Child MapMan terms

Original MapMan term
19.2
Description
Protein homeostasis.ubiquitin-proteasome system
Type
mapman

MapMan description genes species aco aof ash ath atr bdi calsi cam cre egu hvu lpe mac mco mpo msi obr osa osaindica oth pab ped peq ppa ptr sbi sit sly smo spo ssp tae ttu vvi zjn zma zma-b104 zma-ph207 zosmarina
19.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation 14838 37 311 273 263 433 215 384 555 295 71 422 392 411 604 50 152 0 315 395 341 275 433 450 306 296 524 389 392 440 350 234 899 1390 781 287 333 482 0 436 259
19.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation) 8556 37 168 147 152 258 116 227 281 163 30 237 240 246 356 23 81 0 168 230 202 156 265 263 166 157 290 241 243 229 206 126 515 824 464 161 207 303 0 267 148
19.2.2.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities 7114 37 142 118 127 217 98 190 240 138 17 198 193 200 305 11 63 0 140 201 172 130 204 211 136 116 244 203 203 195 162 103 427 696 390 133 183 257 0 224 127
19.2.2.1.5.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities 5179 37 104 86 94 152 66 139 193 92 7 146 143 143 245 5 36 0 100 146 122 91 143 149 98 77 180 148 147 143 112 75 279 507 282 95 153 206 0 173 102
19.2.2.8 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes 4300 37 94 78 73 125 70 106 204 80 11 135 104 115 172 12 46 0 98 113 95 79 127 131 93 89 173 95 101 154 92 75 258 389 223 85 80 129 0 122 74
19.2.2.8.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes 3411 37 72 63 59 103 50 79 178 70 6 103 84 85 137 8 36 0 82 95 76 64 105 107 74 60 144 77 83 126 70 62 198 297 162 68 71 102 0 97 58
19.2.2.1.5.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-H2-class E3 ligase 2676 37 46 27 47 87 32 73 87 37 1 79 78 76 134 1 18 0 45 85 63 36 90 64 53 32 88 85 84 73 56 35 111 303 148 41 93 119 0 89 60
19.2.2.8.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components 2520 37 51 46 47 76 44 60 116 49 2 81 49 58 109 4 31 0 55 63 51 54 70 89 63 41 121 60 61 98 59 53 151 181 108 55 60 82 0 73 49
19.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation 2477 37 59 58 44 57 43 69 78 57 26 75 63 61 80 22 33 0 61 65 60 51 61 82 48 64 90 62 63 60 72 50 156 193 122 58 40 69 0 75 50
19.2.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome 2460 37 47 50 39 57 43 59 99 61 35 69 61 61 72 34 36 0 53 59 58 54 50 79 51 78 82 54 60 48 77 41 192 178 108 43 66 77 0 79 50
19.2.2.8.1.4.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component FBX 1942 37 41 33 36 62 32 46 81 38 2 63 36 41 87 4 24 0 43 49 40 39 55 69 49 34 103 45 46 82 46 39 113 139 84 45 42 61 0 54 39
19.2.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation 1678 37 42 40 29 37 29 47 54 40 15 50 35 40 56 11 21 0 42 47 41 37 42 60 32 38 60 40 44 39 46 34 113 131 84 41 27 47 0 55 32
19.2.2.1.5.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-HC-class E3 ligase 1471 37 33 29 28 32 20 37 69 34 4 43 35 37 61 3 12 0 32 35 34 30 30 50 29 31 57 40 39 39 38 24 93 115 77 29 37 56 0 55 24
19.2.6.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle 1445 37 27 29 20 32 25 37 57 37 19 40 36 37 43 19 20 0 30 35 35 35 28 45 31 43 52 30 37 28 46 24 114 113 65 26 37 43 0 44 26
19.2.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD) 1260 37 22 33 23 30 22 27 47 27 16 33 31 36 40 14 20 0 26 26 26 27 29 35 20 37 47 29 29 29 40 25 86 106 66 25 24 42 0 44 21
19.2.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways 1120 37 27 25 18 30 17 24 39 26 13 38 24 33 39 7 17 0 26 30 26 26 31 34 18 43 33 26 28 24 33 19 66 85 64 23 23 31 0 32 22
19.2.3.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities 1103 37 27 27 18 25 17 32 37 27 6 34 21 25 37 4 13 0 29 32 28 24 33 42 20 22 37 26 30 26 33 22 74 87 56 28 15 32 0 37 20
19.2.6.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle 960 37 18 20 18 23 17 21 40 23 15 28 23 23 28 14 15 0 22 23 22 18 21 32 19 34 29 23 22 19 29 16 72 60 40 16 27 33 0 34 23
19.2.6.2.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components 900 37 14 17 14 19 15 21 41 22 12 25 23 23 25 12 13 0 19 22 22 24 22 26 22 26 34 17 22 17 26 14 67 69 39 15 23 33 0 33 12
19.2.2.1.5.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities 815 37 12 13 9 38 12 22 11 22 6 12 22 32 16 2 9 0 18 26 24 18 16 19 8 11 20 27 26 18 15 7 74 116 63 11 11 19 0 22 8
19.2.2.1.5.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities 759 37 17 9 17 20 14 19 26 14 1 27 20 17 34 1 12 0 14 21 20 15 33 28 23 15 31 19 19 20 25 13 52 50 29 19 15 21 0 17 12
19.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation) 707 37 16 18 13 18 8 21 23 26 15 14 15 25 19 7 9 0 17 18 13 14 14 17 18 21 19 20 18 21 15 11 42 72 36 15 15 19 0 14 11
19.2.2.1.5.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.E3 ubiquitin ligase (PUB) 676 35 16 7 16 19 12 17 23 12 0 25 17 15 32 0 10 0 12 19 18 12 28 27 20 13 30 17 17 19 23 12 46 44 25 15 14 19 0 15 10
19.2.2.8.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.target protein binding component SKP1/ASK1 630 37 14 12 7 21 2 13 49 15 1 14 29 21 18 1 2 0 22 26 18 3 30 9 8 11 14 11 16 18 5 4 30 93 42 8 7 14 0 19 3
19.2.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation) 623 37 10 11 11 14 9 17 20 16 10 15 19 15 16 7 8 0 16 19 17 13 13 17 10 19 19 19 17 16 21 10 46 58 31 12 9 16 0 16 11
19.2.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway 579 37 15 13 9 11 8 13 23 16 5 21 10 14 23 4 6 0 17 19 16 17 16 16 9 21 17 17 18 12 14 9 40 36 27 12 13 15 0 15 12
19.2.3.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities 575 37 15 13 11 12 12 15 17 13 9 16 14 15 19 7 8 0 13 15 13 13 9 18 12 16 23 14 14 13 13 12 39 44 28 13 12 15 0 18 12
19.2.2.8.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes 563 36 14 9 9 13 14 18 20 8 1 20 15 22 23 0 4 0 10 12 12 10 15 16 10 8 16 11 11 17 10 6 42 71 45 9 7 14 0 14 7
19.2.2.1.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination 537 37 14 12 9 13 9 11 29 11 3 19 12 14 22 2 4 0 13 13 13 10 21 17 11 11 19 14 13 11 11 9 35 40 24 12 13 17 0 18 8
19.2.4.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction 528 37 8 10 8 12 9 11 14 12 5 14 17 18 15 5 8 0 11 11 11 11 10 14 8 12 17 13 14 10 16 10 40 58 36 10 9 16 0 18 7
19.2.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation 524 37 17 14 11 14 9 10 21 8 3 18 9 11 35 3 4 0 11 12 11 9 14 17 13 10 18 11 10 17 9 9 36 36 23 12 16 16 0 16 11
19.2.2.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-conjugating E2 protein (UBC) 520 37 12 14 10 12 8 14 21 10 7 20 16 13 23 6 7 0 8 8 7 9 13 20 10 11 16 11 13 16 16 11 29 38 26 12 7 19 0 18 9
19.2.6.1.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components 482 37 7 10 10 12 9 11 22 10 7 14 13 12 15 7 8 0 11 13 12 7 8 17 9 20 15 12 10 10 13 8 35 33 22 7 12 16 0 17 8
19.2.6.1.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components 478 37 11 10 8 11 8 10 18 13 8 14 10 11 13 7 7 0 11 10 10 11 13 15 10 14 14 11 12 9 16 8 37 27 18 9 15 17 0 17 15
19.2.2.8.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components 473 35 13 7 8 11 13 15 18 6 0 18 13 19 18 0 3 0 7 9 9 8 14 11 9 6 14 9 9 15 6 4 35 65 41 8 5 11 0 11 5
19.2.2.1.5.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-v-class E3 ligase 461 36 9 11 10 13 5 12 15 10 1 14 13 12 24 0 1 0 11 14 14 10 12 18 8 3 17 11 12 15 10 7 32 33 25 12 8 15 0 13 11
19.2.6.2.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components 459 37 12 10 5 11 8 14 13 12 6 13 10 11 16 6 6 0 9 11 11 9 6 15 8 16 16 10 12 10 18 9 36 38 22 10 12 7 0 8 13
19.2.1.2.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification 453 37 13 8 7 9 6 11 18 14 3 16 8 11 20 2 4 0 13 16 14 15 13 13 7 6 13 15 16 9 10 7 33 27 20 10 10 13 0 13 10
19.2.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin 426 37 11 9 8 10 8 9 16 8 8 14 17 8 14 8 8 0 8 8 8 7 12 13 9 13 18 8 8 11 14 9 23 26 18 11 10 14 0 13 9
19.2.3.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex 426 37 11 9 8 10 8 9 16 8 8 14 17 8 14 8 8 0 8 8 8 7 12 13 9 13 18 8 8 11 14 9 23 26 18 11 10 14 0 13 9
19.2.2.1.5.3.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (SINA) 379 35 12 11 6 15 5 12 14 8 0 4 11 13 15 0 2 0 7 7 8 11 7 10 5 4 14 8 8 13 4 5 30 45 25 10 8 9 0 9 4
19.2.2.1.5.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities 361 37 9 10 7 7 6 10 10 10 3 13 8 8 10 3 6 0 8 8 6 6 12 15 7 13 13 9 11 14 10 8 22 23 16 8 4 11 0 12 5
19.2.2.1.5.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities.monomeric E3 ubiquitin ligase (HECT) 361 37 9 10 7 7 6 10 10 10 3 13 8 8 10 3 6 0 8 8 6 6 12 15 7 13 13 9 11 14 10 8 22 23 16 8 4 11 0 12 5
19.2.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway 346 37 7 8 6 14 6 7 11 7 6 12 8 11 10 1 8 0 6 7 7 7 10 13 6 15 11 6 6 8 13 6 16 27 17 7 6 11 0 12 7
19.2.1.3.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex 346 37 7 8 6 14 6 7 11 7 6 12 8 11 10 1 8 0 6 7 7 7 10 13 6 15 11 6 6 8 13 6 16 27 17 7 6 11 0 12 7
19.2.2.5.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.conjugation E2 protein 345 37 11 10 8 8 6 7 14 5 2 11 6 8 23 2 3 0 7 8 7 6 7 12 8 7 11 7 6 12 7 6 23 27 17 7 11 9 0 9 7
19.2.4.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex 341 37 7 12 6 9 6 7 15 7 5 10 6 7 12 5 6 0 6 6 6 7 8 8 6 12 14 7 7 9 10 6 22 23 13 7 9 14 0 15 6
19.2.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation 336 37 5 8 6 9 5 12 8 8 2 10 11 12 9 3 3 0 10 9 10 6 6 8 6 12 11 13 10 9 10 6 19 33 18 5 2 8 0 6 8
19.2.2.1.5.4.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.plant-specific E3 ubiquitin ligase (RSL/RFA) 330 36 5 4 4 20 7 9 4 11 3 4 4 12 7 0 2 0 6 10 9 7 8 7 3 4 10 10 11 9 7 1 34 48 23 5 4 7 0 7 4
19.2.2.8.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes 326 37 8 6 5 9 6 9 6 2 4 12 5 8 12 4 6 0 6 6 7 5 7 8 9 21 13 7 7 11 12 7 18 21 16 8 2 13 0 11 9
19.2.1.2.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.cysteine oxidase (PCO) 324 37 9 5 4 5 3 8 15 11 1 13 6 7 17 1 1 0 10 13 11 11 9 10 5 4 9 11 13 6 4 4 24 18 13 7 10 10 0 10 6
19.2.2.1.5.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Ariadne) 304 37 4 6 3 15 2 9 5 7 2 5 12 8 7 1 5 0 8 9 9 8 7 9 3 6 7 12 9 6 6 4 27 31 17 4 7 10 0 12 2
19.2.3.1.2.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU6-12) 288 37 7 7 6 7 5 9 7 6 3 7 8 8 10 3 3 0 7 8 6 7 1 10 6 7 11 7 7 8 6 7 17 23 14 7 8 8 0 10 7
19.2.2.1.6.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.ligating E3 protein (RGLG) 276 36 7 5 3 5 4 6 20 6 1 9 5 7 11 0 2 0 6 7 7 4 11 9 5 4 11 8 7 4 4 4 23 25 14 6 5 7 0 9 5
19.2.2.1.6.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex 261 37 7 7 6 8 5 5 9 5 2 10 7 7 11 2 2 0 7 6 6 6 10 8 6 7 8 6 6 7 7 5 12 15 10 6 8 10 0 9 3
19.2.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).ubiquitin-fold protein (SUMO) 255 37 7 6 5 9 2 9 4 12 8 3 3 12 5 1 2 0 6 8 4 5 3 4 11 6 5 9 6 6 6 3 15 36 12 6 5 5 0 4 2
19.2.2.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-fold protein (UBQ) 245 30 1 0 2 9 0 7 0 0 1 0 13 15 5 1 5 0 4 5 7 0 28 6 5 9 10 10 10 3 11 1 5 42 17 3 0 4 0 2 4
19.2.2.8.1.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component SKP2 229 35 5 4 4 6 6 5 7 4 0 9 4 5 7 0 6 0 4 4 3 6 18 6 6 4 8 6 6 5 7 5 10 17 10 2 9 7 0 7 7
19.2.2.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation 218 37 3 5 3 4 4 6 5 7 3 6 6 6 4 3 3 0 6 8 7 4 1 7 3 3 4 9 7 4 6 2 22 20 12 3 4 6 0 8 4
19.2.4.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome 200 37 4 7 5 5 3 6 8 5 2 4 4 5 7 2 2 0 5 5 5 5 4 8 4 8 8 5 4 5 4 5 14 12 7 4 4 6 0 6 3
19.2.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway 195 37 5 4 3 5 3 4 5 3 2 5 6 8 6 2 3 0 3 4 3 2 5 5 3 7 5 3 4 4 6 4 10 22 20 4 4 5 0 5 3
19.2.1.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex 195 37 5 4 3 5 3 4 5 3 2 5 6 8 6 2 3 0 3 4 3 2 5 5 3 7 5 3 4 4 6 4 10 22 20 4 4 5 0 5 3
19.2.4.2.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.platform ATPase (CDC48) 193 35 0 3 3 3 2 4 4 4 1 4 10 11 4 2 3 0 4 3 3 4 0 4 1 6 5 5 5 5 4 2 15 34 19 3 2 5 0 4 2
19.2.4.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing 191 37 3 4 4 4 4 3 10 3 4 5 4 6 6 2 4 0 4 4 4 4 7 5 2 5 8 4 4 5 10 4 10 13 10 4 2 6 0 5 5
19.2.2.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation 190 36 5 5 4 4 4 4 7 4 3 4 7 4 7 0 4 0 5 4 4 5 3 7 6 4 5 4 4 5 8 4 11 15 6 4 7 4 0 5 4
19.2.2.8.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component LRB 190 35 3 2 1 3 8 9 5 2 0 5 9 12 4 0 1 0 2 2 2 2 9 4 1 2 4 2 2 5 2 1 10 38 25 3 1 3 0 3 3
19.2.2.1.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin receptor regulatory protein (DA1) 187 37 4 4 3 8 2 5 5 4 1 4 4 4 7 1 1 0 4 4 4 5 3 7 4 9 7 4 4 5 4 3 20 13 8 4 4 5 0 6 3
19.2.2.5.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.ubiquitin-fold protein (MUB) 179 37 6 4 3 6 3 3 7 3 1 7 3 3 12 1 1 0 4 4 4 3 7 5 5 3 7 4 4 5 2 3 13 9 6 5 5 7 0 7 4
19.2.4.2.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer 178 37 3 2 2 5 4 4 4 5 2 5 5 4 5 1 2 0 4 5 5 4 5 6 3 2 5 5 6 2 4 3 17 15 11 2 3 7 0 9 2
19.2.2.8.2.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BT 167 35 6 3 4 5 3 4 7 1 0 8 1 4 9 0 1 0 3 4 4 4 2 4 4 3 6 4 4 6 2 1 14 15 10 3 4 6 0 7 1
19.2.2.1.6.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Uev1 165 37 5 4 4 5 3 3 6 3 1 5 5 5 7 1 1 0 5 4 4 4 9 7 4 3 4 4 4 3 5 3 9 9 6 3 6 5 0 5 1
19.2.3.1.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP5|8-11) 161 35 3 3 3 5 3 4 5 3 1 5 4 4 7 0 2 0 4 4 4 4 4 8 3 0 7 4 4 3 6 4 14 12 8 4 2 3 0 4 3
19.2.2.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities 159 37 3 4 3 2 2 6 3 4 2 4 5 5 5 1 3 0 5 4 3 4 4 4 1 9 5 3 4 4 2 3 12 15 10 2 5 3 0 3 2
19.2.3.1.1.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP15-21) 159 35 4 4 3 5 3 4 7 4 0 5 2 4 9 0 1 0 4 4 4 3 3 3 4 5 7 4 4 4 3 2 10 12 8 5 1 5 0 6 3
19.2.4.4.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.shuttle protein (RAD23) 149 37 3 5 3 4 2 5 5 4 1 4 3 4 6 1 1 0 4 4 4 4 2 6 3 6 6 4 3 4 2 4 9 9 5 3 4 5 0 5 2
19.2.3.1.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP12-13) 146 36 4 4 2 2 1 4 3 4 1 4 5 4 4 0 1 0 4 4 4 3 5 8 2 3 4 4 4 5 4 3 7 11 8 3 2 5 0 7 3
19.2.2.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-activating E1 protein (UBA) 143 37 1 2 3 2 1 4 3 3 1 3 4 4 3 1 2 0 3 4 4 4 7 7 4 4 3 4 4 2 4 2 11 14 9 2 3 5 0 5 1
19.2.3.1.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU3-4) 138 37 3 3 2 2 3 3 5 4 1 4 3 4 3 2 2 0 3 4 4 3 4 3 3 5 6 4 4 2 3 2 9 12 8 4 2 3 0 4 2
19.2.2.3.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities 137 37 3 2 3 3 2 4 4 4 3 4 2 3 5 1 2 0 3 3 3 4 4 4 2 6 4 4 4 4 6 4 10 9 4 3 2 3 0 3 3
19.2.2.8.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex 133 34 4 2 3 4 3 3 2 1 0 5 1 2 7 0 2 0 3 2 3 2 3 2 5 11 7 3 3 6 4 3 6 6 6 4 0 4 0 6 5
19.2.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer 130 37 3 4 2 4 2 2 13 3 2 4 4 2 3 2 2 0 2 2 2 4 2 4 3 3 4 2 3 3 3 2 9 9 6 2 3 3 0 3 4
19.2.3.1.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP1-2) 128 35 1 5 1 2 1 7 4 3 0 2 3 1 1 0 1 0 6 8 4 3 4 3 1 3 2 4 5 2 2 1 8 18 12 1 2 3 0 3 1
19.2.1.2.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities 126 37 2 5 2 2 2 2 5 2 2 5 2 3 3 2 2 0 4 3 2 2 3 3 2 15 4 2 2 3 4 2 7 9 7 2 3 2 0 2 2
19.2.2.8.1.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EBF 126 35 2 3 1 2 2 2 22 2 0 3 5 2 8 0 1 0 2 2 2 2 2 4 2 2 4 2 2 6 2 5 8 6 4 2 3 4 0 4 1
19.2.2.8.1.4.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EDL 126 34 2 3 4 3 2 4 5 2 0 5 1 6 5 0 0 0 3 4 3 4 2 6 4 1 2 4 4 3 2 2 10 10 5 3 2 5 0 4 1
19.2.2.1.5.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (ARA54) 124 36 1 1 1 1 2 3 1 2 1 1 4 10 1 1 1 0 3 6 6 1 1 1 1 1 1 4 5 1 2 1 9 28 17 1 0 1 0 2 1
19.2.4.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component UFD1 120 36 2 1 1 3 3 3 3 4 1 3 2 3 3 0 1 0 3 4 4 3 2 4 2 1 3 4 5 1 2 2 17 12 9 1 1 3 0 3 1
19.2.2.1.5.3.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (DA2) 119 36 2 6 1 2 2 3 5 2 1 4 5 3 5 1 0 0 3 3 2 3 2 3 2 3 2 3 3 1 2 3 10 8 5 1 5 6 0 6 1
19.2.2.8.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.scaffold component CUL1/CUL2 118 36 5 3 2 3 1 3 7 3 1 4 3 3 5 1 1 0 2 3 3 1 0 7 1 3 4 3 3 7 2 2 8 9 5 2 2 2 0 2 2
19.2.3.1.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP3-4) 115 37 4 3 2 2 1 3 4 3 1 3 3 3 4 1 1 0 3 3 3 3 2 5 2 3 2 3 3 2 4 2 7 8 6 2 2 4 0 5 3
19.2.2.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO conjugation E2 enzyme (SCE1) 112 35 2 2 2 1 1 3 0 6 3 1 3 5 4 3 1 0 3 3 3 0 3 4 2 2 4 5 4 6 2 2 3 9 6 2 1 7 0 3 1
19.2.2.2.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (SIZ1) 112 35 2 3 2 1 1 4 3 3 1 3 4 4 4 0 1 0 3 3 2 3 2 4 1 5 4 2 3 3 0 2 9 12 8 1 4 2 0 2 1
19.2.2.8.1.4.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component ADO 108 33 2 3 3 3 2 3 3 3 0 3 2 3 3 0 1 0 3 3 3 3 0 5 3 0 4 3 3 2 2 3 8 8 5 3 1 5 0 6 1
19.2.4.2.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.membrane protein retrotranslocation factor (DFM1) 108 37 4 4 2 3 2 2 5 2 2 3 2 2 4 2 2 0 2 2 2 2 4 2 3 3 5 2 2 2 4 3 5 6 4 4 2 2 0 4 2
19.2.2.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer 107 37 2 2 2 3 2 2 9 2 2 2 2 2 2 2 2 0 2 2 2 2 3 4 2 4 4 2 2 3 4 2 5 9 6 2 2 3 0 2 2
19.2.4.1.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc7/13/14 102 37 2 4 2 3 2 2 4 2 1 5 2 2 4 1 1 0 2 2 2 2 2 2 2 4 4 2 2 4 2 2 3 6 4 3 2 5 0 6 2
19.2.1.1.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E3 ubiquitin ligase component Doa10 100 35 2 2 1 2 1 2 2 2 0 2 3 6 2 0 1 0 1 2 2 1 3 2 1 5 2 1 2 1 2 2 4 16 16 2 2 2 0 2 1
19.2.3.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (ELS) 100 35 0 3 2 3 1 3 2 3 1 2 3 3 2 2 1 0 3 3 2 3 1 3 3 2 3 3 3 2 3 2 9 9 5 1 0 3 0 4 2
19.2.6.2.2.10 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN11 97 37 2 3 1 1 2 2 4 2 1 3 3 3 2 1 2 0 2 3 3 3 3 3 2 3 2 1 2 1 4 1 4 8 5 1 4 5 0 4 1
19.2.2.1.6.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Ubc13 96 37 2 3 2 3 2 2 3 2 1 5 2 2 4 1 1 0 2 2 2 2 1 1 2 4 4 2 2 4 2 2 3 6 4 3 2 5 0 4 2
19.2.2.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB conjugation E2 protein (RCE1) 96 37 2 2 1 2 1 3 2 3 1 2 2 2 3 1 1 0 3 3 3 2 3 2 2 5 4 2 2 4 5 1 8 6 4 3 1 2 0 2 1
19.2.6.2.1.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT4 94 37 2 2 1 2 1 4 3 2 1 3 2 3 3 1 1 0 1 2 2 2 2 3 1 3 4 2 2 2 2 2 7 9 6 2 3 2 0 1 3
19.2.2.8.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.scaffold component CUL3 90 36 1 2 1 2 1 3 2 2 1 2 2 3 5 0 1 0 3 3 3 2 1 5 1 2 2 2 2 2 4 2 7 6 4 1 2 3 0 3 2
19.2.2.8.3.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex 90 36 2 2 1 2 1 2 2 0 2 4 1 1 2 2 2 0 1 2 2 1 2 2 2 5 2 2 2 2 4 2 9 7 5 2 1 5 0 2 2
19.2.6.1.1.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-4 89 37 1 1 2 2 3 2 9 2 1 2 3 2 2 1 1 0 2 2 2 1 1 4 1 4 2 2 2 1 2 1 7 5 3 2 4 3 0 3 1
19.2.2.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.2.2.1.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation.ubiquitin carboxyl-terminal hydrolase (UCH) 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.2.2.3.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH1|2) 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.2.6.2.2.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN2 86 37 1 1 2 2 1 2 2 2 1 2 1 2 1 1 1 0 2 2 2 1 3 4 1 4 2 2 2 2 2 2 9 6 4 2 3 4 0 4 1
19.2.6.2.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ubiquitin C-terminal hydrolase cofactor 86 36 1 2 1 2 2 2 3 3 1 2 3 3 2 1 1 0 2 2 2 2 0 4 1 1 2 3 3 1 2 1 11 6 4 1 2 3 0 3 1
19.2.2.3.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH3) 85 35 1 3 1 1 1 2 1 3 1 4 2 2 1 1 1 0 3 3 3 2 0 3 1 1 1 3 3 2 2 0 8 9 6 1 1 2 0 4 2
19.2.2.1.5.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.bifunctional co-chaperone and E3 ubiquitin ligase (CHIP) 83 37 1 2 1 1 2 2 3 2 1 2 3 2 2 1 2 0 2 2 2 3 5 1 3 2 1 2 2 1 2 1 6 6 4 4 1 2 0 2 2
19.2.6.1.2.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-3 82 37 2 2 2 2 1 2 5 2 1 2 2 1 2 1 1 0 2 2 2 1 3 2 1 2 2 2 2 1 2 1 8 6 3 1 3 4 0 3 1
19.2.2.3.5.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (RBX1) 81 37 1 1 2 2 1 2 3 2 1 2 1 2 4 1 1 0 2 2 2 2 4 1 1 3 3 2 2 2 2 2 6 6 2 2 2 3 0 2 2
19.2.2.8.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.UBQ-E2-recruiting component RBX1 81 37 1 1 2 2 1 2 3 2 1 2 1 2 4 1 1 0 2 2 2 2 4 1 1 3 3 2 2 2 2 2 6 6 2 2 2 3 0 2 2
19.2.6.2.1.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT1 81 37 5 2 1 2 2 2 2 2 1 3 2 2 3 1 1 0 1 2 2 2 2 2 1 2 4 2 2 2 2 2 6 6 2 2 2 1 0 1 2
19.2.6.2.2.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN6 81 35 1 2 1 1 1 2 4 2 1 3 3 3 2 1 1 0 1 2 2 1 2 3 2 2 4 2 2 1 2 1 7 8 3 0 0 3 0 4 1
19.2.2.8.3.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.regulator component SPA 80 33 3 1 2 3 2 2 1 0 0 4 1 1 5 0 1 0 2 1 2 1 2 1 4 2 4 2 2 4 2 2 4 3 4 2 0 3 0 4 3
19.2.5 Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD) 80 34 2 2 3 3 2 2 2 1 0 2 2 2 3 0 1 0 2 2 2 2 2 2 2 2 3 2 2 2 2 2 5 6 4 2 0 2 0 3 2
19.2.6.2.2.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN7 80 36 1 0 1 1 2 2 6 2 1 1 3 2 3 1 1 0 2 2 2 2 1 3 2 2 2 2 2 1 2 1 9 6 3 1 3 2 0 2 1
19.2.6.1.2.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-6 79 37 1 2 1 1 1 2 3 3 1 2 1 2 3 1 1 0 2 2 2 2 1 3 1 2 2 2 2 1 4 1 8 3 2 2 2 4 0 5 1
19.2.3.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (OTS) 78 31 2 2 1 2 1 3 2 1 0 4 3 2 2 0 1 0 3 2 3 0 0 1 2 5 1 6 3 2 3 1 0 9 6 1 0 1 0 1 2
19.2.6.2.2.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN1 78 36 1 1 1 2 2 2 6 2 1 2 2 1 1 1 1 0 2 3 3 2 1 2 2 2 3 1 3 2 2 1 3 9 5 1 0 2 0 2 1
19.2.6.1.1.7 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-7 77 36 1 1 2 1 1 1 4 1 1 2 3 1 2 1 1 0 2 2 2 2 1 3 1 2 2 2 1 2 2 1 8 6 4 1 0 4 0 4 2
19.2.6.2.2.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN3 77 37 1 2 1 2 1 2 2 2 1 3 2 2 3 1 1 0 2 2 2 2 1 4 1 4 4 1 2 2 2 1 4 6 1 2 3 2 0 2 1
19.2.6.2.1.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT6 76 37 2 1 1 2 2 2 2 2 1 2 1 2 2 1 1 0 2 2 2 1 1 3 2 2 2 2 2 2 3 1 8 6 3 2 1 1 0 2 2
19.2.6.2.2.8 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN9 76 37 1 1 1 2 1 2 4 2 1 2 3 3 3 1 1 0 2 2 2 2 2 3 2 2 2 1 2 2 2 1 4 4 3 2 2 2 0 3 1
19.2.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation 74 34 2 2 1 2 1 2 3 3 1 1 2 1 3 1 2 0 3 3 2 2 1 3 1 1 3 3 3 0 2 1 6 6 2 0 2 1 0 0 2
19.2.2.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation.ubiquitin-fold protein (HUB) 74 34 2 2 1 2 1 2 3 3 1 1 2 1 3 1 2 0 3 3 2 2 1 3 1 1 3 3 3 0 2 1 6 6 2 0 2 1 0 0 2
19.2.6.2.2.11 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN12 74 36 1 1 1 2 1 2 2 2 1 1 0 2 2 1 1 0 1 1 1 2 1 2 3 2 2 1 2 1 2 1 4 10 8 1 2 3 0 3 1
19.2.1.3.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.catalytic component GID2 73 36 2 2 1 3 1 2 2 1 1 2 3 4 2 0 1 0 1 1 1 1 1 4 1 4 4 1 1 1 2 1 3 9 5 1 1 1 0 1 1
19.2.2.1.5.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-C2-class E3 ligase 73 35 2 2 2 3 2 2 3 1 0 2 1 2 6 0 3 0 2 2 1 1 2 4 1 4 2 1 1 2 2 1 3 3 2 2 2 1 0 1 2
19.2.6.1.1.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-5 73 36 1 2 2 2 1 2 3 2 1 2 2 2 3 1 2 0 1 1 1 0 2 2 2 3 2 2 1 2 2 1 8 6 4 1 1 1 0 1 1
19.2.6.2.2.9 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN10 73 36 1 2 1 1 1 1 4 3 1 3 1 1 3 1 1 0 2 2 2 1 3 0 2 1 3 2 2 1 2 2 8 3 2 1 2 3 0 3 1
19.2.6.2.1.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT3 72 36 1 1 1 1 1 2 2 2 1 2 2 1 3 1 1 0 1 1 1 1 0 2 1 4 2 1 2 2 7 2 6 6 4 1 1 1 0 1 3
19.2.2.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.large component SAE2 71 37 1 1 1 1 1 1 12 1 1 3 1 1 2 1 1 0 1 1 1 2 2 2 2 2 2 1 1 1 2 1 6 3 2 1 2 2 0 2 3
19.2.6.1.2.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-1 70 37 1 1 1 1 1 1 2 2 2 1 2 2 2 1 1 0 2 2 2 2 2 2 2 1 2 2 2 1 2 1 3 6 5 2 3 2 0 2 1
19.2.4.1.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E3 ubiquitin ligase component HRD1 69 37 1 3 1 2 1 2 1 2 1 1 1 2 1 1 2 0 1 1 1 1 1 2 1 1 2 2 2 2 2 1 8 8 3 1 1 3 0 2 1
19.2.6.2.1.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT5 69 36 1 2 1 2 1 2 2 2 1 1 1 1 3 1 1 0 2 2 2 2 0 3 1 2 2 2 2 1 2 1 4 5 3 2 4 1 0 2 2
19.2.3.3.1.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN1 67 37 1 2 1 1 1 2 3 1 1 2 4 2 3 1 1 0 1 1 1 1 1 2 1 2 2 1 1 1 2 1 4 8 4 1 2 1 0 1 2
19.2.6.1.1.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-2 67 35 1 2 1 2 0 1 1 2 1 2 2 2 2 1 1 0 2 2 2 1 0 1 2 2 2 2 2 2 2 1 4 6 4 1 2 3 0 2 1
19.2.6.1.2.5 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-5 67 37 2 2 1 2 1 1 3 1 1 3 2 1 1 1 1 0 1 1 1 2 3 2 3 2 2 1 1 2 2 1 5 3 1 1 2 1 0 1 6
19.2.6.2.1.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT2 67 36 1 2 0 2 1 2 2 2 1 2 2 2 2 1 1 0 2 2 2 1 1 2 2 3 2 1 2 1 2 1 5 6 4 1 1 1 0 1 1
19.2.6.2.2.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN5 67 36 2 1 1 2 1 2 2 1 1 2 3 2 2 1 1 0 1 1 1 2 2 0 1 2 3 2 1 2 2 1 8 3 1 1 1 4 0 3 1
19.2.3.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.peptidase (DeSI) 66 37 2 1 2 1 1 2 1 2 1 2 2 2 2 1 1 0 2 2 3 1 2 2 1 2 1 2 2 1 2 1 5 5 2 1 2 2 0 1 1
19.2.2.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).ubiquitin-fold protein (RUB) 65 27 0 0 2 2 0 2 0 0 1 1 7 2 2 0 0 0 2 3 2 1 2 0 1 1 3 2 2 1 0 1 1 14 5 1 0 2 0 1 1
19.2.6.1.1.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-1 65 37 1 2 1 2 1 2 2 1 1 2 1 2 2 1 1 0 2 2 2 1 2 2 1 4 3 2 1 1 1 1 3 4 3 1 1 2 0 3 1
19.2.6.1.2.2 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-2 65 36 2 0 1 2 1 2 2 2 1 2 1 2 2 1 1 0 1 1 1 1 3 3 1 2 2 2 3 2 2 2 7 1 2 1 1 2 0 2 1
19.2.1.2.2.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-I-residues E3 ubiquitin ligase (PRT6) 63 37 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2 0 1 1 1 1 2 2 1 10 1 1 1 2 2 1 3 6 4 1 1 1 0 1 1
19.2.1.2.2.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-II-residues E3 ubiquitin ligase (PRT1) 63 36 1 4 1 1 1 1 3 1 1 3 1 2 2 1 0 0 3 2 1 1 1 1 1 5 3 1 1 1 2 1 4 3 3 1 2 1 0 1 1
19.2.2.3.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.small component AXR1/AXL 63 37 1 1 1 2 1 1 6 1 1 1 1 1 1 1 1 0 1 1 1 1 3 2 1 2 2 1 1 2 2 1 4 6 4 1 1 2 0 2 1
19.2.2.8.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.adaptor protein exchange factor (CAND1) 62 36 1 1 1 1 2 1 3 1 1 2 2 1 1 1 1 0 1 1 2 4 1 1 1 2 2 1 1 1 2 1 3 8 5 1 0 1 0 1 2
19.2.3.1.1.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP14) 62 36 1 1 1 1 1 1 2 2 1 3 0 1 2 1 1 0 1 1 1 1 4 4 1 1 2 1 2 1 2 1 5 3 2 5 2 1 0 1 1
19.2.1.3.1.5 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID8 61 34 1 2 1 3 1 1 3 1 1 2 2 3 3 0 2 0 1 1 1 1 1 1 1 3 2 1 1 2 2 1 0 6 4 2 0 1 0 2 1
19.2.3.1.1.9 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP23) 61 34 2 1 1 1 1 2 1 2 0 2 1 2 3 0 1 0 1 1 2 2 2 1 2 1 2 1 2 1 2 2 5 6 3 2 1 0 0 1 1
19.2.6.1.2.7 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-7 61 37 1 1 1 1 1 1 2 2 1 2 1 2 1 1 1 0 2 1 1 2 1 2 1 2 2 1 1 1 2 1 3 5 4 1 2 2 0 2 3
19.2.1.3.1.1 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID1 60 36 1 1 1 5 1 1 3 1 2 3 0 1 1 1 1 0 1 1 1 1 1 3 1 3 2 1 1 1 2 1 4 3 2 1 2 2 0 2 1
19.2.2.8.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.core adaptor component DDB1 60 37 1 1 1 2 1 3 2 1 1 2 2 4 1 1 1 0 1 1 1 1 2 2 1 2 2 1 1 1 2 1 2 5 3 1 1 2 0 2 1
19.2.4.1.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.substrate recruitment component OS9 60 37 1 1 1 1 1 1 5 1 2 1 1 1 1 1 1 0 1 1 1 2 2 2 1 2 4 1 1 1 2 1 5 3 2 1 2 2 0 2 1
19.2.2.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.small component SAE1 59 36 2 3 1 3 1 1 1 2 1 1 3 1 1 1 1 0 1 1 1 2 0 2 1 1 2 1 2 2 1 1 3 6 4 1 1 1 0 1 1
19.2.6.2.2.7 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN8 59 37 1 2 2 2 1 1 3 1 1 1 1 1 2 1 1 0 1 1 1 2 1 1 3 1 3 1 1 1 2 1 4 3 2 2 2 2 0 2 1
19.2.2.8.3.3.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.regulator component DET1 58 36 1 1 1 1 1 1 1 0 1 3 1 1 1 1 1 0 1 1 2 1 2 2 1 3 1 1 1 1 2 1 6 4 3 1 1 4 0 2 1
19.2.3.1.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP6-7) 58 37 1 1 1 2 1 3 2 1 1 1 1 1 1 1 2 0 1 1 1 1 3 2 1 1 2 1 1 1 2 1 3 5 2 1 2 2 0 3 1
19.2.3.3.1.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN2 58 37 1 2 1 1 1 1 2 1 1 3 1 1 2 1 1 0 1 1 1 1 2 1 1 3 2 1 1 3 2 1 4 3 2 1 2 2 0 2 1
19.2.4.1.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.adaptor protein component HRD3 58 36 2 3 1 2 1 1 3 1 1 2 1 1 2 1 1 0 1 1 1 1 0 2 1 3 2 1 1 1 2 1 3 3 2 1 2 2 0 3 1
19.2.4.2.2.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component NPL4 58 36 1 1 1 2 1 1 1 1 1 2 3 1 2 1 1 0 1 1 1 1 3 2 1 1 2 1 1 1 2 1 0 3 2 1 2 4 0 6 1
19.2.2.1.5.4.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Helicase) 57 30 2 2 1 2 1 1 1 2 0 2 2 2 1 0 1 0 1 1 0 2 0 2 1 0 2 1 1 2 0 1 4 9 6 1 0 1 0 1 1
19.2.3.1.1.8 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP22) 57 36 2 2 1 1 1 1 3 1 0 5 1 1 2 1 1 0 1 1 1 1 1 1 2 1 3 1 1 2 2 2 5 3 1 1 1 1 0 1 1
19.2.3.3.1.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN7 57 36 1 1 0 1 1 1 2 1 1 2 1 1 2 1 1 0 1 1 1 1 3 1 2 2 4 1 1 1 2 1 3 3 2 2 1 3 0 3 1
19.2.6.1.1.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-3 57 36 1 1 1 1 2 2 2 1 1 2 1 2 2 1 1 0 1 3 2 1 1 3 1 3 2 1 1 1 2 1 2 3 2 0 1 2 0 2 1
19.2.2.3.5.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (DCN1) 56 33 2 1 1 1 1 2 1 2 2 2 1 1 1 0 1 0 1 1 1 2 0 3 1 3 1 2 2 2 4 2 4 3 2 1 0 0 0 1 1
19.2.1.3.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.N-recognin component GID4 55 35 1 1 1 1 1 1 1 2 1 2 1 1 1 0 2 0 1 2 2 1 2 1 1 1 1 1 1 2 1 1 4 3 2 1 0 4 0 4 2
19.2.4.3.1 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.E4 multiubiquitination enzyme (UFD2) 55 35 0 1 1 1 1 1 2 1 1 2 1 3 1 0 1 0 1 1 1 1 4 2 1 1 3 1 1 2 2 1 2 3 3 1 1 3 0 2 1
19.2.6.3 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation 55 37 2 1 1 2 1 1 2 1 1 1 2 1 1 1 1 0 1 1 1 1 1 2 1 1 1 1 1 1 2 1 6 5 3 1 2 1 0 1 1
19.2.6.3.1 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation.regulatory protein (PTRE1) 55 37 2 1 1 2 1 1 2 1 1 1 2 1 1 1 1 0 1 1 1 1 1 2 1 1 1 1 1 1 2 1 6 5 3 1 2 1 0 1 1
19.2.6.1.1.6 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-6 54 37 1 1 1 2 1 1 1 1 1 2 1 1 2 1 1 0 1 1 1 1 1 2 1 2 2 1 2 1 2 2 3 3 2 1 3 1 0 2 1
19.2.6.1.2.4 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-4 54 36 2 2 1 2 2 1 1 1 1 2 1 1 2 1 1 0 1 1 1 1 0 1 1 3 2 1 1 1 2 1 3 3 1 1 2 2 0 2 2
19.2.2.8.3.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.component COP1 53 33 1 1 1 1 1 1 1 1 0 1 0 1 2 0 1 0 1 1 1 1 1 1 1 9 3 1 1 2 2 1 2 3 2 2 0 1 0 2 2
19.2.3.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (FUG) 52 28 0 1 0 1 1 3 1 1 0 2 2 4 1 0 0 0 1 1 1 1 3 1 0 3 2 1 1 2 0 1 4 7 3 1 0 1 0 0 1
19.2.3.3.1.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN5 52 36 1 1 1 2 1 1 2 1 1 2 6 1 1 1 1 0 1 1 1 1 1 2 1 2 2 1 1 2 2 2 0 2 2 1 1 1 0 1 1
19.2.4.1.5 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.associated plant-specific component EBS7 52 35 1 1 1 1 1 1 2 1 0 1 1 1 4 1 1 0 1 1 1 1 3 0 1 2 2 1 1 1 2 1 3 3 2 1 2 2 0 2 1
19.2.6.2.2.12 Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN13 52 37 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 0 1 1 1 4 2 1 1 1 4 1 1 1 2 1 3 3 2 1 1 1 0 1 1
19.2.2.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO chain-forming-ligase E4 enzyme (PIAL) 51 34 1 2 1 2 1 1 3 1 0 2 0 1 2 0 1 0 1 1 1 1 2 1 1 1 1 1 1 2 2 1 3 3 2 3 1 1 0 1 2
19.2.3.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (SPF) 51 31 1 1 1 2 1 1 2 1 0 2 1 1 2 0 1 0 1 1 1 1 0 1 0 8 4 1 1 2 2 1 1 3 2 1 0 1 0 0 2
19.2.3.3.1.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN3 51 36 3 1 2 1 1 1 1 1 1 1 1 0 2 1 1 0 1 1 1 1 3 1 1 1 3 1 1 1 2 1 2 3 2 1 1 2 0 2 1
19.2.4.3.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.ubiquitin-binding adaptor (UFD3) 51 36 1 1 1 1 1 1 6 1 1 1 1 1 1 1 1 0 1 1 1 1 1 2 0 1 2 1 1 1 2 1 3 4 3 1 1 1 0 1 1
19.2.4.4.2 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.proteasome adaptor protein (DDI1) 51 35 1 2 2 1 1 1 3 1 1 0 1 1 1 1 1 0 1 1 1 1 2 2 1 2 2 1 1 1 2 1 5 3 2 1 0 1 0 1 1
19.2.1.3.1.4 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID5 50 35 1 1 1 1 1 1 1 1 0 1 1 1 1 0 1 0 1 1 1 1 4 3 1 2 1 1 1 1 2 1 3 3 2 1 2 2 0 2 1
19.2.2.6.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.ubiquitin-fold protein (UFM) 50 34 1 1 1 1 1 1 3 1 0 1 4 1 3 0 1 0 1 1 1 1 1 2 1 1 2 1 1 2 2 1 3 3 0 1 2 1 0 1 1
19.2.2.8.2.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BPH1 50 27 3 0 1 2 1 0 2 1 0 3 1 1 3 0 0 0 1 1 1 1 0 2 3 0 2 1 1 1 0 1 5 5 4 1 0 1 0 0 1
19.2.1.1.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc32 49 35 2 1 1 1 1 1 2 1 1 1 1 1 2 1 1 0 1 1 0 0 1 2 1 1 2 1 1 1 2 1 5 3 2 1 2 1 0 1 1
19.2.1.2.1.2 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.arginyl-tRNA-protein transferase (ATE) 49 36 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 3 1 1 1 2 2 1 1 2 2 3 3 2 1 0 1 0 1 2
19.2.3.1.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU1) 49 35 2 1 1 1 1 1 2 1 1 1 1 1 3 0 1 0 1 1 1 1 1 2 1 2 2 1 1 1 2 1 4 3 2 1 0 1 0 1 1
19.2.3.3.1.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN4 49 36 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 0 1 1 1 1 1 3 1 1 2 1 1 1 2 1 3 3 2 3 0 1 0 1 1
19.2.4.2.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.associated factor (PUX1) 49 34 1 1 1 1 1 1 1 1 0 2 0 1 2 0 1 0 1 1 1 1 1 2 1 1 2 1 1 1 4 2 3 3 2 1 2 2 0 1 1
19.2.2.6.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-ligase E3 protein 48 36 1 1 1 1 1 1 2 1 1 1 2 1 1 0 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 3 6 3 1 1 1 0 1 1
19.2.3.1.2.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU2) 48 37 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 0 1 1 1 1 1 2 1 1 3 1 1 1 2 1 4 3 2 1 1 1 0 1 1
19.2.3.1.2.5 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.histone deubiquinating protease (OTLD1) 48 35 1 1 1 1 1 1 2 1 0 2 1 1 2 0 1 0 1 1 1 1 1 2 1 1 2 1 1 2 2 1 3 3 1 1 1 2 0 2 1
19.2.1.3.1.6 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID9 47 36 1 1 1 1 1 1 1 1 1 2 1 1 2 0 1 0 1 1 1 2 1 1 1 2 1 1 1 1 4 1 2 3 2 1 1 1 0 1 1
19.2.2.2.4.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (HPY2) 47 34 1 1 1 1 1 2 0 1 1 1 1 1 1 1 2 0 2 1 1 1 2 0 0 4 1 1 1 1 2 1 3 3 2 1 1 1 0 1 1
19.2.2.3.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.deneddylase (DEN1) 47 33 1 0 1 1 1 2 1 1 1 0 1 1 1 1 1 0 1 3 2 0 1 0 1 1 1 3 1 1 2 1 3 5 2 1 1 1 0 1 1
19.2.3.1.1.10 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP24) 47 34 1 1 1 1 1 1 3 1 1 2 1 1 2 0 1 0 1 1 1 1 1 2 1 1 1 1 1 2 0 1 3 3 2 1 0 2 0 2 1
19.2.3.1.2.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU5) 47 35 2 1 1 1 2 1 2 1 1 2 1 1 2 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 4 3 2 0 1 0 0 1 1
19.2.1.1.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc33/34 46 35 1 1 1 2 1 1 1 0 1 2 2 1 2 1 1 0 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 3 2 1 0 2 0 2 1
19.2.2.6.2 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-activating E1 protein 46 33 2 3 1 1 1 1 1 1 1 0 0 1 1 0 1 0 1 1 1 2 0 2 1 1 1 1 1 1 2 1 5 3 1 1 2 1 0 1 1
19.2.2.6.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-conjugation E2 protein 46 34 1 0 1 1 1 1 1 1 1 2 1 1 2 0 1 0 2 1 1 1 1 2 3 1 1 1 1 1 2 1 0 3 2 1 2 1 0 2 1
19.2.3.3.1.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN6 46 34 1 0 1 2 1 1 2 1 1 2 1 1 1 1 1 0 1 1 1 0 0 2 1 1 1 1 1 1 2 1 4 2 2 1 1 2 0 2 1
19.2.3.3.1.8 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN8 46 36 1 1 1 1 1 1 3 1 1 1 2 1 1 1 1 0 1 1 1 1 1 1 1 1 2 1 1 1 0 1 3 2 2 1 2 2 0 1 1
19.2.3.1.1.12 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP26) 45 32 1 1 1 1 1 1 2 1 0 1 0 2 1 0 1 0 1 2 1 1 1 3 1 1 2 1 1 1 2 2 0 3 2 1 0 2 0 2 1
19.2.5.1 Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).ubiquitin protein ligase (SP1) 45 34 1 1 2 2 1 1 1 1 0 1 1 1 1 0 1 0 1 1 1 1 2 1 1 2 1 1 1 1 2 1 2 3 2 1 0 1 0 2 2
19.2.2.3.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.large component ECR1 44 35 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 0 1 1 1 1 0 2 1 2 2 1 1 1 2 1 1 3 2 1 1 1 0 0 1
19.2.2.7 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation 44 34 1 1 1 2 1 1 2 1 1 2 1 0 2 0 1 0 1 1 1 1 1 0 1 1 2 1 1 1 1 1 2 4 2 1 1 1 0 1 1
19.2.2.7.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation.ubiquitin-fold protein (URM) 44 34 1 1 1 2 1 1 2 1 1 2 1 0 2 0 1 0 1 1 1 1 1 0 1 1 2 1 1 1 1 1 2 4 2 1 1 1 0 1 1
19.2.4.3.4 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deglycosylating peptide:N-glycanase (PNG1) 44 36 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 5 1 1 3 2 1 0 1 0 1 2
19.2.2.8.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.scaffold component CUL4 43 32 1 1 0 1 1 1 0 0 1 1 1 1 2 1 1 0 1 1 1 1 0 2 1 3 2 1 1 2 2 1 1 3 2 1 0 2 0 1 1
19.2.3.1.1.13 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP27) 42 31 2 1 0 1 1 1 1 1 0 1 0 1 1 0 1 0 1 1 1 1 1 1 0 1 1 1 1 1 2 1 4 3 2 1 0 3 0 2 1
19.2.1.2.1.4 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-asparagine amidase (NTAN) 41 31 2 1 1 1 1 1 1 1 0 1 1 2 1 0 1 0 1 1 1 1 0 1 0 0 1 1 1 1 3 1 4 3 2 1 0 1 0 1 1
19.2.4.3.3 Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deubiquinating protease (OTU1) 41 31 1 1 1 1 1 0 1 0 1 1 1 1 3 0 1 0 1 1 1 1 1 0 0 2 2 1 1 1 1 1 4 3 2 1 0 1 0 1 1
19.2.1.2.1.3 Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-glutamine amidase (NTAQ) 39 33 1 1 1 1 1 1 1 1 1 1 0 1 1 0 1 0 1 1 1 2 1 1 1 1 1 1 1 1 1 0 2 3 3 1 0 1 0 1 1
19.2.3.4 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation 37 33 1 1 1 1 1 1 0 1 1 1 0 1 1 0 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 3 2 1 1 0 0 1 1
19.2.3.4.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation.UFM1-specific protease 37 33 1 1 1 1 1 1 0 1 1 1 0 1 1 0 1 0 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 3 2 1 1 0 0 1 1
19.2.3.1.2.6 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU7) 36 31 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 0 1 1 1 1 0 0 0 2 1 1 1 1 0 1 0 3 2 1 0 1 0 1 1
19.2.2.8.1.4.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component UFO 35 24 0 0 1 1 1 1 0 0 0 0 1 1 1 0 0 0 1 1 0 1 3 0 1 0 2 1 1 1 2 0 3 3 1 1 3 2 0 0 1
19.2.2.8.2.2.3 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component FBL 35 28 0 1 1 1 0 1 1 1 0 1 1 1 1 0 1 0 1 1 1 1 1 1 0 1 0 1 1 1 2 1 3 4 2 1 0 0 0 1 0
19.2.5.2 Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).protein retrotranslocase (SP2) 35 28 1 1 1 1 1 1 1 0 0 1 1 1 2 0 0 0 1 1 1 1 0 1 1 0 2 1 1 1 0 1 3 3 2 1 0 1 0 1 0
19.2.2.8.3.3.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.E2 conjugating component COP10 32 25 1 1 0 1 0 1 1 0 1 1 0 0 1 1 1 0 0 1 0 0 0 0 1 2 1 1 1 1 2 1 3 3 2 1 0 1 0 0 1
19.2.2.8.2.2.1 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component NPH3 31 22 1 1 1 0 1 1 3 1 0 1 1 1 1 0 0 0 0 1 1 0 2 0 1 0 2 1 1 2 0 0 3 3 0 0 0 1 0 0 0
19.2.3.1.1.11 Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP25) 23 18 1 0 1 1 1 0 0 1 0 0 0 0 0 0 0 0 1 1 1 0 2 1 0 1 2 0 1 1 2 0 3 0 0 1 0 1 0 0 0