Child MapMan terms
- Original MapMan term
- 19.2
- Description
- .Protein homeostasis.ubiquitin-proteasome system
- Type
- mapman
MapMan | description | genes | species | ach | ahy | aip | aly | ath | atr | bol | bra | bvu | can | car | ccaj | ccan | ccl | cla | cme | col | cpa | cqu | cre | cru | csa | dca | egr | egut | fve | gma | gra | hbr | mco | mdo | mes | mpo | mtr | nnu | osa | pab | pax | pbr | ppa | ppe | ptr | rco | sly | smo | spa | stu | tca | tha | tpr | ugi | vra | vvi | zju | zma |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
19.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation | 21675 | 54 | 461 | 0 | 395 | 467 | 433 | 215 | 675 | 664 | 302 | 453 | 308 | 397 | 314 | 345 | 289 | 285 | 399 | 258 | 596 | 71 | 465 | 282 | 464 | 381 | 495 | 407 | 780 | 560 | 517 | 50 | 392 | 460 | 152 | 699 | 365 | 395 | 433 | 496 | 540 | 296 | 382 | 524 | 300 | 440 | 189 | 377 | 504 | 346 | 465 | 448 | 292 | 324 | 287 | 359 | 482 |
19.2.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation) | 11788 | 54 | 257 | 0 | 180 | 285 | 258 | 116 | 408 | 404 | 159 | 172 | 176 | 232 | 175 | 188 | 172 | 168 | 172 | 151 | 299 | 30 | 290 | 167 | 260 | 207 | 239 | 177 | 437 | 297 | 293 | 23 | 208 | 269 | 81 | 299 | 204 | 230 | 265 | 235 | 289 | 157 | 195 | 290 | 162 | 229 | 112 | 223 | 232 | 180 | 260 | 245 | 166 | 188 | 161 | 213 | 303 |
19.2.2.1.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities | 9964 | 54 | 234 | 0 | 151 | 236 | 217 | 98 | 348 | 341 | 137 | 126 | 152 | 197 | 148 | 156 | 152 | 146 | 146 | 126 | 248 | 17 | 250 | 145 | 228 | 182 | 202 | 149 | 366 | 247 | 249 | 11 | 180 | 225 | 63 | 266 | 171 | 201 | 204 | 202 | 252 | 116 | 162 | 244 | 143 | 195 | 83 | 194 | 195 | 153 | 214 | 213 | 142 | 167 | 133 | 184 | 257 |
19.2.2.8 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes | 7227 | 54 | 154 | 0 | 177 | 128 | 125 | 70 | 185 | 175 | 104 | 217 | 100 | 126 | 99 | 114 | 80 | 81 | 180 | 74 | 222 | 11 | 130 | 78 | 152 | 130 | 206 | 180 | 264 | 186 | 160 | 12 | 115 | 130 | 46 | 349 | 118 | 113 | 127 | 203 | 158 | 89 | 139 | 173 | 102 | 154 | 50 | 111 | 220 | 116 | 139 | 155 | 86 | 103 | 85 | 97 | 129 |
19.2.2.1.5.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities | 7212 | 54 | 170 | 0 | 110 | 162 | 152 | 66 | 266 | 260 | 101 | 57 | 112 | 147 | 102 | 108 | 115 | 114 | 102 | 90 | 177 | 7 | 179 | 110 | 166 | 133 | 142 | 99 | 280 | 185 | 176 | 5 | 127 | 161 | 36 | 195 | 122 | 146 | 143 | 148 | 177 | 77 | 116 | 180 | 107 | 143 | 57 | 146 | 140 | 109 | 165 | 153 | 111 | 129 | 95 | 130 | 206 |
19.2.2.8.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes | 6057 | 54 | 132 | 0 | 156 | 104 | 103 | 50 | 151 | 143 | 85 | 193 | 80 | 104 | 84 | 95 | 65 | 64 | 166 | 59 | 191 | 6 | 106 | 61 | 126 | 111 | 184 | 164 | 216 | 156 | 135 | 8 | 97 | 107 | 36 | 323 | 98 | 95 | 105 | 173 | 131 | 60 | 120 | 144 | 85 | 126 | 38 | 88 | 196 | 98 | 117 | 133 | 62 | 79 | 68 | 78 | 102 |
19.2.2.8.1.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components | 4900 | 54 | 119 | 0 | 135 | 79 | 76 | 44 | 109 | 107 | 73 | 156 | 64 | 93 | 72 | 75 | 54 | 52 | 142 | 44 | 147 | 2 | 74 | 52 | 110 | 81 | 161 | 131 | 190 | 130 | 113 | 4 | 77 | 89 | 31 | 258 | 81 | 63 | 70 | 142 | 105 | 41 | 97 | 121 | 70 | 98 | 33 | 71 | 156 | 81 | 102 | 97 | 56 | 69 | 55 | 66 | 82 |
19.2.2.8.1.4.6 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component FBX | 4114 | 54 | 98 | 0 | 117 | 64 | 62 | 32 | 86 | 84 | 62 | 139 | 51 | 76 | 62 | 64 | 41 | 40 | 131 | 37 | 125 | 2 | 58 | 41 | 93 | 65 | 148 | 118 | 160 | 103 | 96 | 4 | 61 | 75 | 24 | 244 | 63 | 49 | 55 | 126 | 84 | 34 | 85 | 103 | 59 | 82 | 26 | 57 | 139 | 71 | 79 | 83 | 44 | 53 | 45 | 53 | 61 |
19.2.2.1.5.3.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-H2-class E3 ligase | 3693 | 54 | 84 | 0 | 38 | 88 | 87 | 32 | 143 | 145 | 57 | 5 | 57 | 81 | 47 | 56 | 58 | 59 | 51 | 44 | 93 | 1 | 89 | 56 | 88 | 75 | 67 | 52 | 152 | 94 | 90 | 1 | 45 | 87 | 18 | 98 | 57 | 85 | 90 | 70 | 88 | 32 | 56 | 88 | 58 | 73 | 26 | 85 | 74 | 60 | 84 | 76 | 53 | 69 | 41 | 71 | 119 |
19.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation | 3348 | 54 | 84 | 0 | 61 | 64 | 57 | 43 | 99 | 94 | 49 | 66 | 54 | 60 | 54 | 49 | 50 | 50 | 49 | 51 | 88 | 26 | 59 | 46 | 70 | 68 | 65 | 48 | 119 | 85 | 85 | 22 | 76 | 79 | 33 | 66 | 52 | 65 | 61 | 59 | 103 | 64 | 53 | 90 | 50 | 60 | 41 | 57 | 45 | 52 | 75 | 61 | 47 | 53 | 58 | 64 | 69 |
19.2.6 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome | 3105 | 54 | 81 | 0 | 59 | 65 | 57 | 43 | 101 | 93 | 43 | 55 | 50 | 51 | 40 | 43 | 46 | 42 | 52 | 38 | 90 | 35 | 57 | 42 | 54 | 52 | 49 | 47 | 101 | 81 | 74 | 34 | 57 | 67 | 36 | 57 | 66 | 59 | 50 | 64 | 86 | 78 | 48 | 82 | 39 | 48 | 43 | 53 | 51 | 46 | 82 | 56 | 43 | 49 | 43 | 50 | 77 |
19.2.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation | 2252 | 54 | 62 | 0 | 41 | 41 | 37 | 29 | 68 | 62 | 33 | 43 | 37 | 42 | 36 | 34 | 36 | 35 | 35 | 35 | 59 | 15 | 37 | 31 | 43 | 51 | 46 | 33 | 79 | 54 | 58 | 11 | 47 | 50 | 21 | 42 | 36 | 47 | 42 | 39 | 75 | 38 | 36 | 60 | 32 | 39 | 26 | 36 | 28 | 35 | 51 | 42 | 34 | 38 | 41 | 47 | 47 |
19.2.2.1.5.3.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-HC-class E3 ligase | 2086 | 54 | 57 | 0 | 42 | 38 | 32 | 20 | 65 | 61 | 25 | 24 | 33 | 42 | 31 | 30 | 37 | 36 | 31 | 29 | 50 | 4 | 37 | 34 | 41 | 37 | 48 | 28 | 81 | 55 | 51 | 3 | 53 | 47 | 12 | 58 | 42 | 35 | 30 | 50 | 56 | 31 | 38 | 57 | 30 | 39 | 18 | 33 | 38 | 30 | 47 | 47 | 34 | 41 | 29 | 33 | 56 |
19.2.6.2 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle | 1773 | 54 | 50 | 0 | 31 | 34 | 32 | 25 | 52 | 50 | 25 | 31 | 29 | 30 | 22 | 22 | 25 | 24 | 28 | 25 | 56 | 19 | 32 | 23 | 28 | 33 | 29 | 30 | 61 | 48 | 41 | 19 | 34 | 40 | 20 | 32 | 41 | 35 | 28 | 38 | 44 | 43 | 27 | 52 | 22 | 28 | 27 | 28 | 27 | 26 | 46 | 34 | 23 | 27 | 26 | 28 | 43 |
19.2.4 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD) | 1668 | 54 | 37 | 0 | 32 | 31 | 30 | 22 | 44 | 45 | 25 | 26 | 24 | 31 | 28 | 29 | 22 | 25 | 29 | 22 | 50 | 16 | 28 | 22 | 31 | 29 | 29 | 27 | 61 | 40 | 39 | 14 | 45 | 37 | 20 | 30 | 31 | 26 | 29 | 31 | 51 | 37 | 28 | 47 | 23 | 29 | 22 | 30 | 24 | 27 | 39 | 28 | 23 | 28 | 25 | 28 | 42 |
19.2.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways | 1454 | 54 | 31 | 0 | 33 | 29 | 30 | 17 | 52 | 43 | 19 | 31 | 21 | 27 | 21 | 20 | 21 | 18 | 18 | 23 | 46 | 13 | 28 | 18 | 29 | 28 | 23 | 22 | 51 | 36 | 34 | 7 | 37 | 32 | 17 | 28 | 27 | 30 | 31 | 26 | 38 | 43 | 26 | 33 | 21 | 24 | 18 | 23 | 16 | 22 | 27 | 24 | 23 | 21 | 23 | 24 | 31 |
19.2.3.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities | 1433 | 54 | 45 | 0 | 25 | 26 | 25 | 17 | 45 | 41 | 20 | 27 | 25 | 27 | 22 | 19 | 21 | 20 | 21 | 22 | 37 | 6 | 24 | 18 | 29 | 26 | 29 | 20 | 55 | 34 | 35 | 4 | 26 | 32 | 13 | 24 | 22 | 32 | 33 | 24 | 55 | 22 | 22 | 37 | 19 | 26 | 17 | 24 | 15 | 22 | 36 | 30 | 20 | 25 | 28 | 32 | 32 |
19.2.6.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle | 1248 | 54 | 28 | 0 | 21 | 28 | 23 | 17 | 46 | 40 | 17 | 22 | 20 | 19 | 17 | 19 | 20 | 17 | 23 | 13 | 32 | 15 | 23 | 18 | 25 | 18 | 19 | 15 | 38 | 32 | 32 | 14 | 21 | 26 | 15 | 24 | 22 | 23 | 21 | 25 | 37 | 34 | 19 | 29 | 16 | 19 | 15 | 24 | 23 | 18 | 35 | 21 | 19 | 21 | 16 | 21 | 33 |
19.2.6.2.2 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components | 1124 | 54 | 29 | 0 | 18 | 20 | 19 | 15 | 33 | 30 | 14 | 21 | 19 | 19 | 14 | 13 | 14 | 14 | 16 | 16 | 33 | 12 | 19 | 14 | 19 | 25 | 19 | 19 | 38 | 31 | 27 | 12 | 24 | 26 | 13 | 21 | 28 | 22 | 22 | 24 | 28 | 26 | 19 | 34 | 14 | 17 | 14 | 19 | 16 | 16 | 27 | 24 | 14 | 17 | 15 | 19 | 33 |
19.2.2.1.5.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities | 1117 | 54 | 18 | 0 | 18 | 42 | 38 | 12 | 44 | 44 | 13 | 29 | 10 | 13 | 21 | 23 | 11 | 10 | 19 | 15 | 27 | 6 | 43 | 13 | 27 | 20 | 34 | 25 | 24 | 18 | 24 | 2 | 24 | 23 | 9 | 37 | 15 | 26 | 16 | 24 | 34 | 11 | 19 | 20 | 14 | 18 | 9 | 24 | 19 | 16 | 15 | 31 | 8 | 7 | 11 | 25 | 19 |
19.2.2.1.5.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities | 1107 | 54 | 31 | 0 | 13 | 22 | 20 | 14 | 27 | 27 | 16 | 21 | 17 | 26 | 18 | 18 | 18 | 16 | 18 | 14 | 30 | 1 | 20 | 16 | 24 | 19 | 20 | 18 | 42 | 31 | 32 | 1 | 14 | 31 | 12 | 20 | 25 | 21 | 33 | 20 | 29 | 15 | 20 | 31 | 15 | 20 | 11 | 17 | 21 | 21 | 24 | 21 | 14 | 20 | 19 | 22 | 21 |
19.2.2.1.5.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.E3 ubiquitin ligase (PUB) | 1024 | 52 | 29 | 0 | 12 | 21 | 19 | 12 | 25 | 25 | 15 | 20 | 16 | 24 | 17 | 17 | 16 | 15 | 18 | 13 | 28 | 0 | 19 | 15 | 23 | 18 | 19 | 17 | 37 | 29 | 31 | 0 | 12 | 29 | 10 | 19 | 24 | 19 | 28 | 18 | 26 | 13 | 19 | 30 | 14 | 19 | 10 | 16 | 20 | 20 | 22 | 20 | 12 | 19 | 15 | 21 | 19 |
19.2.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation) | 915 | 54 | 16 | 0 | 13 | 18 | 18 | 8 | 30 | 30 | 15 | 23 | 10 | 12 | 13 | 12 | 10 | 10 | 21 | 11 | 31 | 15 | 16 | 10 | 21 | 17 | 17 | 17 | 23 | 25 | 20 | 7 | 25 | 17 | 9 | 23 | 12 | 18 | 14 | 23 | 28 | 21 | 17 | 19 | 10 | 21 | 9 | 15 | 20 | 19 | 19 | 21 | 12 | 9 | 15 | 11 | 19 |
19.2.3.1.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities | 819 | 54 | 17 | 0 | 16 | 15 | 12 | 12 | 23 | 21 | 13 | 16 | 12 | 15 | 14 | 15 | 15 | 15 | 14 | 13 | 22 | 9 | 13 | 13 | 14 | 25 | 17 | 13 | 24 | 20 | 23 | 7 | 21 | 18 | 8 | 18 | 14 | 15 | 9 | 15 | 20 | 16 | 14 | 23 | 13 | 13 | 9 | 12 | 13 | 13 | 15 | 12 | 14 | 13 | 13 | 15 | 15 |
19.2.2.8.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.target protein binding component SKP1/ASK1 | 792 | 54 | 6 | 0 | 13 | 21 | 21 | 2 | 30 | 23 | 7 | 29 | 11 | 6 | 6 | 14 | 5 | 5 | 18 | 11 | 34 | 1 | 27 | 5 | 10 | 13 | 16 | 24 | 13 | 15 | 10 | 1 | 13 | 11 | 2 | 59 | 12 | 26 | 30 | 23 | 18 | 11 | 16 | 14 | 10 | 18 | 3 | 13 | 34 | 12 | 7 | 26 | 2 | 6 | 8 | 7 | 14 |
19.2.2.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation | 772 | 54 | 16 | 0 | 6 | 14 | 14 | 9 | 24 | 26 | 7 | 18 | 11 | 13 | 11 | 12 | 12 | 10 | 13 | 9 | 14 | 3 | 13 | 12 | 13 | 12 | 16 | 12 | 28 | 31 | 23 | 3 | 19 | 23 | 4 | 14 | 14 | 12 | 14 | 16 | 30 | 10 | 13 | 18 | 8 | 17 | 5 | 12 | 16 | 14 | 24 | 13 | 14 | 12 | 12 | 17 | 16 |
19.2.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation) | 755 | 54 | 10 | 0 | 13 | 15 | 14 | 9 | 22 | 26 | 13 | 20 | 7 | 10 | 14 | 16 | 11 | 11 | 9 | 8 | 26 | 10 | 14 | 10 | 16 | 13 | 11 | 16 | 20 | 15 | 16 | 7 | 18 | 16 | 8 | 10 | 12 | 19 | 13 | 15 | 23 | 19 | 13 | 19 | 14 | 16 | 9 | 13 | 14 | 12 | 19 | 11 | 9 | 8 | 12 | 15 | 16 |
19.2.1.2 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway | 723 | 54 | 14 | 0 | 20 | 11 | 11 | 8 | 24 | 17 | 9 | 19 | 11 | 14 | 11 | 10 | 11 | 9 | 8 | 13 | 23 | 5 | 11 | 9 | 14 | 18 | 11 | 12 | 27 | 17 | 16 | 4 | 21 | 15 | 6 | 18 | 10 | 19 | 16 | 14 | 19 | 21 | 12 | 17 | 10 | 12 | 8 | 11 | 9 | 12 | 13 | 14 | 10 | 12 | 12 | 10 | 15 |
19.2.2.1.6 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination | 708 | 54 | 12 | 0 | 10 | 15 | 13 | 9 | 20 | 23 | 7 | 11 | 10 | 15 | 10 | 10 | 10 | 11 | 9 | 8 | 15 | 3 | 13 | 11 | 16 | 13 | 16 | 9 | 32 | 21 | 19 | 2 | 16 | 16 | 4 | 19 | 20 | 13 | 21 | 12 | 24 | 11 | 9 | 19 | 10 | 11 | 6 | 12 | 10 | 9 | 22 | 12 | 7 | 14 | 12 | 9 | 17 |
19.2.4.2 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction | 708 | 54 | 19 | 0 | 18 | 12 | 12 | 9 | 15 | 16 | 10 | 11 | 9 | 15 | 14 | 15 | 10 | 11 | 15 | 8 | 20 | 5 | 10 | 10 | 14 | 14 | 13 | 13 | 28 | 17 | 15 | 5 | 20 | 15 | 8 | 16 | 15 | 11 | 10 | 14 | 26 | 12 | 12 | 17 | 10 | 10 | 7 | 12 | 10 | 13 | 14 | 15 | 8 | 12 | 10 | 12 | 16 |
19.2.2.1.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-conjugating E2 protein (UBC) | 701 | 54 | 6 | 0 | 12 | 14 | 12 | 8 | 24 | 25 | 10 | 14 | 9 | 16 | 10 | 12 | 10 | 9 | 8 | 11 | 26 | 7 | 14 | 9 | 14 | 10 | 18 | 8 | 29 | 19 | 19 | 6 | 10 | 19 | 7 | 9 | 18 | 8 | 13 | 14 | 10 | 11 | 12 | 16 | 9 | 16 | 10 | 11 | 15 | 10 | 20 | 13 | 11 | 8 | 12 | 11 | 19 |
19.2.2.1.5.3.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-v-class E3 ligase | 688 | 53 | 11 | 0 | 18 | 12 | 13 | 5 | 26 | 24 | 10 | 14 | 12 | 16 | 11 | 11 | 10 | 11 | 12 | 8 | 20 | 1 | 13 | 11 | 17 | 12 | 12 | 8 | 33 | 18 | 17 | 0 | 18 | 15 | 1 | 15 | 10 | 14 | 12 | 15 | 15 | 3 | 10 | 17 | 10 | 15 | 8 | 13 | 14 | 10 | 14 | 10 | 13 | 11 | 12 | 12 | 15 |
19.2.2.8.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes | 664 | 53 | 14 | 0 | 13 | 13 | 13 | 14 | 21 | 19 | 9 | 17 | 13 | 13 | 9 | 11 | 9 | 10 | 7 | 8 | 15 | 1 | 13 | 9 | 15 | 12 | 12 | 8 | 25 | 19 | 12 | 0 | 10 | 13 | 4 | 18 | 13 | 12 | 15 | 17 | 16 | 8 | 10 | 16 | 9 | 17 | 5 | 12 | 19 | 10 | 12 | 14 | 15 | 13 | 9 | 9 | 14 |
19.2.6.1.2 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components | 639 | 54 | 19 | 0 | 11 | 15 | 11 | 8 | 25 | 22 | 7 | 11 | 10 | 9 | 10 | 9 | 10 | 9 | 13 | 6 | 15 | 8 | 12 | 9 | 11 | 11 | 8 | 8 | 17 | 16 | 15 | 7 | 14 | 13 | 7 | 12 | 13 | 10 | 13 | 12 | 21 | 14 | 11 | 14 | 8 | 9 | 8 | 12 | 11 | 8 | 18 | 10 | 11 | 11 | 9 | 11 | 17 |
19.2.3.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin | 615 | 54 | 16 | 0 | 10 | 12 | 10 | 8 | 18 | 19 | 9 | 14 | 8 | 9 | 9 | 9 | 8 | 8 | 9 | 8 | 16 | 8 | 12 | 8 | 10 | 9 | 9 | 8 | 20 | 18 | 14 | 8 | 19 | 16 | 8 | 14 | 10 | 8 | 12 | 12 | 18 | 13 | 10 | 18 | 10 | 11 | 8 | 11 | 11 | 10 | 13 | 10 | 7 | 8 | 11 | 9 | 14 |
19.2.3.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex | 615 | 54 | 16 | 0 | 10 | 12 | 10 | 8 | 18 | 19 | 9 | 14 | 8 | 9 | 9 | 9 | 8 | 8 | 9 | 8 | 16 | 8 | 12 | 8 | 10 | 9 | 9 | 8 | 20 | 18 | 14 | 8 | 19 | 16 | 8 | 14 | 10 | 8 | 12 | 12 | 18 | 13 | 10 | 18 | 10 | 11 | 8 | 11 | 11 | 10 | 13 | 10 | 7 | 8 | 11 | 9 | 14 |
19.2.6.1.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components | 609 | 54 | 9 | 0 | 10 | 13 | 12 | 9 | 21 | 18 | 10 | 11 | 10 | 10 | 7 | 10 | 10 | 8 | 10 | 7 | 17 | 7 | 11 | 9 | 14 | 7 | 11 | 7 | 21 | 16 | 17 | 7 | 7 | 13 | 8 | 12 | 9 | 13 | 8 | 13 | 16 | 20 | 8 | 15 | 8 | 10 | 7 | 12 | 12 | 10 | 17 | 11 | 8 | 10 | 7 | 10 | 16 |
19.2.6.2.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components | 579 | 54 | 20 | 0 | 11 | 12 | 11 | 8 | 18 | 18 | 10 | 9 | 9 | 10 | 7 | 8 | 10 | 9 | 11 | 8 | 21 | 6 | 11 | 8 | 8 | 7 | 9 | 11 | 21 | 16 | 13 | 6 | 8 | 13 | 6 | 10 | 10 | 11 | 6 | 13 | 15 | 16 | 7 | 16 | 7 | 10 | 12 | 7 | 9 | 9 | 16 | 9 | 9 | 9 | 10 | 8 | 7 |
19.2.2.1.5.4.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.plant-specific E3 ubiquitin ligase (RSL/RFA) | 570 | 53 | 7 | 0 | 10 | 28 | 20 | 7 | 19 | 22 | 5 | 16 | 4 | 8 | 9 | 14 | 5 | 5 | 10 | 6 | 9 | 3 | 27 | 7 | 15 | 14 | 15 | 14 | 14 | 8 | 12 | 0 | 12 | 11 | 2 | 24 | 6 | 10 | 8 | 10 | 19 | 4 | 12 | 10 | 7 | 9 | 5 | 10 | 11 | 9 | 5 | 19 | 5 | 3 | 5 | 14 | 7 |
19.2.2.8.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components | 559 | 52 | 11 | 0 | 11 | 11 | 11 | 13 | 19 | 18 | 8 | 15 | 10 | 11 | 8 | 9 | 8 | 8 | 6 | 8 | 13 | 0 | 11 | 8 | 15 | 10 | 10 | 7 | 20 | 16 | 10 | 0 | 7 | 11 | 3 | 9 | 11 | 9 | 14 | 15 | 14 | 6 | 8 | 14 | 8 | 15 | 3 | 11 | 17 | 9 | 10 | 9 | 13 | 11 | 8 | 8 | 11 |
19.2.1.2.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification | 550 | 54 | 11 | 0 | 18 | 9 | 9 | 6 | 18 | 12 | 7 | 12 | 8 | 11 | 8 | 7 | 8 | 7 | 7 | 9 | 16 | 3 | 9 | 7 | 12 | 14 | 8 | 8 | 23 | 11 | 13 | 2 | 17 | 12 | 4 | 14 | 9 | 16 | 13 | 10 | 16 | 6 | 9 | 13 | 7 | 9 | 6 | 9 | 8 | 9 | 10 | 10 | 9 | 10 | 10 | 8 | 13 |
19.2.2.1.5.3.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (SINA) | 538 | 52 | 14 | 0 | 8 | 19 | 15 | 5 | 23 | 22 | 6 | 11 | 7 | 6 | 10 | 9 | 8 | 6 | 5 | 6 | 9 | 0 | 35 | 7 | 11 | 6 | 12 | 8 | 10 | 13 | 14 | 0 | 9 | 9 | 2 | 21 | 7 | 7 | 7 | 9 | 14 | 4 | 9 | 14 | 7 | 13 | 3 | 9 | 11 | 6 | 13 | 17 | 7 | 5 | 10 | 11 | 9 |
19.2.2.1.5.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities | 528 | 54 | 15 | 0 | 10 | 10 | 7 | 6 | 11 | 10 | 7 | 19 | 13 | 11 | 7 | 7 | 8 | 6 | 7 | 7 | 14 | 3 | 8 | 6 | 11 | 10 | 6 | 7 | 20 | 13 | 17 | 3 | 15 | 10 | 6 | 14 | 9 | 8 | 12 | 10 | 12 | 13 | 7 | 13 | 7 | 14 | 6 | 7 | 15 | 7 | 10 | 8 | 9 | 11 | 8 | 7 | 11 |
19.2.2.1.5.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities.monomeric E3 ubiquitin ligase (HECT) | 528 | 54 | 15 | 0 | 10 | 10 | 7 | 6 | 11 | 10 | 7 | 19 | 13 | 11 | 7 | 7 | 8 | 6 | 7 | 7 | 14 | 3 | 8 | 6 | 11 | 10 | 6 | 7 | 20 | 13 | 17 | 3 | 15 | 10 | 6 | 14 | 9 | 8 | 12 | 10 | 12 | 13 | 7 | 13 | 7 | 14 | 6 | 7 | 15 | 7 | 10 | 8 | 9 | 11 | 8 | 7 | 11 |
19.2.2.8.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes | 506 | 54 | 8 | 0 | 8 | 11 | 9 | 6 | 13 | 13 | 10 | 7 | 7 | 9 | 6 | 8 | 6 | 7 | 7 | 7 | 16 | 4 | 11 | 8 | 11 | 7 | 10 | 8 | 23 | 11 | 13 | 4 | 8 | 10 | 6 | 8 | 7 | 6 | 7 | 13 | 11 | 21 | 9 | 13 | 8 | 11 | 7 | 11 | 5 | 8 | 10 | 8 | 9 | 11 | 8 | 10 | 13 |
19.2.1.3 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway | 481 | 54 | 11 | 0 | 9 | 10 | 14 | 6 | 13 | 13 | 7 | 7 | 7 | 8 | 7 | 7 | 7 | 6 | 7 | 7 | 15 | 6 | 10 | 6 | 10 | 7 | 9 | 8 | 16 | 13 | 12 | 1 | 12 | 11 | 8 | 7 | 8 | 7 | 10 | 8 | 18 | 15 | 7 | 11 | 7 | 8 | 7 | 8 | 4 | 7 | 8 | 7 | 9 | 8 | 7 | 9 | 11 |
19.2.1.3.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex | 481 | 54 | 11 | 0 | 9 | 10 | 14 | 6 | 13 | 13 | 7 | 7 | 7 | 8 | 7 | 7 | 7 | 6 | 7 | 7 | 15 | 6 | 10 | 6 | 10 | 7 | 9 | 8 | 16 | 13 | 12 | 1 | 12 | 11 | 8 | 7 | 8 | 7 | 10 | 8 | 18 | 15 | 7 | 11 | 7 | 8 | 7 | 8 | 4 | 7 | 8 | 7 | 9 | 8 | 7 | 9 | 11 |
19.2.2.5.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.conjugation E2 protein | 471 | 54 | 9 | 0 | 3 | 8 | 8 | 6 | 15 | 14 | 5 | 11 | 7 | 8 | 4 | 7 | 9 | 7 | 9 | 5 | 11 | 2 | 7 | 8 | 9 | 8 | 10 | 7 | 18 | 18 | 12 | 2 | 7 | 13 | 3 | 6 | 7 | 8 | 7 | 13 | 21 | 7 | 8 | 11 | 5 | 12 | 4 | 7 | 11 | 9 | 17 | 8 | 7 | 6 | 7 | 11 | 9 |
19.2.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex | 426 | 54 | 7 | 0 | 6 | 8 | 9 | 6 | 15 | 12 | 6 | 6 | 8 | 7 | 6 | 6 | 5 | 6 | 6 | 7 | 12 | 5 | 9 | 5 | 8 | 7 | 7 | 6 | 12 | 10 | 10 | 5 | 6 | 10 | 6 | 7 | 8 | 6 | 8 | 8 | 12 | 12 | 6 | 14 | 6 | 9 | 5 | 10 | 7 | 6 | 13 | 6 | 6 | 6 | 7 | 6 | 14 |
19.2.3.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation | 422 | 54 | 4 | 0 | 7 | 10 | 9 | 5 | 12 | 12 | 6 | 8 | 8 | 8 | 8 | 5 | 5 | 6 | 5 | 6 | 12 | 2 | 9 | 6 | 16 | 7 | 9 | 6 | 18 | 12 | 11 | 3 | 8 | 12 | 3 | 9 | 5 | 9 | 6 | 7 | 8 | 12 | 6 | 11 | 7 | 9 | 6 | 9 | 5 | 6 | 10 | 8 | 5 | 6 | 5 | 7 | 8 |
19.2.2.1.5.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Ariadne) | 411 | 54 | 8 | 0 | 6 | 13 | 15 | 2 | 23 | 19 | 6 | 8 | 4 | 3 | 10 | 6 | 4 | 3 | 7 | 6 | 14 | 2 | 13 | 4 | 9 | 4 | 17 | 9 | 7 | 7 | 8 | 1 | 10 | 10 | 5 | 8 | 5 | 9 | 7 | 11 | 13 | 6 | 5 | 7 | 5 | 6 | 3 | 12 | 5 | 5 | 8 | 7 | 1 | 3 | 4 | 8 | 10 |
19.2.3.1.2.7 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU6-12) | 409 | 54 | 9 | 0 | 7 | 10 | 7 | 5 | 17 | 14 | 5 | 10 | 6 | 8 | 7 | 7 | 7 | 8 | 7 | 7 | 6 | 3 | 8 | 7 | 7 | 15 | 9 | 6 | 11 | 11 | 12 | 3 | 10 | 8 | 3 | 9 | 4 | 8 | 1 | 7 | 7 | 7 | 6 | 11 | 7 | 8 | 4 | 7 | 7 | 6 | 10 | 6 | 7 | 6 | 7 | 6 | 8 |
19.2.2.1.6.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.ligating E3 protein (RGLG) | 380 | 53 | 8 | 0 | 7 | 6 | 5 | 4 | 10 | 11 | 3 | 3 | 6 | 9 | 5 | 6 | 6 | 7 | 5 | 4 | 6 | 1 | 6 | 7 | 7 | 9 | 13 | 5 | 17 | 9 | 11 | 0 | 10 | 8 | 2 | 15 | 13 | 7 | 11 | 4 | 14 | 4 | 5 | 11 | 6 | 4 | 2 | 6 | 3 | 5 | 13 | 9 | 3 | 10 | 6 | 6 | 7 |
19.2.2.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).ubiquitin-fold protein (SUMO) | 377 | 54 | 4 | 0 | 4 | 9 | 9 | 2 | 13 | 14 | 8 | 10 | 3 | 5 | 5 | 4 | 4 | 4 | 12 | 3 | 17 | 8 | 7 | 4 | 9 | 8 | 8 | 8 | 8 | 12 | 9 | 1 | 10 | 7 | 2 | 12 | 3 | 8 | 3 | 12 | 15 | 6 | 9 | 5 | 4 | 6 | 2 | 5 | 8 | 10 | 8 | 11 | 4 | 1 | 6 | 3 | 5 |
19.2.1.2.1.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.cysteine oxidase (PCO) | 367 | 54 | 6 | 0 | 14 | 5 | 5 | 3 | 14 | 8 | 4 | 8 | 6 | 8 | 5 | 4 | 5 | 4 | 5 | 5 | 10 | 1 | 5 | 4 | 9 | 6 | 4 | 5 | 19 | 8 | 10 | 1 | 12 | 9 | 1 | 11 | 7 | 13 | 9 | 5 | 11 | 4 | 6 | 9 | 4 | 6 | 2 | 5 | 5 | 6 | 7 | 7 | 7 | 8 | 7 | 5 | 10 |
19.2.2.8.1.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component SKP2 | 363 | 52 | 12 | 0 | 7 | 7 | 6 | 6 | 14 | 14 | 5 | 7 | 5 | 8 | 5 | 6 | 6 | 5 | 5 | 4 | 10 | 0 | 8 | 5 | 8 | 7 | 4 | 6 | 15 | 13 | 8 | 0 | 7 | 6 | 6 | 6 | 9 | 4 | 18 | 7 | 9 | 4 | 5 | 8 | 5 | 5 | 3 | 8 | 5 | 4 | 8 | 6 | 4 | 6 | 2 | 5 | 7 |
19.2.2.1.6.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex | 328 | 54 | 4 | 0 | 3 | 9 | 8 | 5 | 10 | 12 | 4 | 8 | 4 | 6 | 5 | 4 | 4 | 4 | 4 | 4 | 9 | 2 | 7 | 4 | 9 | 4 | 3 | 4 | 15 | 12 | 8 | 2 | 6 | 8 | 2 | 4 | 7 | 6 | 10 | 8 | 10 | 7 | 4 | 8 | 4 | 7 | 4 | 6 | 7 | 4 | 9 | 3 | 4 | 4 | 6 | 3 | 10 |
19.2.2.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-fold protein (UBQ) | 313 | 46 | 6 | 0 | 4 | 14 | 9 | 0 | 8 | 11 | 3 | 13 | 2 | 4 | 7 | 9 | 0 | 3 | 8 | 4 | 6 | 1 | 9 | 3 | 0 | 0 | 6 | 8 | 10 | 10 | 6 | 1 | 0 | 8 | 5 | 12 | 0 | 5 | 28 | 0 | 6 | 9 | 6 | 10 | 0 | 3 | 10 | 3 | 6 | 6 | 5 | 6 | 4 | 1 | 3 | 8 | 4 |
19.2.2.5.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.ubiquitin-fold protein (MUB) | 301 | 54 | 7 | 0 | 3 | 6 | 6 | 3 | 9 | 12 | 2 | 7 | 4 | 5 | 7 | 5 | 3 | 3 | 4 | 4 | 3 | 1 | 6 | 4 | 4 | 4 | 6 | 5 | 10 | 13 | 11 | 1 | 12 | 10 | 1 | 8 | 7 | 4 | 7 | 3 | 9 | 3 | 5 | 7 | 3 | 5 | 1 | 5 | 5 | 5 | 7 | 5 | 7 | 6 | 5 | 6 | 7 |
19.2.4.4 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome | 290 | 54 | 7 | 0 | 4 | 7 | 5 | 3 | 8 | 10 | 5 | 5 | 4 | 5 | 4 | 4 | 4 | 4 | 4 | 3 | 10 | 2 | 5 | 3 | 6 | 3 | 5 | 4 | 13 | 9 | 9 | 2 | 14 | 7 | 2 | 3 | 5 | 5 | 4 | 5 | 7 | 8 | 5 | 8 | 4 | 5 | 2 | 5 | 4 | 4 | 8 | 3 | 5 | 6 | 4 | 4 | 6 |
19.2.2.1.7 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin receptor regulatory protein (DA1) | 274 | 54 | 2 | 0 | 6 | 7 | 8 | 2 | 13 | 9 | 2 | 7 | 6 | 6 | 3 | 4 | 4 | 4 | 3 | 3 | 4 | 1 | 6 | 4 | 4 | 8 | 6 | 6 | 11 | 3 | 7 | 1 | 8 | 5 | 1 | 5 | 4 | 4 | 3 | 7 | 7 | 9 | 8 | 7 | 3 | 5 | 2 | 5 | 5 | 4 | 6 | 5 | 3 | 5 | 4 | 4 | 5 |
19.2.2.6 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation | 255 | 53 | 6 | 0 | 4 | 6 | 4 | 4 | 8 | 6 | 4 | 5 | 4 | 4 | 4 | 4 | 4 | 5 | 4 | 4 | 8 | 3 | 4 | 4 | 3 | 4 | 6 | 4 | 10 | 6 | 5 | 0 | 9 | 4 | 4 | 5 | 4 | 4 | 3 | 5 | 10 | 4 | 5 | 5 | 4 | 5 | 3 | 4 | 5 | 4 | 7 | 4 | 4 | 4 | 4 | 4 | 4 |
19.2.1.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway | 250 | 54 | 6 | 0 | 4 | 8 | 5 | 3 | 15 | 13 | 3 | 5 | 3 | 5 | 3 | 3 | 3 | 3 | 3 | 3 | 8 | 2 | 7 | 3 | 5 | 3 | 3 | 2 | 8 | 6 | 6 | 2 | 4 | 6 | 3 | 3 | 9 | 4 | 5 | 4 | 1 | 7 | 7 | 5 | 4 | 4 | 3 | 4 | 3 | 3 | 6 | 3 | 4 | 1 | 4 | 5 | 5 |
19.2.1.1.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex | 250 | 54 | 6 | 0 | 4 | 8 | 5 | 3 | 15 | 13 | 3 | 5 | 3 | 5 | 3 | 3 | 3 | 3 | 3 | 3 | 8 | 2 | 7 | 3 | 5 | 3 | 3 | 2 | 8 | 6 | 6 | 2 | 4 | 6 | 3 | 3 | 9 | 4 | 5 | 4 | 1 | 7 | 7 | 5 | 4 | 4 | 3 | 4 | 3 | 3 | 6 | 3 | 4 | 1 | 4 | 5 | 5 |
19.2.2.8.3.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex | 246 | 52 | 4 | 0 | 4 | 5 | 4 | 3 | 6 | 7 | 5 | 1 | 3 | 5 | 4 | 4 | 3 | 3 | 4 | 4 | 10 | 0 | 5 | 4 | 7 | 4 | 5 | 4 | 12 | 5 | 6 | 0 | 5 | 5 | 2 | 4 | 2 | 2 | 3 | 7 | 5 | 11 | 5 | 7 | 4 | 6 | 3 | 5 | 4 | 4 | 5 | 3 | 4 | 6 | 4 | 5 | 4 |
19.2.3.1.1.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP5|8-11) | 246 | 52 | 7 | 0 | 5 | 6 | 5 | 3 | 8 | 6 | 4 | 3 | 4 | 4 | 4 | 4 | 4 | 5 | 4 | 5 | 8 | 1 | 5 | 4 | 5 | 4 | 4 | 4 | 9 | 5 | 7 | 0 | 6 | 5 | 2 | 4 | 4 | 4 | 4 | 3 | 8 | 0 | 5 | 7 | 4 | 3 | 2 | 4 | 1 | 4 | 5 | 5 | 4 | 4 | 4 | 14 | 3 |
19.2.4.3 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing | 244 | 54 | 4 | 0 | 4 | 4 | 4 | 4 | 6 | 7 | 4 | 4 | 3 | 4 | 4 | 4 | 3 | 4 | 4 | 4 | 8 | 4 | 4 | 4 | 3 | 5 | 4 | 4 | 8 | 4 | 5 | 2 | 5 | 5 | 4 | 4 | 3 | 4 | 7 | 4 | 6 | 5 | 5 | 8 | 3 | 5 | 8 | 3 | 3 | 4 | 4 | 4 | 4 | 4 | 4 | 6 | 6 |
19.2.4.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer | 236 | 54 | 7 | 0 | 8 | 5 | 5 | 4 | 4 | 4 | 4 | 3 | 3 | 6 | 5 | 4 | 3 | 4 | 4 | 3 | 8 | 2 | 3 | 3 | 4 | 2 | 6 | 5 | 10 | 6 | 6 | 1 | 8 | 3 | 2 | 5 | 5 | 5 | 5 | 3 | 6 | 2 | 4 | 5 | 3 | 2 | 2 | 5 | 3 | 6 | 6 | 5 | 2 | 5 | 2 | 3 | 7 |
19.2.2.3.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation | 235 | 54 | 2 | 0 | 6 | 6 | 4 | 4 | 5 | 6 | 6 | 6 | 3 | 4 | 5 | 5 | 3 | 3 | 3 | 2 | 11 | 3 | 4 | 3 | 6 | 3 | 3 | 4 | 6 | 4 | 5 | 3 | 5 | 5 | 3 | 3 | 5 | 8 | 1 | 4 | 8 | 3 | 4 | 4 | 6 | 4 | 3 | 4 | 5 | 3 | 5 | 4 | 2 | 3 | 3 | 6 | 6 |
19.2.3.1.1.7 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP15-21) | 235 | 51 | 7 | 0 | 6 | 5 | 5 | 3 | 8 | 8 | 4 | 4 | 5 | 6 | 2 | 3 | 3 | 2 | 3 | 1 | 8 | 0 | 4 | 3 | 5 | 4 | 5 | 4 | 12 | 7 | 5 | 0 | 4 | 6 | 1 | 4 | 3 | 4 | 3 | 3 | 7 | 5 | 4 | 7 | 3 | 4 | 2 | 5 | 0 | 4 | 7 | 5 | 3 | 5 | 5 | 4 | 5 |
19.2.4.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.platform ATPase (CDC48) | 217 | 53 | 5 | 0 | 6 | 3 | 3 | 2 | 6 | 6 | 3 | 5 | 3 | 5 | 5 | 5 | 3 | 3 | 7 | 2 | 6 | 1 | 3 | 3 | 4 | 5 | 4 | 3 | 10 | 4 | 3 | 2 | 3 | 5 | 3 | 4 | 4 | 3 | 0 | 7 | 7 | 6 | 3 | 5 | 3 | 5 | 2 | 3 | 5 | 2 | 4 | 5 | 4 | 4 | 3 | 2 | 5 |
19.2.4.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.shuttle protein (RAD23) | 215 | 54 | 7 | 0 | 3 | 4 | 4 | 2 | 6 | 7 | 3 | 4 | 3 | 4 | 3 | 3 | 3 | 3 | 3 | 2 | 6 | 1 | 4 | 3 | 5 | 2 | 4 | 3 | 9 | 7 | 7 | 1 | 8 | 6 | 1 | 3 | 4 | 4 | 2 | 4 | 6 | 6 | 4 | 6 | 3 | 4 | 2 | 4 | 3 | 3 | 5 | 2 | 4 | 4 | 3 | 3 | 5 |
19.2.2.8.2.2.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BT | 209 | 52 | 3 | 0 | 3 | 5 | 5 | 3 | 9 | 8 | 3 | 5 | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 3 | 6 | 0 | 5 | 3 | 6 | 6 | 4 | 3 | 5 | 7 | 3 | 0 | 3 | 4 | 1 | 3 | 5 | 4 | 2 | 6 | 4 | 3 | 3 | 6 | 3 | 6 | 1 | 5 | 6 | 3 | 5 | 2 | 4 | 3 | 3 | 3 | 6 |
19.2.3.1.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU3-4) | 205 | 54 | 5 | 0 | 5 | 2 | 2 | 3 | 2 | 2 | 4 | 3 | 3 | 4 | 4 | 4 | 5 | 4 | 4 | 3 | 8 | 1 | 2 | 3 | 4 | 4 | 4 | 5 | 7 | 5 | 6 | 2 | 5 | 5 | 2 | 5 | 6 | 4 | 4 | 4 | 5 | 5 | 4 | 6 | 4 | 2 | 2 | 2 | 3 | 4 | 2 | 3 | 3 | 3 | 4 | 5 | 3 |
19.2.2.1.6.1.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Uev1 | 201 | 54 | 4 | 0 | 2 | 7 | 5 | 3 | 5 | 7 | 2 | 6 | 2 | 4 | 3 | 2 | 3 | 3 | 2 | 2 | 6 | 1 | 4 | 3 | 5 | 2 | 2 | 2 | 11 | 8 | 4 | 1 | 6 | 4 | 1 | 2 | 5 | 4 | 9 | 5 | 6 | 3 | 2 | 4 | 2 | 3 | 3 | 3 | 3 | 2 | 5 | 2 | 3 | 3 | 3 | 2 | 5 |
19.2.2.8.1.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.scaffold component CUL1/CUL2 | 194 | 53 | 6 | 0 | 4 | 2 | 3 | 1 | 7 | 8 | 2 | 5 | 3 | 2 | 2 | 3 | 2 | 3 | 4 | 2 | 4 | 1 | 2 | 2 | 4 | 13 | 4 | 7 | 6 | 7 | 7 | 1 | 2 | 4 | 1 | 3 | 3 | 3 | 0 | 5 | 5 | 3 | 4 | 4 | 2 | 7 | 1 | 2 | 5 | 3 | 3 | 6 | 2 | 2 | 2 | 3 | 2 |
19.2.3.1.1.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP12-13) | 187 | 53 | 3 | 0 | 2 | 2 | 2 | 1 | 6 | 6 | 2 | 7 | 2 | 4 | 2 | 2 | 2 | 2 | 3 | 3 | 4 | 1 | 2 | 2 | 4 | 3 | 4 | 2 | 8 | 5 | 5 | 0 | 5 | 4 | 1 | 3 | 2 | 4 | 5 | 4 | 16 | 3 | 3 | 4 | 2 | 5 | 2 | 2 | 2 | 3 | 6 | 3 | 2 | 3 | 3 | 4 | 5 |
19.2.2.2.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities | 179 | 54 | 4 | 0 | 4 | 3 | 2 | 2 | 4 | 4 | 3 | 3 | 2 | 3 | 2 | 3 | 2 | 2 | 4 | 2 | 6 | 2 | 3 | 2 | 6 | 4 | 3 | 4 | 5 | 3 | 2 | 1 | 5 | 3 | 3 | 3 | 3 | 4 | 4 | 3 | 5 | 9 | 3 | 5 | 2 | 4 | 3 | 3 | 3 | 4 | 4 | 3 | 2 | 3 | 2 | 3 | 3 |
19.2.4.2.4 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.membrane protein retrotranslocation factor (DFM1) | 177 | 54 | 6 | 0 | 4 | 3 | 3 | 2 | 4 | 5 | 2 | 2 | 2 | 3 | 3 | 4 | 3 | 3 | 3 | 2 | 4 | 2 | 3 | 3 | 4 | 5 | 2 | 3 | 6 | 5 | 5 | 2 | 4 | 5 | 2 | 3 | 5 | 2 | 4 | 2 | 6 | 3 | 3 | 5 | 3 | 2 | 2 | 3 | 1 | 4 | 3 | 3 | 2 | 2 | 4 | 4 | 2 |
19.2.1.2.2 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities | 173 | 54 | 3 | 0 | 2 | 2 | 2 | 2 | 6 | 5 | 2 | 7 | 3 | 3 | 3 | 3 | 3 | 2 | 1 | 4 | 7 | 2 | 2 | 2 | 2 | 4 | 3 | 4 | 4 | 6 | 3 | 2 | 4 | 3 | 2 | 4 | 1 | 3 | 3 | 4 | 3 | 15 | 3 | 4 | 3 | 3 | 2 | 2 | 1 | 3 | 3 | 4 | 1 | 2 | 2 | 2 | 2 |
19.2.2.8.1.4.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EBF | 172 | 52 | 4 | 0 | 3 | 2 | 2 | 2 | 3 | 3 | 2 | 4 | 3 | 4 | 2 | 2 | 4 | 4 | 2 | 2 | 4 | 0 | 2 | 4 | 3 | 4 | 3 | 2 | 7 | 7 | 4 | 0 | 5 | 3 | 1 | 4 | 4 | 2 | 2 | 3 | 5 | 2 | 2 | 4 | 2 | 6 | 2 | 2 | 8 | 2 | 6 | 4 | 3 | 4 | 2 | 2 | 4 |
19.2.2.3.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities | 168 | 54 | 1 | 0 | 3 | 2 | 3 | 2 | 6 | 6 | 3 | 3 | 2 | 3 | 4 | 3 | 3 | 3 | 1 | 2 | 4 | 3 | 3 | 2 | 2 | 4 | 3 | 3 | 6 | 5 | 4 | 1 | 5 | 3 | 2 | 3 | 2 | 3 | 4 | 4 | 3 | 6 | 3 | 4 | 3 | 4 | 2 | 2 | 2 | 2 | 5 | 4 | 3 | 1 | 3 | 2 | 3 |
19.2.2.8.2.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component LRB | 167 | 52 | 6 | 0 | 3 | 3 | 3 | 8 | 5 | 5 | 2 | 7 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 4 | 0 | 3 | 2 | 4 | 2 | 3 | 1 | 5 | 5 | 3 | 0 | 3 | 3 | 1 | 1 | 2 | 2 | 9 | 4 | 3 | 2 | 2 | 4 | 2 | 5 | 1 | 3 | 7 | 2 | 2 | 2 | 4 | 3 | 3 | 2 | 3 |
19.2.4.2.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component UFD1 | 161 | 53 | 4 | 0 | 7 | 3 | 3 | 3 | 3 | 3 | 3 | 2 | 2 | 4 | 4 | 3 | 2 | 3 | 3 | 2 | 6 | 1 | 2 | 2 | 3 | 1 | 5 | 4 | 8 | 4 | 4 | 0 | 5 | 2 | 1 | 4 | 3 | 4 | 2 | 2 | 5 | 1 | 3 | 3 | 2 | 1 | 1 | 3 | 2 | 5 | 3 | 4 | 1 | 4 | 1 | 2 | 3 |
19.2.2.8.3.4.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.regulator component SPA | 152 | 51 | 1 | 0 | 3 | 4 | 3 | 2 | 5 | 6 | 3 | 1 | 2 | 4 | 2 | 2 | 1 | 1 | 2 | 2 | 6 | 0 | 4 | 2 | 4 | 3 | 3 | 2 | 10 | 3 | 5 | 0 | 4 | 4 | 1 | 3 | 0 | 1 | 2 | 4 | 3 | 2 | 3 | 4 | 3 | 4 | 1 | 4 | 2 | 2 | 4 | 2 | 1 | 5 | 2 | 2 | 3 |
19.2.2.3.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer | 146 | 54 | 3 | 0 | 2 | 3 | 3 | 2 | 7 | 7 | 2 | 3 | 1 | 2 | 2 | 2 | 3 | 2 | 2 | 2 | 4 | 2 | 3 | 2 | 3 | 3 | 2 | 3 | 4 | 2 | 3 | 2 | 3 | 4 | 2 | 2 | 3 | 2 | 3 | 2 | 3 | 4 | 2 | 4 | 2 | 3 | 2 | 3 | 2 | 2 | 3 | 2 | 2 | 2 | 2 | 3 | 3 |
19.2.2.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer | 143 | 54 | 4 | 0 | 2 | 3 | 4 | 2 | 5 | 3 | 2 | 4 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 4 | 2 | 3 | 2 | 2 | 2 | 2 | 2 | 4 | 4 | 4 | 2 | 4 | 4 | 2 | 2 | 2 | 2 | 2 | 3 | 5 | 3 | 2 | 4 | 2 | 3 | 2 | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 |
19.2.2.3.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB conjugation E2 protein (RCE1) | 141 | 54 | 3 | 0 | 1 | 2 | 2 | 1 | 3 | 4 | 1 | 5 | 1 | 1 | 1 | 4 | 2 | 2 | 2 | 2 | 5 | 1 | 2 | 2 | 5 | 2 | 1 | 4 | 2 | 3 | 2 | 1 | 5 | 2 | 1 | 1 | 2 | 3 | 3 | 5 | 8 | 5 | 3 | 4 | 2 | 4 | 2 | 2 | 4 | 2 | 4 | 1 | 1 | 2 | 3 | 3 | 2 |
19.2.2.1.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-activating E1 protein (UBA) | 138 | 54 | 4 | 0 | 2 | 3 | 2 | 1 | 4 | 4 | 2 | 3 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 2 | 4 | 1 | 2 | 1 | 4 | 2 | 3 | 2 | 4 | 5 | 3 | 1 | 2 | 3 | 2 | 2 | 1 | 4 | 7 | 3 | 3 | 4 | 2 | 3 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 4 | 2 | 2 | 2 | 2 | 5 |
19.2.2.8.1.4.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EDL | 137 | 51 | 3 | 0 | 4 | 3 | 3 | 2 | 3 | 3 | 2 | 3 | 2 | 3 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 0 | 3 | 2 | 3 | 3 | 3 | 2 | 4 | 4 | 4 | 0 | 3 | 3 | 0 | 2 | 3 | 4 | 2 | 4 | 3 | 1 | 2 | 2 | 2 | 3 | 1 | 3 | 3 | 2 | 5 | 2 | 2 | 3 | 3 | 3 | 5 |
19.2.2.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO conjugation E2 enzyme (SCE1) | 134 | 54 | 3 | 0 | 2 | 1 | 1 | 1 | 4 | 4 | 1 | 6 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 3 | 1 | 1 | 1 | 2 | 3 | 2 | 4 | 5 | 2 | 3 | 4 | 2 | 1 | 2 | 3 | 3 | 3 | 3 | 2 | 2 | 2 | 4 | 1 | 6 | 1 | 2 | 5 | 2 | 3 | 2 | 3 | 2 | 2 | 2 | 7 |
19.2.4.1.2 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc7/13/14 | 133 | 52 | 0 | 0 | 1 | 3 | 3 | 2 | 5 | 5 | 2 | 3 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 4 | 1 | 3 | 1 | 4 | 2 | 1 | 2 | 4 | 4 | 4 | 1 | 0 | 4 | 1 | 2 | 2 | 2 | 2 | 3 | 4 | 4 | 2 | 4 | 2 | 4 | 1 | 3 | 4 | 2 | 4 | 3 | 1 | 1 | 3 | 1 | 5 |
19.2.2.1.6.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Ubc13 | 127 | 52 | 0 | 0 | 1 | 2 | 3 | 2 | 5 | 5 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 3 | 1 | 3 | 1 | 4 | 2 | 1 | 2 | 4 | 4 | 4 | 1 | 0 | 4 | 1 | 2 | 2 | 2 | 1 | 3 | 4 | 4 | 2 | 4 | 2 | 4 | 1 | 3 | 4 | 2 | 4 | 1 | 1 | 1 | 3 | 1 | 5 |
19.2.2.8.1.4.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component ADO | 125 | 50 | 3 | 0 | 3 | 3 | 3 | 2 | 3 | 3 | 2 | 3 | 2 | 3 | 2 | 2 | 2 | 2 | 2 | 1 | 4 | 0 | 3 | 1 | 3 | 2 | 3 | 1 | 6 | 4 | 2 | 0 | 2 | 2 | 1 | 2 | 3 | 3 | 0 | 2 | 3 | 0 | 2 | 4 | 2 | 2 | 1 | 1 | 1 | 2 | 4 | 2 | 3 | 2 | 3 | 3 | 5 |
19.2.5 | .Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD) | 124 | 50 | 1 | 0 | 3 | 2 | 3 | 2 | 3 | 4 | 1 | 3 | 2 | 3 | 2 | 3 | 1 | 1 | 0 | 2 | 3 | 0 | 4 | 1 | 2 | 2 | 5 | 2 | 5 | 3 | 2 | 0 | 0 | 2 | 1 | 6 | 4 | 2 | 2 | 2 | 3 | 2 | 3 | 3 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 5 | 2 | 2 | 2 | 3 | 2 |
19.2.2.1.5.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-C2-class E3 ligase | 119 | 51 | 3 | 0 | 3 | 3 | 3 | 2 | 5 | 4 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 3 | 0 | 3 | 1 | 7 | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 0 | 2 | 3 | 2 | 2 | 2 | 2 | 3 | 2 | 4 | 2 | 2 | 1 | 2 | 1 | 3 | 3 | 2 | 4 | 2 | 3 | 2 | 2 | 2 | 1 |
19.2.2.2.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (SIZ1) | 115 | 53 | 3 | 0 | 2 | 2 | 1 | 1 | 3 | 3 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 4 | 1 | 4 | 1 | 2 | 1 | 5 | 3 | 2 | 2 | 4 | 2 | 1 | 0 | 3 | 2 | 1 | 2 | 2 | 3 | 2 | 2 | 3 | 5 | 2 | 4 | 1 | 3 | 1 | 2 | 2 | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 2 |
19.2.1.3.1.2 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.catalytic component GID2 | 113 | 53 | 3 | 0 | 1 | 3 | 3 | 1 | 3 | 3 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 4 | 1 | 3 | 1 | 2 | 1 | 2 | 2 | 4 | 3 | 4 | 0 | 2 | 3 | 1 | 2 | 1 | 1 | 1 | 2 | 6 | 4 | 2 | 4 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 2 | 1 | 3 | 1 |
19.2.2.8.3.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex | 112 | 54 | 1 | 0 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 6 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 5 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 3 | 2 | 2 | 5 |
19.2.6.2.1.4 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT4 | 110 | 52 | 3 | 0 | 2 | 3 | 2 | 1 | 3 | 4 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 6 | 1 | 3 | 1 | 0 | 1 | 2 | 2 | 5 | 3 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 3 | 4 | 3 | 1 | 4 | 2 | 2 | 1 | 2 | 1 | 1 | 3 | 1 | 0 | 3 | 2 | 2 | 2 |
19.2.3.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (SPF) | 108 | 48 | 0 | 0 | 1 | 2 | 2 | 1 | 3 | 3 | 1 | 2 | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 2 | 1 | 2 | 1 | 2 | 2 | 9 | 4 | 4 | 0 | 1 | 4 | 1 | 4 | 0 | 1 | 0 | 2 | 2 | 8 | 2 | 4 | 2 | 2 | 1 | 2 | 0 | 2 | 3 | 4 | 1 | 2 | 1 | 2 | 1 |
19.2.6.2.2.9 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN10 | 108 | 54 | 4 | 0 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 3 | 4 | 4 | 4 | 1 | 4 | 3 | 1 | 2 | 2 | 2 | 3 | 2 | 3 | 1 | 2 | 3 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 3 |
19.2.3.1.1.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP3-4) | 107 | 54 | 5 | 0 | 2 | 1 | 2 | 1 | 3 | 3 | 2 | 2 | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 2 | 1 | 2 | 1 | 3 | 1 | 4 | 3 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 3 | 2 | 2 | 2 | 3 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 3 | 2 | 2 | 2 | 2 | 1 | 4 |
19.2.6.2.2.10 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN11 | 107 | 54 | 3 | 0 | 2 | 1 | 1 | 2 | 2 | 3 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 5 | 2 | 3 | 4 | 3 | 2 | 1 | 2 | 2 | 2 | 2 | 4 | 3 | 3 | 2 | 4 | 3 | 2 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 5 |
19.2.6.2.2.4 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN5 | 106 | 54 | 2 | 0 | 2 | 2 | 2 | 1 | 3 | 3 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 6 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 5 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 5 | 1 | 2 | 2 | 1 | 2 | 3 | 3 | 1 | 2 | 1 | 2 | 2 | 1 | 4 | 2 | 2 | 2 | 1 | 1 | 4 |
19.2.2.8.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.scaffold component CUL3 | 105 | 51 | 3 | 0 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 1 | 0 | 2 | 1 | 2 | 1 | 0 | 2 | 2 | 1 | 5 | 3 | 2 | 0 | 3 | 2 | 1 | 9 | 2 | 3 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 5 | 2 | 2 | 1 | 1 | 3 |
19.2.3.3.1.7 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN7 | 104 | 54 | 3 | 0 | 1 | 1 | 1 | 1 | 3 | 3 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 3 | 3 | 3 | 1 | 5 | 3 | 1 | 1 | 2 | 1 | 3 | 2 | 7 | 2 | 2 | 4 | 3 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 3 |
19.2.6.1.1.3 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-3 | 104 | 51 | 3 | 0 | 3 | 2 | 1 | 2 | 4 | 3 | 2 | 3 | 3 | 2 | 0 | 1 | 2 | 2 | 2 | 1 | 4 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 4 | 1 | 2 | 1 | 0 | 2 | 1 | 2 | 2 | 3 | 1 | 2 | 3 | 3 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 3 | 2 | 2 | 2 | 0 | 3 | 2 |
19.2.3.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (ELS) | 103 | 54 | 2 | 0 | 2 | 4 | 3 | 1 | 4 | 4 | 1 | 2 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 2 | 2 | 2 | 1 | 4 | 3 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 3 | 1 | 2 | 1 | 2 | 1 | 3 | 1 | 2 | 1 | 3 | 1 | 1 | 3 | 2 | 2 | 2 | 1 | 1 | 3 |
19.2.6.2.1.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT1 | 103 | 53 | 3 | 0 | 2 | 2 | 2 | 2 | 3 | 3 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 3 | 1 | 3 | 1 | 2 | 1 | 2 | 2 | 1 | 3 | 4 | 3 | 3 | 1 | 1 | 3 | 1 | 2 | 2 | 2 | 2 | 2 | 0 | 2 | 1 | 4 | 2 | 2 | 1 | 1 | 2 | 2 | 3 | 1 | 2 | 1 | 2 | 2 | 1 |
19.2.6.2.2.3 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN3 | 103 | 54 | 4 | 0 | 1 | 2 | 2 | 1 | 3 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 4 | 2 | 3 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 4 | 1 | 4 | 2 | 4 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 |
19.2.2.3.5.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (RBX1) | 102 | 51 | 0 | 0 | 2 | 1 | 2 | 1 | 3 | 3 | 2 | 2 | 1 | 2 | 3 | 2 | 2 | 2 | 1 | 1 | 4 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | 4 | 3 | 3 | 1 | 3 | 2 | 1 | 2 | 0 | 2 | 4 | 2 | 1 | 3 | 2 | 3 | 2 | 2 | 0 | 1 | 1 | 1 | 3 | 3 | 1 | 1 | 2 | 1 | 3 |
19.2.2.8.1.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.UBQ-E2-recruiting component RBX1 | 102 | 51 | 0 | 0 | 2 | 1 | 2 | 1 | 3 | 3 | 2 | 2 | 1 | 2 | 3 | 2 | 2 | 2 | 1 | 1 | 4 | 1 | 2 | 1 | 1 | 3 | 2 | 1 | 4 | 3 | 3 | 1 | 3 | 2 | 1 | 2 | 0 | 2 | 4 | 2 | 1 | 3 | 2 | 3 | 2 | 2 | 0 | 1 | 1 | 1 | 3 | 3 | 1 | 1 | 2 | 1 | 3 |
19.2.6.2.2.7 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN8 | 102 | 54 | 3 | 0 | 2 | 2 | 2 | 1 | 3 | 3 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 3 | 2 | 3 | 1 | 4 | 4 | 1 | 2 | 2 | 1 | 1 | 1 | 5 | 1 | 2 | 3 | 1 | 1 | 1 | 2 | 1 | 2 | 4 | 2 | 1 | 1 | 2 | 2 | 2 |
19.2.1.1.1.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E3 ubiquitin ligase component Doa10 | 101 | 50 | 5 | 0 | 1 | 4 | 2 | 1 | 10 | 8 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 3 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 3 | 0 | 2 | 2 | 1 | 1 | 2 | 2 | 3 | 1 | 0 | 5 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 2 | 3 | 2 |
19.2.6.1.2.3 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-3 | 101 | 54 | 3 | 0 | 1 | 2 | 2 | 1 | 5 | 4 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 3 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 5 | 3 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 3 | 2 | 5 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 4 | 1 | 1 | 2 | 1 | 3 | 4 |
19.2.3.1.1.8 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP22) | 100 | 52 | 3 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 0 | 1 | 2 | 2 | 5 | 2 | 1 | 4 | 4 | 4 | 1 | 0 | 2 | 1 | 2 | 3 | 1 | 1 | 2 | 6 | 1 | 2 | 3 | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 1 |
19.2.6.2.1.6 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT6 | 98 | 51 | 3 | 0 | 2 | 2 | 2 | 2 | 3 | 3 | 2 | 0 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 4 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 3 | 3 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 4 | 2 | 2 | 2 | 0 | 2 | 3 | 1 | 0 | 1 | 3 | 2 | 2 | 1 | 2 | 1 | 1 |
19.2.6.2.2.2 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN2 | 98 | 53 | 0 | 0 | 1 | 3 | 2 | 1 | 3 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 3 | 1 | 2 | 1 | 3 | 1 | 2 | 4 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 1 | 3 | 4 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 1 | 4 |
19.2.6.1.1.4 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-4 | 97 | 53 | 0 | 0 | 1 | 2 | 2 | 3 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 3 | 1 | 1 | 2 | 3 | 1 | 2 | 1 | 2 | 3 | 3 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 4 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 4 | 2 | 1 | 2 | 1 | 3 |
19.2.6.1.2.7 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-7 | 97 | 53 | 3 | 0 | 3 | 2 | 1 | 1 | 3 | 3 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 0 | 2 | 1 | 2 | 1 | 2 | 3 | 1 | 3 | 2 | 3 | 2 | 1 | 5 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 4 | 2 | 3 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 2 | 1 | 1 | 1 | 2 |
19.2.6.2.1.2 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT2 | 96 | 54 | 4 | 0 | 2 | 2 | 2 | 1 | 3 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 4 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 4 | 3 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 3 | 1 | 1 | 2 | 1 | 1 | 1 |
19.2.2.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation | 95 | 51 | 4 | 0 | 5 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 3 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 3 | 2 | 1 | 2 | 3 | 2 | 1 | 3 | 3 | 1 | 1 | 3 | 1 | 2 | 3 | 2 | 0 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 1 | 0 | 3 | 1 |
19.2.2.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation.ubiquitin-fold protein (HUB) | 95 | 51 | 4 | 0 | 5 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 3 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 3 | 2 | 1 | 2 | 3 | 2 | 1 | 3 | 3 | 1 | 1 | 3 | 1 | 2 | 3 | 2 | 0 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 1 | 0 | 3 | 1 |
19.2.6.2.2.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN1 | 95 | 54 | 4 | 0 | 1 | 2 | 2 | 2 | 4 | 4 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 3 | 1 | 2 | 3 | 2 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 4 | 1 | 1 | 1 | 3 | 2 |
19.2.2.8.3.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.component COP1 | 94 | 51 | 3 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 4 | 0 | 1 | 2 | 3 | 1 | 2 | 2 | 2 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 2 | 9 | 2 | 3 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 3 | 1 | 2 | 3 | 1 |
19.2.6.1.2.2 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-2 | 94 | 54 | 2 | 0 | 1 | 5 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 3 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 3 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 3 | 1 | 2 | 1 | 1 | 1 | 2 |
19.2.6.2.2.8 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN9 | 92 | 54 | 4 | 0 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 3 | 2 | 1 | 1 | 2 | 3 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 4 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 3 | 2 | 2 | 2 | 2 | 2 | 2 |
19.2.6.1.2.4 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-4 | 91 | 53 | 3 | 0 | 2 | 2 | 2 | 2 | 4 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 3 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 3 | 1 | 1 | 3 | 1 | 2 | 2 | 1 | 0 | 2 | 2 | 3 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 |
19.2.1.2.2.2 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-II-residues E3 ubiquitin ligase (PRT1) | 89 | 51 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 5 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 3 | 2 | 3 | 2 | 3 | 1 | 1 | 2 | 1 | 0 | 3 | 1 | 2 | 1 | 1 | 2 | 5 | 2 | 3 | 2 | 1 | 0 | 1 | 1 | 2 | 2 | 3 | 0 | 1 | 1 | 1 | 1 |
19.2.3.1.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP1-2) | 89 | 51 | 3 | 0 | 1 | 2 | 2 | 1 | 3 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 2 | 1 | 1 | 1 | 3 | 1 | 2 | 1 | 2 | 0 | 3 | 2 | 1 | 1 | 0 | 8 | 4 | 2 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 3 |
19.2.6.1.2.5 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-5 | 89 | 53 | 3 | 0 | 2 | 2 | 2 | 1 | 3 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 3 | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 1 |
19.2.6.2.2.5 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN6 | 89 | 52 | 2 | 0 | 3 | 1 | 1 | 1 | 3 | 3 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 4 | 3 | 3 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 0 | 1 | 3 |
19.2.2.1.5.3.6 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (DA2) | 88 | 52 | 1 | 0 | 1 | 2 | 2 | 2 | 4 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 3 | 2 | 1 | 2 | 1 | 0 | 1 | 4 | 3 | 2 | 1 | 2 | 3 | 1 | 2 | 1 | 1 | 1 | 3 | 0 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 6 |
19.2.6.1.2.6 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-6 | 88 | 53 | 3 | 0 | 1 | 1 | 1 | 1 | 5 | 3 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 4 | 2 | 1 | 4 |
19.2.6.2.1.3 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT3 | 88 | 53 | 4 | 0 | 1 | 1 | 1 | 1 | 3 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 0 | 2 | 2 | 4 | 1 | 2 | 1 | 2 | 5 | 1 | 3 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 1 |
19.2.3.3.1.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN2 | 87 | 54 | 3 | 0 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 4 | 2 | 1 | 1 | 4 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 3 | 3 | 1 | 2 | 1 | 3 | 1 | 1 | 3 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 |
19.2.6.1.1.2 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-2 | 85 | 50 | 0 | 0 | 2 | 2 | 2 | 0 | 3 | 3 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 4 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 0 | 2 | 3 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 3 |
19.2.1.2.2.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.Arg/N-recognin activities.type-I-residues E3 ubiquitin ligase (PRT6) | 84 | 51 | 1 | 0 | 1 | 1 | 1 | 1 | 4 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 0 | 2 | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 2 | 1 | 2 | 2 | 2 | 1 | 0 | 1 | 2 | 3 | 1 | 10 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.1.3.1.1 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID1 | 84 | 53 | 1 | 0 | 1 | 2 | 5 | 1 | 4 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 3 | 2 | 1 | 1 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 3 | 1 | 2 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.6.2.1.5 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ATPase components.regulatory component RPT5 | 84 | 51 | 3 | 0 | 2 | 2 | 2 | 1 | 3 | 3 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 2 | 1 | 0 | 2 | 1 | 2 | 0 | 2 | 0 | 2 | 4 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 1 |
19.2.6.2.2.6 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN7 | 84 | 54 | 1 | 0 | 1 | 1 | 1 | 2 | 3 | 3 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 4 | 4 | 2 | 1 | 2 | 2 | 1 | 3 | 2 | 2 | 1 | 1 | 3 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 2 |
19.2.6.3 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation | 84 | 53 | 3 | 0 | 7 | 3 | 2 | 1 | 3 | 3 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 0 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 5 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.6.3.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.regulation.regulatory protein (PTRE1) | 84 | 53 | 3 | 0 | 7 | 3 | 2 | 1 | 3 | 3 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 0 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 5 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.2.1.5.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.bifunctional co-chaperone and E3 ubiquitin ligase (CHIP) | 83 | 53 | 2 | 0 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 5 | 2 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 4 | 1 | 2 |
19.2.6.1.1.6 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-6 | 83 | 53 | 2 | 0 | 1 | 2 | 2 | 1 | 4 | 3 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 3 | 3 | 2 | 1 | 0 | 2 | 1 | 3 | 1 | 1 | 1 | 2 | 3 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 |
19.2.1.1.1.2 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc32 | 82 | 53 | 1 | 0 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 3 | 1 | 1 | 1 | 4 | 2 | 2 | 1 | 0 | 2 | 1 | 1 | 6 | 1 | 1 | 1 | 1 | 1 | 5 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 |
19.2.2.2.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO chain-forming-ligase E4 enzyme (PIAL) | 82 | 51 | 1 | 0 | 1 | 2 | 2 | 1 | 4 | 5 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 0 | 2 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 3 | 0 | 2 | 1 | 1 | 4 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 3 | 1 | 1 | 3 | 1 | 1 |
19.2.2.3.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH3) | 82 | 52 | 0 | 0 | 3 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 0 | 2 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 4 | 2 |
19.2.2.3.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.deneddylase (DEN1) | 82 | 53 | 1 | 0 | 1 | 2 | 1 | 1 | 2 | 2 | 4 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 7 | 1 | 1 | 1 | 3 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 4 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.4.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.E3 ubiquitin ligase component HRD1 | 82 | 53 | 2 | 0 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 0 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 3 |
19.2.6.1.1.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-1 | 82 | 53 | 1 | 0 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 4 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 4 | 1 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.1.3.1.5 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID8 | 81 | 52 | 2 | 0 | 2 | 2 | 3 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 4 | 2 | 0 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 |
19.2.2.3.3.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.small component AXR1/AXL | 81 | 53 | 1 | 0 | 1 | 2 | 2 | 1 | 5 | 5 | 1 | 2 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 2 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.6.1.1.5 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-5 | 81 | 52 | 1 | 0 | 0 | 2 | 2 | 1 | 3 | 3 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 4 | 3 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 0 | 2 | 1 | 1 | 1 |
19.2.2.8.3.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.core adaptor component DDB1 | 80 | 52 | 3 | 0 | 1 | 3 | 2 | 1 | 2 | 2 | 2 | 3 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 |
19.2.3.1.1.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP6-7) | 80 | 53 | 3 | 0 | 2 | 2 | 2 | 1 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 3 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.3.2.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (FUG) | 80 | 47 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 0 | 1 | 2 | 1 | 6 | 0 | 1 | 1 | 9 | 1 | 3 | 2 | 1 | 2 | 2 | 0 | 1 | 2 | 0 | 1 | 1 | 1 | 3 | 1 | 1 | 3 | 1 | 2 | 2 | 2 | 0 | 1 | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
19.2.6.2.2.11 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN12 | 80 | 53 | 0 | 0 | 1 | 2 | 2 | 1 | 3 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 1 | 1 | 1 | 2 | 6 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 3 |
19.2.1.2.1.2 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.arginyl-tRNA-protein transferase (ATE) | 79 | 54 | 3 | 0 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 2 | 1 | 1 | 5 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 3 | 3 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.6.1.2.1 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.beta-type components.component beta type-1 | 79 | 54 | 2 | 0 | 1 | 1 | 1 | 1 | 3 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 2 | 1 | 3 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 |
19.2.4.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.associated factor (PUX1) | 78 | 50 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | 0 | 5 | 2 | 1 | 4 | 1 | 1 | 1 | 2 | 7 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 3 | 2 |
19.2.3.1.1.10 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP24) | 77 | 53 | 4 | 0 | 1 | 1 | 1 | 1 | 3 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 2 | 1 | 2 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 |
19.2.3.1.1.6 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP14) | 77 | 52 | 4 | 0 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 3 | 1 | 4 | 2 | 3 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 0 | 1 | 5 | 1 | 1 |
19.2.3.2.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.peptidase (DeSI) | 77 | 54 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 3 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.6.1.1.7 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.20S core particle.alpha-type components.component alpha type-7 | 77 | 50 | 2 | 0 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 0 | 3 | 1 | 1 | 0 | 2 | 1 | 2 | 3 | 2 | 1 | 2 | 0 | 2 | 1 | 2 | 2 | 2 | 3 | 1 | 1 | 0 | 1 | 1 | 4 |
19.2.5.1 | .Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).ubiquitin protein ligase (SP1) | 76 | 50 | 1 | 0 | 1 | 1 | 2 | 1 | 2 | 3 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 0 | 1 | 2 | 0 | 3 | 1 | 1 | 1 | 4 | 1 | 2 | 2 | 1 | 0 | 0 | 1 | 1 | 4 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 |
19.2.3.1.1.12 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP26) | 75 | 51 | 2 | 0 | 0 | 2 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 4 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 5 | 1 | 2 | 1 | 1 | 2 |
19.2.4.2.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate extraction.NPL4-UFD1 CDC48-cofactor heterodimer.component NPL4 | 75 | 54 | 3 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 4 |
19.2.4.4.2 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).delivery to proteasome.proteasome adaptor protein (DDI1) | 75 | 50 | 0 | 0 | 1 | 3 | 1 | 1 | 2 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 4 | 2 | 2 | 1 | 6 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 1 |
19.2.2.2.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.small component SAE1 | 74 | 53 | 1 | 0 | 1 | 2 | 3 | 1 | 3 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 3 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.3.1.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN1 | 74 | 53 | 2 | 0 | 2 | 2 | 1 | 1 | 3 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 |
19.2.3.3.1.8 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN8 | 74 | 50 | 2 | 0 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 3 | 1 | 2 | 1 | 3 | 2 | 1 | 5 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 2 | 0 | 0 | 1 | 1 | 2 |
19.2.1.3.1.4 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID5 | 73 | 51 | 3 | 0 | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 0 | 2 | 1 | 1 | 1 | 2 | 1 | 4 | 1 | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 |
19.2.2.8.2.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component NPH3 | 73 | 42 | 1 | 0 | 2 | 0 | 0 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 0 | 0 | 2 | 2 | 1 | 2 | 1 | 5 | 2 | 2 | 0 | 0 | 2 | 0 | 2 | 1 | 1 | 2 | 2 | 4 | 0 | 1 | 2 | 1 | 2 | 0 | 0 | 2 | 1 | 0 | 2 | 3 | 2 | 0 | 1 | 1 |
19.2.4.1.3 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.adaptor protein component HRD3 | 72 | 51 | 2 | 0 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 3 | 1 | 2 | 1 | 1 | 1 | 3 | 0 | 1 | 2 | 1 | 0 | 1 | 1 | 2 | 2 |
19.2.2.3.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH1|2) | 71 | 51 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 3 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 0 | 1 | 1 | 1 | 3 |
19.2.2.6.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.ubiquitin-fold protein (UFM) | 71 | 51 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 0 | 1 | 2 | 1 | 4 | 2 | 2 | 0 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 4 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.3.1.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN3 | 71 | 53 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 3 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 3 | 2 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.3.3.1.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN5 | 71 | 54 | 2 | 0 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
19.2.2.1.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation | 70 | 51 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 0 | 1 | 1 | 1 | 3 |
19.2.2.1.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation.ubiquitin carboxyl-terminal hydrolase (UCH) | 70 | 51 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 0 | 1 | 1 | 1 | 3 |
19.2.4.1.5 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.associated plant-specific component EBS7 | 70 | 53 | 1 | 0 | 1 | 1 | 1 | 1 | 4 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 1 | 1 | 1 | 2 |
19.2.6.2.3 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.ubiquitin C-terminal hydrolase cofactor | 70 | 51 | 1 | 0 | 2 | 2 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 3 | 1 | 0 | 1 | 1 | 1 | 3 |
19.2.2.2.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.large component SAE2 | 69 | 54 | 3 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.2.8.1.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.adaptor protein exchange factor (CAND1) | 69 | 53 | 1 | 0 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.1.2.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.histone deubiquinating protease (OTLD1) | 69 | 50 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 3 | 0 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.3.3.1.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN4 | 69 | 53 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 1 |
19.2.4.1.4 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).HRD1 E3 ubiquitin ligase complex.substrate recruitment component OS9 | 69 | 52 | 2 | 0 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | 2 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 2 |
19.2.4.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.E4 multiubiquitination enzyme (UFD2) | 69 | 53 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 2 | 1 | 1 | 3 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 |
19.2.2.1.5.4.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (ARA54) | 68 | 51 | 1 | 0 | 1 | 0 | 1 | 2 | 0 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 0 | 1 | 2 | 1 |
19.2.2.1.5.4.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Helicase) | 68 | 48 | 2 | 0 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 3 | 0 | 0 | 1 | 1 | 4 | 3 | 1 | 0 | 2 | 1 | 0 | 1 | 2 | 1 | 2 | 0 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 |
19.2.2.8.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.scaffold component CUL4 | 68 | 49 | 0 | 0 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 3 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 3 | 1 | 2 | 1 | 2 | 1 | 2 | 0 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 2 |
19.2.1.1.1.3 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Ac/N-degron pathway.Doa10 E3 ubiquitin ligase complex.E2 ubiquitin-conjugating component Ubc33/34 | 67 | 48 | 0 | 0 | 1 | 2 | 2 | 1 | 3 | 3 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 2 | 1 | 0 | 1 | 1 | 0 | 2 | 2 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 1 | 1 | 2 |
19.2.1.3.1.6 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.component GID9 | 67 | 53 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 |
19.2.3.1.2.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU5) | 67 | 51 | 1 | 0 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 0 |
19.2.2.3.5.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (DCN1) | 66 | 48 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 0 | 2 | 1 | 1 | 1 | 2 | 1 | 0 | 2 | 2 | 3 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 1 | 1 | 0 |
19.2.2.8.3.3.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.regulator component DET1 | 66 | 53 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 4 |
19.2.4.3.4 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deglycosylating peptide:N-glycanase (PNG1) | 66 | 54 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 |
19.2.2.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).ubiquitin-fold protein (RUB) | 65 | 40 | 1 | 0 | 1 | 2 | 2 | 0 | 1 | 3 | 1 | 3 | 0 | 0 | 2 | 2 | 0 | 1 | 1 | 0 | 2 | 1 | 2 | 1 | 0 | 1 | 2 | 2 | 2 | 1 | 2 | 0 | 0 | 2 | 0 | 1 | 0 | 3 | 2 | 0 | 1 | 1 | 1 | 3 | 1 | 1 | 0 | 2 | 1 | 3 | 2 | 0 | 1 | 0 | 1 | 1 | 2 |
19.2.2.3.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.large component ECR1 | 65 | 52 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 |
19.2.2.6.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-conjugation E2 protein | 65 | 52 | 2 | 0 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | 0 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.1.1.9 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP23) | 65 | 49 | 2 | 0 | 2 | 1 | 1 | 1 | 3 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 0 |
19.2.3.3.1.6 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.RUB deconjugation of neddylated cullin.COP9 signalosome complex.component CSN6 | 65 | 49 | 1 | 0 | 1 | 2 | 2 | 1 | 2 | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 0 | 0 | 1 | 1 | 2 |
19.2.2.2.4.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (HPY2) | 64 | 52 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 4 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.2.8.2.2.5 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BPH1 | 64 | 43 | 0 | 0 | 2 | 2 | 2 | 1 | 2 | 3 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 2 | 1 | 2 | 1 | 0 | 1 | 4 | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 2 | 1 | 0 | 2 | 1 | 0 | 1 | 2 | 1 | 1 | 0 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 1 | 1 |
19.2.1.3.1.3 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Pro/N-degron pathway.ubiquitin protein ligase complex.N-recognin component GID4 | 63 | 52 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 |
19.2.3.1.2.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU2) | 63 | 54 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.SUMO deconjugation.protease (OTS) | 63 | 45 | 1 | 0 | 1 | 2 | 2 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 2 | 0 | 1 | 2 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | 5 | 1 | 1 | 1 | 2 | 2 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 2 | 1 |
19.2.2.6.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-ligase E3 protein | 61 | 53 | 3 | 0 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.2.8.1.4.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component UFO | 61 | 49 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 3 | 1 | 3 | 0 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 |
19.2.6.2.2.12 | .Protein homeostasis.ubiquitin-proteasome system.26S proteasome.19S regulatory particle.non-ATPase components.regulatory component RPN13 | 60 | 51 | 2 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 4 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
19.2.3.1.2.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU1) | 59 | 50 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.1.2.6 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.OTU deubiquitinase activities.deubiquitinase (OTU7) | 59 | 46 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 11 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 2 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
19.2.3.4 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation | 59 | 51 | 2 | 0 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
19.2.3.4.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.UFM deconjugation.UFM1-specific protease | 59 | 51 | 2 | 0 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
19.2.2.6.2 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-activating E1 protein | 58 | 51 | 0 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 2 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.4.3.2 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.ubiquitin-binding adaptor (UFD3) | 58 | 51 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.1.2.1.4 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-asparagine amidase (NTAN) | 54 | 48 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 3 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.2.7 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation | 54 | 49 | 0 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.2.7.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation.ubiquitin-fold protein (URM) | 54 | 49 | 0 | 0 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.1.1.13 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP27) | 53 | 50 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 |
19.2.4.3.3 | .Protein homeostasis.ubiquitin-proteasome system.ER-associated protein degradation (ERAD).substrate processing.deubiquinating protease (OTU1) | 51 | 44 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 1 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 2 | 1 | 2 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.1.2.1.3 | .Protein homeostasis.ubiquitin-proteasome system.N-degron pathways.Arg/N-degron pathway.N-terminal modification.Nt-glutamine amidase (NTAQ) | 50 | 47 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
19.2.5.2 | .Protein homeostasis.ubiquitin-proteasome system.chloroplast-associated protein degradation (CHLORAD).protein retrotranslocase (SP2) | 48 | 40 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 2 | 1 | 0 | 1 | 1 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 1 |
19.2.2.8.2.2.3 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component FBL | 46 | 43 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
19.2.2.8.3.3.1 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.E2 conjugating component COP10 | 46 | 45 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
19.2.3.1.1.11 | .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein deconjugation.ubiquitin deconjugation.UBP deubiquitinase activities.deubiquitinase (UBP25) | 43 | 36 | 1 | 0 | 0 | 1 | 1 | 1 | 2 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 2 | 1 | 0 | 1 | 0 | 2 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |