Child MapMan terms

Original MapMan term
19.2
Description
.Protein homeostasis.ubiquitin-proteasome system
Type
mapman

MapMan description genes species ach ahy aip aly ath atr bol bra bvu can car ccaj ccan ccl cla cme col cpa cqu cre cru csa dca egr egut fve gma gra hbr mco mdo mes mpo mtr nnu osa pab pax pbr ppa ppe ptr rco sly smo spa stu tca tha tpr ugi vra vvi zju zma
19.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation 21675 54 461 0 395 467 433 215 675 664 302 453 308 397 314 345 289 285 399 258 596 71 465 282 464 381 495 407 780 560 517 50 392 460 152 699 365 395 433 496 540 296 382 524 300 440 189 377 504 346 465 448 292 324 287 359 482
19.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation) 11788 54 257 0 180 285 258 116 408 404 159 172 176 232 175 188 172 168 172 151 299 30 290 167 260 207 239 177 437 297 293 23 208 269 81 299 204 230 265 235 289 157 195 290 162 229 112 223 232 180 260 245 166 188 161 213 303
19.2.2.1.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities 9964 54 234 0 151 236 217 98 348 341 137 126 152 197 148 156 152 146 146 126 248 17 250 145 228 182 202 149 366 247 249 11 180 225 63 266 171 201 204 202 252 116 162 244 143 195 83 194 195 153 214 213 142 167 133 184 257
19.2.2.8 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes 7227 54 154 0 177 128 125 70 185 175 104 217 100 126 99 114 80 81 180 74 222 11 130 78 152 130 206 180 264 186 160 12 115 130 46 349 118 113 127 203 158 89 139 173 102 154 50 111 220 116 139 155 86 103 85 97 129
19.2.2.1.5.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities 7212 54 170 0 110 162 152 66 266 260 101 57 112 147 102 108 115 114 102 90 177 7 179 110 166 133 142 99 280 185 176 5 127 161 36 195 122 146 143 148 177 77 116 180 107 143 57 146 140 109 165 153 111 129 95 130 206
19.2.2.8.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes 6057 54 132 0 156 104 103 50 151 143 85 193 80 104 84 95 65 64 166 59 191 6 106 61 126 111 184 164 216 156 135 8 97 107 36 323 98 95 105 173 131 60 120 144 85 126 38 88 196 98 117 133 62 79 68 78 102
19.2.2.8.1.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components 4900 54 119 0 135 79 76 44 109 107 73 156 64 93 72 75 54 52 142 44 147 2 74 52 110 81 161 131 190 130 113 4 77 89 31 258 81 63 70 142 105 41 97 121 70 98 33 71 156 81 102 97 56 69 55 66 82
19.2.2.8.1.4.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component FBX 4114 54 98 0 117 64 62 32 86 84 62 139 51 76 62 64 41 40 131 37 125 2 58 41 93 65 148 118 160 103 96 4 61 75 24 244 63 49 55 126 84 34 85 103 59 82 26 57 139 71 79 83 44 53 45 53 61
19.2.2.1.5.3.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-H2-class E3 ligase 3693 54 84 0 38 88 87 32 143 145 57 5 57 81 47 56 58 59 51 44 93 1 89 56 88 75 67 52 152 94 90 1 45 87 18 98 57 85 90 70 88 32 56 88 58 73 26 85 74 60 84 76 53 69 41 71 119
19.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation 3348 54 84 0 61 64 57 43 99 94 49 66 54 60 54 49 50 50 49 51 88 26 59 46 70 68 65 48 119 85 85 22 76 79 33 66 52 65 61 59 103 64 53 90 50 60 41 57 45 52 75 61 47 53 58 64 69
19.2.6 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome 3105 54 81 0 59 65 57 43 101 93 43 55 50 51 40 43 46 42 52 38 90 35 57 42 54 52 49 47 101 81 74 34 57 67 36 57 66 59 50 64 86 78 48 82 39 48 43 53 51 46 82 56 43 49 43 50 77
19.2.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation 2252 54 62 0 41 41 37 29 68 62 33 43 37 42 36 34 36 35 35 35 59 15 37 31 43 51 46 33 79 54 58 11 47 50 21 42 36 47 42 39 75 38 36 60 32 39 26 36 28 35 51 42 34 38 41 47 47
19.2.2.1.5.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-HC-class E3 ligase 2086 54 57 0 42 38 32 20 65 61 25 24 33 42 31 30 37 36 31 29 50 4 37 34 41 37 48 28 81 55 51 3 53 47 12 58 42 35 30 50 56 31 38 57 30 39 18 33 38 30 47 47 34 41 29 33 56
19.2.6.2 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle 1773 54 50 0 31 34 32 25 52 50 25 31 29 30 22 22 25 24 28 25 56 19 32 23 28 33 29 30 61 48 41 19 34 40 20 32 41 35 28 38 44 43 27 52 22 28 27 28 27 26 46 34 23 27 26 28 43
19.2.4 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD) 1668 54 37 0 32 31 30 22 44 45 25 26 24 31 28 29 22 25 29 22 50 16 28 22 31 29 29 27 61 40 39 14 45 37 20 30 31 26 29 31 51 37 28 47 23 29 22 30 24 27 39 28 23 28 25 28 42
19.2.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways 1454 54 31 0 33 29 30 17 52 43 19 31 21 27 21 20 21 18 18 23 46 13 28 18 29 28 23 22 51 36 34 7 37 32 17 28 27 30 31 26 38 43 26 33 21 24 18 23 16 22 27 24 23 21 23 24 31
19.2.3.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities 1433 54 45 0 25 26 25 17 45 41 20 27 25 27 22 19 21 20 21 22 37 6 24 18 29 26 29 20 55 34 35 4 26 32 13 24 22 32 33 24 55 22 22 37 19 26 17 24 15 22 36 30 20 25 28 32 32
19.2.6.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle 1248 54 28 0 21 28 23 17 46 40 17 22 20 19 17 19 20 17 23 13 32 15 23 18 25 18 19 15 38 32 32 14 21 26 15 24 22 23 21 25 37 34 19 29 16 19 15 24 23 18 35 21 19 21 16 21 33
19.2.6.2.2 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components 1124 54 29 0 18 20 19 15 33 30 14 21 19 19 14 13 14 14 16 16 33 12 19 14 19 25 19 19 38 31 27 12 24 26 13 21 28 22 22 24 28 26 19 34 14 17 14 19 16 16 27 24 14 17 15 19 33
19.2.2.1.5.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities 1117 54 18 0 18 42 38 12 44 44 13 29 10 13 21 23 11 10 19 15 27 6 43 13 27 20 34 25 24 18 24 2 24 23 9 37 15 26 16 24 34 11 19 20 14 18 9 24 19 16 15 31 8 7 11 25 19
19.2.2.1.5.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities 1107 54 31 0 13 22 20 14 27 27 16 21 17 26 18 18 18 16 18 14 30 1 20 16 24 19 20 18 42 31 32 1 14 31 12 20 25 21 33 20 29 15 20 31 15 20 11 17 21 21 24 21 14 20 19 22 21
19.2.2.1.5.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.E3 ubiquitin ligase (PUB) 1024 52 29 0 12 21 19 12 25 25 15 20 16 24 17 17 16 15 18 13 28 0 19 15 23 18 19 17 37 29 31 0 12 29 10 19 24 19 28 18 26 13 19 30 14 19 10 16 20 20 22 20 12 19 15 21 19
19.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation) 915 54 16 0 13 18 18 8 30 30 15 23 10 12 13 12 10 10 21 11 31 15 16 10 21 17 17 17 23 25 20 7 25 17 9 23 12 18 14 23 28 21 17 19 10 21 9 15 20 19 19 21 12 9 15 11 19
19.2.3.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities 819 54 17 0 16 15 12 12 23 21 13 16 12 15 14 15 15 15 14 13 22 9 13 13 14 25 17 13 24 20 23 7 21 18 8 18 14 15 9 15 20 16 14 23 13 13 9 12 13 13 15 12 14 13 13 15 15
19.2.2.8.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.target protein binding component SKP1/ASK1 792 54 6 0 13 21 21 2 30 23 7 29 11 6 6 14 5 5 18 11 34 1 27 5 10 13 16 24 13 15 10 1 13 11 2 59 12 26 30 23 18 11 16 14 10 18 3 13 34 12 7 26 2 6 8 7 14
19.2.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation 772 54 16 0 6 14 14 9 24 26 7 18 11 13 11 12 12 10 13 9 14 3 13 12 13 12 16 12 28 31 23 3 19 23 4 14 14 12 14 16 30 10 13 18 8 17 5 12 16 14 24 13 14 12 12 17 16
19.2.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation) 755 54 10 0 13 15 14 9 22 26 13 20 7 10 14 16 11 11 9 8 26 10 14 10 16 13 11 16 20 15 16 7 18 16 8 10 12 19 13 15 23 19 13 19 14 16 9 13 14 12 19 11 9 8 12 15 16
19.2.1.2 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway 723 54 14 0 20 11 11 8 24 17 9 19 11 14 11 10 11 9 8 13 23 5 11 9 14 18 11 12 27 17 16 4 21 15 6 18 10 19 16 14 19 21 12 17 10 12 8 11 9 12 13 14 10 12 12 10 15
19.2.2.1.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination 708 54 12 0 10 15 13 9 20 23 7 11 10 15 10 10 10 11 9 8 15 3 13 11 16 13 16 9 32 21 19 2 16 16 4 19 20 13 21 12 24 11 9 19 10 11 6 12 10 9 22 12 7 14 12 9 17
19.2.4.2 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction 708 54 19 0 18 12 12 9 15 16 10 11 9 15 14 15 10 11 15 8 20 5 10 10 14 14 13 13 28 17 15 5 20 15 8 16 15 11 10 14 26 12 12 17 10 10 7 12 10 13 14 15 8 12 10 12 16
19.2.2.1.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-conjugating E2 protein (UBC) 701 54 6 0 12 14 12 8 24 25 10 14 9 16 10 12 10 9 8 11 26 7 14 9 14 10 18 8 29 19 19 6 10 19 7 9 18 8 13 14 10 11 12 16 9 16 10 11 15 10 20 13 11 8 12 11 19
19.2.2.1.5.3.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-v-class E3 ligase 688 53 11 0 18 12 13 5 26 24 10 14 12 16 11 11 10 11 12 8 20 1 13 11 17 12 12 8 33 18 17 0 18 15 1 15 10 14 12 15 15 3 10 17 10 15 8 13 14 10 14 10 13 11 12 12 15
19.2.2.8.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes 664 53 14 0 13 13 13 14 21 19 9 17 13 13 9 11 9 10 7 8 15 1 13 9 15 12 12 8 25 19 12 0 10 13 4 18 13 12 15 17 16 8 10 16 9 17 5 12 19 10 12 14 15 13 9 9 14
19.2.6.1.2 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components 639 54 19 0 11 15 11 8 25 22 7 11 10 9 10 9 10 9 13 6 15 8 12 9 11 11 8 8 17 16 15 7 14 13 7 12 13 10 13 12 21 14 11 14 8 9 8 12 11 8 18 10 11 11 9 11 17
19.2.3.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin 615 54 16 0 10 12 10 8 18 19 9 14 8 9 9 9 8 8 9 8 16 8 12 8 10 9 9 8 20 18 14 8 19 16 8 14 10 8 12 12 18 13 10 18 10 11 8 11 11 10 13 10 7 8 11 9 14
19.2.3.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex 615 54 16 0 10 12 10 8 18 19 9 14 8 9 9 9 8 8 9 8 16 8 12 8 10 9 9 8 20 18 14 8 19 16 8 14 10 8 12 12 18 13 10 18 10 11 8 11 11 10 13 10 7 8 11 9 14
19.2.6.1.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components 609 54 9 0 10 13 12 9 21 18 10 11 10 10 7 10 10 8 10 7 17 7 11 9 14 7 11 7 21 16 17 7 7 13 8 12 9 13 8 13 16 20 8 15 8 10 7 12 12 10 17 11 8 10 7 10 16
19.2.6.2.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components 579 54 20 0 11 12 11 8 18 18 10 9 9 10 7 8 10 9 11 8 21 6 11 8 8 7 9 11 21 16 13 6 8 13 6 10 10 11 6 13 15 16 7 16 7 10 12 7 9 9 16 9 9 9 10 8 7
19.2.2.1.5.4.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.plant-specific E3 ubiquitin ligase (RSL/RFA) 570 53 7 0 10 28 20 7 19 22 5 16 4 8 9 14 5 5 10 6 9 3 27 7 15 14 15 14 14 8 12 0 12 11 2 24 6 10 8 10 19 4 12 10 7 9 5 10 11 9 5 19 5 3 5 14 7
19.2.2.8.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components 559 52 11 0 11 11 11 13 19 18 8 15 10 11 8 9 8 8 6 8 13 0 11 8 15 10 10 7 20 16 10 0 7 11 3 9 11 9 14 15 14 6 8 14 8 15 3 11 17 9 10 9 13 11 8 8 11
19.2.1.2.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification 550 54 11 0 18 9 9 6 18 12 7 12 8 11 8 7 8 7 7 9 16 3 9 7 12 14 8 8 23 11 13 2 17 12 4 14 9 16 13 10 16 6 9 13 7 9 6 9 8 9 10 10 9 10 10 8 13
19.2.2.1.5.3.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (SINA) 538 52 14 0 8 19 15 5 23 22 6 11 7 6 10 9 8 6 5 6 9 0 35 7 11 6 12 8 10 13 14 0 9 9 2 21 7 7 7 9 14 4 9 14 7 13 3 9 11 6 13 17 7 5 10 11 9
19.2.2.1.5.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities 528 54 15 0 10 10 7 6 11 10 7 19 13 11 7 7 8 6 7 7 14 3 8 6 11 10 6 7 20 13 17 3 15 10 6 14 9 8 12 10 12 13 7 13 7 14 6 7 15 7 10 8 9 11 8 7 11
19.2.2.1.5.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities.monomeric E3 ubiquitin ligase (HECT) 528 54 15 0 10 10 7 6 11 10 7 19 13 11 7 7 8 6 7 7 14 3 8 6 11 10 6 7 20 13 17 3 15 10 6 14 9 8 12 10 12 13 7 13 7 14 6 7 15 7 10 8 9 11 8 7 11
19.2.2.8.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes 506 54 8 0 8 11 9 6 13 13 10 7 7 9 6 8 6 7 7 7 16 4 11 8 11 7 10 8 23 11 13 4 8 10 6 8 7 6 7 13 11 21 9 13 8 11 7 11 5 8 10 8 9 11 8 10 13
19.2.1.3 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway 481 54 11 0 9 10 14 6 13 13 7 7 7 8 7 7 7 6 7 7 15 6 10 6 10 7 9 8 16 13 12 1 12 11 8 7 8 7 10 8 18 15 7 11 7 8 7 8 4 7 8 7 9 8 7 9 11
19.2.1.3.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex 481 54 11 0 9 10 14 6 13 13 7 7 7 8 7 7 7 6 7 7 15 6 10 6 10 7 9 8 16 13 12 1 12 11 8 7 8 7 10 8 18 15 7 11 7 8 7 8 4 7 8 7 9 8 7 9 11
19.2.2.5.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.conjugation E2 protein 471 54 9 0 3 8 8 6 15 14 5 11 7 8 4 7 9 7 9 5 11 2 7 8 9 8 10 7 18 18 12 2 7 13 3 6 7 8 7 13 21 7 8 11 5 12 4 7 11 9 17 8 7 6 7 11 9
19.2.4.1 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex 426 54 7 0 6 8 9 6 15 12 6 6 8 7 6 6 5 6 6 7 12 5 9 5 8 7 7 6 12 10 10 5 6 10 6 7 8 6 8 8 12 12 6 14 6 9 5 10 7 6 13 6 6 6 7 6 14
19.2.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation 422 54 4 0 7 10 9 5 12 12 6 8 8 8 8 5 5 6 5 6 12 2 9 6 16 7 9 6 18 12 11 3 8 12 3 9 5 9 6 7 8 12 6 11 7 9 6 9 5 6 10 8 5 6 5 7 8
19.2.2.1.5.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Ariadne) 411 54 8 0 6 13 15 2 23 19 6 8 4 3 10 6 4 3 7 6 14 2 13 4 9 4 17 9 7 7 8 1 10 10 5 8 5 9 7 11 13 6 5 7 5 6 3 12 5 5 8 7 1 3 4 8 10
19.2.3.1.2.7 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU6-12) 409 54 9 0 7 10 7 5 17 14 5 10 6 8 7 7 7 8 7 7 6 3 8 7 7 15 9 6 11 11 12 3 10 8 3 9 4 8 1 7 7 7 6 11 7 8 4 7 7 6 10 6 7 6 7 6 8
19.2.2.1.6.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.ligating E3 protein (RGLG) 380 53 8 0 7 6 5 4 10 11 3 3 6 9 5 6 6 7 5 4 6 1 6 7 7 9 13 5 17 9 11 0 10 8 2 15 13 7 11 4 14 4 5 11 6 4 2 6 3 5 13 9 3 10 6 6 7
19.2.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).ubiquitin-fold protein (SUMO) 377 54 4 0 4 9 9 2 13 14 8 10 3 5 5 4 4 4 12 3 17 8 7 4 9 8 8 8 8 12 9 1 10 7 2 12 3 8 3 12 15 6 9 5 4 6 2 5 8 10 8 11 4 1 6 3 5
19.2.1.2.1.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.cysteine oxidase (PCO) 367 54 6 0 14 5 5 3 14 8 4 8 6 8 5 4 5 4 5 5 10 1 5 4 9 6 4 5 19 8 10 1 12 9 1 11 7 13 9 5 11 4 6 9 4 6 2 5 5 6 7 7 7 8 7 5 10
19.2.2.8.1.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component SKP2 363 52 12 0 7 7 6 6 14 14 5 7 5 8 5 6 6 5 5 4 10 0 8 5 8 7 4 6 15 13 8 0 7 6 6 6 9 4 18 7 9 4 5 8 5 5 3 8 5 4 8 6 4 6 2 5 7
19.2.2.1.6.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex 328 54 4 0 3 9 8 5 10 12 4 8 4 6 5 4 4 4 4 4 9 2 7 4 9 4 3 4 15 12 8 2 6 8 2 4 7 6 10 8 10 7 4 8 4 7 4 6 7 4 9 3 4 4 6 3 10
19.2.2.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-fold protein (UBQ) 313 46 6 0 4 14 9 0 8 11 3 13 2 4 7 9 0 3 8 4 6 1 9 3 0 0 6 8 10 10 6 1 0 8 5 12 0 5 28 0 6 9 6 10 0 3 10 3 6 6 5 6 4 1 3 8 4
19.2.2.5.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.ubiquitin-fold protein (MUB) 301 54 7 0 3 6 6 3 9 12 2 7 4 5 7 5 3 3 4 4 3 1 6 4 4 4 6 5 10 13 11 1 12 10 1 8 7 4 7 3 9 3 5 7 3 5 1 5 5 5 7 5 7 6 5 6 7
19.2.4.4 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome 290 54 7 0 4 7 5 3 8 10 5 5 4 5 4 4 4 4 4 3 10 2 5 3 6 3 5 4 13 9 9 2 14 7 2 3 5 5 4 5 7 8 5 8 4 5 2 5 4 4 8 3 5 6 4 4 6
19.2.2.1.7 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin receptor regulatory protein (DA1) 274 54 2 0 6 7 8 2 13 9 2 7 6 6 3 4 4 4 3 3 4 1 6 4 4 8 6 6 11 3 7 1 8 5 1 5 4 4 3 7 7 9 8 7 3 5 2 5 5 4 6 5 3 5 4 4 5
19.2.2.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation 255 53 6 0 4 6 4 4 8 6 4 5 4 4 4 4 4 5 4 4 8 3 4 4 3 4 6 4 10 6 5 0 9 4 4 5 4 4 3 5 10 4 5 5 4 5 3 4 5 4 7 4 4 4 4 4 4
19.2.1.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway 250 54 6 0 4 8 5 3 15 13 3 5 3 5 3 3 3 3 3 3 8 2 7 3 5 3 3 2 8 6 6 2 4 6 3 3 9 4 5 4 1 7 7 5 4 4 3 4 3 3 6 3 4 1 4 5 5
19.2.1.1.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex 250 54 6 0 4 8 5 3 15 13 3 5 3 5 3 3 3 3 3 3 8 2 7 3 5 3 3 2 8 6 6 2 4 6 3 3 9 4 5 4 1 7 7 5 4 4 3 4 3 3 6 3 4 1 4 5 5
19.2.2.8.3.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex 246 52 4 0 4 5 4 3 6 7 5 1 3 5 4 4 3 3 4 4 10 0 5 4 7 4 5 4 12 5 6 0 5 5 2 4 2 2 3 7 5 11 5 7 4 6 3 5 4 4 5 3 4 6 4 5 4
19.2.3.1.1.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP5|8-11) 246 52 7 0 5 6 5 3 8 6 4 3 4 4 4 4 4 5 4 5 8 1 5 4 5 4 4 4 9 5 7 0 6 5 2 4 4 4 4 3 8 0 5 7 4 3 2 4 1 4 5 5 4 4 4 14 3
19.2.4.3 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing 244 54 4 0 4 4 4 4 6 7 4 4 3 4 4 4 3 4 4 4 8 4 4 4 3 5 4 4 8 4 5 2 5 5 4 4 3 4 7 4 6 5 5 8 3 5 8 3 3 4 4 4 4 4 4 6 6
19.2.4.2.2 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer 236 54 7 0 8 5 5 4 4 4 4 3 3 6 5 4 3 4 4 3 8 2 3 3 4 2 6 5 10 6 6 1 8 3 2 5 5 5 5 3 6 2 4 5 3 2 2 5 3 6 6 5 2 5 2 3 7
19.2.2.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation 235 54 2 0 6 6 4 4 5 6 6 6 3 4 5 5 3 3 3 2 11 3 4 3 6 3 3 4 6 4 5 3 5 5 3 3 5 8 1 4 8 3 4 4 6 4 3 4 5 3 5 4 2 3 3 6 6
19.2.3.1.1.7 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP15-21) 235 51 7 0 6 5 5 3 8 8 4 4 5 6 2 3 3 2 3 1 8 0 4 3 5 4 5 4 12 7 5 0 4 6 1 4 3 4 3 3 7 5 4 7 3 4 2 5 0 4 7 5 3 5 5 4 5
19.2.4.2.1 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.platform ATPase (CDC48) 217 53 5 0 6 3 3 2 6 6 3 5 3 5 5 5 3 3 7 2 6 1 3 3 4 5 4 3 10 4 3 2 3 5 3 4 4 3 0 7 7 6 3 5 3 5 2 3 5 2 4 5 4 4 3 2 5
19.2.4.4.1 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.shuttle protein (RAD23) 215 54 7 0 3 4 4 2 6 7 3 4 3 4 3 3 3 3 3 2 6 1 4 3 5 2 4 3 9 7 7 1 8 6 1 3 4 4 2 4 6 6 4 6 3 4 2 4 3 3 5 2 4 4 3 3 5
19.2.2.8.2.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BT 209 52 3 0 3 5 5 3 9 8 3 5 3 3 3 3 3 3 2 3 6 0 5 3 6 6 4 3 5 7 3 0 3 4 1 3 5 4 2 6 4 3 3 6 3 6 1 5 6 3 5 2 4 3 3 3 6
19.2.3.1.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU3-4) 205 54 5 0 5 2 2 3 2 2 4 3 3 4 4 4 5 4 4 3 8 1 2 3 4 4 4 5 7 5 6 2 5 5 2 5 6 4 4 4 5 5 4 6 4 2 2 2 3 4 2 3 3 3 4 5 3
19.2.2.1.6.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Uev1 201 54 4 0 2 7 5 3 5 7 2 6 2 4 3 2 3 3 2 2 6 1 4 3 5 2 2 2 11 8 4 1 6 4 1 2 5 4 9 5 6 3 2 4 2 3 3 3 3 2 5 2 3 3 3 2 5
19.2.2.8.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.scaffold component CUL1/CUL2 194 53 6 0 4 2 3 1 7 8 2 5 3 2 2 3 2 3 4 2 4 1 2 2 4 13 4 7 6 7 7 1 2 4 1 3 3 3 0 5 5 3 4 4 2 7 1 2 5 3 3 6 2 2 2 3 2
19.2.3.1.1.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP12-13) 187 53 3 0 2 2 2 1 6 6 2 7 2 4 2 2 2 2 3 3 4 1 2 2 4 3 4 2 8 5 5 0 5 4 1 3 2 4 5 4 16 3 3 4 2 5 2 2 2 3 6 3 2 3 3 4 5
19.2.2.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities 179 54 4 0 4 3 2 2 4 4 3 3 2 3 2 3 2 2 4 2 6 2 3 2 6 4 3 4 5 3 2 1 5 3 3 3 3 4 4 3 5 9 3 5 2 4 3 3 3 4 4 3 2 3 2 3 3
19.2.4.2.4 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.membrane protein retrotranslocation factor (DFM1) 177 54 6 0 4 3 3 2 4 5 2 2 2 3 3 4 3 3 3 2 4 2 3 3 4 5 2 3 6 5 5 2 4 5 2 3 5 2 4 2 6 3 3 5 3 2 2 3 1 4 3 3 2 2 4 4 2
19.2.1.2.2 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities 173 54 3 0 2 2 2 2 6 5 2 7 3 3 3 3 3 2 1 4 7 2 2 2 2 4 3 4 4 6 3 2 4 3 2 4 1 3 3 4 3 15 3 4 3 3 2 2 1 3 3 4 1 2 2 2 2
19.2.2.8.1.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EBF 172 52 4 0 3 2 2 2 3 3 2 4 3 4 2 2 4 4 2 2 4 0 2 4 3 4 3 2 7 7 4 0 5 3 1 4 4 2 2 3 5 2 2 4 2 6 2 2 8 2 6 4 3 4 2 2 4
19.2.2.3.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities 168 54 1 0 3 2 3 2 6 6 3 3 2 3 4 3 3 3 1 2 4 3 3 2 2 4 3 3 6 5 4 1 5 3 2 3 2 3 4 4 3 6 3 4 3 4 2 2 2 2 5 4 3 1 3 2 3
19.2.2.8.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component LRB 167 52 6 0 3 3 3 8 5 5 2 7 3 3 2 2 2 2 2 2 4 0 3 2 4 2 3 1 5 5 3 0 3 3 1 1 2 2 9 4 3 2 2 4 2 5 1 3 7 2 2 2 4 3 3 2 3
19.2.4.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component UFD1 161 53 4 0 7 3 3 3 3 3 3 2 2 4 4 3 2 3 3 2 6 1 2 2 3 1 5 4 8 4 4 0 5 2 1 4 3 4 2 2 5 1 3 3 2 1 1 3 2 5 3 4 1 4 1 2 3
19.2.2.8.3.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.regulator component SPA 152 51 1 0 3 4 3 2 5 6 3 1 2 4 2 2 1 1 2 2 6 0 4 2 4 3 3 2 10 3 5 0 4 4 1 3 0 1 2 4 3 2 3 4 3 4 1 4 2 2 4 2 1 5 2 2 3
19.2.2.3.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer 146 54 3 0 2 3 3 2 7 7 2 3 1 2 2 2 3 2 2 2 4 2 3 2 3 3 2 3 4 2 3 2 3 4 2 2 3 2 3 2 3 4 2 4 2 3 2 3 2 2 3 2 2 2 2 3 3
19.2.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer 143 54 4 0 2 3 4 2 5 3 2 4 2 2 2 2 2 2 2 2 4 2 3 2 2 2 2 2 4 4 4 2 4 4 2 2 2 2 2 3 5 3 2 4 2 3 2 3 3 2 2 2 2 2 2 2 3
19.2.2.3.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB conjugation E2 protein (RCE1) 141 54 3 0 1 2 2 1 3 4 1 5 1 1 1 4 2 2 2 2 5 1 2 2 5 2 1 4 2 3 2 1 5 2 1 1 2 3 3 5 8 5 3 4 2 4 2 2 4 2 4 1 1 2 3 3 2
19.2.2.1.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-activating E1 protein (UBA) 138 54 4 0 2 3 2 1 4 4 2 3 2 2 1 2 1 1 2 2 4 1 2 1 4 2 3 2 4 5 3 1 2 3 2 2 1 4 7 3 3 4 2 3 2 2 2 2 2 2 3 4 2 2 2 2 5
19.2.2.8.1.4.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EDL 137 51 3 0 4 3 3 2 3 3 2 3 2 3 1 2 2 2 2 1 2 0 3 2 3 3 3 2 4 4 4 0 3 3 0 2 3 4 2 4 3 1 2 2 2 3 1 3 3 2 5 2 2 3 3 3 5
19.2.2.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO conjugation E2 enzyme (SCE1) 134 54 3 0 2 1 1 1 4 4 1 6 2 1 2 2 1 1 2 2 2 3 1 1 1 2 3 2 4 5 2 3 4 2 1 2 3 3 3 3 2 2 2 4 1 6 1 2 5 2 3 2 3 2 2 2 7
19.2.4.1.2 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc7/13/14 133 52 0 0 1 3 3 2 5 5 2 3 2 2 2 2 1 1 2 2 4 1 3 1 4 2 1 2 4 4 4 1 0 4 1 2 2 2 2 3 4 4 2 4 2 4 1 3 4 2 4 3 1 1 3 1 5
19.2.2.1.6.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Ubc13 127 52 0 0 1 2 3 2 5 5 2 2 2 2 2 2 1 1 2 2 3 1 3 1 4 2 1 2 4 4 4 1 0 4 1 2 2 2 1 3 4 4 2 4 2 4 1 3 4 2 4 1 1 1 3 1 5
19.2.2.8.1.4.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component ADO 125 50 3 0 3 3 3 2 3 3 2 3 2 3 2 2 2 2 2 1 4 0 3 1 3 2 3 1 6 4 2 0 2 2 1 2 3 3 0 2 3 0 2 4 2 2 1 1 1 2 4 2 3 2 3 3 5
19.2.5 .Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD) 124 50 1 0 3 2 3 2 3 4 1 3 2 3 2 3 1 1 0 2 3 0 4 1 2 2 5 2 5 3 2 0 0 2 1 6 4 2 2 2 3 2 3 3 1 2 1 2 2 2 3 5 2 2 2 3 2
19.2.2.1.5.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-C2-class E3 ligase 119 51 3 0 3 3 3 2 5 4 2 2 2 1 2 1 1 1 2 2 3 0 3 1 7 2 2 2 2 2 2 0 0 2 3 2 2 2 2 3 2 4 2 2 1 2 1 3 3 2 4 2 3 2 2 2 1
19.2.2.2.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (SIZ1) 115 53 3 0 2 2 1 1 3 3 2 2 2 2 1 2 1 1 4 1 4 1 2 1 5 3 2 2 4 2 1 0 3 2 1 2 2 3 2 2 3 5 2 4 1 3 1 2 2 2 3 2 1 2 1 2 2
19.2.1.3.1.2 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.catalytic component GID2 113 53 3 0 1 3 3 1 3 3 2 1 2 2 2 2 1 1 2 2 4 1 3 1 2 1 2 2 4 3 4 0 2 3 1 2 1 1 1 2 6 4 2 4 2 1 1 2 1 2 2 2 3 2 1 3 1
19.2.2.8.3.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex 112 54 1 0 2 2 2 1 2 2 2 2 2 2 2 2 1 2 1 1 2 2 2 2 2 1 2 2 6 2 2 2 1 2 2 2 2 2 2 2 3 5 2 2 2 2 2 2 1 2 2 2 2 3 2 2 5
19.2.6.2.1.4 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT4 110 52 3 0 2 3 2 1 3 4 2 1 2 2 1 1 2 1 1 2 6 1 3 1 0 1 2 2 5 3 2 1 2 2 1 2 2 2 2 3 4 3 1 4 2 2 1 2 1 1 3 1 0 3 2 2 2
19.2.3.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (SPF) 108 48 0 0 1 2 2 1 3 3 1 2 3 2 2 1 1 1 1 1 2 0 2 1 2 1 2 2 9 4 4 0 1 4 1 4 0 1 0 2 2 8 2 4 2 2 1 2 0 2 3 4 1 2 1 2 1
19.2.6.2.2.9 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN10 108 54 4 0 2 1 1 1 2 2 1 2 2 2 1 2 2 2 2 2 2 1 1 2 1 1 2 3 4 4 4 1 4 3 1 2 2 2 3 2 3 1 2 3 2 1 1 1 2 2 2 2 2 2 1 2 3
19.2.3.1.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP3-4) 107 54 5 0 2 1 2 1 3 3 2 2 3 2 2 1 1 1 1 1 4 1 2 1 2 1 3 1 4 3 2 1 2 2 1 2 2 3 2 2 2 3 1 2 1 2 2 2 1 1 3 2 2 2 2 1 4
19.2.6.2.2.10 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN11 107 54 3 0 2 1 1 2 2 3 2 1 2 2 1 1 2 1 1 1 2 1 1 1 1 5 2 3 4 3 2 1 2 2 2 2 4 3 3 2 4 3 2 2 1 1 3 1 1 1 2 2 1 2 1 1 5
19.2.6.2.2.4 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN5 106 54 2 0 2 2 2 1 3 3 1 2 2 2 1 1 1 1 1 1 6 1 2 1 1 2 2 2 5 2 2 1 2 2 1 2 5 1 2 2 1 2 3 3 1 2 1 2 2 1 4 2 2 2 1 1 4
19.2.2.8.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.scaffold component CUL3 105 51 3 0 2 2 2 1 2 1 1 2 3 2 1 2 1 2 1 0 2 1 2 1 0 2 2 1 5 3 2 0 3 2 1 9 2 3 1 2 2 2 2 2 1 2 2 1 2 1 2 5 2 2 1 1 3
19.2.3.3.1.7 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN7 104 54 3 0 1 1 1 1 3 3 1 1 1 2 1 2 1 1 2 1 2 1 2 1 1 2 2 2 3 3 3 1 5 3 1 1 2 1 3 2 7 2 2 4 3 1 1 2 1 1 2 1 1 2 2 2 3
19.2.6.1.1.3 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-3 104 51 3 0 3 2 1 2 4 3 2 3 3 2 0 1 2 2 2 1 4 1 2 2 2 1 1 1 4 1 2 1 0 2 1 2 2 3 1 2 3 3 1 2 2 1 1 2 2 2 3 2 2 2 0 3 2
19.2.3.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (ELS) 103 54 2 0 2 4 3 1 4 4 1 2 2 3 1 1 1 1 1 1 2 1 3 1 2 2 2 1 4 3 1 2 2 2 1 2 2 3 1 2 1 2 1 3 1 2 1 3 1 1 3 2 2 2 1 1 3
19.2.6.2.1.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT1 103 53 3 0 2 2 2 2 3 3 2 2 1 2 1 2 1 1 3 1 3 1 2 1 2 2 1 3 4 3 3 1 1 3 1 2 2 2 2 2 0 2 1 4 2 2 1 1 2 2 3 1 2 1 2 2 1
19.2.6.2.2.3 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN3 103 54 4 0 1 2 2 1 3 1 1 2 2 2 2 1 2 2 2 2 2 1 2 2 1 1 2 1 4 2 3 1 2 2 1 2 2 2 1 4 1 4 2 4 2 2 1 2 2 2 1 2 1 2 2 1 2
19.2.2.3.5.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (RBX1) 102 51 0 0 2 1 2 1 3 3 2 2 1 2 3 2 2 2 1 1 4 1 2 1 1 3 2 1 4 3 3 1 3 2 1 2 0 2 4 2 1 3 2 3 2 2 0 1 1 1 3 3 1 1 2 1 3
19.2.2.8.1.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.UBQ-E2-recruiting component RBX1 102 51 0 0 2 1 2 1 3 3 2 2 1 2 3 2 2 2 1 1 4 1 2 1 1 3 2 1 4 3 3 1 3 2 1 2 0 2 4 2 1 3 2 3 2 2 0 1 1 1 3 3 1 1 2 1 3
19.2.6.2.2.7 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN8 102 54 3 0 2 2 2 1 3 3 1 1 2 3 1 1 1 1 1 2 2 1 2 1 2 2 2 2 3 2 3 1 4 4 1 2 2 1 1 1 5 1 2 3 1 1 1 2 1 2 4 2 1 1 2 2 2
19.2.1.1.1.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E3 ubiquitin ligase component Doa10 101 50 5 0 1 4 2 1 10 8 1 2 1 1 1 1 1 1 1 1 2 0 3 1 2 1 1 1 2 2 3 0 2 2 1 1 2 2 3 1 0 5 1 2 2 1 1 1 1 1 2 1 2 0 2 3 2
19.2.6.1.2.3 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-3 101 54 3 0 1 2 2 1 5 4 1 2 1 2 1 1 1 2 3 1 2 1 2 1 1 1 1 1 5 3 1 1 1 1 1 2 2 2 3 2 5 2 2 2 1 1 1 2 1 1 4 1 1 2 1 3 4
19.2.3.1.1.8 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP22) 100 52 3 0 2 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 0 1 2 2 5 2 1 4 4 4 1 0 2 1 2 3 1 1 2 6 1 2 3 2 2 1 1 1 2 2 2 1 2 1 1 1
19.2.6.2.1.6 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT6 98 51 3 0 2 2 2 2 3 3 2 0 2 1 2 1 2 2 2 1 4 1 2 2 2 1 2 1 2 3 3 1 2 2 1 1 2 2 1 2 4 2 2 2 0 2 3 1 0 1 3 2 2 1 2 1 1
19.2.6.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN2 98 53 0 0 1 3 2 1 3 3 1 2 1 1 1 1 1 1 1 1 5 1 3 1 2 1 3 1 2 4 2 1 1 2 1 2 2 2 3 1 3 4 2 2 1 2 1 2 2 2 2 2 1 1 2 1 4
19.2.6.1.1.4 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-4 97 53 0 0 1 2 2 3 3 2 1 1 1 1 1 2 2 2 2 2 3 1 1 2 3 1 2 1 2 3 3 1 2 2 1 2 2 2 1 2 2 4 1 2 1 1 1 2 1 2 2 4 2 1 2 1 3
19.2.6.1.2.7 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-7 97 53 3 0 3 2 1 1 3 3 1 1 2 2 2 1 1 1 2 0 2 1 2 1 2 3 1 3 2 3 2 1 5 2 1 2 1 1 1 2 4 2 3 2 2 1 1 2 1 1 3 1 2 1 1 1 2
19.2.6.2.1.2 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT2 96 54 4 0 2 2 2 1 3 2 1 2 2 2 1 1 2 2 2 2 4 1 2 2 2 1 2 2 4 3 1 1 1 2 1 2 2 2 1 2 1 3 1 2 1 1 1 1 2 2 3 1 1 2 1 1 1
19.2.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation 95 51 4 0 5 2 2 1 1 1 2 1 1 2 1 1 2 2 1 3 3 1 1 2 2 1 2 2 2 3 2 1 2 3 2 1 3 3 1 1 3 1 2 3 2 0 1 1 0 2 2 2 1 1 0 3 1
19.2.2.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation.ubiquitin-fold protein (HUB) 95 51 4 0 5 2 2 1 1 1 2 1 1 2 1 1 2 2 1 3 3 1 1 2 2 1 2 2 2 3 2 1 2 3 2 1 3 3 1 1 3 1 2 3 2 0 1 1 0 2 2 2 1 1 0 3 1
19.2.6.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN1 95 54 4 0 1 2 2 2 4 4 1 2 1 1 2 1 1 1 1 1 2 1 2 1 2 1 1 2 2 2 2 1 2 2 1 1 2 3 1 2 3 2 1 3 1 2 1 2 1 1 2 4 1 1 1 3 2
19.2.2.8.3.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.component COP1 94 51 3 0 1 1 1 1 1 1 2 0 1 1 2 2 2 2 2 2 4 0 1 2 3 1 2 2 2 2 1 0 1 1 1 1 2 1 1 3 2 9 2 3 1 2 2 1 2 2 1 1 3 1 2 3 1
19.2.6.1.2.2 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-2 94 54 2 0 1 5 2 1 2 2 1 2 2 1 1 2 2 1 3 1 2 1 2 2 2 2 1 1 2 2 3 1 2 2 1 2 2 1 3 2 2 2 1 2 1 2 1 2 2 1 3 1 2 1 1 1 2
19.2.6.2.2.8 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN9 92 54 4 0 1 2 2 1 2 2 1 2 1 1 1 1 1 1 1 2 2 1 2 1 3 2 1 1 2 3 2 1 1 2 1 1 2 2 2 4 1 2 1 2 1 2 1 2 2 1 3 2 2 2 2 2 2
19.2.6.1.2.4 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-4 91 53 3 0 2 2 2 2 4 4 1 1 1 1 1 1 2 1 2 1 3 1 2 1 1 2 1 2 2 2 3 1 1 3 1 2 2 1 0 2 2 3 1 2 1 1 1 2 1 1 2 2 2 1 1 2 2
19.2.1.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-II-residues E3 ubiquitin ligase (PRT1) 89 51 2 0 1 1 1 1 2 2 1 5 2 2 2 2 1 1 1 2 2 1 1 1 1 3 2 3 2 3 1 1 2 1 0 3 1 2 1 1 2 5 2 3 2 1 0 1 1 2 2 3 0 1 1 1 1
19.2.3.1.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP1-2) 89 51 3 0 1 2 2 1 3 3 1 2 1 1 1 1 1 1 1 1 2 0 2 1 1 1 3 1 2 1 2 0 3 2 1 1 0 8 4 2 1 3 1 2 1 2 1 2 2 1 2 1 1 1 1 1 3
19.2.6.1.2.5 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-5 89 53 3 0 2 2 2 1 3 3 1 1 1 1 2 1 2 2 1 1 2 1 2 2 2 1 1 0 2 2 2 1 2 2 1 1 2 1 3 2 3 2 1 2 1 2 1 2 2 1 2 2 2 1 1 2 1
19.2.6.2.2.5 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN6 89 52 2 0 3 1 1 1 3 3 2 2 2 2 1 1 1 1 1 1 4 1 1 1 2 1 1 0 4 3 3 1 2 2 1 2 2 2 2 2 1 2 1 4 1 1 1 1 1 1 2 2 1 1 0 1 3
19.2.2.1.5.3.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (DA2) 88 52 1 0 1 2 2 2 4 4 1 1 1 1 1 1 1 1 1 1 2 1 2 1 2 1 1 1 2 3 2 1 2 1 0 1 4 3 2 1 2 3 1 2 1 1 1 3 0 1 3 1 1 1 1 1 6
19.2.6.1.2.6 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-6 88 53 3 0 1 1 1 1 5 3 1 2 2 1 2 2 1 1 1 1 2 1 1 1 1 1 1 0 2 2 2 1 2 2 1 2 1 2 1 1 2 2 1 2 1 1 2 1 2 2 2 2 1 4 2 1 4
19.2.6.2.1.3 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT3 88 53 4 0 1 1 1 1 3 3 1 2 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 2 3 2 2 1 2 2 1 1 2 1 0 2 2 4 1 2 1 2 5 1 3 2 2 2 2 1 1 1 1
19.2.3.3.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN2 87 54 3 0 2 2 1 1 2 2 1 3 1 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 4 2 1 1 4 2 1 1 1 1 2 2 3 3 1 2 1 3 1 1 3 1 2 1 1 2 1 1 2
19.2.6.1.1.2 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-2 85 50 0 0 2 2 2 0 3 3 1 2 2 1 2 1 1 0 1 1 2 1 2 1 2 1 2 1 4 2 2 1 2 1 1 1 1 2 0 2 3 2 2 2 1 2 1 2 2 1 2 1 1 2 1 2 3
19.2.1.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-I-residues E3 ubiquitin ligase (PRT6) 84 51 1 0 1 1 1 1 4 3 1 2 1 1 1 1 2 1 0 2 5 1 1 1 1 1 1 1 2 3 2 1 2 2 2 1 0 1 2 3 1 10 1 1 1 2 2 1 0 1 1 1 1 1 1 1 1
19.2.1.3.1.1 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID1 84 53 1 0 1 2 5 1 4 4 1 1 1 1 1 1 2 1 1 1 2 2 2 1 2 1 2 1 3 2 1 1 3 2 1 1 1 1 1 1 4 3 1 2 1 1 1 2 0 1 1 1 1 1 1 1 2
19.2.6.2.1.5 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT5 84 51 3 0 2 2 2 1 3 3 2 2 1 2 1 2 2 2 1 1 2 1 1 1 1 1 1 1 3 2 2 1 0 2 1 2 0 2 0 2 4 2 1 2 1 1 1 1 1 1 2 2 2 1 2 1 1
19.2.6.2.2.6 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN7 84 54 1 0 1 1 1 2 3 3 1 3 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 4 4 2 1 2 2 1 3 2 2 1 1 3 2 1 2 1 1 1 1 1 1 2 2 1 1 1 2 2
19.2.6.3 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation 84 53 3 0 7 3 2 1 3 3 1 2 1 2 1 2 1 1 1 0 2 1 2 1 1 1 1 2 2 1 1 1 2 1 1 1 3 1 1 1 5 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1
19.2.6.3.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation.regulatory protein (PTRE1) 84 53 3 0 7 3 2 1 3 3 1 2 1 2 1 2 1 1 1 0 2 1 2 1 1 1 1 2 2 1 1 1 2 1 1 1 3 1 1 1 5 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1
19.2.2.1.5.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.bifunctional co-chaperone and E3 ubiquitin ligase (CHIP) 83 53 2 0 1 1 1 2 2 2 1 1 1 2 1 1 2 1 0 1 2 1 1 1 1 1 1 1 5 2 1 1 2 2 2 1 1 2 5 2 3 2 1 1 1 1 1 1 1 1 2 1 2 1 4 1 2
19.2.6.1.1.6 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-6 83 53 2 0 1 2 2 1 4 3 2 1 1 2 1 1 1 1 1 1 2 1 2 1 2 1 1 1 3 3 2 1 0 2 1 3 1 1 1 2 3 2 1 2 1 1 1 2 2 1 2 1 1 2 1 1 1
19.2.1.1.1.2 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc32 82 53 1 0 2 2 1 1 2 2 1 1 1 3 1 1 1 1 1 1 2 1 2 1 3 1 1 1 4 2 2 1 0 2 1 1 6 1 1 1 1 1 5 2 1 1 1 2 1 1 2 1 2 1 1 1 1
19.2.2.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO chain-forming-ligase E4 enzyme (PIAL) 82 51 1 0 1 2 2 1 4 5 1 0 1 1 2 1 1 1 1 2 2 0 2 1 3 1 1 1 2 1 3 0 2 1 1 4 1 1 2 2 1 1 1 1 1 2 1 2 1 1 2 3 1 1 3 1 1
19.2.2.3.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH3) 82 52 0 0 3 2 1 1 2 2 1 2 1 2 3 3 1 1 1 1 2 1 1 1 2 1 1 1 3 2 2 1 1 2 1 1 1 3 0 2 3 1 1 1 1 2 1 1 2 1 1 2 1 1 1 4 2
19.2.2.3.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.deneddylase (DEN1) 82 53 1 0 1 2 1 1 2 2 4 3 1 1 1 1 1 1 1 0 7 1 1 1 3 1 1 3 1 1 2 1 1 2 1 1 1 3 1 1 4 1 2 1 4 1 1 1 1 1 1 1 1 1 1 1 1
19.2.4.1.1 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E3 ubiquitin ligase component HRD1 82 53 2 0 2 2 2 1 2 2 1 0 2 2 1 1 1 1 1 2 2 1 2 1 1 1 2 1 2 2 2 1 1 2 2 2 2 1 1 2 2 1 1 2 1 2 1 2 1 1 2 1 2 2 1 1 3
19.2.6.1.1.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-1 82 53 1 0 1 2 2 1 2 2 1 1 1 2 1 2 2 1 1 0 2 1 1 1 2 1 1 1 2 2 4 1 2 2 1 2 2 2 2 1 1 4 1 3 2 1 1 1 1 1 3 1 1 1 1 1 2
19.2.1.3.1.5 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID8 81 52 2 0 2 2 3 1 1 2 1 2 1 1 1 1 1 1 1 0 2 1 2 1 2 2 2 2 2 4 2 0 1 2 2 1 2 1 1 2 1 3 1 2 1 2 1 1 1 1 2 1 2 1 2 1 1
19.2.2.3.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.small component AXR1/AXL 81 53 1 0 1 2 2 1 5 5 1 2 0 1 1 1 2 1 1 1 2 1 2 1 1 2 1 1 2 1 1 1 3 2 1 1 2 1 3 1 1 2 1 2 1 2 1 2 1 1 2 1 1 1 1 1 2
19.2.6.1.1.5 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-5 81 52 1 0 0 2 2 1 3 3 2 1 1 1 1 2 1 1 1 1 3 1 2 1 2 1 2 1 4 3 2 1 1 1 2 1 1 1 2 2 1 3 1 2 1 2 1 1 2 1 2 1 0 2 1 1 1
19.2.2.8.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.core adaptor component DDB1 80 52 3 0 1 3 2 1 2 2 2 3 2 1 0 1 1 1 1 1 2 1 3 1 1 1 2 1 2 1 3 1 1 1 1 1 2 1 2 3 2 2 1 2 1 1 1 2 0 1 1 2 1 1 1 1 2
19.2.3.1.1.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP6-7) 80 53 3 0 2 2 2 1 3 2 1 1 1 1 1 1 2 1 1 2 2 1 2 1 2 1 1 2 2 1 2 1 2 2 2 1 1 1 3 1 3 1 1 2 1 1 1 2 0 1 2 1 1 1 1 1 2
19.2.3.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (FUG) 80 47 0 0 2 1 1 1 1 1 2 1 1 1 3 1 0 1 2 1 6 0 1 1 9 1 3 2 1 2 2 0 1 2 0 1 1 1 3 1 1 3 1 2 2 2 0 1 3 1 1 0 1 1 1 1 1
19.2.6.2.2.11 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN12 80 53 0 0 1 2 2 1 3 2 1 1 2 1 1 1 1 1 3 1 2 1 1 1 2 6 1 2 2 1 1 1 1 2 1 1 2 1 1 2 1 2 1 2 1 1 1 2 1 1 2 1 1 1 1 2 3
19.2.1.2.1.2 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.arginyl-tRNA-protein transferase (ATE) 79 54 3 0 2 2 2 1 2 2 1 1 1 1 1 1 1 1 1 3 2 1 2 1 1 5 2 1 2 1 1 1 2 1 1 1 1 1 3 3 2 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1
19.2.6.1.2.1 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-1 79 54 2 0 1 1 1 1 3 3 1 2 1 1 1 1 1 1 1 1 2 2 1 1 2 1 2 1 2 2 2 1 1 1 1 1 3 2 2 1 3 1 2 2 1 1 1 1 2 1 2 1 1 1 2 1 2
19.2.4.2.3 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.associated factor (PUX1) 78 50 1 0 0 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 0 1 1 2 2 1 2 2 2 1 0 5 2 1 4 1 1 1 2 7 1 2 2 1 1 1 1 1 1 1 2 0 1 1 3 2
19.2.3.1.1.10 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP24) 77 53 4 0 1 1 1 1 3 3 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 3 1 2 1 2 0 1 2 1 1 1 1 1 1 4 1 1 1 1 2 1 1 3 1 2 1 2 1 1 1 2
19.2.3.1.1.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP14) 77 52 4 0 1 1 1 1 2 3 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2 1 1 1 2 2 1 1 3 1 4 2 3 1 1 2 1 1 1 1 0 1 1 2 0 1 5 1 1
19.2.3.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.peptidase (DeSI) 77 54 1 0 1 1 1 1 2 2 1 1 1 1 1 1 2 2 1 2 2 1 1 2 2 2 1 1 2 2 2 1 3 2 1 1 1 2 2 1 3 2 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2
19.2.6.1.1.7 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-7 77 50 2 0 2 1 1 1 2 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 2 2 1 0 3 1 1 0 2 1 2 3 2 1 2 0 2 1 2 2 2 3 1 1 0 1 1 4
19.2.5.1 .Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).ubiquitin protein ligase (SP1) 76 50 1 0 1 1 2 1 2 3 1 2 1 2 1 2 1 1 0 1 2 0 3 1 1 1 4 1 2 2 1 0 0 1 1 4 2 1 2 1 2 2 2 1 1 1 1 1 1 1 2 3 1 1 1 1 1
19.2.3.1.1.12 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP26) 75 51 2 0 0 2 1 1 2 2 1 1 2 3 1 1 1 1 1 2 2 0 1 1 1 2 1 1 4 1 1 0 1 1 1 2 1 2 1 1 2 1 1 2 1 1 1 1 2 1 1 5 1 2 1 1 2
19.2.4.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component NPL4 75 54 3 0 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 2 1 3 1 1 1 2 1 3 1 1 1 1 2 1 1 1 2 1 1 3 1 1 1 1 1 4
19.2.4.4.2 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.proteasome adaptor protein (DDI1) 75 50 0 0 1 3 1 1 2 3 2 1 1 1 1 1 1 1 1 1 4 1 1 0 1 1 1 1 4 2 2 1 6 1 1 0 1 1 2 1 1 2 1 2 1 1 0 1 1 1 3 1 1 2 1 1 1
19.2.2.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.small component SAE1 74 53 1 0 1 2 3 1 3 1 1 3 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 2 2 2 1 2 2 1 1 1 1 0 2 3 1 1 2 1 2 1 2 2 1 1 1 1 1 1 1 1
19.2.3.3.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN1 74 53 2 0 2 2 1 1 3 2 2 1 2 1 1 1 2 1 1 1 2 1 2 1 1 1 1 0 2 2 1 1 2 1 1 3 1 1 1 2 2 2 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1
19.2.3.3.1.8 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN8 74 50 2 0 1 1 1 1 3 2 1 2 1 1 2 1 1 1 1 1 2 1 1 1 0 1 1 1 3 1 2 1 3 2 1 5 1 1 1 1 0 1 2 2 1 1 1 1 1 3 2 2 0 0 1 1 2
19.2.1.3.1.4 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID5 73 51 3 0 3 1 1 1 2 1 1 1 1 2 1 1 1 1 1 2 2 0 1 1 1 1 1 1 3 1 2 0 2 1 1 1 2 1 4 1 4 2 1 1 1 1 1 1 0 1 1 1 1 2 1 1 2
19.2.2.8.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component NPH3 73 42 1 0 2 0 0 1 2 1 1 2 2 2 1 1 2 2 1 1 2 0 0 2 2 1 2 1 5 2 2 0 0 2 0 2 1 1 2 2 4 0 1 2 1 2 0 0 2 1 0 2 3 2 0 1 1
19.2.4.1.3 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.adaptor protein component HRD3 72 51 2 0 1 2 2 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 2 1 1 2 1 1 2 1 2 1 2 2 1 1 1 1 0 1 2 3 1 2 1 1 1 3 0 1 2 1 0 1 1 2 2
19.2.2.3.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH1|2) 71 51 1 0 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 0 2 1 1 1 3 1 1 1 3 2 0 1 1 1 1 2 1 1 1 2 2 1 3 1 0 1 1 1 3
19.2.2.6.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.ubiquitin-fold protein (UFM) 71 51 1 0 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1 2 0 1 1 0 1 2 1 4 2 2 0 3 1 1 1 1 1 1 2 4 1 1 2 1 2 1 1 2 1 2 1 1 1 1 1 1
19.2.3.3.1.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN3 71 53 1 0 1 1 1 1 2 3 1 3 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2 3 1 1 0 2 1 1 1 1 3 2 2 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 2
19.2.3.3.1.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN5 71 54 2 0 1 2 2 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 2 2 2 1 2 2 1 1 1 1 1 1 1 2 1 2 1 2 1 2 2 1 1 1 2 1 1 1 1
19.2.2.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation 70 51 1 0 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 0 2 1 1 1 2 1 1 1 3 2 0 1 1 1 1 2 1 1 1 2 2 1 3 1 0 1 1 1 3
19.2.2.1.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation.ubiquitin carboxyl-terminal hydrolase (UCH) 70 51 1 0 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 0 2 1 1 1 2 1 1 1 3 2 0 1 1 1 1 2 1 1 1 2 2 1 3 1 0 1 1 1 3
19.2.4.1.5 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.associated plant-specific component EBS7 70 53 1 0 1 1 1 1 4 3 1 1 1 1 1 1 1 1 1 1 2 0 1 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1 3 1 1 2 1 2 1 1 1 1 1 1 3 1 2 1 1 1 2
19.2.6.2.3 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ubiquitin C-terminal hydrolase cofactor 70 51 1 0 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 0 2 1 1 1 2 1 1 1 3 2 0 1 1 1 1 2 1 1 1 2 2 1 3 1 0 1 1 1 3
19.2.2.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.large component SAE2 69 54 3 0 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 2 1 2 2 1 1 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2
19.2.2.8.1.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.adaptor protein exchange factor (CAND1) 69 53 1 0 2 1 1 2 2 2 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1 3 1 2 1 2 1 1 1 2 1 1 1 2 2 1 2 1 1 1 1 0 1 2 1 1 1 1 1 1
19.2.3.1.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.histone deubiquinating protease (OTLD1) 69 50 2 0 1 1 1 1 2 2 1 2 1 1 1 2 1 1 1 0 2 0 1 0 1 1 1 1 2 2 3 0 2 2 1 1 1 1 1 2 2 1 1 2 1 2 1 1 2 1 2 1 1 1 1 1 2
19.2.3.3.1.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN4 69 53 2 0 1 1 1 1 2 2 1 2 0 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 3 2 1 2 2 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 2 1 1 1 3 1 1
19.2.4.1.4 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.substrate recruitment component OS9 69 52 2 0 1 0 1 1 2 1 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 1 2 1 3 2 1 4 1 1 1 1 1 1 2 0 1 1 1 1 2
19.2.4.3.1 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.E4 multiubiquitination enzyme (UFD2) 69 53 2 0 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 0 1 1 1 1 1 1 4 1 2 1 1 3 1 2 1 1 2 1 1 1 1 1 1 1 3
19.2.2.1.5.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (ARA54) 68 51 1 0 1 0 1 2 0 1 1 3 1 1 1 2 1 1 1 2 2 1 2 1 2 1 1 1 1 1 1 1 2 1 1 1 1 6 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 0 1 2 1
19.2.2.1.5.4.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Helicase) 68 48 2 0 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1 1 2 0 1 1 1 1 1 1 2 2 3 0 0 1 1 4 3 1 0 2 1 0 1 2 1 2 0 1 2 1 1 2 1 1 1 1 1
19.2.2.8.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.scaffold component CUL4 68 49 0 0 1 1 1 1 3 2 1 1 0 1 0 1 1 1 1 1 2 1 1 1 1 1 1 1 3 3 2 1 1 2 1 1 1 1 0 1 1 3 1 2 1 2 1 2 0 1 2 1 2 1 1 2 2
19.2.1.1.1.3 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc33/34 67 48 0 0 1 2 2 1 3 3 1 2 1 1 1 1 1 1 1 1 4 1 2 1 0 1 1 0 2 2 1 1 2 2 1 1 1 1 1 2 0 1 1 1 1 2 1 1 1 1 2 1 0 0 1 1 2
19.2.1.3.1.6 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID9 67 53 2 0 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 3 1 1 1 2 1 1 1 2 2 1 0 3 2 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1
19.2.3.1.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU5) 67 51 1 0 1 1 1 2 2 2 2 1 1 0 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 2 1 2 2 1 2 2 1 1 1 1 1 2 1 1 1 3 1 1 1 1 1 1 1 0 2 0
19.2.2.3.5.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (DCN1) 66 48 1 0 1 1 1 1 3 3 1 1 1 1 1 1 1 1 0 1 0 2 1 1 1 1 1 2 2 2 1 0 2 1 1 1 2 1 0 2 2 3 1 1 1 2 2 1 1 1 2 1 2 0 1 1 0
19.2.2.8.3.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.regulator component DET1 66 53 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 2 1 1 1 1 1 1 1 5 1 1 1 1 1 1 1 1 1 2 1 2 3 1 1 1 1 1 1 1 1 1 1 1 2 1 1 4
19.2.4.3.4 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deglycosylating peptide:N-glycanase (PNG1) 66 54 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 3 1 1 2 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 5 1 1 1 1 1 1 1 1 3 1
19.2.2.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).ubiquitin-fold protein (RUB) 65 40 1 0 1 2 2 0 1 3 1 3 0 0 2 2 0 1 1 0 2 1 2 1 0 1 2 2 2 1 2 0 0 2 0 1 0 3 2 0 1 1 1 3 1 1 0 2 1 3 2 0 1 0 1 1 2
19.2.2.3.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.large component ECR1 65 52 2 0 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 2 2 1 2 1 0 2 1 1 1 1 0 1 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1
19.2.2.6.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-conjugation E2 protein 65 52 2 0 1 1 1 1 3 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 2 1 0 3 1 1 1 1 1 1 1 1 1 2 1 1 1 0 1 1 1 3 1 1 1 1 1 1
19.2.3.1.1.9 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP23) 65 49 2 0 2 1 1 1 3 3 1 1 1 1 2 1 1 1 1 1 0 0 1 1 2 1 1 1 2 2 2 0 0 1 1 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1 0
19.2.3.3.1.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN6 65 49 1 0 1 2 2 1 2 3 1 1 1 0 1 1 0 1 1 1 2 1 2 1 2 1 1 1 2 2 2 1 1 2 1 1 2 1 0 1 1 1 1 1 1 1 1 2 1 1 2 1 0 0 1 1 2
19.2.2.2.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (HPY2) 64 52 1 0 2 1 1 1 1 1 1 1 0 1 1 1 1 1 0 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 2 1 2 4 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1
19.2.2.8.2.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BPH1 64 43 0 0 2 2 2 1 2 3 1 0 1 2 1 1 1 1 1 1 0 0 2 1 2 1 0 1 4 1 1 0 0 1 0 2 2 1 0 2 1 0 1 2 1 1 0 2 1 1 2 2 2 2 1 1 1
19.2.1.3.1.3 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.N-recognin component GID4 63 52 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 0 1 1 2 1 1 2 2 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 4
19.2.3.1.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU2) 63 54 1 0 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 1 3 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.3.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (OTS) 63 45 1 0 1 2 2 1 2 2 1 2 1 1 1 1 1 1 0 1 0 0 2 1 1 1 1 0 2 1 2 0 1 2 1 1 1 2 0 1 1 5 1 1 1 2 2 2 0 1 1 1 0 0 1 2 1
19.2.2.6.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-ligase E3 protein 61 53 3 0 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 2 1 1 0 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.8.1.4.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component UFO 61 49 2 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 2 0 1 1 1 1 1 3 2 1 1 0 1 1 0 1 1 1 3 1 3 0 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2
19.2.6.2.2.12 .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN13 60 51 2 0 1 1 1 1 2 1 1 1 1 1 1 1 0 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 2 1 1 4 1 1 1 1 0 1 1 1 0 1 1 1 1
19.2.3.1.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU1) 59 50 0 0 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 0 2 1 1 0 1 2 1 1 1 1 1 1 3 2 1 2 0 1 1 1 1 1 1 1 1 1 1 1 1
19.2.3.1.2.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU7) 59 46 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 11 1 0 1 1 1 1 0 1 1 1 0 1 0 1 0 2 0 1 1 1 0 1 1 1 1 1 0 1 1 1 1
19.2.3.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation 59 51 2 0 3 1 1 1 1 1 1 1 1 1 1 1 1 1 0 2 1 1 1 1 1 1 1 1 2 1 2 0 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0
19.2.3.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation.UFM1-specific protease 59 51 2 0 3 1 1 1 1 1 1 1 1 1 1 1 1 1 0 2 1 1 1 1 1 1 1 1 2 1 2 0 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0
19.2.2.6.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-activating E1 protein 58 51 0 0 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 0 2 1 1 2 1 1 0 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.4.3.2 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.ubiquitin-binding adaptor (UFD3) 58 51 1 0 1 1 1 1 2 3 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 0 1 1 1 0 1 1 2 1 1 1 1 0 1 1 1 1 1 1 1 1
19.2.1.2.1.4 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-asparagine amidase (NTAN) 54 48 1 0 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 0 2 0 1 1 1 2 1 1 1 1 1 0 2 1 1 1 0 1 0 1 3 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.7 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation 54 49 0 0 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 0 0 1 1 1 0 1 1 1 2 1 2 0 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.7.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation.ubiquitin-fold protein (URM) 54 49 0 0 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 0 0 1 1 1 0 1 1 1 2 1 2 0 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.3.1.1.13 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP27) 53 50 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1 2 1 1 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3
19.2.4.3.3 .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deubiquinating protease (OTU1) 51 44 0 0 1 1 1 1 1 1 1 1 0 1 1 1 0 1 1 1 2 1 1 1 0 0 1 0 2 1 1 0 1 2 1 1 1 1 1 1 3 2 1 2 0 1 1 0 0 1 1 1 1 1 1 1 1
19.2.1.2.1.3 .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-glutamine amidase (NTAQ) 50 47 1 0 1 1 1 1 0 1 1 2 0 1 1 1 1 1 0 1 2 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 0 1 1 1 1 1 2 1 1 1 1 1 0 0 1 1 1
19.2.5.2 .Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).protein retrotranslocase (SP2) 48 40 0 0 2 1 1 1 1 1 0 1 1 1 1 1 0 0 0 1 1 0 1 0 1 1 1 1 3 1 1 0 0 1 0 2 2 1 0 1 1 0 1 2 0 1 0 1 1 1 1 2 1 1 1 2 1
19.2.2.8.2.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component FBL 46 43 1 0 1 1 1 0 1 1 1 1 1 1 1 2 0 0 0 1 1 0 1 0 1 0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 2 1 1 0 1 1 1 1 1 2 1 1 0 1 1 1 0
19.2.2.8.3.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.E2 conjugating component COP10 46 45 0 0 1 1 1 0 1 1 1 1 1 1 1 1 0 1 1 0 0 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 0 1 1 2 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1
19.2.3.1.1.11 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP25) 43 36 1 0 0 1 1 1 2 0 0 1 1 0 1 0 1 1 1 1 0 0 1 0 0 1 0 0 2 2 1 0 0 2 0 1 0 1 2 1 0 1 0 2 0 1 1 1 1 1 2 1 1 1 1 1 1