8 17 20 13 6 5 11 0 11 6
19.1.2.1 Protein homeostasis.protein quality control.ribosome-associated chaperone activities.NAC chaperone heterodimer 309 37 5 5 3 7 3 6 10 8 2 10 20 7 13 3 2 0 6 8 6 2 9 9 6 11 9 6 7 6 6 4 24 30 22 4 9 9 0 9 3
19.4.5.6.6 Protein homeostasis.proteolysis.metallopeptidase activities.aminopeptidase activities.M20-class IAA-amino acid hydrolase 306 37 4 6 5 7 6 8 11 8 2 8 7 10 8 2 1 0 8 8 9 2 7 9 6 3 9 10 12 7 6 6 25 31 16 8 9 9 0 9 4
19.2.2.1.5.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Ariadne) 304 37 4 6 3 15 2 9 5 7 2 5 12 8 7 1 5 0 8 9 9 8 7 9 3 6 7 12 9 6 6 4 27 31 17 4 7 10 0 12 2
19.4.5.8.1 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH mitochondrial protease complexes 302 37 6 3 4 6 5 7 7 5 4 8 5 12 9 4 4 0 6 6 7 6 2 11 5 8 7 7 7 9 9 3 24 48 22 3 8 6 0 4 5
19.2.3.1.2.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU6-12) 288 37 7 7 6 7 5 9 7 6 3 7 8 8 10 3 3 0 7 8 6 7 1 10 6 7 11 7 7 8 6 7 17 23 14 7 8 8 0 10 7
19.4.2.7 Protein homeostasis.proteolysis.serine-type peptidase activities.S28-class serine carboxypeptidase 287 37 4 10 3 7 4 5 12 6 2 5 7 7 6 1 4 0 5 5 5 5 17 9 5 2 16 7 5 6 10 3 19 27 14 11 5 16 0 10 2
19.1.1.2.1 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.ERdj3B-BiP-SDF2 chaperone complex 281 37 7 7 6 5 4 6 16 6 3 10 5 7 10 4 4 0 6 6 6 5 4 6 3 8 8 7 7 5 10 5 25 18 11 4 8 11 0 11 7
19.2.2.1.6.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.ligating E3 protein (RGLG) 276 36 7 5 3 5 4 6 20 6 1 9 5 7 11 0 2 0 6 7 7 4 11 9 5 4 11 8 7 4 4 4 23 25 14 6 5 7 0 9 5
19.4.5.7.3 Protein homeostasis.proteolysis.metallopeptidase activities.carboxypeptidase activities.M28-class carboxypeptidase 273 37 7 4 7 5 5 8 14 5 1 5 15 8 5 2 3 0 7 6 6 7 13 6 7 7 6 5 6 6 16 4 9 21 18 8 5 6 0 6 4
19.1.3 Protein homeostasis.protein quality control.mitochondrial Hsp70 chaperone system 268 37 8 8 6 6 7 8 8 6 2 9 8 8 9 3 3 0 7 7 6 3 3 10 5 8 7 7 8 6 10 5 15 21 14 4 2 8 0 7 6
19.2.2.1.6.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex 261 37 7 7 6 8 5 5 9 5 2 10 7 7 11 2 2 0 7 6 6 6 10 8 6 7 8 6 6 7 7 5 12 15 10 6 8 10 0 9 3
19.1.5.1 Protein homeostasis.protein quality control.cytosolic Hsp70 chaperone system.chaperone (Hsp70) 256 35 6 6 6 7 0 7 6 7 1 4 6 8 12 1 2 0 7 7 8 1 5 9 4 7 12 7 7 9 8 7 16 29 15 1 4 5 0 0 9
19.2.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).ubiquitin-fold protein (SUMO) 255 37 7 6 5 9 2 9 4 12 8 3 3 12 5 1 2 0 6 8 4 5 3 4 11 6 5 9 6 6 6 3 15 36 12 6 5 5 0 4 2
19.2.2.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-fold protein (UBQ) 245 30 1 0 2 9 0 7 0 0 1 0 13 15 5 1 5 0 4 5 7 0 28 6 5 9 10 10 10 3 11 1 5 42 17 3 0 4 0 2 4
19.1.8.1 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-C-I protein 240 30 3 5 5 6 8 6 13 4 0 12 5 11 10 0 0 0 3 7 4 6 5 3 4 0 12 7 7 5 0 10 17 33 8 0 7 7 0 7 0
19.1.1.1.1 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.calnexin/calreticulin chaperone system.CNX-CRT cycle 231 37 5 5 6 5 4 5 9 5 2 10 5 5 9 2 2 0 5 6 5 4 5 9 6 7 9 5 5 5 8 3 17 15 11 5 5 6 0 6 5
19.4.5.6.5 Protein homeostasis.proteolysis.metallopeptidase activities.aminopeptidase activities.M1-class neutral/aromatic-hydroxyl amino acid aminopeptidase 230 37 5 4 3 3 3 5 9 5 3 6 6 8 6 3 3 0 6 5 6 5 2 10 3 4 7 5 5 3 16 3 19 22 12 4 6 5 0 6 4
19.2.2.8.1.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component SKP2 229 35 5 4 4 6 6 5 7 4 0 9 4 5 7 0 6 0 4 4 3 6 18 6 6 4 8 6 6 5 7 5 10 17 10 2 9 7 0 7 7
19.1.5.5 Protein homeostasis.protein quality control.cytosolic Hsp70 chaperone system.nucleotide exchange factor (BAG) 220 35 4 6 5 4 4 5 9 5 0 8 6 6 10 0 1 0 5 5 5 5 3 8 4 2 8 5 5 5 4 3 21 15 10 4 4 12 0 10 4
19.4.5.5 Protein homeostasis.proteolysis.metallopeptidase activities.M48 families 220 37 3 3 3 3 3 12 5 5 4 4 3 11 4 2 4 0 3 4 4 5 7 2 3 3 5 3 3 3 5 4 9 40 13 3 2 14 0 13 3
19.2.2.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation 218 37 3 5 3 4 4 6 5 7 3 6 6 6 4 3 3 0 6 8 7 4 1 7 3 3 4 9 7 4 6 2 22 20 12 3 4 6 0 8 4
19.3.3.1 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ubiquitin-fold protein (ATG8) 212 37 9 10 3 9 3 4 10 9 1 6 3 4 10 1 2 0 5 5 4 3 1 4 6 7 11 4 4 7 6 4 21 9 2 6 4 6 0 5 4
19.4.2.8 Protein homeostasis.proteolysis.serine-type peptidase activities.mitochondrion Clp-type protease complex 211 37 4 4 4 4 2 5 10 5 5 6 4 4 5 3 3 0 5 5 5 4 8 7 5 8 5 5 5 6 14 3 13 12 8 5 6 5 0 6 3
19.4.1.3 Protein homeostasis.proteolysis.cysteine-type peptidase activities.C13-class asparaginyl endopeptidase (Legumain) 206 35 3 2 4 4 4 4 4 4 1 0 6 9 8 0 1 0 4 5 5 4 6 8 2 4 6 4 4 16 4 2 10 29 15 4 5 5 0 5 5
19.2.4.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome 200 37 4 7 5 5 3 6 8 5 2 4 4 5 7 2 2 0 5 5 5 5 4 8 4 8 8 5 4 5 4 5 14 12 7 4 4 6 0 6 3
19.2.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway 195 37 5 4 3 5 3 4 5 3 2 5 6 8 6 2 3 0 3 4 3 2 5 5 3 7 5 3 4 4 6 4 10 22 20 4 4 5 0 5 3
19.2.1.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex 195 37 5 4 3 5 3 4 5 3 2 5 6 8 6 2 3 0 3 4 3 2 5 5 3 7 5 3 4 4 6 4 10 22 20 4 4 5 0 5 3
19.4.2.9.1 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex.proteolytic core component ClpP1|3-6 195 37 5 5 3 5 3 5 6 4 2 5 14 4 4 2 4 0 4 6 5 4 3 2 6 10 6 4 4 5 8 4 11 12 9 4 2 6 0 4 5
19.2.4.2.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.platform ATPase (CDC48) 193 35 0 3 3 3 2 4 4 4 1 4 10 11 4 2 3 0 4 3 3 4 0 4 1 6 5 5 5 5 4 2 15 34 19 3 2 5 0 4 2
19.2.4.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing 191 37 3 4 4 4 4 3 10 3 4 5 4 6 6 2 4 0 4 4 4 4 7 5 2 5 8 4 4 5 10 4 10 13 10 4 2 6 0 5 5
19.2.2.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation 190 36 5 5 4 4 4 4 7 4 3 4 7 4 7 0 4 0 5 4 4 5 3 7 6 4 5 4 4 5 8 4 11 15 6 4 7 4 0 5 4
19.2.2.8.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component LRB 190 35 3 2 1 3 8 9 5 2 0 5 9 12 4 0 1 0 2 2 2 2 9 4 1 2 4 2 2 5 2 1 10 38 25 3 1 3 0 3 3
19.2.2.1.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin receptor regulatory protein (DA1) 187 37 4 4 3 8 2 5 5 4 1 4 4 4 7 1 1 0 4 4 4 5 3 7 4 9 7 4 4 5 4 3 20 13 8 4 4 5 0 6 3
19.4.5.6.1 Protein homeostasis.proteolysis.metallopeptidase activities.aminopeptidase activities.M24-class methionyl aminopeptidase (MAP1) 186 37 5 3 4 4 4 5 5 5 2 4 5 5 5 4 2 0 5 5 5 5 3 1 4 5 3 5 5 3 6 3 18 18 13 3 2 3 0 6 3
19.4.2.1.5 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families.protease (SBT5) 184 32 5 3 4 6 4 7 6 3 0 0 4 6 7 0 1 0 1 6 8 0 4 1 2 2 15 6 8 6 4 9 11 14 13 7 0 5 0 3 3
19.4.5.4 Protein homeostasis.proteolysis.metallopeptidase activities.M16 families 182 37 5 3 2 5 6 4 5 3 3 3 4 4 3 2 3 0 5 7 7 4 5 9 3 9 2 4 4 4 6 3 13 12 8 4 2 6 0 6 4
19.2.2.5.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.ubiquitin-fold protein (MUB) 179 37 6 4 3 6 3 3 7 3 1 7 3 3 12 1 1 0 4 4 4 3 7 5 5 3 7 4 4 5 2 3 13 9 6 5 5 7 0 7 4
19.4.5.8.2 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH plastidial protease complexes 179 37 4 4 2 6 3 4 4 4 2 5 2 4 5 3 3 0 4 4 4 3 2 5 3 9 8 4 4 4 8 5 14 12 7 3 7 4 0 6 4
19.2.4.2.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer 178 37 3 2 2 5 4 4 4 5 2 5 5 4 5 1 2 0 4 5 5 4 5 6 3 2 5 5 6 2 4 3 17 15 11 2 3 7 0 9 2
19.4.5.3 Protein homeostasis.proteolysis.metallopeptidase activities.M10-class metalloprotease (Matrixin) 178 36 3 3 2 5 2 4 2 4 1 2 4 4 4 0 1 0 4 4 4 4 10 2 2 2 24 4 5 6 4 2 7 13 5 8 5 3 0 3 16
19.1.2.1.1 Protein homeostasis.protein quality control.ribosome-associated chaperone activities.NAC chaperone heterodimer.subunit alpha 170 36 2 2 1 5 2 3 4 6 1 5 7 4 7 2 1 0 4 5 4 0 4 5 4 6 5 3 4 3 2 2 12 23 16 3 4 4 0 4 1
19.4.2.8.2 Protein homeostasis.proteolysis.serine-type peptidase activities.mitochondrion Clp-type protease complex.chaperone component ClpX 169 37 3 3 3 3 1 4 9 4 4 5 3 3 4 2 2 0 4 4 4 4 7 6 3 6 4 4 4 5 10 2 12 9 6 4 6 4 0 6 2
19.2.2.8.2.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BT 167 35 6 3 4 5 3 4 7 1 0 8 1 4 9 0 1 0 3 4 4 4 2 4 4 3 6 4 4 6 2 1 14 15 10 3 4 6 0 7 1
19.2.2.1.6.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Uev1 165 37 5 4 4 5 3 3 6 3 1 5 5 5 7 1 1 0 5 4 4 4 9 7 4 3 4 4 4 3 5 3 9 9 6 3 6 5 0 5 1
19.2.3.1.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP5|8-11) 161 35 3 3 3 5 3 4 5 3 1 5 4 4 7 0 2 0 4 4 4 4 4 8 3 0 7 4 4 3 6 4 14 12 8 4 2 3 0 4 3
19.2.2.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities 159 37 3 4 3 2 2 6 3 4 2 4 5 5 5 1 3 0 5 4 3 4 4 4 1 9 5 3 4 4 2 3 12 15 10 2 5 3 0 3 2
19.2.3.1.1.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP15-21) 159 35 4 4 3 5 3 4 7 4 0 5 2 4 9 0 1 0 4 4 4 3 3 3 4 5 7 4 4 4 3 2 10 12 8 5 1 5 0 6 3
19.4.5.8.1.2 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH mitochondrial protease complexes.FtsH3/10 matrix-AAA protease heterodimers 154 37 5 1 2 4 3 3 3 4 2 5 2 4 5 2 2 0 3 4 4 5 2 6 2 5 4 4 4 6 6 2 13 14 9 1 6 3 0 1 3
19.1.7.3 Protein homeostasis.protein quality control.Hsp60 chaperone system.Hsp60-co-chaperone (Hsp10) 153 37 3 2 3 4 3 2 3 5 2 2 4 3 5 1 2 0 3 3 3 3 5 4 6 6 6 4 3 3 10 4 12 6 3 4 3 8 0 6 4
19.1.1.1.1.2 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.calnexin/calreticulin chaperone system.CNX-CRT cycle.lectin chaperone (CRT) 152 37 4 3 4 3 3 3 6 4 1 7 3 3 5 1 1 0 4 5 4 3 2 6 4 2 6 4 4 3 2 3 14 9 7 4 4 4 0 4 3
19.2.4.4.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.shuttle protein (RAD23) 149 37 3 5 3 4 2 5 5 4 1 4 3 4 6 1 1 0 4 4 4 4 2 6 3 6 6 4 3 4 2 4 9 9 5 3 4 5 0 5 2
19.4.5.8.1.1 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH mitochondrial protease complexes.component FtsH4|11 148 36 1 2 2 2 2 4 4 1 2 3 3 8 4 2 2 0 3 2 3 1 0 5 3 3 3 3 3 3 3 1 11 34 13 2 2 3 0 3 2
19.2.3.1.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP12-13) 146 36 4 4 2 2 1 4 3 4 1 4 5 4 4 0 1 0 4 4 4 3 5 8 2 3 4 4 4 5 4 3 7 11 8 3 2 5 0 7 3
19.4.1.5 Protein homeostasis.proteolysis.cysteine-type peptidase activities.C26-class gamma-glutamyl peptidase 145 36 6 2 2 5 7 3 3 3 0 4 3 2 5 1 2 0 3 3 3 4 4 4 4 3 2 4 5 2 4 4 8 15 6 2 3 6 0 4 4
19.4.2.1.2 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families.protease (SBT2) 145 34 6 3 4 6 3 3 5 3 0 0 3 3 4 0 4 0 3 3 3 3 2 3 1 7 6 4 4 5 7 3 12 10 6 3 1 6 0 4 2
19.2.2.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-activating E1 protein (UBA) 143 37 1 2 3 2 1 4 3 3 1 3 4 4 3 1 2 0 3 4 4 4 7 7 4 4 3 4 4 2 4 2 11 14 9 2 3 5 0 5 1
19.4.5.4.2 Protein homeostasis.proteolysis.metallopeptidase activities.M16 families.peptidase (Nardilysin-like) 140 37 3 2 1 4 5 3 4 2 3 2 3 3 2 1 2 0 4 6 6 3 5 6 2 7 2 3 3 3 4 2 10 9 6 3 2 5 0 5 4
19.1.2.1.2 Protein homeostasis.protein quality control.ribosome-associated chaperone activities.NAC chaperone heterodimer.subunit beta 139 37 3 3 2 2 1 3 6 2 1 5 13 3 6 1 1 0 2 3 2 2 5 4 2 5 4 3 3 3 4 2 12 7 6 1 5 5 0 5 2
19.1.8.2 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-C-II protein 139 34 1 2 2 2 5 1 15 2 0 3 4 1 5 0 10 0 2 1 1 1 3 3 4 3 1 1 2 2 11 2 4 22 7 4 3 5 0 4 0
19.2.3.1.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU3-4) 138 37 3 3 2 2 3 3 5 4 1 4 3 4 3 2 2 0 3 4 4 3 4 3 3 5 6 4 4 2 3 2 9 12 8 4 2 3 0 4 2
19.1.6.2 Protein homeostasis.protein quality control.Hsp90 chaperone system.Hsp90-co-chaperone (P23) 137 37 4 4 2 2 2 3 6 3 1 6 2 3 6 1 1 0 3 3 3 2 3 4 4 4 5 3 3 4 4 4 9 10 5 3 5 4 0 4 2
19.2.2.3.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities 137 37 3 2 3 3 2 4 4 4 3 4 2 3 5 1 2 0 3 3 3 4 4 4 2 6 4 4 4 4 6 4 10 9 4 3 2 3 0 3 3
19.4.2.9.2 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex.non-proteolytic core component ClpR 137 37 4 4 3 3 3 3 9 3 3 4 3 3 4 3 3 0 3 3 2 2 2 4 3 7 5 3 3 3 7 2 7 9 5 3 2 1 0 3 3
19.1.5.3 Protein homeostasis.protein quality control.cytosolic Hsp70 chaperone system.nucleotide exchange factor & co-chaperone (Hsp110) 136 37 4 3 3 3 2 3 8 3 1 4 3 3 5 1 2 0 3 3 3 3 2 5 2 3 4 3 3 3 4 3 8 9 6 1 3 6 0 6 5
19.2.2.8.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex 133 34 4 2 3 4 3 3 2 1 0 5 1 2 7 0 2 0 3 2 3 2 3 2 5 11 7 3 3 6 4 3 6 6 6 4 0 4 0 6 5
19.4.5.8.2.1 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH plastidial protease complexes.component FtsH1|2|5|6|8 133 37 3 3 1 4 2 3 3 3 2 4 1 3 4 2 2 0 3 3 3 3 1 3 2 7 6 3 3 3 6 4 12 9 5 2 6 2 0 4 3
19.1.1.2.1.1 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.ERdj3B-BiP-SDF2 chaperone complex.chaperone component BiP 132 37 4 3 3 3 2 3 7 3 1 4 3 3 5 1 2 0 3 3 3 3 2 3 1 3 4 3 3 3 4 3 8 9 6 1 3 6 0 6 5
19.4.5.1 Protein homeostasis.proteolysis.metallopeptidase activities.M3-class metalloprotease 132 36 3 4 4 4 4 3 2 3 1 3 3 3 3 2 3 0 3 3 3 3 0 3 3 3 5 3 3 3 9 3 13 9 6 4 2 2 0 1 3
19.2.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer 130 37 3 4 2 4 2 2 13 3 2 4 4 2 3 2 2 0 2 2 2 4 2 4 3 3 4 2 3 3 3 2 9 9 6 2 3 3 0 3 4
19.2.3.1.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP1-2) 128 35 1 5 1 2 1 7 4 3 0 2 3 1 1 0 1 0 6 8 4 3 4 3 1 3 2 4 5 2 2 1 8 18 12 1 2 3 0 3 1
19.4.4 Protein homeostasis.proteolysis.threonine-type peptidase activities 127 37 2 2 2 4 21 2 6 2 1 2 2 4 3 2 1 0 2 3 3 3 2 5 2 2 5 2 3 3 4 3 6 8 4 2 4 2 0 2 1
19.4.4.1 Protein homeostasis.proteolysis.threonine-type peptidase activities.T3-class gamma-glutamyl transpeptidase (GGT) 127 37 2 2 2 4 21 2 6 2 1 2 2 4 3 2 1 0 2 3 3 3 2 5 2 2 5 2 3 3 4 3 6 8 4 2 4 2 0 2 1
19.2.1.2.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities 126 37 2 5 2 2 2 2 5 2 2 5 2 3 3 2 2 0 4 3 2 2 3 3 2 15 4 2 2 3 4 2 7 9 7 2 3 2 0 2 2
19.2.2.8.1.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EBF 126 35 2 3 1 2 2 2 22 2 0 3 5 2 8 0 1 0 2 2 2 2 2 4 2 2 4 2 2 6 2 5 8 6 4 2 3 4 0 4 1
19.2.2.8.1.4.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EDL 126 34 2 3 4 3 2 4 5 2 0 5 1 6 5 0 0 0 3 4 3 4 2 6 4 1 2 4 4 3 2 2 10 10 5 3 2 5 0 4 1
19.3.1.2 Protein homeostasis.autophagy.ATG1-13 autophagosome assembly control complex.accessory component ATG13 126 36 2 2 3 2 2 3 5 3 1 4 3 3 3 0 1 0 3 3 3 3 5 2 3 3 5 3 3 2 4 2 10 9 6 1 6 6 0 6 1
19.1.4.2 Protein homeostasis.protein quality control.plastidial Hsp70 chaperone system.co-chaperone (Hsp40) 124 36 4 4 3 4 3 2 3 3 1 2 2 3 5 0 2 0 3 3 4 1 2 4 3 7 4 3 3 3 7 3 3 9 5 2 2 4 0 4 4
19.2.2.1.5.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (ARA54) 124 36 1 1 1 1 2 3 1 2 1 1 4 10 1 1 1 0 3 6 6 1 1 1 1 1 1 4 5 1 2 1 9 28 17 1 0 1 0 2 1
19.1.7.2 Protein homeostasis.protein quality control.Hsp60 chaperone system.Hsp60-co-chaperone (Hsp20) 122 37 2 4 2 1 1 3 3 3 2 3 4 3 4 1 1 0 3 4 3 3 4 4 1 5 2 3 3 2 4 2 12 9 5 2 5 3 0 5 1
19.2.4.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component UFD1 120 36 2 1 1 3 3 3 3 4 1 3 2 3 3 0 1 0 3 4 4 3 2 4 2 1 3 4 5 1 2 2 17 12 9 1 1 3 0 3 1
19.2.2.1.5.3.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (DA2) 119 36 2 6 1 2 2 3 5 2 1 4 5 3 5 1 0 0 3 3 2 3 2 3 2 3 2 3 3 1 2 3 10 8 5 1 5 6 0 6 1
19.2.2.8.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.scaffold component CUL1/CUL2 118 36 5 3 2 3 1 3 7 3 1 4 3 3 5 1 1 0 2 3 3 1 0 7 1 3 4 3 3 7 2 2 8 9 5 2 2 2 0 2 2
19.2.3.1.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP3-4) 115 37 4 3 2 2 1 3 4 3 1 3 3 3 4 1 1 0 3 3 3 3 2 5 2 3 2 3 3 2 4 2 7 8 6 2 2 4 0 5 3
19.3.4.5 Protein homeostasis.autophagy.autophagic cargo receptor activities.adaptor protein (PUX7/8/9/13) 115 35 2 3 2 4 2 3 3 3 0 3 3 3 4 0 2 0 3 3 2 3 2 4 2 1 5 3 3 3 4 1 7 9 6 2 3 5 0 5 2
19.2.2.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO conjugation E2 enzyme (SCE1) 112 35 2 2 2 1 1 3 0 6 3 1 3 5 4 3 1 0 3 3 3 0 3 4 2 2 4 5 4 6 2 2 3 9 6 2 1 7 0 3 1
19.2.2.2.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (SIZ1) 112 35 2 3 2 1 1 4 3 3 1 3 4 4 4 0 1 0 3 3 2 3 2 4 1 5 4 2 3 3 0 2 9 12 8 1 4 2 0 2 1
19.4.2.9.4 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex.chaperone component ClpC 110 36 2 3 1 2 1 4 2 4 0 2 3 4 5 1 1 0 2 4 3 3 1 4 1 5 2 2 4 2 2 3 7 12 8 1 2 2 0 3 2
19.2.2.8.1.4.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component ADO 108 33 2 3 3 3 2 3 3 3 0 3 2 3 3 0 1 0 3 3 3 3 0 5 3 0 4 3 3 2 2 3 8 8 5 3 1 5 0 6 1
19.2.4.2.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.membrane protein retrotranslocation factor (DFM1) 108 37 4 4 2 3 2 2 5 2 2 3 2 2 4 2 2 0 2 2 2 2 4 2 3 3 5 2 2 2 4 3 5 6 4 4 2 2 0 4 2
19.2.2.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer 107 37 2 2 2 3 2 2 9 2 2 2 2 2 2 2 2 0 2 2 2 2 3 4 2 4 4 2 2 3 4 2 5 9 6 2 2 3 0 2 2
19.4.5.5.3 Protein homeostasis.proteolysis.metallopeptidase activities.M48 families.zinc metalloprotease (OMA1) 107 36 1 1 1 1 1 10 2 2 2 1 1 9 1 1 1 0 1 2 2 3 2 0 1 1 2 1 1 1 1 2 4 34 9 1 1 1 0 1 1
19.3.1.1 Protein homeostasis.autophagy.ATG1-13 autophagosome assembly control complex.kinase component ATG1 106 36 4 3 2 4 3 3 4 2 1 1 2 3 2 1 1 0 2 3 2 2 0 3 2 3 6 3 3 3 3 1 3 9 5 5 2 4 0 5 1
19.1.3.1 Protein homeostasis.protein quality control.mitochondrial Hsp70 chaperone system.chaperone (mtHsc70) 105 35 4 3 2 2 2 3 3 3 1 5 5 3 3 1 1 0 2 3 3 0 2 4 2 4 2 2 3 2 2 2 8 10 6 1 0 2 0 2 2
19.3.4.6 Protein homeostasis.autophagy.autophagic cargo receptor activities.adaptor protein (DSK2) 104 36 1 2 2 2 1 2 7 2 1 4 2 2 5 1 1 0 4 2 2 2 1 4 2 4 3 2 2 9 2 1 7 6 4 2 0 4 0 4 2
19.2.4.1.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc7/13/14 102 37 2 4 2 3 2 2 4 2 1 5 2 2 4 1 1 0 2 2 2 2 2 2 2 4 4 2 2 4 2 2 3 6 4 3 2 5 0 6 2
19.4.2.1.4 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families.protease (SBT4) 102 23 1 2 2 14 3 2 5 1 0 0 1 0 2 0 1 0 0 0 0 0 0 0 4 0 8 3 4 3 3 1 13 1 0 25 0 1 0 2 0
19.1.4.3 Protein homeostasis.protein quality control.plastidial Hsp70 chaperone system.nucleotide exchange factor (CGE) 101 37 2 4 3 2 2 2 3 2 2 4 2 2 3 1 1 0 2 2 2 2 3 4 2 2 3 2 2 2 4 3 8 5 4 2 3 4 0 4 1
19.2.1.1.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E3 ubiquitin ligase component Doa10 100 35 2 2 1 2 1 2 2 2 0 2 3 6 2 0 1 0 1 2 2 1 3 2 1 5 2 1 2 1 2 2 4 16 16 2 2 2 0 2 1
19.2.3.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (ELS) 100 35 0 3 2 3 1 3 2 3 1 2 3 3 2 2 1 0 3 3 2 3 1 3 3 2 3 3 3 2 3 2 9 9 5 1 0 3 0 4 2
19.4.5.6.4 Protein homeostasis.proteolysis.metallopeptidase activities.aminopeptidase activities.M18-class aspartyl aminopeptidase (DAP) 100 37 2 2 2 2 3 2 3 2 1 2 4 2 3 2 1 0 2 2 2 2 7 3 2 5 3 2 2 2 5 2 6 6 3 3 2 2 0 2 2
19.3.4.3 Protein homeostasis.autophagy.autophagic cargo receptor activities.adapter protein (ATI1/2) 98 33 3 2 2 2 1 4 4 2 0 3 1 3 5 0 1 0 3 2 1 2 4 4 2 0 2 3 3 2 0 2 8 6 4 1 3 6 0 6 1
19.2.6.2.2.10 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN11 97 37 2 3 1 1 2 2 4 2 1 3 3 3 2 1 2 0 2 3 3 3 3 3 2 3 2 1 2 1 4 1 4 8 5 1 4 5 0 4 1
19.1.3.2 Protein homeostasis.protein quality control.mitochondrial Hsp70 chaperone system.co-chaperone (Hsp40) 96 33 3 3 2 2 3 3 3 2 0 3 2 3 4 0 1 0 3 2 1 2 0 3 2 2 3 3 3 2 6 1 3 8 6 2 0 4 0 3 3
19.2.2.1.6.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Ubc13 96 37 2 3 2 3 2 2 3 2 1 5 2 2 4 1 1 0 2 2 2 2 1 1 2 4 4 2 2 4 2 2 3 6 4 3 2 5 0 4 2
19.2.2.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB conjugation E2 protein (RCE1) 96 37 2 2 1 2 1 3 2 3 1 2 2 2 3 1 1 0 3 3 3 2 3 2 2 5 4 2 2 4 5 1 8 6 4 3 1 2 0 2 1
19.3.3.5 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ATG12-ATG5 ATG8-PE-ligase E3 heterodimer 95 37 3 3 1 3 2 3 1 2 2 2 1 2 2 1 2 0 2 2 2 2 2 2 3 2 3 2 2 3 4 2 8 9 3 2 4 2 0 2 2
19.2.6.2.1.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT4 94 37 2 2 1 2 1 4 3 2 1 3 2 3 3 1 1 0 1 2 2 2 2 3 1 3 4 2 2 2 2 2 7 9 6 2 3 2 0 1 3
19.5 Protein homeostasis.protein repair 93 37 2 2 2 2 1 2 4 2 5 5 2 2 4 1 1 0 2 2 2 2 1 3 2 8 2 2 2 1 4 2 5 6 3 1 2 1 0 2 1
19.5.1 Protein homeostasis.protein repair.protein-L-isoaspartate methyltransferase 93 37 2 2 2 2 1 2 4 2 5 5 2 2 4 1 1 0 2 2 2 2 1 3 2 8 2 2 2 1 4 2 5 6 3 1 2 1 0 2 1
19.3.4.2 Protein homeostasis.autophagy.autophagic cargo receptor activities.adapter protein (NBR1) 92 34 1 2 1 1 1 2 3 2 0 2 3 2 2 0 4 0 2 2 2 2 11 4 1 2 3 2 2 2 2 1 8 6 4 1 3 3 0 3 0
19.4.5.6.3 Protein homeostasis.proteolysis.metallopeptidase activities.aminopeptidase activities.M17-class leucyl aminopeptidase (LAP) 92 37 3 2 2 3 1 2 2 1 1 2 1 2 2 2 1 0 2 2 2 2 4 2 2 3 2 2 2 3 2 1 6 6 3 1 3 6 0 7 2
19.2.2.8.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.scaffold component CUL3 90 36 1 2 1 2 1 3 2 2 1 2 2 3 5 0 1 0 3 3 3 2 1 5 1 2 2 2 2 2 4 2 7 6 4 1 2 3 0 3 2
19.2.2.8.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex 90 36 2 2 1 2 1 2 2 0 2 4 1 1 2 2 2 0 1 2 2 1 2 2 2 5 2 2 2 2 4 2 9 7 5 2 1 5 0 2 2
19.2.6.1.1.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-4 89 37 1 1 2 2 3 2 9 2 1 2 3 2 2 1 1 0 2 2 2 1 1 4 1 4 2 2 2 1 2 1 7 5 3 2 4 3 0 3 1
19.4.1.4 Protein homeostasis.proteolysis.cysteine-type peptidase activities.C15-class pyrrolidone-carboxylate peptidase 89 36 1 3 2 2 1 1 11 3 1 4 1 1 4 0 1 0 2 3 3 2 1 3 2 2 3 2 3 2 2 2 5 3 2 2 2 3 0 2 2
19.1.1.2.1.3 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.ERdj3B-BiP-SDF2 chaperone complex.component SDF2 87 37 2 2 2 1 1 2 5 2 1 4 1 3 3 1 1 0 2 2 2 1 2 2 1 3 2 2 2 1 4 1 10 6 3 2 3 2 0 2 1
19.2.2.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.2.2.1.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation.ubiquitin carboxyl-terminal hydrolase (UCH) 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.2.2.3.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH1|2) 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.2.6.2.2.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN2 86 37 1 1 2 2 1 2 2 2 1 2 1 2 1 1 1 0 2 2 2 1 3 4 1 4 2 2 2 2 2 2 9 6 4 2 3 4 0 4 1
19.2.6.2.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ubiquitin C-terminal hydrolase cofactor 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.1.4.1 Protein homeostasis.protein quality control.plastidial Hsp70 chaperone system.chaperone (cpHsc70) 85 35 2 3 2 2 1 2 3 1 1 3 2 2 3 1 2 0 2 2 2 0 1 3 1 5 2 2 2 2 4 2 6 6 4 2 0 3 0 3 1
19.2.2.3.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH3) 85 35 1 3 1 1 1 2 1 3 1 4 2 2 1 1 1 0 3 3 3 2 0 3 1 1 1 3 3 2 2 0 8 9 6 1 1 2 0 4 2
19.2.2.1.5.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.bifunctional co-chaperone and E3 ubiquitin ligase (CHIP) 83 37 1 2 1 1 2 2 3 2 1 2 3 2 2 1 2 0 2 2 2 3 5 1 3 2 1 2 2 1 2 1 6 6 4 4 1 2 0 2 2
19.2.6.1.2.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-3 82 37 2 2 2 2 1 2 5 2 1 2 2 1 2 1 1 0 2 2 2 1 3 2 1 2 2 2 2 1 2 1 8 6 3 1 3 4 0 3 1
19.4.5.8.1.2.1 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH mitochondrial protease complexes.FtsH3/10 matrix-AAA protease heterodimers.component Fts3|10 82 36 3 1 1 2 2 1 1 2 1 3 1 2 3 1 1 0 2 2 2 3 0 3 1 3 2 2 2 3 4 1 10 6 4 1 2 1 0 1 2
19.2.2.3.5.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (RBX1) 81 37 1 1 2 2 1 2 3 2 1 2 1 2 4 1 1 0 2 2 2 2 4 1 1 3 3 2 2 2 2 2 6 6 2 2 2 3 0 2 2
19.2.2.8.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.UBQ-E2-recruiting component RBX1 81 37 1 1 2 2 1 2 3 2 1 2 1 2 4 1 1 0 2 2 2 2 4 1 1 3 3 2 2 2 2 2 6 6 2 2 2 3 0 2 2
19.2.6.2.1.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT1 81 37 5 2 1 2 2 2 2 2 1 3 2 2 3 1 1 0 1 2 2 2 2 2 1 2 4 2 2 2 2 2 6 6 2 2 2 1 0 1 2
19.2.6.2.2.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN6 81 35 1 2 1 1 1 2 4 2 1 3 3 3 2 1 1 0 1 2 2 1 2 3 2 2 4 2 2 1 2 1 7 8 3 0 0 3 0 4 1
19.2.2.8.3.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.regulator component SPA 80 33 3 1 2 3 2 2 1 0 0 4 1 1 5 0 1 0 2 1 2 1 2 1 4 2 4 2 2 4 2 2 4 3 4 2 0 3 0 4 3
19.2.5 Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD) 80 34 2 2 3 3 2 2 2 1 0 2 2 2 3 0 1 0 2 2 2 2 2 2 2 2 3 2 2 2 2 2 5 6 4 2 0 2 0 3 2
19.2.6.2.2.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN7 80 36 1 0 1 1 2 2 6 2 1 1 3 2 3 1 1 0 2 2 2 2 1 3 2 2 2 2 2 1 2 1 9 6 3 1 3 2 0 2 1
19.1.1.1.1.1 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.calnexin/calreticulin chaperone system.CNX-CRT cycle.lectin chaperone (CNX) 79 36 1 2 2 2 1 2 3 1 1 3 2 2 4 1 1 0 1 1 1 1 3 3 2 5 3 1 1 2 6 0 3 6 4 1 1 2 0 2 2
19.2.6.1.2.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-6 79 37 1 2 1 1 1 2 3 3 1 2 1 2 3 1 1 0 2 2 2 2 1 3 1 2 2 2 2 1 4 1 8 3 2 2 2 4 0 5 1
19.2.3.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (OTS) 78 31 2 2 1 2 1 3 2 1 0 4 3 2 2 0 1 0 3 2 3 0 0 1 2 5 1 6 3 2 3 1 0 9 6 1 0 1 0 1 2
19.2.6.2.2.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN1 78 36 1 1 1 2 2 2 6 2 1 2 2 1 1 1 1 0 2 3 3 2 1 2 2 2 3 1 3 2 2 1 3 9 5 1 0 2 0 2 1
19.2.6.1.1.7 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-7 77 36 1 1 2 1 1 1 4 1 1 2 3 1 2 1 1 0 2 2 2 2 1 3 1 2 2 2 1 2 2 1 8 6 4 1 0 4 0 4 2
19.2.6.2.2.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN3 77 37 1 2 1 2 1 2 2 2 1 3 2 2 3 1 1 0 2 2 2 2 1 4 1 4 4 1 2 2 2 1 4 6 1 2 3 2 0 2 1
19.2.6.2.1.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT6 76 37 2 1 1 2 2 2 2 2 1 2 1 2 2 1 1 0 2 2 2 1 1 3 2 2 2 2 2 2 3 1 8 6 3 2 1 1 0 2 2
19.2.6.2.2.8 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN9 76 37 1 1 1 2 1 2 4 2 1 2 3 3 3 1 1 0 2 2 2 2 2 3 2 2 2 1 2 2 2 1 4 4 3 2 2 2 0 3 1
19.1.1.1.4 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.calnexin/calreticulin chaperone system.alpha-1,2 exomannosidase (MNL) 75 35 2 2 2 2 2 2 1 2 1 2 1 2 2 1 2 0 2 2 1 2 0 2 2 1 3 2 2 2 5 1 5 6 4 2 0 1 0 2 2
19.2.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation 74 34 2 2 1 2 1 2 3 3 1 1 2 1 3 1 2 0 3 3 2 2 1 3 1 1 3 3 3 0 2 1 6 6 2 0 2 1 0 0 2
19.2.2.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation.ubiquitin-fold protein (HUB) 74 34 2 2 1 2 1 2 3 3 1 1 2 1 3 1 2 0 3 3 2 2 1 3 1 1 3 3 3 0 2 1 6 6 2 0 2 1 0 0 2
19.2.6.2.2.11 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN12 74 36 1 1 1 2 1 2 2 2 1 1 0 2 2 1 1 0 1 1 1 2 1 2 3 2 2 1 2 1 2 1 4 10 8 1 2 3 0 3 1
19.1.5.4 Protein homeostasis.protein quality control.cytosolic Hsp70 chaperone system.nucleotide exchange factor (FES1) 73 35 3 1 1 3 1 2 3 2 0 2 2 2 1 0 1 0 2 2 2 2 1 4 1 2 2 2 2 1 1 1 5 6 3 1 1 3 0 3 2
19.2.1.3.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.catalytic component GID2 73 36 2 2 1 3 1 2 2 1 1 2 3 4 2 0 1 0 1 1 1 1 1 4 1 4 4 1 1 1 2 1 3 9 5 1 1 1 0 1 1
19.2.2.1.5.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-C2-class E3 ligase 73 35 2 2 2 3 2 2 3 1 0 2 1 2 6 0 3 0 2 2 1 1 2 4 1 4 2 1 1 2 2 1 3 3 2 2 2 1 0 1 2
19.2.6.1.1.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-5 73 36 1 2 2 2 1 2 3 2 1 2 2 2 3 1 2 0 1 1 1 0 2 2 2 3 2 2 1 2 2 1 8 6 4 1 1 1 0 1 1
19.2.6.2.2.9 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN10 73 36 1 2 1 1 1 1 4 3 1 3 1 1 3 1 1 0 2 2 2 1 3 0 2 1 3 2 2 1 2 2 8 3 2 1 2 3 0 3 1
19.2.6.2.1.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT3 72 36 1 1 1 1 1 2 2 2 1 2 2 1 3 1 1 0 1 1 1 1 0 2 1 4 2 1 2 2 7 2 6 6 4 1 1 1 0 1 3
19.4.1.6 Protein homeostasis.proteolysis.cysteine-type peptidase activities.C50-class protease separase (AESP) 72 35 1 3 1 1 2 1 4 1 1 2 1 3 2 0 1 0 1 3 3 1 2 3 2 1 1 2 3 1 1 1 7 3 4 6 0 1 0 1 1
19.4.5.8.1.2.2 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH mitochondrial protease complexes.FtsH3/10 matrix-AAA protease heterodimers.component prohibitin 72 34 2 0 1 2 1 2 2 2 1 2 1 2 2 1 1 0 1 2 2 2 2 3 1 2 2 2 2 3 2 1 3 8 5 0 4 2 0 0 1
19.2.2.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.large component SAE2 71 37 1 1 1 1 1 1 12 1 1 3 1 1 2 1 1 0 1 1 1 2 2 2 2 2 2 1 1 1 2 1 6 3 2 1 2 2 0 2 3
19.2.6.1.2.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-1 70 37 1 1 1 1 1 1 2 2 2 1 2 2 2 1 1 0 2 2 2 2 2 2 2 1 2 2 2 1 2 1 3 6 5 2 3 2 0 2 1
19.4.2.1.3 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families.protease (SBT3) 70 24 2 0 0 15 3 2 4 1 0 0 0 2 2 0 0 0 1 2 1 0 0 2 0 0 5 2 2 1 0 1 2 6 2 7 0 2 0 2 1
19.2.4.1.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E3 ubiquitin ligase component HRD1 69 37 1 3 1 2 1 2 1 2 1 1 1 2 1 1 2 0 1 1 1 1 1 2 1 1 2 2 2 2 2 1 8 8 3 1 1 3 0 2 1
19.2.6.2.1.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT5 69 36 1 2 1 2 1 2 2 2 1 1 1 1 3 1 1 0 2 2 2 2 0 3 1 2 2 2 2 1 2 1 4 5 3 2 4 1 0 2 2
19.1.3.3 Protein homeostasis.protein quality control.mitochondrial Hsp70 chaperone system.nucleotide exchange factor (MGE) 67 37 1 2 2 2 2 2 2 1 1 1 1 2 2 2 1 0 2 2 2 1 1 3 1 2 2 2 2 2 2 2 4 3 2 1 2 2 0 2 1
19.2.3.3.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN1 67 37 1 2 1 1 1 2 3 1 1 2 4 2 3 1 1 0 1 1 1 1 1 2 1 2 2 1 1 1 2 1 4 8 4 1 2 1 0 1 2
19.2.6.1.1.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-2 67 35 1 2 1 2 0 1 1 2 1 2 2 2 2 1 1 0 2 2 2 1 0 1 2 2 2 2 2 2 2 1 4 6 4 1 2 3 0 2 1
19.2.6.1.2.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-5 67 37 2 2 1 2 1 1 3 1 1 3 2 1 1 1 1 0 1 1 1 2 3 2 3 2 2 1 1 2 2 1 5 3 1 1 2 1 0 1 6
19.2.6.2.1.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT2 67 36 1 2 0 2 1 2 2 2 1 2 2 2 2 1 1 0 2 2 2 1 1 2 2 3 2 1 2 1 2 1 5 6 4 1 1 1 0 1 1
19.2.6.2.2.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN5 67 36 2 1 1 2 1 2 2 1 1 2 3 2 2 1 1 0 1 1 1 2 2 0 1 2 3 2 1 2 2 1 8 3 1 1 1 4 0 3 1
19.3.3.2 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ATG8-maturation peptidase (ATG4) 67 37 2 2 1 2 2 1 2 1 1 1 1 1 2 1 1 0 1 2 2 1 4 3 1 2 2 1 1 1 2 1 2 3 2 1 1 4 0 6 3
19.4.5.6.2 Protein homeostasis.proteolysis.metallopeptidase activities.aminopeptidase activities.M24-class methionyl aminopeptidase (MAP2) 67 35 1 3 1 2 1 1 0 2 1 1 1 3 1 1 2 0 1 2 2 1 2 2 1 2 2 1 3 1 4 0 8 5 3 1 2 1 0 1 1
19.1.6.3 Protein homeostasis.protein quality control.Hsp90 chaperone system.Hsp90-co-chaperone (SGT1) 66 36 2 1 1 2 1 1 4 2 1 4 1 1 3 1 1 0 0 2 1 1 2 2 1 1 3 2 3 2 2 2 4 2 1 2 2 2 0 2 1
19.2.3.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.peptidase (DeSI) 66 37 2 1 2 1 1 2 1 2 1 2 2 2 2 1 1 0 2 2 3 1 2 2 1 2 1 2 2 1 2 1 5 5 2 1 2 2 0 1 1
19.2.2.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).ubiquitin-fold protein (RUB) 65 27 0 0 2 2 0 2 0 0 1 1 7 2 2 0 0 0 2 3 2 1 2 0 1 1 3 2 2 1 0 1 1 14 5 1 0 2 0 1 1
19.2.6.1.1.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-1 65 37 1 2 1 2 1 2 2 1 1 2 1 2 2 1 1 0 2 2 2 1 2 2 1 4 3 2 1 1 1 1 3 4 3 1 1 2 0 3 1
19.2.6.1.2.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-2 65 36 2 0 1 2 1 2 2 2 1 2 1 2 2 1 1 0 1 1 1 1 3 3 1 2 2 2 3 2 2 2 7 1 2 1 1 2 0 2 1
19.3.2.1.2 Protein homeostasis.autophagy.ATG9-2-18 membrane shuttling complex.components.component ATG2 65 36 1 1 1 1 1 1 2 2 0 2 2 2 3 1 1 0 1 1 1 2 3 1 1 1 2 1 1 1 2 1 6 6 5 1 1 2 0 2 2
19.2.1.2.2.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-I-residues E3 ubiquitin ligase (PRT6) 63 37 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2 0 1 1 1 1 2 2 1 10 1 1 1 2 2 1 3 6 4 1 1 1 0 1 1
19.2.1.2.2.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-II-residues E3 ubiquitin ligase (PRT1) 63 36 1 4 1 1 1 1 3 1 1 3 1 2 2 1 0 0 3 2 1 1 1 1 1 5 3 1 1 1 2 1 4 3 3 1 2 1 0 1 1
19.2.2.3.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.small component AXR1/AXL 63 37 1 1 1 2 1 1 6 1 1 1 1 1 1 1 1 0 1 1 1 1 3 2 1 2 2 1 1 2 2 1 4 6 4 1 1 2 0 2 1
19.4.2.9.5 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex.chaperone component ClpD 63 33 2 1 2 1 1 2 0 2 0 1 2 2 2 1 1 0 2 1 2 0 2 2 1 2 2 2 2 1 0 1 7 6 3 1 1 2 0 2 1
19.1.1.2.1.2 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.ERdj3B-BiP-SDF2 chaperone complex.co-chaperone component ERdj3a 62 36 1 2 1 1 1 1 4 1 1 2 1 1 2 2 1 0 1 1 1 1 0 1 1 2 2 2 2 1 2 1 7 3 2 1 2 3 0 3 1
19.2.2.8.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.adaptor protein exchange factor (CAND1) 62 36 1 1 1 1 2 1 3 1 1 2 2 1 1 1 1 0 1 1 2 4 1 1 1 2 2 1 1 1 2 1 3 8 5 1 0 1 0 1 2
19.2.3.1.1.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP14) 62 36 1 1 1 1 1 1 2 2 1 3 0 1 2 1 1 0 1 1 1 1 4 4 1 1 2 1 2 1 2 1 5 3 2 5 2 1 0 1 1
19.3.2.1.1 Protein homeostasis.autophagy.ATG9-2-18 membrane shuttling complex.components.component ATG9 62 35 1 1 1 1 2 2 2 2 1 2 1 2 2 1 1 0 2 2 2 1 0 3 1 2 2 2 2 1 2 1 8 3 2 1 0 1 0 1 1
19.3.3.4 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ATG8-conjugation E2 protein (ATG3) 62 37 1 1 1 1 1 1 2 1 1 2 1 1 2 1 1 0 1 2 2 1 1 2 1 1 3 2 1 1 2 1 7 3 2 1 2 5 0 2 1
19.2.1.3.1.5 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID8 61 34 1 2 1 3 1 1 3 1 1 2 2 3 3 0 2 0 1 1 1 1 1 1 1 3 2 1 1 2 2 1 0 6 4 2 0 1 0 2 1
19.2.3.1.1.9 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP23) 61 34 2 1 1 1 1 2 1 2 0 2 1 2 3 0 1 0 1 1 2 2 2 1 2 1 2 1 2 1 2 2 5 6 3 2 1 0 0 1 1
19.2.6.1.2.7 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-7 61 37 1 1 1 1 1 1 2 2 1 2 1 2 1 1 1 0 2 1 1 2 1 2 1 2 2 1 1 1 2 1 3 5 4 1 2 2 0 2 3
19.2.1.3.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID1 60 36 1 1 1 5 1 1 3 1 2 3 0 1 1 1 1 0 1 1 1 1 1 3 1 3 2 1 1 1 2 1 4 3 2 1 2 2 0 2 1
19.2.2.8.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.core adaptor component DDB1 60 37 1 1 1 2 1 3 2 1 1 2 2 4 1 1 1 0 1 1 1 1 2 2 1 2 2 1 1 1 2 1 2 5 3 1 1 2 0 2 1
19.2.4.1.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.substrate recruitment component OS9 60 37 1 1 1 1 1 1 5 1 2 1 1 1 1 1 1 0 1 1 1 2 2 2 1 2 4 1 1 1 2 1 5 3 2 1 2 2 0 2 1
19.4.2.1.7 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families.protease (SBT6.2) 60 35 1 1 1 1 1 1 4 1 1 3 4 1 1 0 1 0 1 1 1 1 3 2 0 2 2 1 1 3 2 1 2 3 2 1 1 3 0 3 2
19.1.2.3 Protein homeostasis.protein quality control.ribosome-associated chaperone activities.co-chaperone (ZRF) 59 36 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 0 1 1 1 1 1 1 1 3 2 2 1 1 2 1 6 3 2 1 0 4 0 5 2
19.2.2.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.small component SAE1 59 36 2 3 1 3 1 1 1 2 1 1 3 1 1 1 1 0 1 1 1 2 0 2 1 1 2 1 2 2 1 1 3 6 4 1 1 1 0 1 1
19.2.6.2.2.7 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN8 59 37 1 2 2 2 1 1 3 1 1 1 1 1 2 1 1 0 1 1 1 2 1 1 3 1 3 1 1 1 2 1 4 3 2 2 2 2 0 2 1
19.3.1.3 Protein homeostasis.autophagy.ATG1-13 autophagosome assembly control complex.multifunctional scaffold component ATG11 59 36 2 1 1 1 1 1 2 1 0 1 1 1 1 1 1 0 1 1 1 1 1 2 1 2 2 1 1 1 4 1 6 3 2 1 1 4 0 5 1
19.4.5.5.1 Protein homeostasis.proteolysis.metallopeptidase activities.M48 families.zinc metalloprotease (PGM48) 59 35 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 0 1 0 1 1 1 1 2 1 3 3 2 1 1 10 0 10 1
19.2.2.8.3.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.regulator component DET1 58 36 1 1 1 1 1 1 1 0 1 3 1 1 1 1 1 0 1 1 2 1 2 2 1 3 1 1 1 1 2 1 6 4 3 1 1 4 0 2 1
19.2.3.1.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP6-7) 58 37 1 1 1 2 1 3 2 1 1 1 1 1 1 1 2 0 1 1 1 1 3 2 1 1 2 1 1 1 2 1 3 5 2 1 2 2 0 3 1
19.2.3.3.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN2 58 37 1 2 1 1 1 1 2 1 1 3 1 1 2 1 1 0 1 1 1 1 2 1 1 3 2 1 1 3 2 1 4 3 2 1 2 2 0 2 1
19.2.4.1.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.adaptor protein component HRD3 58 36 2 3 1 2 1 1 3 1 1 2 1 1 2 1 1 0 1 1 1 1 0 2 1 3 2 1 1 1 2 1 3 3 2 1 2 2 0 3 1
19.2.4.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component NPL4 58 36 1 1 1 2 1 1 1 1 1 2 3 1 2 1 1 0 1 1 1 1 3 2 1 1 2 1 1 1 2 1 0 3 2 1 2 4 0 6 1
19.2.2.1.5.4.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Helicase) 57 30 2 2 1 2 1 1 1 2 0 2 2 2 1 0 1 0 1 1 0 2 0 2 1 0 2 1 1 2 0 1 4 9 6 1 0 1 0 1 1
19.2.3.1.1.8 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP22) 57 36 2 2 1 1 1 1 3 1 0 5 1 1 2 1 1 0 1 1 1 1 1 1 2 1 3 1 1 2 2 2 5 3 1 1 1 1 0 1 1
19.2.3.3.1.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN7 57 36 1 1 0 1 1 1 2 1 1 2 1 1 2 1 1 0 1 1 1 1 3 1 2 2 4 1 1 1 2 1 3 3 2 2 1 3 0 3 1
19.2.6.1.1.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-3 57 36 1 1 1 1 2 2 2 1 1 2 1 2 2 1 1 0 1 3 2 1 1 3 1 3 2 1 1 1 2 1 2 3 2 0 1 2 0 2 1
19.4.5.7.2 Protein homeostasis.proteolysis.metallopeptidase activities.carboxypeptidase activities.M14-class carboxypeptidase (SOL) 57 36 1 1 0 1 1 1 1 1 2 2 1 1 1 1 1 0 1 1 1 1 4 3 1 3 2 1 1 1 2 1 5 3 1 1 1 3 0 3 1
19.1.8.12 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-ER protein 56 28 3 2 2 1 0 2 1 1 0 3 2 2 2 0 0 0 0 1 1 2 1 2 0 0 1 2 2 3 0 1 2 5 3 1 2 3 0 3 0
19.2.2.3.5.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (DCN1) 56 33 2 1 1 1 1 2 1 2 2 2 1 1 1 0 1 0 1 1 1 2 0 3 1 3 1 2 2 2 4 2 4 3 2 1 0 0 0 1 1
19.1.2.2 Protein homeostasis.protein quality control.ribosome-associated chaperone activities.co-chaperone (Jjj1) 55 35 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 0 1 1 1 1 3 2 1 1 0 1 1 2 4 1 4 3 2 0 1 4 0 4 1
19.2.1.3.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.N-recognin component GID4 55 35 1 1 1 1 1 1 1 2 1 2 1 1 1 0 2 0 1 2 2 1 2 1 1 1 1 1 1 2 1 1 4 3 2 1 0 4 0 4 2
19.2.4.3.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.E4 multiubiquitination enzyme (UFD2) 55 35 0 1 1 1 1 1 2 1 1 2 1 3 1 0 1 0 1 1 1 1 4 2 1 1 3 1 1 2 2 1 2 3 3 1 1 3 0 2 1
19.2.6.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation 55 37 2 1 1 2 1 1 2 1 1 1 2 1 1 1 1 0 1 1 1 1 1 2 1 1 1 1 1 1 2 1 6 5 3 1 2 1 0 1 1
19.2.6.3.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation.regulatory protein (PTRE1) 55 37 2 1 1 2 1 1 2 1 1 1 2 1 1 1 1 0 1 1 1 1 1 2 1 1 1 1 1 1 2 1 6 5 3 1 2 1 0 1 1
19.2.6.1.1.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-6 54 37 1 1 1 2 1 1 1 1 1 2 1 1 2 1 1 0 1 1 1 1 1 2 1 2 2 1 2 1 2 2 3 3 2 1 3 1 0 2 1
19.2.6.1.2.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-4 54 36 2 2 1 2 2 1 1 1 1 2 1 1 2 1 1 0 1 1 1 1 0 1 1 3 2 1 1 1 2 1 3 3 1 1 2 2 0 2 2
19.4.2.9.3 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex.plant-specific stabilizing component ClpT 54 35 1 1 1 2 1 1 1 1 0 1 1 1 2 0 1 0 1 1 1 1 2 2 1 2 3 1 1 2 2 1 6 3 2 1 1 2 0 2 1
19.4.5.5.2 Protein homeostasis.proteolysis.metallopeptidase activities.M48 families.zinc metalloprotease (STE24) 54 35 1 1 1 1 1 1 2 2 1 2 1 1 2 0 2 0 1 1 1 1 4 2 1 2 2 1 1 1 2 1 2 3 2 1 0 3 0 2 1
19.1.1.2.3 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.co-chaperone (P58/ERdj6) 53 37 1 1 1 1 2 1 2 1 1 2 4 1 1 1 1 0 1 2 2 2 2 1 1 1 1 1 1 1 2 1 2 3 2 1 2 1 0 1 1
19.2.2.8.3.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.component COP1 53 33 1 1 1 1 1 1 1 1 0 1 0 1 2 0 1 0 1 1 1 1 1 1 1 9 3 1 1 2 2 1 2 3 2 2 0 1 0 2 2
19.3.3.5.2 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ATG12-ATG5 ATG8-PE-ligase E3 heterodimer.component ATG5 53 36 2 2 1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 2 2 2 1 1 1 1 2 2 1 5 5 2 1 2 1 0 1 1
19.1.1.2.6 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.nucleotide exchange factor (Sil1) 52 35 1 1 1 1 1 1 1 2 1 1 1 1 1 0 1 0 1 1 1 1 0 3 1 3 2 3 2 1 2 3 2 3 1 1 1 2 0 2 1
19.2.3.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (FUG) 52 28 0 1 0 1 1 3 1 1 0 2 2 4 1 0 0 0 1 1 1 1 3 1 0 3 2 1 1 2 0 1 4 7 3 1 0 1 0 0 1
19.2.3.3.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN5 52 36 1 1 1 2 1 1 2 1 1 2 6 1 1 1 1 0 1 1 1 1 1 2 1 2 2 1 1 2 2 2 0 2 2 1 1 1 0 1 1
19.2.4.1.5 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.associated plant-specific component EBS7 52 35 1 1 1 1 1 1 2 1 0 1 1 1 4 1 1 0 1 1 1 1 3 0 1 2 2 1 1 1 2 1 3 3 2 1 2 2 0 2 1
19.2.6.2.2.12 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN13 52 37 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 0 1 1 1 4 2 1 1 1 4 1 1 1 2 1 3 3 2 1 1 1 0 1 1
19.2.2.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO chain-forming-ligase E4 enzyme (PIAL) 51 34 1 2 1 2 1 1 3 1 0 2 0 1 2 0 1 0 1 1 1 1 2 1 1 1 1 1 1 2 2 1 3 3 2 3 1 1 0 1 2
19.2.3.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (SPF) 51 31 1 1 1 2 1 1 2 1 0 2 1 1 2 0 1 0 1 1 1 1 0 1 0 8 4 1 1 2 2 1 1 3 2 1 0 1 0 0 2
19.2.3.3.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN3 51 36 3 1 2 1 1 1 1 1 1 1 1 0 2 1 1 0 1 1 1 1 3 1 1 1 3 1 1 1 2 1 2 3 2 1 1 2 0 2 1
19.2.4.3.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.ubiquitin-binding adaptor (UFD3) 51 36 1 1 1 1 1 1 6 1 1 1 1 1 1 1 1 0 1 1 1 1 1 2 0 1 2 1 1 1 2 1 3 4 3 1 1 1 0 1 1
19.2.4.4.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.proteasome adaptor protein (DDI1) 51 35 1 2 2 1 1 1 3 1 1 0 1 1 1 1 1 0 1 1 1 1 2 2 1 2 2 1 1 1 2 1 5 3 2 1 0 1 0 1 1
19.3.4.1 Protein homeostasis.autophagy.autophagic cargo receptor activities.adapter protein (TSPO) 51 31 1 1 1 1 1 1 2 0 2 2 1 0 1 1 2 0 0 1 0 1 1 1 1 5 3 1 1 1 6 1 2 3 2 0 0 2 0 1 1
19.4.5.2 Protein homeostasis.proteolysis.metallopeptidase activities.M8-class metalloprotease (Leishmanolysin) 51 36 1 1 1 1 1 1 1 1 1 1 1 1 3 0 1 0 1 1 1 1 1 2 1 4 2 1 1 1 2 2 3 3 2 1 2 1 0 1 1
19.2.1.3.1.4 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID5 50 35 1 1 1 1 1 1 1 1 0 1 1 1 1 0 1 0 1 1 1 1 4 3 1 2 1 1 1 1 2 1 3 3 2 1 2 2 0 2 1
19.2.2.6.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.ubiquitin-fold protein (UFM) 50 34 1 1 1 1 1 1 3 1 0 1 4 1 3 0 1 0 1 1 1 1 1 2 1 1 2 1 1 2 2 1 3 3 0 1 2 1 0 1 1
19.2.2.8.2.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BPH1 50 27 3 0 1 2 1 0 2 1 0 3 1 1 3 0 0 0 1 1 1 1 0 2 3 0 2 1 1 1 0 1 5 5 4 1 0 1 0 0 1
19.3.1.4 Protein homeostasis.autophagy.ATG1-13 autophagosome assembly control complex.accessory component ATG101 50 35 2 1 1 1 1 1 1 2 1 2 2 1 3 1 1 0 1 1 2 1 1 2 1 1 1 1 2 2 0 1 2 2 2 1 0 2 0 2 1
19.4.2.9.6 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex.adaptor component ClpS 50 36 1 1 1 1 1 1 2 1 1 1 1 1 1 0 1 0 1 1 1 1 1 1 1 2 2 1 1 1 2 1 4 3 2 2 2 2 0 2 1
19.1.1.2.2 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.co-chaperone (ERdj3a) 49 35 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 0 1 1 1 1 1 2 1 1 1 1 1 1 2 1 6 3 0 1 1 3 0 3 0
19.1.1.2.5 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.nucleotide exchange factor (Grp170) 49 34 1 2 1 1 1 1 3 1 1 1 1 0 2 1 1 0 1 1 1 0 1 2 1 1 2 1 1 1 2 1 3 3 2 2 0 2 0 2 1
19.2.1.1.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc32 49 35 2 1 1 1 1 1 2 1 1 1 1 1 2 1 1 0 1 1 0 0 1 2 1 1 2 1 1 1 2 1 5 3 2 1 2 1 0 1 1
19.2.1.2.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.arginyl-tRNA-protein transferase (ATE) 49 36 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 3 1 1 1 2 2 1 1 2 2 3 3 2 1 0 1 0 1 2
19.2.3.1.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU1) 49 35 2 1 1 1 1 1 2 1 1 1 1 1 3 0 1 0 1 1 1 1 1 2 1 2 2 1 1 1 2 1 4 3 2 1 0 1 0 1 1
19.2.3.3.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN4 49 36 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 0 1 1 1 1 1 3 1 1 2 1 1 1 2 1 3 3 2 3 0 1 0 1 1
19.2.4.2.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.associated factor (PUX1) 49 34 1 1 1 1 1 1 1 1 0 2 0 1 2 0 1 0 1 1 1 1 1 2 1 1 2 1 1 1 4 2 3 3 2 1 2 2 0 1 1
19.2.2.6.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-ligase E3 protein 48 36 1 1 1 1 1 1 2 1 1 1 2 1 1 0 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 3 6 3 1 1 1 0 1 1
19.2.3.1.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU2) 48 37 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 0 1 1 1 1 1 2 1 1 3 1 1 1 2 1 4 3 2 1 1 1 0 1 1
19.2.3.1.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.histone deubiquinating protease (OTLD1) 48 35 1 1 1 1 1 1 2 1 0 2 1 1 2 0 1 0 1 1 1 1 1 2 1 1 2 1 1 2 2 1 3 3 1 1 1 2 0 2 1
19.2.1.3.1.6 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID9 47 36 1 1 1 1 1 1 1 1 1 2 1 1 2 0 1 0 1 1 1 2 1 1 1 2 1 1 1 1 4 1 2 3 2 1 1 1 0 1 1
19.2.2.2.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (HPY2) 47 34 1 1 1 1 1 2 0 1 1 1 1 1 1 1 2 0 2 1 1 1 2 0 0 4 1 1 1 1 2 1 3 3 2 1 1 1 0 1 1
19.2.2.3.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.deneddylase (DEN1) 47 33 1 0 1 1 1 2 1 1 1 0 1 1 1 1 1 0 1 3 2 0 1 0 1 1 1 3 1 1 2 1 3 5 2 1 1 1 0 1 1
19.2.3.1.1.10 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP24) 47 34 1 1 1 1 1 1 3 1 1 2 1 1 2 0 1 0 1 1 1 1 1 2 1 1 1 1 1 2 0 1 3 3 2 1 0 2 0 2 1
19.2.3.1.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU5) 47 35 2 1 1 1 2 1 2 1 1 2 1 1 2 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 4 3 2 0 1 0 0 1 1
19.1.8.8 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-M-I protein 46 28 1 0 1 2 0 1 2 1 0 3 1 2 1 0 0 0 1 2 2 0 4 1 1 0 3 1 1 1 0 1 3 3 1 3 1 1 0 1 0
19.2.1.1.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc33/34 46 35 1 1 1 2 1 1 1 0 1 2 2 1 2 1 1 0 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 3 2 1 0 2 0 2 1
19.2.2.6.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-activating E1 protein 46 33 2 3 1 1 1 1 1 1 1 0 0 1 1 0 1 0 1 1 1 2 0 2 1 1 1 1 1 1 2 1 5 3 1 1 2 1 0 1 1
19.2.2.6.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-conjugation E2 protein 46 34 1 0 1 1 1 1 1 1 1 2 1 1 2 0 1 0 2 1 1 1 1 2 3 1 1 1 1 1 2 1 0 3 2 1 2 1 0 2 1
19.2.3.3.1.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN6 46 34 1 0 1 2 1 1 2 1 1 2 1 1 1 1 1 0 1 1 1 0 0 2 1 1 1 1 1 1 2 1 4 2 2 1 1 2 0 2 1
19.2.3.3.1.8 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN8 46 36 1 1 1 1 1 1 3 1 1 1 2 1 1 1 1 0 1 1 1 1 1 1 1 1 2 1 1 1 0 1 3 2 2 1 2 2 0 1 1
19.4.5.7.1 Protein homeostasis.proteolysis.metallopeptidase activities.carboxypeptidase activities.M14-class carboxypeptidase 46 37 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 0 1 1 1 1 3 1 1 1 2 1 1 1 2 1 2 3 2 1 1 1 0 1 1
19.4.5.8.2.2 Protein homeostasis.proteolysis.metallopeptidase activities.FtsH endopeptidase activities.FtsH plastidial protease complexes.component FtsH7|9 46 35 1 1 1 2 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 0 1 2 1 2 2 1 1 1 2 1 2 3 2 1 1 2 0 2 1
19.1.1.1.3 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.calnexin/calreticulin chaperone system.alpha-1,2 mannosidase (MNS) 45 35 1 1 1 1 1 1 1 1 0 2 1 1 2 0 1 0 1 1 1 1 1 2 1 1 1 1 1 1 2 1 4 3 2 1 1 1 0 1 1
19.2.3.1.1.12 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP26) 45 32 1 1 1 1 1 1 2 1 0 1 0 2 1 0 1 0 1 2 1 1 1 3 1 1 2 1 1 1 2 2 0 3 2 1 0 2 0 2 1
19.2.5.1 Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).ubiquitin protein ligase (SP1) 45 34 1 1 2 2 1 1 1 1 0 1 1 1 1 0 1 0 1 1 1 1 2 1 1 2 1 1 1 1 2 1 2 3 2 1 0 1 0 2 2
19.3.2.2 Protein homeostasis.autophagy.ATG9-2-18 membrane shuttling complex.ATG9-transport factor (ATG27) 45 35 1 1 1 1 1 1 2 1 0 1 1 1 1 0 1 0 1 1 1 1 1 1 1 2 1 1 1 1 2 2 4 3 2 1 1 1 0 1 1
19.3.3.3 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ATG8/12-activating E1 protein (ATG7) 45 36 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 0 1 1 1 1 1 1 1 1 1 1 2 1 2 1 2 4 2 1 0 1 0 1 1
19.4.2.5 Protein homeostasis.proteolysis.serine-type peptidase activities.S49-class plastidial protease (SppA) 45 34 1 1 0 1 2 1 1 1 1 1 1 1 2 0 1 0 2 1 1 1 0 1 1 2 1 1 1 1 2 1 3 3 2 2 1 1 0 1 1
19.1.1.1.2 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.calnexin/calreticulin chaperone system.UDP-glucose glycoprotein glucosyltransferase (UGGT) 44 34 1 1 0 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 2 4 2 1 1 1 1 1 2 1 2 3 2 1 0 1 0 1 1
19.2.2.3.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.large component ECR1 44 35 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 0 1 1 1 1 0 2 1 2 2 1 1 1 2 1 1 3 2 1 1 1 0 0 1
19.2.2.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation 44 34 1 1 1 2 1 1 2 1 1 2 1 0 2 0 1 0 1 1 1 1 1 0 1 1 2 1 1 1 1 1 2 4 2 1 1 1 0 1 1
19.2.2.7.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation.ubiquitin-fold protein (URM) 44 34 1 1 1 2 1 1 2 1 1 2 1 0 2 0 1 0 1 1 1 1 1 0 1 1 2 1 1 1 1 1 2 4 2 1 1 1 0 1 1
19.2.4.3.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deglycosylating peptide:N-glycanase (PNG1) 44 36 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 5 1 1 3 2 1 0 1 0 1 2
19.4.1.2 Protein homeostasis.proteolysis.cysteine-type peptidase activities.C2-class calcium-activated protease (Phytocalpain) 44 33 1 1 1 1 1 1 1 1 0 2 0 1 1 0 2 0 1 1 1 1 1 3 1 1 2 1 1 1 2 1 3 3 2 1 0 1 0 1 1
19.1.1.2.4 Protein homeostasis.protein quality control.ER Quality Control (ERQC) machinery.BiP chaperone system.co-chaperone (ERdj7) 43 35 1 1 1 1 1 1 1 1 0 1 1 1 1 0 1 0 1 1 1 1 2 1 2 1 1 1 2 1 2 1 3 3 1 1 1 1 0 1 1
19.1.8.6 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-C-VI protein 43 30 2 1 0 1 1 1 1 1 0 1 2 1 2 0 0 0 1 1 0 1 1 1 1 0 2 1 1 1 0 1 4 3 2 1 2 2 0 2 1
19.2.2.8.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.scaffold component CUL4 43 32 1 1 0 1 1 1 0 0 1 1 1 1 2 1 1 0 1 1 1 1 0 2 1 3 2 1 1 2 2 1 1 3 2 1 0 2 0 1 1
19.4.2.1.6 Protein homeostasis.proteolysis.serine-type peptidase activities.S8-class protease (subtilisin) families.protease (SBT6.1) 43 37 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 3 3 2 1 1 1 0 1 1
19.4.2.9.7 Protein homeostasis.proteolysis.serine-type peptidase activities.chloroplast Clp-type protease complex.adaptor component ClpF 43 36 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 2 1 1 1 1 1 1 1 1 1 1 2 1 3 3 2 1 1 1 0 1 1
19.2.3.1.1.13 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP27) 42 31 2 1 0 1 1 1 1 1 0 1 0 1 1 0 1 0 1 1 1 1 1 1 0 1 1 1 1 1 2 1 4 3 2 1 0 3 0 2 1
19.3.3.5.1 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ATG12-ATG5 ATG8-PE-ligase E3 heterodimer.ubiquitin-fold component ATG12 42 32 1 1 0 2 1 2 0 1 1 1 0 1 1 1 1 0 1 1 1 1 0 0 1 1 2 1 1 1 2 1 3 4 1 1 2 1 0 1 1
19.4.2.8.1 Protein homeostasis.proteolysis.serine-type peptidase activities.mitochondrion Clp-type protease complex.proteolytic component ClpP2 42 34 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 0 1 1 2 2 1 1 1 1 4 1 1 3 2 1 0 1 0 0 1
19.4.5.4.1 Protein homeostasis.proteolysis.metallopeptidase activities.M16 families.peptidase (PQQL-like) 42 32 2 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 0 3 1 2 0 1 1 1 2 1 3 3 2 1 0 1 0 1 0
19.2.1.2.1.4 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-asparagine amidase (NTAN) 41 31 2 1 1 1 1 1 1 1 0 1 1 2 1 0 1 0 1 1 1 1 0 1 0 0 1 1 1 1 3 1 4 3 2 1 0 1 0 1 1
19.2.4.3.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deubiquinating protease (OTU1) 41 31 1 1 1 1 1 0 1 0 1 1 1 1 3 0 1 0 1 1 1 1 1 0 0 2 2 1 1 1 1 1 4 3 2 1 0 1 0 1 1
19.3.3.6 Protein homeostasis.autophagy.ATG8/ATG12 conjugation system.ATG12-conjugation E2 protein (ATG10) 41 32 1 1 0 1 1 1 2 1 0 1 2 1 1 0 1 0 1 2 0 1 1 1 1 1 1 1 1 1 2 1 3 3 2 1 1 1 0 0 1
19.1.8.11 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-P protein 39 27 2 0 1 1 0 1 1 1 0 3 1 1 2 0 0 0 1 1 0 1 0 2 2 0 1 1 1 1 0 1 2 4 3 1 1 1 0 1 0
19.2.1.2.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-glutamine amidase (NTAQ) 39 33 1 1 1 1 1 1 1 1 1 1 0 1 1 0 1 0 1 1 1 2 1 1 1 1 1 1 1 1 1 0 2 3 3 1 0 1 0 1 1
19.2.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation 37 33 1 1 1 1 1 1 0 1 1 1 0 1 1 0 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 3 2 1 1 0 0 1 1
19.2.3.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation.UFM1-specific protease 37 33 1 1 1 1 1 1 0 1 1 1 0 1 1 0 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 3 2 1 1 0 0 1 1
19.2.3.1.2.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU7) 36 31 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 0 1 1 1 1 0 0 0 2 1 1 1 1 0 1 0 3 2 1 0 1 0 1 1
19.2.2.8.1.4.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component UFO 35 24 0 0 1 1 1 1 0 0 0 0 1 1 1 0 0 0 1 1 0 1 3 0 1 0 2 1 1 1 2 0 3 3 1 1 3 2 0 0 1
19.2.2.8.2.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component FBL 35 28 0 1 1 1 0 1 1 1 0 1 1 1 1 0 1 0 1 1 1 1 1 1 0 1 0 1 1 1 2 1 3 4 2 1 0 0 0 1 0
19.2.5.2 Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).protein retrotranslocase (SP2) 35 28 1 1 1 1 1 1 1 0 0 1 1 1 2 0 0 0 1 1 1 1 0 1 1 0 2 1 1 1 0 1 3 3 2 1 0 1 0 1 0
19.1.8.10 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-PX protein 33 27 0 1 1 1 1 1 2 0 0 1 1 1 1 0 0 0 1 1 1 0 1 1 0 0 1 1 1 1 0 1 3 3 2 1 1 1 0 1 0
19.2.2.8.3.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.E2 conjugating component COP10 32 25 1 1 0 1 0 1 1 0 1 1 0 0 1 1 1 0 0 1 0 0 0 0 1 2 1 1 1 1 2 1 3 3 2 1 0 1 0 0 1
19.1.8.3 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-C-III protein 31 26 1 0 1 1 0 1 1 0 0 1 0 1 1 0 0 0 1 1 1 1 1 1 0 0 2 1 1 1 0 1 1 2 2 1 3 1 0 1 0
19.2.2.8.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component NPH3 31 22 1 1 1 0 1 1 3 1 0 1 1 1 1 0 0 0 0 1 1 0 2 0 1 0 2 1 1 2 0 0 3 3 0 0 0 1 0 0 0
19.2.3.1.1.11 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP25) 23 18 1 0 1 1 1 0 0 1 0 0 0 0 0 0 0 0 1 1 1 0 2 1 0 1 2 0 1 1 2 0 3 0 0 1 0 1 0 0 0
19.3.4.4 Protein homeostasis.autophagy.autophagic cargo receptor activities.adapter protein (ATI3) 23 9 0 0 0 4 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 2 0 0 0 6 0 0 4 2 1 0 0 0 2 0 0 0 0 0
19.1.8.5 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-C-V protein 18 15 0 0 0 1 0 1 1 0 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 1 0 0 2 2 1 2 0 1 0 1 0
19.1.8.9 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-M-II protein 11 9 1 0 0 1 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 3 1 1 0 0 0 0 0
19.1.8.4 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-C-IV protein 3 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0
19.1.8.7 Protein homeostasis.protein quality control.smallHsp holdase chaperone activities.class-C-VII protein 3 3 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0