Child MapMan terms
- Original MapMan term
- 19.2
- Description
- Protein homeostasis.ubiquitin-proteasome system
- Type
- mapman
MapMan | description | genes | species | aco | aof | ash | ath | atr | bdi | calsi | cam | cre | egu | hvu | lpe | mac | mco | mpo | msi | obr | osa | osaindica | oth | pab | ped | peq | ppa | ptr | sbi | sit | sly | smo | spo | ssp | tae | ttu | vvi | zjn | zma | zma-b104 | zma-ph207 | zosmarina |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
19.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation | 14838 | 37 | 311 | 273 | 263 | 433 | 215 | 384 | 555 | 295 | 71 | 422 | 392 | 411 | 604 | 50 | 152 | 0 | 315 | 395 | 341 | 275 | 433 | 450 | 306 | 296 | 524 | 389 | 392 | 440 | 350 | 234 | 899 | 1390 | 781 | 287 | 333 | 482 | 0 | 436 | 259 |
19.2.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation) | 8556 | 37 | 168 | 147 | 152 | 258 | 116 | 227 | 281 | 163 | 30 | 237 | 240 | 246 | 356 | 23 | 81 | 0 | 168 | 230 | 202 | 156 | 265 | 263 | 166 | 157 | 290 | 241 | 243 | 229 | 206 | 126 | 515 | 824 | 464 | 161 | 207 | 303 | 0 | 267 | 148 |
19.2.2.1.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities | 7114 | 37 | 142 | 118 | 127 | 217 | 98 | 190 | 240 | 138 | 17 | 198 | 193 | 200 | 305 | 11 | 63 | 0 | 140 | 201 | 172 | 130 | 204 | 211 | 136 | 116 | 244 | 203 | 203 | 195 | 162 | 103 | 427 | 696 | 390 | 133 | 183 | 257 | 0 | 224 | 127 |
19.2.2.1.5.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities | 5179 | 37 | 104 | 86 | 94 | 152 | 66 | 139 | 193 | 92 | 7 | 146 | 143 | 143 | 245 | 5 | 36 | 0 | 100 | 146 | 122 | 91 | 143 | 149 | 98 | 77 | 180 | 148 | 147 | 143 | 112 | 75 | 279 | 507 | 282 | 95 | 153 | 206 | 0 | 173 | 102 |
19.2.2.8 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes | 4300 | 37 | 94 | 78 | 73 | 125 | 70 | 106 | 204 | 80 | 11 | 135 | 104 | 115 | 172 | 12 | 46 | 0 | 98 | 113 | 95 | 79 | 127 | 131 | 93 | 89 | 173 | 95 | 101 | 154 | 92 | 75 | 258 | 389 | 223 | 85 | 80 | 129 | 0 | 122 | 74 |
19.2.2.8.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes | 3411 | 37 | 72 | 63 | 59 | 103 | 50 | 79 | 178 | 70 | 6 | 103 | 84 | 85 | 137 | 8 | 36 | 0 | 82 | 95 | 76 | 64 | 105 | 107 | 74 | 60 | 144 | 77 | 83 | 126 | 70 | 62 | 198 | 297 | 162 | 68 | 71 | 102 | 0 | 97 | 58 |
19.2.2.1.5.3.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-H2-class E3 ligase | 2676 | 37 | 46 | 27 | 47 | 87 | 32 | 73 | 87 | 37 | 1 | 79 | 78 | 76 | 134 | 1 | 18 | 0 | 45 | 85 | 63 | 36 | 90 | 64 | 53 | 32 | 88 | 85 | 84 | 73 | 56 | 35 | 111 | 303 | 148 | 41 | 93 | 119 | 0 | 89 | 60 |
19.2.2.8.1.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components | 2520 | 37 | 51 | 46 | 47 | 76 | 44 | 60 | 116 | 49 | 2 | 81 | 49 | 58 | 109 | 4 | 31 | 0 | 55 | 63 | 51 | 54 | 70 | 89 | 63 | 41 | 121 | 60 | 61 | 98 | 59 | 53 | 151 | 181 | 108 | 55 | 60 | 82 | 0 | 73 | 49 |
19.2.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation | 2477 | 37 | 59 | 58 | 44 | 57 | 43 | 69 | 78 | 57 | 26 | 75 | 63 | 61 | 80 | 22 | 33 | 0 | 61 | 65 | 60 | 51 | 61 | 82 | 48 | 64 | 90 | 62 | 63 | 60 | 72 | 50 | 156 | 193 | 122 | 58 | 40 | 69 | 0 | 75 | 50 |
19.2.6 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome | 2460 | 37 | 47 | 50 | 39 | 57 | 43 | 59 | 99 | 61 | 35 | 69 | 61 | 61 | 72 | 34 | 36 | 0 | 53 | 59 | 58 | 54 | 50 | 79 | 51 | 78 | 82 | 54 | 60 | 48 | 77 | 41 | 192 | 178 | 108 | 43 | 66 | 77 | 0 | 79 | 50 |
19.2.2.8.1.4.6 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component FBX | 1942 | 37 | 41 | 33 | 36 | 62 | 32 | 46 | 81 | 38 | 2 | 63 | 36 | 41 | 87 | 4 | 24 | 0 | 43 | 49 | 40 | 39 | 55 | 69 | 49 | 34 | 103 | 45 | 46 | 82 | 46 | 39 | 113 | 139 | 84 | 45 | 42 | 61 | 0 | 54 | 39 |
19.2.3.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation | 1678 | 37 | 42 | 40 | 29 | 37 | 29 | 47 | 54 | 40 | 15 | 50 | 35 | 40 | 56 | 11 | 21 | 0 | 42 | 47 | 41 | 37 | 42 | 60 | 32 | 38 | 60 | 40 | 44 | 39 | 46 | 34 | 113 | 131 | 84 | 41 | 27 | 47 | 0 | 55 | 32 |
19.2.2.1.5.3.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-HC-class E3 ligase | 1471 | 37 | 33 | 29 | 28 | 32 | 20 | 37 | 69 | 34 | 4 | 43 | 35 | 37 | 61 | 3 | 12 | 0 | 32 | 35 | 34 | 30 | 30 | 50 | 29 | 31 | 57 | 40 | 39 | 39 | 38 | 24 | 93 | 115 | 77 | 29 | 37 | 56 | 0 | 55 | 24 |
19.2.6.2 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle | 1445 | 37 | 27 | 29 | 20 | 32 | 25 | 37 | 57 | 37 | 19 | 40 | 36 | 37 | 43 | 19 | 20 | 0 | 30 | 35 | 35 | 35 | 28 | 45 | 31 | 43 | 52 | 30 | 37 | 28 | 46 | 24 | 114 | 113 | 65 | 26 | 37 | 43 | 0 | 44 | 26 |
19.2.4 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD) | 1260 | 37 | 22 | 33 | 23 | 30 | 22 | 27 | 47 | 27 | 16 | 33 | 31 | 36 | 40 | 14 | 20 | 0 | 26 | 26 | 26 | 27 | 29 | 35 | 20 | 37 | 47 | 29 | 29 | 29 | 40 | 25 | 86 | 106 | 66 | 25 | 24 | 42 | 0 | 44 | 21 |
19.2.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways | 1120 | 37 | 27 | 25 | 18 | 30 | 17 | 24 | 39 | 26 | 13 | 38 | 24 | 33 | 39 | 7 | 17 | 0 | 26 | 30 | 26 | 26 | 31 | 34 | 18 | 43 | 33 | 26 | 28 | 24 | 33 | 19 | 66 | 85 | 64 | 23 | 23 | 31 | 0 | 32 | 22 |
19.2.3.1.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities | 1103 | 37 | 27 | 27 | 18 | 25 | 17 | 32 | 37 | 27 | 6 | 34 | 21 | 25 | 37 | 4 | 13 | 0 | 29 | 32 | 28 | 24 | 33 | 42 | 20 | 22 | 37 | 26 | 30 | 26 | 33 | 22 | 74 | 87 | 56 | 28 | 15 | 32 | 0 | 37 | 20 |
19.2.6.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle | 960 | 37 | 18 | 20 | 18 | 23 | 17 | 21 | 40 | 23 | 15 | 28 | 23 | 23 | 28 | 14 | 15 | 0 | 22 | 23 | 22 | 18 | 21 | 32 | 19 | 34 | 29 | 23 | 22 | 19 | 29 | 16 | 72 | 60 | 40 | 16 | 27 | 33 | 0 | 34 | 23 |
19.2.6.2.2 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components | 900 | 37 | 14 | 17 | 14 | 19 | 15 | 21 | 41 | 22 | 12 | 25 | 23 | 23 | 25 | 12 | 13 | 0 | 19 | 22 | 22 | 24 | 22 | 26 | 22 | 26 | 34 | 17 | 22 | 17 | 26 | 14 | 67 | 69 | 39 | 15 | 23 | 33 | 0 | 33 | 12 |
19.2.2.1.5.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities | 815 | 37 | 12 | 13 | 9 | 38 | 12 | 22 | 11 | 22 | 6 | 12 | 22 | 32 | 16 | 2 | 9 | 0 | 18 | 26 | 24 | 18 | 16 | 19 | 8 | 11 | 20 | 27 | 26 | 18 | 15 | 7 | 74 | 116 | 63 | 11 | 11 | 19 | 0 | 22 | 8 |
19.2.2.1.5.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities | 759 | 37 | 17 | 9 | 17 | 20 | 14 | 19 | 26 | 14 | 1 | 27 | 20 | 17 | 34 | 1 | 12 | 0 | 14 | 21 | 20 | 15 | 33 | 28 | 23 | 15 | 31 | 19 | 19 | 20 | 25 | 13 | 52 | 50 | 29 | 19 | 15 | 21 | 0 | 17 | 12 |
19.2.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation) | 707 | 37 | 16 | 18 | 13 | 18 | 8 | 21 | 23 | 26 | 15 | 14 | 15 | 25 | 19 | 7 | 9 | 0 | 17 | 18 | 13 | 14 | 14 | 17 | 18 | 21 | 19 | 20 | 18 | 21 | 15 | 11 | 42 | 72 | 36 | 15 | 15 | 19 | 0 | 14 | 11 |
19.2.2.1.5.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.E3 ubiquitin ligase (PUB) | 676 | 35 | 16 | 7 | 16 | 19 | 12 | 17 | 23 | 12 | 0 | 25 | 17 | 15 | 32 | 0 | 10 | 0 | 12 | 19 | 18 | 12 | 28 | 27 | 20 | 13 | 30 | 17 | 17 | 19 | 23 | 12 | 46 | 44 | 25 | 15 | 14 | 19 | 0 | 15 | 10 |
19.2.2.8.1.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.target protein binding component SKP1/ASK1 | 630 | 37 | 14 | 12 | 7 | 21 | 2 | 13 | 49 | 15 | 1 | 14 | 29 | 21 | 18 | 1 | 2 | 0 | 22 | 26 | 18 | 3 | 30 | 9 | 8 | 11 | 14 | 11 | 16 | 18 | 5 | 4 | 30 | 93 | 42 | 8 | 7 | 14 | 0 | 19 | 3 |
19.2.2.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation) | 623 | 37 | 10 | 11 | 11 | 14 | 9 | 17 | 20 | 16 | 10 | 15 | 19 | 15 | 16 | 7 | 8 | 0 | 16 | 19 | 17 | 13 | 13 | 17 | 10 | 19 | 19 | 19 | 17 | 16 | 21 | 10 | 46 | 58 | 31 | 12 | 9 | 16 | 0 | 16 | 11 |
19.2.1.2 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway | 579 | 37 | 15 | 13 | 9 | 11 | 8 | 13 | 23 | 16 | 5 | 21 | 10 | 14 | 23 | 4 | 6 | 0 | 17 | 19 | 16 | 17 | 16 | 16 | 9 | 21 | 17 | 17 | 18 | 12 | 14 | 9 | 40 | 36 | 27 | 12 | 13 | 15 | 0 | 15 | 12 |
19.2.3.1.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities | 575 | 37 | 15 | 13 | 11 | 12 | 12 | 15 | 17 | 13 | 9 | 16 | 14 | 15 | 19 | 7 | 8 | 0 | 13 | 15 | 13 | 13 | 9 | 18 | 12 | 16 | 23 | 14 | 14 | 13 | 13 | 12 | 39 | 44 | 28 | 13 | 12 | 15 | 0 | 18 | 12 |
19.2.2.8.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes | 563 | 36 | 14 | 9 | 9 | 13 | 14 | 18 | 20 | 8 | 1 | 20 | 15 | 22 | 23 | 0 | 4 | 0 | 10 | 12 | 12 | 10 | 15 | 16 | 10 | 8 | 16 | 11 | 11 | 17 | 10 | 6 | 42 | 71 | 45 | 9 | 7 | 14 | 0 | 14 | 7 |
19.2.2.1.6 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination | 537 | 37 | 14 | 12 | 9 | 13 | 9 | 11 | 29 | 11 | 3 | 19 | 12 | 14 | 22 | 2 | 4 | 0 | 13 | 13 | 13 | 10 | 21 | 17 | 11 | 11 | 19 | 14 | 13 | 11 | 11 | 9 | 35 | 40 | 24 | 12 | 13 | 17 | 0 | 18 | 8 |
19.2.4.2 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction | 528 | 37 | 8 | 10 | 8 | 12 | 9 | 11 | 14 | 12 | 5 | 14 | 17 | 18 | 15 | 5 | 8 | 0 | 11 | 11 | 11 | 11 | 10 | 14 | 8 | 12 | 17 | 13 | 14 | 10 | 16 | 10 | 40 | 58 | 36 | 10 | 9 | 16 | 0 | 18 | 7 |
19.2.2.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation | 524 | 37 | 17 | 14 | 11 | 14 | 9 | 10 | 21 | 8 | 3 | 18 | 9 | 11 | 35 | 3 | 4 | 0 | 11 | 12 | 11 | 9 | 14 | 17 | 13 | 10 | 18 | 11 | 10 | 17 | 9 | 9 | 36 | 36 | 23 | 12 | 16 | 16 | 0 | 16 | 11 |
19.2.2.1.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-conjugating E2 protein (UBC) | 520 | 37 | 12 | 14 | 10 | 12 | 8 | 14 | 21 | 10 | 7 | 20 | 16 | 13 | 23 | 6 | 7 | 0 | 8 | 8 | 7 | 9 | 13 | 20 | 10 | 11 | 16 | 11 | 13 | 16 | 16 | 11 | 29 | 38 | 26 | 12 | 7 | 19 | 0 | 18 | 9 |
19.2.6.1.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components | 482 | 37 | 7 | 10 | 10 | 12 | 9 | 11 | 22 | 10 | 7 | 14 | 13 | 12 | 15 | 7 | 8 | 0 | 11 | 13 | 12 | 7 | 8 | 17 | 9 | 20 | 15 | 12 | 10 | 10 | 13 | 8 | 35 | 33 | 22 | 7 | 12 | 16 | 0 | 17 | 8 |
19.2.6.1.2 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components | 478 | 37 | 11 | 10 | 8 | 11 | 8 | 10 | 18 | 13 | 8 | 14 | 10 | 11 | 13 | 7 | 7 | 0 | 11 | 10 | 10 | 11 | 13 | 15 | 10 | 14 | 14 | 11 | 12 | 9 | 16 | 8 | 37 | 27 | 18 | 9 | 15 | 17 | 0 | 17 | 15 |
19.2.2.8.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components | 473 | 35 | 13 | 7 | 8 | 11 | 13 | 15 | 18 | 6 | 0 | 18 | 13 | 19 | 18 | 0 | 3 | 0 | 7 | 9 | 9 | 8 | 14 | 11 | 9 | 6 | 14 | 9 | 9 | 15 | 6 | 4 | 35 | 65 | 41 | 8 | 5 | 11 | 0 | 11 | 5 |
19.2.2.1.5.3.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-v-class E3 ligase | 461 | 36 | 9 | 11 | 10 | 13 | 5 | 12 | 15 | 10 | 1 | 14 | 13 | 12 | 24 | 0 | 1 | 0 | 11 | 14 | 14 | 10 | 12 | 18 | 8 | 3 | 17 | 11 | 12 | 15 | 10 | 7 | 32 | 33 | 25 | 12 | 8 | 15 | 0 | 13 | 11 |
19.2.6.2.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components | 459 | 37 | 12 | 10 | 5 | 11 | 8 | 14 | 13 | 12 | 6 | 13 | 10 | 11 | 16 | 6 | 6 | 0 | 9 | 11 | 11 | 9 | 6 | 15 | 8 | 16 | 16 | 10 | 12 | 10 | 18 | 9 | 36 | 38 | 22 | 10 | 12 | 7 | 0 | 8 | 13 |
19.2.1.2.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification | 453 | 37 | 13 | 8 | 7 | 9 | 6 | 11 | 18 | 14 | 3 | 16 | 8 | 11 | 20 | 2 | 4 | 0 | 13 | 16 | 14 | 15 | 13 | 13 | 7 | 6 | 13 | 15 | 16 | 9 | 10 | 7 | 33 | 27 | 20 | 10 | 10 | 13 | 0 | 13 | 10 |
19.2.3.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin | 426 | 37 | 11 | 9 | 8 | 10 | 8 | 9 | 16 | 8 | 8 | 14 | 17 | 8 | 14 | 8 | 8 | 0 | 8 | 8 | 8 | 7 | 12 | 13 | 9 | 13 | 18 | 8 | 8 | 11 | 14 | 9 | 23 | 26 | 18 | 11 | 10 | 14 | 0 | 13 | 9 |
19.2.3.3.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex | 426 | 37 | 11 | 9 | 8 | 10 | 8 | 9 | 16 | 8 | 8 | 14 | 17 | 8 | 14 | 8 | 8 | 0 | 8 | 8 | 8 | 7 | 12 | 13 | 9 | 13 | 18 | 8 | 8 | 11 | 14 | 9 | 23 | 26 | 18 | 11 | 10 | 14 | 0 | 13 | 9 |
19.2.2.1.5.3.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (SINA) | 379 | 35 | 12 | 11 | 6 | 15 | 5 | 12 | 14 | 8 | 0 | 4 | 11 | 13 | 15 | 0 | 2 | 0 | 7 | 7 | 8 | 11 | 7 | 10 | 5 | 4 | 14 | 8 | 8 | 13 | 4 | 5 | 30 | 45 | 25 | 10 | 8 | 9 | 0 | 9 | 4 |
19.2.2.1.5.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities | 361 | 37 | 9 | 10 | 7 | 7 | 6 | 10 | 10 | 10 | 3 | 13 | 8 | 8 | 10 | 3 | 6 | 0 | 8 | 8 | 6 | 6 | 12 | 15 | 7 | 13 | 13 | 9 | 11 | 14 | 10 | 8 | 22 | 23 | 16 | 8 | 4 | 11 | 0 | 12 | 5 |
19.2.2.1.5.1.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities.monomeric E3 ubiquitin ligase (HECT) | 361 | 37 | 9 | 10 | 7 | 7 | 6 | 10 | 10 | 10 | 3 | 13 | 8 | 8 | 10 | 3 | 6 | 0 | 8 | 8 | 6 | 6 | 12 | 15 | 7 | 13 | 13 | 9 | 11 | 14 | 10 | 8 | 22 | 23 | 16 | 8 | 4 | 11 | 0 | 12 | 5 |
19.2.1.3 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway | 346 | 37 | 7 | 8 | 6 | 14 | 6 | 7 | 11 | 7 | 6 | 12 | 8 | 11 | 10 | 1 | 8 | 0 | 6 | 7 | 7 | 7 | 10 | 13 | 6 | 15 | 11 | 6 | 6 | 8 | 13 | 6 | 16 | 27 | 17 | 7 | 6 | 11 | 0 | 12 | 7 |
19.2.1.3.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex | 346 | 37 | 7 | 8 | 6 | 14 | 6 | 7 | 11 | 7 | 6 | 12 | 8 | 11 | 10 | 1 | 8 | 0 | 6 | 7 | 7 | 7 | 10 | 13 | 6 | 15 | 11 | 6 | 6 | 8 | 13 | 6 | 16 | 27 | 17 | 7 | 6 | 11 | 0 | 12 | 7 |
19.2.2.5.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.conjugation E2 protein | 345 | 37 | 11 | 10 | 8 | 8 | 6 | 7 | 14 | 5 | 2 | 11 | 6 | 8 | 23 | 2 | 3 | 0 | 7 | 8 | 7 | 6 | 7 | 12 | 8 | 7 | 11 | 7 | 6 | 12 | 7 | 6 | 23 | 27 | 17 | 7 | 11 | 9 | 0 | 9 | 7 |
19.2.4.1 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex | 341 | 37 | 7 | 12 | 6 | 9 | 6 | 7 | 15 | 7 | 5 | 10 | 6 | 7 | 12 | 5 | 6 | 0 | 6 | 6 | 6 | 7 | 8 | 8 | 6 | 12 | 14 | 7 | 7 | 9 | 10 | 6 | 22 | 23 | 13 | 7 | 9 | 14 | 0 | 15 | 6 |
19.2.3.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation | 336 | 37 | 5 | 8 | 6 | 9 | 5 | 12 | 8 | 8 | 2 | 10 | 11 | 12 | 9 | 3 | 3 | 0 | 10 | 9 | 10 | 6 | 6 | 8 | 6 | 12 | 11 | 13 | 10 | 9 | 10 | 6 | 19 | 33 | 18 | 5 | 2 | 8 | 0 | 6 | 8 |
19.2.2.1.5.4.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.plant-specific E3 ubiquitin ligase (RSL/RFA) | 330 | 36 | 5 | 4 | 4 | 20 | 7 | 9 | 4 | 11 | 3 | 4 | 4 | 12 | 7 | 0 | 2 | 0 | 6 | 10 | 9 | 7 | 8 | 7 | 3 | 4 | 10 | 10 | 11 | 9 | 7 | 1 | 34 | 48 | 23 | 5 | 4 | 7 | 0 | 7 | 4 |
19.2.2.8.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes | 326 | 37 | 8 | 6 | 5 | 9 | 6 | 9 | 6 | 2 | 4 | 12 | 5 | 8 | 12 | 4 | 6 | 0 | 6 | 6 | 7 | 5 | 7 | 8 | 9 | 21 | 13 | 7 | 7 | 11 | 12 | 7 | 18 | 21 | 16 | 8 | 2 | 13 | 0 | 11 | 9 |
19.2.1.2.1.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.cysteine oxidase (PCO) | 324 | 37 | 9 | 5 | 4 | 5 | 3 | 8 | 15 | 11 | 1 | 13 | 6 | 7 | 17 | 1 | 1 | 0 | 10 | 13 | 11 | 11 | 9 | 10 | 5 | 4 | 9 | 11 | 13 | 6 | 4 | 4 | 24 | 18 | 13 | 7 | 10 | 10 | 0 | 10 | 6 |
19.2.2.1.5.4.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Ariadne) | 304 | 37 | 4 | 6 | 3 | 15 | 2 | 9 | 5 | 7 | 2 | 5 | 12 | 8 | 7 | 1 | 5 | 0 | 8 | 9 | 9 | 8 | 7 | 9 | 3 | 6 | 7 | 12 | 9 | 6 | 6 | 4 | 27 | 31 | 17 | 4 | 7 | 10 | 0 | 12 | 2 |
19.2.3.1.2.7 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU6-12) | 288 | 37 | 7 | 7 | 6 | 7 | 5 | 9 | 7 | 6 | 3 | 7 | 8 | 8 | 10 | 3 | 3 | 0 | 7 | 8 | 6 | 7 | 1 | 10 | 6 | 7 | 11 | 7 | 7 | 8 | 6 | 7 | 17 | 23 | 14 | 7 | 8 | 8 | 0 | 10 | 7 |
19.2.2.1.6.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.ligating E3 protein (RGLG) | 276 | 36 | 7 | 5 | 3 | 5 | 4 | 6 | 20 | 6 | 1 | 9 | 5 | 7 | 11 | 0 | 2 | 0 | 6 | 7 | 7 | 4 | 11 | 9 | 5 | 4 | 11 | 8 | 7 | 4 | 4 | 4 | 23 | 25 | 14 | 6 | 5 | 7 | 0 | 9 | 5 |
19.2.2.1.6.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex | 261 | 37 | 7 | 7 | 6 | 8 | 5 | 5 | 9 | 5 | 2 | 10 | 7 | 7 | 11 | 2 | 2 | 0 | 7 | 6 | 6 | 6 | 10 | 8 | 6 | 7 | 8 | 6 | 6 | 7 | 7 | 5 | 12 | 15 | 10 | 6 | 8 | 10 | 0 | 9 | 3 |
19.2.2.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).ubiquitin-fold protein (SUMO) | 255 | 37 | 7 | 6 | 5 | 9 | 2 | 9 | 4 | 12 | 8 | 3 | 3 | 12 | 5 | 1 | 2 | 0 | 6 | 8 | 4 | 5 | 3 | 4 | 11 | 6 | 5 | 9 | 6 | 6 | 6 | 3 | 15 | 36 | 12 | 6 | 5 | 5 | 0 | 4 | 2 |
19.2.2.1.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-fold protein (UBQ) | 245 | 30 | 1 | 0 | 2 | 9 | 0 | 7 | 0 | 0 | 1 | 0 | 13 | 15 | 5 | 1 | 5 | 0 | 4 | 5 | 7 | 0 | 28 | 6 | 5 | 9 | 10 | 10 | 10 | 3 | 11 | 1 | 5 | 42 | 17 | 3 | 0 | 4 | 0 | 2 | 4 |
19.2.2.8.1.4.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component SKP2 | 229 | 35 | 5 | 4 | 4 | 6 | 6 | 5 | 7 | 4 | 0 | 9 | 4 | 5 | 7 | 0 | 6 | 0 | 4 | 4 | 3 | 6 | 18 | 6 | 6 | 4 | 8 | 6 | 6 | 5 | 7 | 5 | 10 | 17 | 10 | 2 | 9 | 7 | 0 | 7 | 7 |
19.2.2.3.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation | 218 | 37 | 3 | 5 | 3 | 4 | 4 | 6 | 5 | 7 | 3 | 6 | 6 | 6 | 4 | 3 | 3 | 0 | 6 | 8 | 7 | 4 | 1 | 7 | 3 | 3 | 4 | 9 | 7 | 4 | 6 | 2 | 22 | 20 | 12 | 3 | 4 | 6 | 0 | 8 | 4 |
19.2.4.4 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome | 200 | 37 | 4 | 7 | 5 | 5 | 3 | 6 | 8 | 5 | 2 | 4 | 4 | 5 | 7 | 2 | 2 | 0 | 5 | 5 | 5 | 5 | 4 | 8 | 4 | 8 | 8 | 5 | 4 | 5 | 4 | 5 | 14 | 12 | 7 | 4 | 4 | 6 | 0 | 6 | 3 |
19.2.1.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway | 195 | 37 | 5 | 4 | 3 | 5 | 3 | 4 | 5 | 3 | 2 | 5 | 6 | 8 | 6 | 2 | 3 | 0 | 3 | 4 | 3 | 2 | 5 | 5 | 3 | 7 | 5 | 3 | 4 | 4 | 6 | 4 | 10 | 22 | 20 | 4 | 4 | 5 | 0 | 5 | 3 |
19.2.1.1.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex | 195 | 37 | 5 | 4 | 3 | 5 | 3 | 4 | 5 | 3 | 2 | 5 | 6 | 8 | 6 | 2 | 3 | 0 | 3 | 4 | 3 | 2 | 5 | 5 | 3 | 7 | 5 | 3 | 4 | 4 | 6 | 4 | 10 | 22 | 20 | 4 | 4 | 5 | 0 | 5 | 3 |
19.2.4.2.1 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.platform ATPase (CDC48) | 193 | 35 | 0 | 3 | 3 | 3 | 2 | 4 | 4 | 4 | 1 | 4 | 10 | 11 | 4 | 2 | 3 | 0 | 4 | 3 | 3 | 4 | 0 | 4 | 1 | 6 | 5 | 5 | 5 | 5 | 4 | 2 | 15 | 34 | 19 | 3 | 2 | 5 | 0 | 4 | 2 |
19.2.4.3 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing | 191 | 37 | 3 | 4 | 4 | 4 | 4 | 3 | 10 | 3 | 4 | 5 | 4 | 6 | 6 | 2 | 4 | 0 | 4 | 4 | 4 | 4 | 7 | 5 | 2 | 5 | 8 | 4 | 4 | 5 | 10 | 4 | 10 | 13 | 10 | 4 | 2 | 6 | 0 | 5 | 5 |
19.2.2.6 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation | 190 | 36 | 5 | 5 | 4 | 4 | 4 | 4 | 7 | 4 | 3 | 4 | 7 | 4 | 7 | 0 | 4 | 0 | 5 | 4 | 4 | 5 | 3 | 7 | 6 | 4 | 5 | 4 | 4 | 5 | 8 | 4 | 11 | 15 | 6 | 4 | 7 | 4 | 0 | 5 | 4 |
19.2.2.8.2.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component LRB | 190 | 35 | 3 | 2 | 1 | 3 | 8 | 9 | 5 | 2 | 0 | 5 | 9 | 12 | 4 | 0 | 1 | 0 | 2 | 2 | 2 | 2 | 9 | 4 | 1 | 2 | 4 | 2 | 2 | 5 | 2 | 1 | 10 | 38 | 25 | 3 | 1 | 3 | 0 | 3 | 3 |
19.2.2.1.7 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin receptor regulatory protein (DA1) | 187 | 37 | 4 | 4 | 3 | 8 | 2 | 5 | 5 | 4 | 1 | 4 | 4 | 4 | 7 | 1 | 1 | 0 | 4 | 4 | 4 | 5 | 3 | 7 | 4 | 9 | 7 | 4 | 4 | 5 | 4 | 3 | 20 | 13 | 8 | 4 | 4 | 5 | 0 | 6 | 3 |
19.2.2.5.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.ubiquitin-fold protein (MUB) | 179 | 37 | 6 | 4 | 3 | 6 | 3 | 3 | 7 | 3 | 1 | 7 | 3 | 3 | 12 | 1 | 1 | 0 | 4 | 4 | 4 | 3 | 7 | 5 | 5 | 3 | 7 | 4 | 4 | 5 | 2 | 3 | 13 | 9 | 6 | 5 | 5 | 7 | 0 | 7 | 4 |
19.2.4.2.2 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer | 178 | 37 | 3 | 2 | 2 | 5 | 4 | 4 | 4 | 5 | 2 | 5 | 5 | 4 | 5 | 1 | 2 | 0 | 4 | 5 | 5 | 4 | 5 | 6 | 3 | 2 | 5 | 5 | 6 | 2 | 4 | 3 | 17 | 15 | 11 | 2 | 3 | 7 | 0 | 9 | 2 |
19.2.2.8.2.2.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BT | 167 | 35 | 6 | 3 | 4 | 5 | 3 | 4 | 7 | 1 | 0 | 8 | 1 | 4 | 9 | 0 | 1 | 0 | 3 | 4 | 4 | 4 | 2 | 4 | 4 | 3 | 6 | 4 | 4 | 6 | 2 | 1 | 14 | 15 | 10 | 3 | 4 | 6 | 0 | 7 | 1 |
19.2.2.1.6.1.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Uev1 | 165 | 37 | 5 | 4 | 4 | 5 | 3 | 3 | 6 | 3 | 1 | 5 | 5 | 5 | 7 | 1 | 1 | 0 | 5 | 4 | 4 | 4 | 9 | 7 | 4 | 3 | 4 | 4 | 4 | 3 | 5 | 3 | 9 | 9 | 6 | 3 | 6 | 5 | 0 | 5 | 1 |
19.2.3.1.1.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP5|8-11) | 161 | 35 | 3 | 3 | 3 | 5 | 3 | 4 | 5 | 3 | 1 | 5 | 4 | 4 | 7 | 0 | 2 | 0 | 4 | 4 | 4 | 4 | 4 | 8 | 3 | 0 | 7 | 4 | 4 | 3 | 6 | 4 | 14 | 12 | 8 | 4 | 2 | 3 | 0 | 4 | 3 |
19.2.2.2.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities | 159 | 37 | 3 | 4 | 3 | 2 | 2 | 6 | 3 | 4 | 2 | 4 | 5 | 5 | 5 | 1 | 3 | 0 | 5 | 4 | 3 | 4 | 4 | 4 | 1 | 9 | 5 | 3 | 4 | 4 | 2 | 3 | 12 | 15 | 10 | 2 | 5 | 3 | 0 | 3 | 2 |
19.2.3.1.1.7 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP15-21) | 159 | 35 | 4 | 4 | 3 | 5 | 3 | 4 | 7 | 4 | 0 | 5 | 2 | 4 | 9 | 0 | 1 | 0 | 4 | 4 | 4 | 3 | 3 | 3 | 4 | 5 | 7 | 4 | 4 | 4 | 3 | 2 | 10 | 12 | 8 | 5 | 1 | 5 | 0 | 6 | 3 |
19.2.4.4.1 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.shuttle protein (RAD23) | 149 | 37 | 3 | 5 | 3 | 4 | 2 | 5 | 5 | 4 | 1 | 4 | 3 | 4 | 6 | 1 | 1 | 0 | 4 | 4 | 4 | 4 | 2 | 6 | 3 | 6 | 6 | 4 | 3 | 4 | 2 | 4 | 9 | 9 | 5 | 3 | 4 | 5 | 0 | 5 | 2 |
19.2.3.1.1.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP12-13) | 146 | 36 | 4 | 4 | 2 | 2 | 1 | 4 | 3 | 4 | 1 | 4 | 5 | 4 | 4 | 0 | 1 | 0 | 4 | 4 | 4 | 3 | 5 | 8 | 2 | 3 | 4 | 4 | 4 | 5 | 4 | 3 | 7 | 11 | 8 | 3 | 2 | 5 | 0 | 7 | 3 |
19.2.2.1.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-activating E1 protein (UBA) | 143 | 37 | 1 | 2 | 3 | 2 | 1 | 4 | 3 | 3 | 1 | 3 | 4 | 4 | 3 | 1 | 2 | 0 | 3 | 4 | 4 | 4 | 7 | 7 | 4 | 4 | 3 | 4 | 4 | 2 | 4 | 2 | 11 | 14 | 9 | 2 | 3 | 5 | 0 | 5 | 1 |
19.2.3.1.2.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU3-4) | 138 | 37 | 3 | 3 | 2 | 2 | 3 | 3 | 5 | 4 | 1 | 4 | 3 | 4 | 3 | 2 | 2 | 0 | 3 | 4 | 4 | 3 | 4 | 3 | 3 | 5 | 6 | 4 | 4 | 2 | 3 | 2 | 9 | 12 | 8 | 4 | 2 | 3 | 0 | 4 | 2 |
19.2.2.3.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities | 137 | 37 | 3 | 2 | 3 | 3 | 2 | 4 | 4 | 4 | 3 | 4 | 2 | 3 | 5 | 1 | 2 | 0 | 3 | 3 | 3 | 4 | 4 | 4 | 2 | 6 | 4 | 4 | 4 | 4 | 6 | 4 | 10 | 9 | 4 | 3 | 2 | 3 | 0 | 3 | 3 |
19.2.2.8.3.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex | 133 | 34 | 4 | 2 | 3 | 4 | 3 | 3 | 2 | 1 | 0 | 5 | 1 | 2 | 7 | 0 | 2 | 0 | 3 | 2 | 3 | 2 | 3 | 2 | 5 | 11 | 7 | 3 | 3 | 6 | 4 | 3 | 6 | 6 | 6 | 4 | 0 | 4 | 0 | 6 | 5 |
19.2.2.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer | 130 | 37 | 3 | 4 | 2 | 4 | 2 | 2 | 13 | 3 | 2 | 4 | 4 | 2 | 3 | 2 | 2 | 0 | 2 | 2 | 2 | 4 | 2 | 4 | 3 | 3 | 4 | 2 | 3 | 3 | 3 | 2 | 9 | 9 | 6 | 2 | 3 | 3 | 0 | 3 | 4 |
19.2.3.1.1.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP1-2) | 128 | 35 | 1 | 5 | 1 | 2 | 1 | 7 | 4 | 3 | 0 | 2 | 3 | 1 | 1 | 0 | 1 | 0 | 6 | 8 | 4 | 3 | 4 | 3 | 1 | 3 | 2 | 4 | 5 | 2 | 2 | 1 | 8 | 18 | 12 | 1 | 2 | 3 | 0 | 3 | 1 |
19.2.1.2.2 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities | 126 | 37 | 2 | 5 | 2 | 2 | 2 | 2 | 5 | 2 | 2 | 5 | 2 | 3 | 3 | 2 | 2 | 0 | 4 | 3 | 2 | 2 | 3 | 3 | 2 | 15 | 4 | 2 | 2 | 3 | 4 | 2 | 7 | 9 | 7 | 2 | 3 | 2 | 0 | 2 | 2 |
19.2.2.8.1.4.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EBF | 126 | 35 | 2 | 3 | 1 | 2 | 2 | 2 | 22 | 2 | 0 | 3 | 5 | 2 | 8 | 0 | 1 | 0 | 2 | 2 | 2 | 2 | 2 | 4 | 2 | 2 | 4 | 2 | 2 | 6 | 2 | 5 | 8 | 6 | 4 | 2 | 3 | 4 | 0 | 4 | 1 |
19.2.2.8.1.4.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EDL | 126 | 34 | 2 | 3 | 4 | 3 | 2 | 4 | 5 | 2 | 0 | 5 | 1 | 6 | 5 | 0 | 0 | 0 | 3 | 4 | 3 | 4 | 2 | 6 | 4 | 1 | 2 | 4 | 4 | 3 | 2 | 2 | 10 | 10 | 5 | 3 | 2 | 5 | 0 | 4 | 1 |
19.2.2.1.5.4.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (ARA54) | 124 | 36 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 2 | 1 | 1 | 4 | 10 | 1 | 1 | 1 | 0 | 3 | 6 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 5 | 1 | 2 | 1 | 9 | 28 | 17 | 1 | 0 | 1 | 0 | 2 | 1 |
19.2.4.2.2.1 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component UFD1 | 120 | 36 | 2 | 1 | 1 | 3 | 3 | 3 | 3 | 4 | 1 | 3 | 2 | 3 | 3 | 0 | 1 | 0 | 3 | 4 | 4 | 3 | 2 | 4 | 2 | 1 | 3 | 4 | 5 | 1 | 2 | 2 | 17 | 12 | 9 | 1 | 1 | 3 | 0 | 3 | 1 |
19.2.2.1.5.3.6 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (DA2) | 119 | 36 | 2 | 6 | 1 | 2 | 2 | 3 | 5 | 2 | 1 | 4 | 5 | 3 | 5 | 1 | 0 | 0 | 3 | 3 | 2 | 3 | 2 | 3 | 2 | 3 | 2 | 3 | 3 | 1 | 2 | 3 | 10 | 8 | 5 | 1 | 5 | 6 | 0 | 6 | 1 |
19.2.2.8.1.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.scaffold component CUL1/CUL2 | 118 | 36 | 5 | 3 | 2 | 3 | 1 | 3 | 7 | 3 | 1 | 4 | 3 | 3 | 5 | 1 | 1 | 0 | 2 | 3 | 3 | 1 | 0 | 7 | 1 | 3 | 4 | 3 | 3 | 7 | 2 | 2 | 8 | 9 | 5 | 2 | 2 | 2 | 0 | 2 | 2 |
19.2.3.1.1.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP3-4) | 115 | 37 | 4 | 3 | 2 | 2 | 1 | 3 | 4 | 3 | 1 | 3 | 3 | 3 | 4 | 1 | 1 | 0 | 3 | 3 | 3 | 3 | 2 | 5 | 2 | 3 | 2 | 3 | 3 | 2 | 4 | 2 | 7 | 8 | 6 | 2 | 2 | 4 | 0 | 5 | 3 |
19.2.2.2.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO conjugation E2 enzyme (SCE1) | 112 | 35 | 2 | 2 | 2 | 1 | 1 | 3 | 0 | 6 | 3 | 1 | 3 | 5 | 4 | 3 | 1 | 0 | 3 | 3 | 3 | 0 | 3 | 4 | 2 | 2 | 4 | 5 | 4 | 6 | 2 | 2 | 3 | 9 | 6 | 2 | 1 | 7 | 0 | 3 | 1 |
19.2.2.2.4.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (SIZ1) | 112 | 35 | 2 | 3 | 2 | 1 | 1 | 4 | 3 | 3 | 1 | 3 | 4 | 4 | 4 | 0 | 1 | 0 | 3 | 3 | 2 | 3 | 2 | 4 | 1 | 5 | 4 | 2 | 3 | 3 | 0 | 2 | 9 | 12 | 8 | 1 | 4 | 2 | 0 | 2 | 1 |
19.2.2.8.1.4.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component ADO | 108 | 33 | 2 | 3 | 3 | 3 | 2 | 3 | 3 | 3 | 0 | 3 | 2 | 3 | 3 | 0 | 1 | 0 | 3 | 3 | 3 | 3 | 0 | 5 | 3 | 0 | 4 | 3 | 3 | 2 | 2 | 3 | 8 | 8 | 5 | 3 | 1 | 5 | 0 | 6 | 1 |
19.2.4.2.4 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.membrane protein retrotranslocation factor (DFM1) | 108 | 37 | 4 | 4 | 2 | 3 | 2 | 2 | 5 | 2 | 2 | 3 | 2 | 2 | 4 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 4 | 2 | 3 | 3 | 5 | 2 | 2 | 2 | 4 | 3 | 5 | 6 | 4 | 4 | 2 | 2 | 0 | 4 | 2 |
19.2.2.3.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer | 107 | 37 | 2 | 2 | 2 | 3 | 2 | 2 | 9 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 3 | 4 | 2 | 4 | 4 | 2 | 2 | 3 | 4 | 2 | 5 | 9 | 6 | 2 | 2 | 3 | 0 | 2 | 2 |
19.2.4.1.2 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc7/13/14 | 102 | 37 | 2 | 4 | 2 | 3 | 2 | 2 | 4 | 2 | 1 | 5 | 2 | 2 | 4 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 4 | 4 | 2 | 2 | 4 | 2 | 2 | 3 | 6 | 4 | 3 | 2 | 5 | 0 | 6 | 2 |
19.2.1.1.1.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E3 ubiquitin ligase component Doa10 | 100 | 35 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 0 | 2 | 3 | 6 | 2 | 0 | 1 | 0 | 1 | 2 | 2 | 1 | 3 | 2 | 1 | 5 | 2 | 1 | 2 | 1 | 2 | 2 | 4 | 16 | 16 | 2 | 2 | 2 | 0 | 2 | 1 |
19.2.3.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (ELS) | 100 | 35 | 0 | 3 | 2 | 3 | 1 | 3 | 2 | 3 | 1 | 2 | 3 | 3 | 2 | 2 | 1 | 0 | 3 | 3 | 2 | 3 | 1 | 3 | 3 | 2 | 3 | 3 | 3 | 2 | 3 | 2 | 9 | 9 | 5 | 1 | 0 | 3 | 0 | 4 | 2 |
19.2.6.2.2.10 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN11 | 97 | 37 | 2 | 3 | 1 | 1 | 2 | 2 | 4 | 2 | 1 | 3 | 3 | 3 | 2 | 1 | 2 | 0 | 2 | 3 | 3 | 3 | 3 | 3 | 2 | 3 | 2 | 1 | 2 | 1 | 4 | 1 | 4 | 8 | 5 | 1 | 4 | 5 | 0 | 4 | 1 |
19.2.2.1.6.1.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Ubc13 | 96 | 37 | 2 | 3 | 2 | 3 | 2 | 2 | 3 | 2 | 1 | 5 | 2 | 2 | 4 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 4 | 4 | 2 | 2 | 4 | 2 | 2 | 3 | 6 | 4 | 3 | 2 | 5 | 0 | 4 | 2 |
19.2.2.3.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB conjugation E2 protein (RCE1) | 96 | 37 | 2 | 2 | 1 | 2 | 1 | 3 | 2 | 3 | 1 | 2 | 2 | 2 | 3 | 1 | 1 | 0 | 3 | 3 | 3 | 2 | 3 | 2 | 2 | 5 | 4 | 2 | 2 | 4 | 5 | 1 | 8 | 6 | 4 | 3 | 1 | 2 | 0 | 2 | 1 |
19.2.6.2.1.4 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT4 | 94 | 37 | 2 | 2 | 1 | 2 | 1 | 4 | 3 | 2 | 1 | 3 | 2 | 3 | 3 | 1 | 1 | 0 | 1 | 2 | 2 | 2 | 2 | 3 | 1 | 3 | 4 | 2 | 2 | 2 | 2 | 2 | 7 | 9 | 6 | 2 | 3 | 2 | 0 | 1 | 3 |
19.2.2.8.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.scaffold component CUL3 | 90 | 36 | 1 | 2 | 1 | 2 | 1 | 3 | 2 | 2 | 1 | 2 | 2 | 3 | 5 | 0 | 1 | 0 | 3 | 3 | 3 | 2 | 1 | 5 | 1 | 2 | 2 | 2 | 2 | 2 | 4 | 2 | 7 | 6 | 4 | 1 | 2 | 3 | 0 | 3 | 2 |
19.2.2.8.3.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex | 90 | 36 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 0 | 2 | 4 | 1 | 1 | 2 | 2 | 2 | 0 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 5 | 2 | 2 | 2 | 2 | 4 | 2 | 9 | 7 | 5 | 2 | 1 | 5 | 0 | 2 | 2 |
19.2.6.1.1.4 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-4 | 89 | 37 | 1 | 1 | 2 | 2 | 3 | 2 | 9 | 2 | 1 | 2 | 3 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 1 | 4 | 1 | 4 | 2 | 2 | 2 | 1 | 2 | 1 | 7 | 5 | 3 | 2 | 4 | 3 | 0 | 3 | 1 |
19.2.2.1.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation | 86 | 36 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 3 | 1 | 2 | 3 | 3 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 0 | 4 | 1 | 1 | 2 | 3 | 3 | 1 | 2 | 1 | 11 | 6 | 4 | 1 | 2 | 3 | 0 | 3 | 1 |
19.2.2.1.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation.ubiquitin carboxyl-terminal hydrolase (UCH) | 86 | 36 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 3 | 1 | 2 | 3 | 3 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 0 | 4 | 1 | 1 | 2 | 3 | 3 | 1 | 2 | 1 | 11 | 6 | 4 | 1 | 2 | 3 | 0 | 3 | 1 |
19.2.2.3.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH1|2) | 86 | 36 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 3 | 1 | 2 | 3 | 3 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 0 | 4 | 1 | 1 | 2 | 3 | 3 | 1 | 2 | 1 | 11 | 6 | 4 | 1 | 2 | 3 | 0 | 3 | 1 |
19.2.6.2.2.2 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN2 | 86 | 37 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 3 | 4 | 1 | 4 | 2 | 2 | 2 | 2 | 2 | 2 | 9 | 6 | 4 | 2 | 3 | 4 | 0 | 4 | 1 |
19.2.6.2.3 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ubiquitin C-terminal hydrolase cofactor | 86 | 36 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 3 | 1 | 2 | 3 | 3 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 0 | 4 | 1 | 1 | 2 | 3 | 3 | 1 | 2 | 1 | 11 | 6 | 4 | 1 | 2 | 3 | 0 | 3 | 1 |
19.2.2.3.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH3) | 85 | 35 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 4 | 2 | 2 | 1 | 1 | 1 | 0 | 3 | 3 | 3 | 2 | 0 | 3 | 1 | 1 | 1 | 3 | 3 | 2 | 2 | 0 | 8 | 9 | 6 | 1 | 1 | 2 | 0 | 4 | 2 |
19.2.2.1.5.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.bifunctional co-chaperone and E3 ubiquitin ligase (CHIP) | 83 | 37 | 1 | 2 | 1 | 1 | 2 | 2 | 3 | 2 | 1 | 2 | 3 | 2 | 2 | 1 | 2 | 0 | 2 | 2 | 2 | 3 | 5 | 1 | 3 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 6 | 6 | 4 | 4 | 1 | 2 | 0 | 2 | 2 |
19.2.6.1.2.3 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-3 | 82 | 37 | 2 | 2 | 2 | 2 | 1 | 2 | 5 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 3 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 8 | 6 | 3 | 1 | 3 | 4 | 0 | 3 | 1 |
19.2.2.3.5.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (RBX1) | 81 | 37 | 1 | 1 | 2 | 2 | 1 | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 4 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 4 | 1 | 1 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 6 | 6 | 2 | 2 | 2 | 3 | 0 | 2 | 2 |
19.2.2.8.1.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.UBQ-E2-recruiting component RBX1 | 81 | 37 | 1 | 1 | 2 | 2 | 1 | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 4 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 4 | 1 | 1 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 6 | 6 | 2 | 2 | 2 | 3 | 0 | 2 | 2 |
19.2.6.2.1.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT1 | 81 | 37 | 5 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | 3 | 1 | 1 | 0 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 4 | 2 | 2 | 2 | 2 | 2 | 6 | 6 | 2 | 2 | 2 | 1 | 0 | 1 | 2 |
19.2.6.2.2.5 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN6 | 81 | 35 | 1 | 2 | 1 | 1 | 1 | 2 | 4 | 2 | 1 | 3 | 3 | 3 | 2 | 1 | 1 | 0 | 1 | 2 | 2 | 1 | 2 | 3 | 2 | 2 | 4 | 2 | 2 | 1 | 2 | 1 | 7 | 8 | 3 | 0 | 0 | 3 | 0 | 4 | 1 |
19.2.2.8.3.4.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.regulator component SPA | 80 | 33 | 3 | 1 | 2 | 3 | 2 | 2 | 1 | 0 | 0 | 4 | 1 | 1 | 5 | 0 | 1 | 0 | 2 | 1 | 2 | 1 | 2 | 1 | 4 | 2 | 4 | 2 | 2 | 4 | 2 | 2 | 4 | 3 | 4 | 2 | 0 | 3 | 0 | 4 | 3 |
19.2.5 | Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD) | 80 | 34 | 2 | 2 | 3 | 3 | 2 | 2 | 2 | 1 | 0 | 2 | 2 | 2 | 3 | 0 | 1 | 0 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 2 | 2 | 2 | 2 | 2 | 5 | 6 | 4 | 2 | 0 | 2 | 0 | 3 | 2 |
19.2.6.2.2.6 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN7 | 80 | 36 | 1 | 0 | 1 | 1 | 2 | 2 | 6 | 2 | 1 | 1 | 3 | 2 | 3 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 9 | 6 | 3 | 1 | 3 | 2 | 0 | 2 | 1 |
19.2.6.1.2.6 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-6 | 79 | 37 | 1 | 2 | 1 | 1 | 1 | 2 | 3 | 3 | 1 | 2 | 1 | 2 | 3 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 3 | 1 | 2 | 2 | 2 | 2 | 1 | 4 | 1 | 8 | 3 | 2 | 2 | 2 | 4 | 0 | 5 | 1 |
19.2.3.2.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (OTS) | 78 | 31 | 2 | 2 | 1 | 2 | 1 | 3 | 2 | 1 | 0 | 4 | 3 | 2 | 2 | 0 | 1 | 0 | 3 | 2 | 3 | 0 | 0 | 1 | 2 | 5 | 1 | 6 | 3 | 2 | 3 | 1 | 0 | 9 | 6 | 1 | 0 | 1 | 0 | 1 | 2 |
19.2.6.2.2.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN1 | 78 | 36 | 1 | 1 | 1 | 2 | 2 | 2 | 6 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 3 | 3 | 2 | 1 | 2 | 2 | 2 | 3 | 1 | 3 | 2 | 2 | 1 | 3 | 9 | 5 | 1 | 0 | 2 | 0 | 2 | 1 |
19.2.6.1.1.7 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-7 | 77 | 36 | 1 | 1 | 2 | 1 | 1 | 1 | 4 | 1 | 1 | 2 | 3 | 1 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 3 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 8 | 6 | 4 | 1 | 0 | 4 | 0 | 4 | 2 |
19.2.6.2.2.3 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN3 | 77 | 37 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | 3 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 4 | 1 | 4 | 4 | 1 | 2 | 2 | 2 | 1 | 4 | 6 | 1 | 2 | 3 | 2 | 0 | 2 | 1 |
19.2.6.2.1.6 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT6 | 76 | 37 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 1 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 1 | 8 | 6 | 3 | 2 | 1 | 1 | 0 | 2 | 2 |
19.2.6.2.2.8 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN9 | 76 | 37 | 1 | 1 | 1 | 2 | 1 | 2 | 4 | 2 | 1 | 2 | 3 | 3 | 3 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 2 | 3 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 4 | 4 | 3 | 2 | 2 | 2 | 0 | 3 | 1 |
19.2.2.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation | 74 | 34 | 2 | 2 | 1 | 2 | 1 | 2 | 3 | 3 | 1 | 1 | 2 | 1 | 3 | 1 | 2 | 0 | 3 | 3 | 2 | 2 | 1 | 3 | 1 | 1 | 3 | 3 | 3 | 0 | 2 | 1 | 6 | 6 | 2 | 0 | 2 | 1 | 0 | 0 | 2 |
19.2.2.4.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation.ubiquitin-fold protein (HUB) | 74 | 34 | 2 | 2 | 1 | 2 | 1 | 2 | 3 | 3 | 1 | 1 | 2 | 1 | 3 | 1 | 2 | 0 | 3 | 3 | 2 | 2 | 1 | 3 | 1 | 1 | 3 | 3 | 3 | 0 | 2 | 1 | 6 | 6 | 2 | 0 | 2 | 1 | 0 | 0 | 2 |
19.2.6.2.2.11 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN12 | 74 | 36 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 4 | 10 | 8 | 1 | 2 | 3 | 0 | 3 | 1 |
19.2.1.3.1.2 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.catalytic component GID2 | 73 | 36 | 2 | 2 | 1 | 3 | 1 | 2 | 2 | 1 | 1 | 2 | 3 | 4 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 4 | 4 | 1 | 1 | 1 | 2 | 1 | 3 | 9 | 5 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.2.1.5.3.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-C2-class E3 ligase | 73 | 35 | 2 | 2 | 2 | 3 | 2 | 2 | 3 | 1 | 0 | 2 | 1 | 2 | 6 | 0 | 3 | 0 | 2 | 2 | 1 | 1 | 2 | 4 | 1 | 4 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 3 | 2 | 2 | 2 | 1 | 0 | 1 | 2 |
19.2.6.1.1.5 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-5 | 73 | 36 | 1 | 2 | 2 | 2 | 1 | 2 | 3 | 2 | 1 | 2 | 2 | 2 | 3 | 1 | 2 | 0 | 1 | 1 | 1 | 0 | 2 | 2 | 2 | 3 | 2 | 2 | 1 | 2 | 2 | 1 | 8 | 6 | 4 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.6.2.2.9 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN10 | 73 | 36 | 1 | 2 | 1 | 1 | 1 | 1 | 4 | 3 | 1 | 3 | 1 | 1 | 3 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 3 | 0 | 2 | 1 | 3 | 2 | 2 | 1 | 2 | 2 | 8 | 3 | 2 | 1 | 2 | 3 | 0 | 3 | 1 |
19.2.6.2.1.3 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT3 | 72 | 36 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 4 | 2 | 1 | 2 | 2 | 7 | 2 | 6 | 6 | 4 | 1 | 1 | 1 | 0 | 1 | 3 |
19.2.2.2.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.large component SAE2 | 71 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 12 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 6 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 3 |
19.2.6.1.2.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-1 | 70 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 3 | 6 | 5 | 2 | 3 | 2 | 0 | 2 | 1 |
19.2.4.1.1 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E3 ubiquitin ligase component HRD1 | 69 | 37 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 8 | 8 | 3 | 1 | 1 | 3 | 0 | 2 | 1 |
19.2.6.2.1.5 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT5 | 69 | 36 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 0 | 2 | 2 | 2 | 2 | 0 | 3 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 4 | 5 | 3 | 2 | 4 | 1 | 0 | 2 | 2 |
19.2.3.3.1.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN1 | 67 | 37 | 1 | 2 | 1 | 1 | 1 | 2 | 3 | 1 | 1 | 2 | 4 | 2 | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 4 | 8 | 4 | 1 | 2 | 1 | 0 | 1 | 2 |
19.2.6.1.1.2 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-2 | 67 | 35 | 1 | 2 | 1 | 2 | 0 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 0 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 4 | 6 | 4 | 1 | 2 | 3 | 0 | 2 | 1 |
19.2.6.1.2.5 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-5 | 67 | 37 | 2 | 2 | 1 | 2 | 1 | 1 | 3 | 1 | 1 | 3 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 3 | 2 | 3 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 5 | 3 | 1 | 1 | 2 | 1 | 0 | 1 | 6 |
19.2.6.2.1.2 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT2 | 67 | 36 | 1 | 2 | 0 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 1 | 5 | 6 | 4 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.6.2.2.4 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN5 | 67 | 36 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 3 | 2 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 2 | 0 | 1 | 2 | 3 | 2 | 1 | 2 | 2 | 1 | 8 | 3 | 1 | 1 | 1 | 4 | 0 | 3 | 1 |
19.2.3.2.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.peptidase (DeSI) | 66 | 37 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 3 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 5 | 5 | 2 | 1 | 2 | 2 | 0 | 1 | 1 |
19.2.2.3.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).ubiquitin-fold protein (RUB) | 65 | 27 | 0 | 0 | 2 | 2 | 0 | 2 | 0 | 0 | 1 | 1 | 7 | 2 | 2 | 0 | 0 | 0 | 2 | 3 | 2 | 1 | 2 | 0 | 1 | 1 | 3 | 2 | 2 | 1 | 0 | 1 | 1 | 14 | 5 | 1 | 0 | 2 | 0 | 1 | 1 |
19.2.6.1.1.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-1 | 65 | 37 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 4 | 3 | 2 | 1 | 1 | 1 | 1 | 3 | 4 | 3 | 1 | 1 | 2 | 0 | 3 | 1 |
19.2.6.1.2.2 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-2 | 65 | 36 | 2 | 0 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 3 | 1 | 2 | 2 | 2 | 3 | 2 | 2 | 2 | 7 | 1 | 2 | 1 | 1 | 2 | 0 | 2 | 1 |
19.2.1.2.2.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-I-residues E3 ubiquitin ligase (PRT6) | 63 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 10 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 6 | 4 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.1.2.2.2 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-II-residues E3 ubiquitin ligase (PRT1) | 63 | 36 | 1 | 4 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 3 | 1 | 2 | 2 | 1 | 0 | 0 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 5 | 3 | 1 | 1 | 1 | 2 | 1 | 4 | 3 | 3 | 1 | 2 | 1 | 0 | 1 | 1 |
19.2.2.3.3.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.small component AXR1/AXL | 63 | 37 | 1 | 1 | 1 | 2 | 1 | 1 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 4 | 6 | 4 | 1 | 1 | 2 | 0 | 2 | 1 |
19.2.2.8.1.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.adaptor protein exchange factor (CAND1) | 62 | 36 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 4 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 8 | 5 | 1 | 0 | 1 | 0 | 1 | 2 |
19.2.3.1.1.6 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP14) | 62 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 0 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 4 | 4 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 5 | 3 | 2 | 5 | 2 | 1 | 0 | 1 | 1 |
19.2.1.3.1.5 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID8 | 61 | 34 | 1 | 2 | 1 | 3 | 1 | 1 | 3 | 1 | 1 | 2 | 2 | 3 | 3 | 0 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 1 | 2 | 2 | 1 | 0 | 6 | 4 | 2 | 0 | 1 | 0 | 2 | 1 |
19.2.3.1.1.9 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP23) | 61 | 34 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 2 | 1 | 2 | 3 | 0 | 1 | 0 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 5 | 6 | 3 | 2 | 1 | 0 | 0 | 1 | 1 |
19.2.6.1.2.7 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-7 | 61 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 5 | 4 | 1 | 2 | 2 | 0 | 2 | 3 |
19.2.1.3.1.1 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID1 | 60 | 36 | 1 | 1 | 1 | 5 | 1 | 1 | 3 | 1 | 2 | 3 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 3 | 2 | 1 | 1 | 1 | 2 | 1 | 4 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 1 |
19.2.2.8.3.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.core adaptor component DDB1 | 60 | 37 | 1 | 1 | 1 | 2 | 1 | 3 | 2 | 1 | 1 | 2 | 2 | 4 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 5 | 3 | 1 | 1 | 2 | 0 | 2 | 1 |
19.2.4.1.4 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.substrate recruitment component OS9 | 60 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 4 | 1 | 1 | 1 | 2 | 1 | 5 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 1 |
19.2.2.2.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.small component SAE1 | 59 | 36 | 2 | 3 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 0 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 3 | 6 | 4 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.6.2.2.7 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN8 | 59 | 37 | 1 | 2 | 2 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 4 | 3 | 2 | 2 | 2 | 2 | 0 | 2 | 1 |
19.2.2.8.3.3.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.regulator component DET1 | 58 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | 6 | 4 | 3 | 1 | 1 | 4 | 0 | 2 | 1 |
19.2.3.1.1.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP6-7) | 58 | 37 | 1 | 1 | 1 | 2 | 1 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 5 | 2 | 1 | 2 | 2 | 0 | 3 | 1 |
19.2.3.3.1.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN2 | 58 | 37 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | 1 | 3 | 2 | 1 | 4 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 1 |
19.2.4.1.3 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.adaptor protein component HRD3 | 58 | 36 | 2 | 3 | 1 | 2 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 3 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 1 | 2 | 2 | 0 | 3 | 1 |
19.2.4.2.2.2 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component NPL4 | 58 | 36 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 0 | 3 | 2 | 1 | 2 | 4 | 0 | 6 | 1 |
19.2.2.1.5.4.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Helicase) | 57 | 30 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 0 | 2 | 2 | 2 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 2 | 0 | 2 | 1 | 0 | 2 | 1 | 1 | 2 | 0 | 1 | 4 | 9 | 6 | 1 | 0 | 1 | 0 | 1 | 1 |
19.2.3.1.1.8 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP22) | 57 | 36 | 2 | 2 | 1 | 1 | 1 | 1 | 3 | 1 | 0 | 5 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 2 | 2 | 2 | 5 | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.3.3.1.7 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN7 | 57 | 36 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 2 | 4 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 2 | 1 | 3 | 0 | 3 | 1 |
19.2.6.1.1.3 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-3 | 57 | 36 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 0 | 1 | 3 | 2 | 1 | 1 | 3 | 1 | 3 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | 2 | 0 | 1 | 2 | 0 | 2 | 1 |
19.2.2.3.5.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (DCN1) | 56 | 33 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 2 | 0 | 3 | 1 | 3 | 1 | 2 | 2 | 2 | 4 | 2 | 4 | 3 | 2 | 1 | 0 | 0 | 0 | 1 | 1 |
19.2.1.3.1.3 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.N-recognin component GID4 | 55 | 35 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 0 | 2 | 0 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 4 | 3 | 2 | 1 | 0 | 4 | 0 | 4 | 2 |
19.2.4.3.1 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.E4 multiubiquitination enzyme (UFD2) | 55 | 35 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 3 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 4 | 2 | 1 | 1 | 3 | 1 | 1 | 2 | 2 | 1 | 2 | 3 | 3 | 1 | 1 | 3 | 0 | 2 | 1 |
19.2.6.3 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation | 55 | 37 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 6 | 5 | 3 | 1 | 2 | 1 | 0 | 1 | 1 |
19.2.6.3.1 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation.regulatory protein (PTRE1) | 55 | 37 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 6 | 5 | 3 | 1 | 2 | 1 | 0 | 1 | 1 |
19.2.6.1.1.6 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-6 | 54 | 37 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 3 | 3 | 2 | 1 | 3 | 1 | 0 | 2 | 1 |
19.2.6.1.2.4 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-4 | 54 | 36 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 3 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 1 | 1 | 2 | 2 | 0 | 2 | 2 |
19.2.2.8.3.4.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.component COP1 | 53 | 33 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 9 | 3 | 1 | 1 | 2 | 2 | 1 | 2 | 3 | 2 | 2 | 0 | 1 | 0 | 2 | 2 |
19.2.3.2.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (FUG) | 52 | 28 | 0 | 1 | 0 | 1 | 1 | 3 | 1 | 1 | 0 | 2 | 2 | 4 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 3 | 1 | 0 | 3 | 2 | 1 | 1 | 2 | 0 | 1 | 4 | 7 | 3 | 1 | 0 | 1 | 0 | 0 | 1 |
19.2.3.3.1.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN5 | 52 | 36 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 6 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 0 | 2 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.4.1.5 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.associated plant-specific component EBS7 | 52 | 35 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 0 | 1 | 1 | 1 | 4 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 1 |
19.2.6.2.2.12 | Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN13 | 52 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 4 | 2 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.2.2.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO chain-forming-ligase E4 enzyme (PIAL) | 51 | 34 | 1 | 2 | 1 | 2 | 1 | 1 | 3 | 1 | 0 | 2 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 3 | 2 | 3 | 1 | 1 | 0 | 1 | 2 |
19.2.3.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (SPF) | 51 | 31 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 0 | 2 | 1 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 8 | 4 | 1 | 1 | 2 | 2 | 1 | 1 | 3 | 2 | 1 | 0 | 1 | 0 | 0 | 2 |
19.2.3.3.1.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN3 | 51 | 36 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | 2 | 1 | 1 | 2 | 0 | 2 | 1 |
19.2.4.3.2 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.ubiquitin-binding adaptor (UFD3) | 51 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 4 | 3 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.4.4.2 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.proteasome adaptor protein (DDI1) | 51 | 35 | 1 | 2 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 5 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 1 |
19.2.1.3.1.4 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID5 | 50 | 35 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 4 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 1 |
19.2.2.6.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.ubiquitin-fold protein (UFM) | 50 | 34 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 0 | 1 | 4 | 1 | 3 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 3 | 0 | 1 | 2 | 1 | 0 | 1 | 1 |
19.2.2.8.2.2.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BPH1 | 50 | 27 | 3 | 0 | 1 | 2 | 1 | 0 | 2 | 1 | 0 | 3 | 1 | 1 | 3 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 2 | 3 | 0 | 2 | 1 | 1 | 1 | 0 | 1 | 5 | 5 | 4 | 1 | 0 | 1 | 0 | 0 | 1 |
19.2.1.1.1.2 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc32 | 49 | 35 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 5 | 3 | 2 | 1 | 2 | 1 | 0 | 1 | 1 |
19.2.1.2.1.2 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.arginyl-tRNA-protein transferase (ATE) | 49 | 36 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 3 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 2 |
19.2.3.1.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU1) | 49 | 35 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 3 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 4 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 1 |
19.2.3.3.1.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN4 | 49 | 36 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 3 | 0 | 1 | 0 | 1 | 1 |
19.2.4.2.3 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.associated factor (PUX1) | 49 | 34 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 4 | 2 | 3 | 3 | 2 | 1 | 2 | 2 | 0 | 1 | 1 |
19.2.2.6.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-ligase E3 protein | 48 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 6 | 3 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.3.1.2.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU2) | 48 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 4 | 3 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.3.1.2.5 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.histone deubiquinating protease (OTLD1) | 48 | 35 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 0 | 2 | 1 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 3 | 1 | 1 | 1 | 2 | 0 | 2 | 1 |
19.2.1.3.1.6 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID9 | 47 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 4 | 1 | 2 | 3 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.2.2.4.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (HPY2) | 47 | 34 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 4 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.2.3.2.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.deneddylase (DEN1) | 47 | 33 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 3 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 3 | 5 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.3.1.1.10 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP24) | 47 | 34 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 3 | 3 | 2 | 1 | 0 | 2 | 0 | 2 | 1 |
19.2.3.1.2.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU5) | 47 | 35 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 4 | 3 | 2 | 0 | 1 | 0 | 0 | 1 | 1 |
19.2.1.1.1.3 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc33/34 | 46 | 35 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 3 | 2 | 1 | 0 | 2 | 0 | 2 | 1 |
19.2.2.6.2 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-activating E1 protein | 46 | 33 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 2 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 5 | 3 | 1 | 1 | 2 | 1 | 0 | 1 | 1 |
19.2.2.6.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-conjugation E2 protein | 46 | 34 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 0 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 0 | 3 | 2 | 1 | 2 | 1 | 0 | 2 | 1 |
19.2.3.3.1.6 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN6 | 46 | 34 | 1 | 0 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 4 | 2 | 2 | 1 | 1 | 2 | 0 | 2 | 1 |
19.2.3.3.1.8 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN8 | 46 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 1 | 3 | 2 | 2 | 1 | 2 | 2 | 0 | 1 | 1 |
19.2.3.1.1.12 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP26) | 45 | 32 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 0 | 1 | 0 | 2 | 1 | 0 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 0 | 3 | 2 | 1 | 0 | 2 | 0 | 2 | 1 |
19.2.5.1 | Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).ubiquitin protein ligase (SP1) | 45 | 34 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | 2 | 1 | 0 | 1 | 0 | 2 | 2 |
19.2.2.3.3.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.large component ECR1 | 44 | 35 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 1 |
19.2.2.7 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation | 44 | 34 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 0 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 4 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.2.7.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation.ubiquitin-fold protein (URM) | 44 | 34 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 0 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 4 | 2 | 1 | 1 | 1 | 0 | 1 | 1 |
19.2.4.3.4 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deglycosylating peptide:N-glycanase (PNG1) | 44 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 1 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 2 |
19.2.2.8.3.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.scaffold component CUL4 | 43 | 32 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 3 | 2 | 1 | 1 | 2 | 2 | 1 | 1 | 3 | 2 | 1 | 0 | 2 | 0 | 1 | 1 |
19.2.3.1.1.13 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP27) | 42 | 31 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 4 | 3 | 2 | 1 | 0 | 3 | 0 | 2 | 1 |
19.2.1.2.1.4 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-asparagine amidase (NTAN) | 41 | 31 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 3 | 1 | 4 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 1 |
19.2.4.3.3 | Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deubiquinating protease (OTU1) | 41 | 31 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 4 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 1 |
19.2.1.2.1.3 | Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-glutamine amidase (NTAQ) | 39 | 33 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 3 | 3 | 1 | 0 | 1 | 0 | 1 | 1 |
19.2.3.4 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation | 37 | 33 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | 1 | 0 | 0 | 1 | 1 |
19.2.3.4.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation.UFM1-specific protease | 37 | 33 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | 1 | 0 | 0 | 1 | 1 |
19.2.3.1.2.6 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU7) | 36 | 31 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 1 |
19.2.2.8.1.4.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component UFO | 35 | 24 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 3 | 0 | 1 | 0 | 2 | 1 | 1 | 1 | 2 | 0 | 3 | 3 | 1 | 1 | 3 | 2 | 0 | 0 | 1 |
19.2.2.8.2.2.3 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component FBL | 35 | 28 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 3 | 4 | 2 | 1 | 0 | 0 | 0 | 1 | 0 |
19.2.5.2 | Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).protein retrotranslocase (SP2) | 35 | 28 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 0 | 1 | 3 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 0 |
19.2.2.8.3.3.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.E2 conjugating component COP10 | 32 | 25 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 1 | 0 | 1 | 0 | 0 | 1 |
19.2.2.8.2.2.1 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component NPH3 | 31 | 22 | 1 | 1 | 1 | 0 | 1 | 1 | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 1 | 0 | 2 | 1 | 1 | 2 | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
19.2.3.1.1.11 | Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP25) | 23 | 18 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 2 | 1 | 0 | 1 | 2 | 0 | 1 | 1 | 2 | 0 | 3 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |