Child MapMan terms

Original MapMan term
19.2.2
Description
.Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation
Type
mapman

MapMan description genes species ach ahy aip aly ath atr bol bra bvu can car ccaj ccan ccl cla cme col cpa cqu cre cru csa dca egr egut fve gma gra hbr mco mdo mes mpo mtr nnu osa pab pax pbr ppa ppe ptr rco sly smo spa stu tca tha tpr ugi vra vvi zju zma
19.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation) 11788 54 257 0 180 285 258 116 408 404 159 172 176 232 175 188 172 168 172 151 299 30 290 167 260 207 239 177 437 297 293 23 208 269 81 299 204 230 265 235 289 157 195 290 162 229 112 223 232 180 260 245 166 188 161 213 303
19.2.2.1.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities 9964 54 234 0 151 236 217 98 348 341 137 126 152 197 148 156 152 146 146 126 248 17 250 145 228 182 202 149 366 247 249 11 180 225 63 266 171 201 204 202 252 116 162 244 143 195 83 194 195 153 214 213 142 167 133 184 257
19.2.2.8 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes 7227 54 154 0 177 128 125 70 185 175 104 217 100 126 99 114 80 81 180 74 222 11 130 78 152 130 206 180 264 186 160 12 115 130 46 349 118 113 127 203 158 89 139 173 102 154 50 111 220 116 139 155 86 103 85 97 129
19.2.2.1.5.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities 7212 54 170 0 110 162 152 66 266 260 101 57 112 147 102 108 115 114 102 90 177 7 179 110 166 133 142 99 280 185 176 5 127 161 36 195 122 146 143 148 177 77 116 180 107 143 57 146 140 109 165 153 111 129 95 130 206
19.2.2.8.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes 6057 54 132 0 156 104 103 50 151 143 85 193 80 104 84 95 65 64 166 59 191 6 106 61 126 111 184 164 216 156 135 8 97 107 36 323 98 95 105 173 131 60 120 144 85 126 38 88 196 98 117 133 62 79 68 78 102
19.2.2.8.1.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components 4900 54 119 0 135 79 76 44 109 107 73 156 64 93 72 75 54 52 142 44 147 2 74 52 110 81 161 131 190 130 113 4 77 89 31 258 81 63 70 142 105 41 97 121 70 98 33 71 156 81 102 97 56 69 55 66 82
19.2.2.8.1.4.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component FBX 4114 54 98 0 117 64 62 32 86 84 62 139 51 76 62 64 41 40 131 37 125 2 58 41 93 65 148 118 160 103 96 4 61 75 24 244 63 49 55 126 84 34 85 103 59 82 26 57 139 71 79 83 44 53 45 53 61
19.2.2.1.5.3.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-H2-class E3 ligase 3693 54 84 0 38 88 87 32 143 145 57 5 57 81 47 56 58 59 51 44 93 1 89 56 88 75 67 52 152 94 90 1 45 87 18 98 57 85 90 70 88 32 56 88 58 73 26 85 74 60 84 76 53 69 41 71 119
19.2.2.1.5.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-HC-class E3 ligase 2086 54 57 0 42 38 32 20 65 61 25 24 33 42 31 30 37 36 31 29 50 4 37 34 41 37 48 28 81 55 51 3 53 47 12 58 42 35 30 50 56 31 38 57 30 39 18 33 38 30 47 47 34 41 29 33 56
19.2.2.1.5.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities 1117 54 18 0 18 42 38 12 44 44 13 29 10 13 21 23 11 10 19 15 27 6 43 13 27 20 34 25 24 18 24 2 24 23 9 37 15 26 16 24 34 11 19 20 14 18 9 24 19 16 15 31 8 7 11 25 19
19.2.2.1.5.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities 1107 54 31 0 13 22 20 14 27 27 16 21 17 26 18 18 18 16 18 14 30 1 20 16 24 19 20 18 42 31 32 1 14 31 12 20 25 21 33 20 29 15 20 31 15 20 11 17 21 21 24 21 14 20 19 22 21
19.2.2.1.5.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.E3 ubiquitin ligase (PUB) 1024 52 29 0 12 21 19 12 25 25 15 20 16 24 17 17 16 15 18 13 28 0 19 15 23 18 19 17 37 29 31 0 12 29 10 19 24 19 28 18 26 13 19 30 14 19 10 16 20 20 22 20 12 19 15 21 19
19.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation) 915 54 16 0 13 18 18 8 30 30 15 23 10 12 13 12 10 10 21 11 31 15 16 10 21 17 17 17 23 25 20 7 25 17 9 23 12 18 14 23 28 21 17 19 10 21 9 15 20 19 19 21 12 9 15 11 19
19.2.2.8.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.target protein binding component SKP1/ASK1 792 54 6 0 13 21 21 2 30 23 7 29 11 6 6 14 5 5 18 11 34 1 27 5 10 13 16 24 13 15 10 1 13 11 2 59 12 26 30 23 18 11 16 14 10 18 3 13 34 12 7 26 2 6 8 7 14
19.2.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation 772 54 16 0 6 14 14 9 24 26 7 18 11 13 11 12 12 10 13 9 14 3 13 12 13 12 16 12 28 31 23 3 19 23 4 14 14 12 14 16 30 10 13 18 8 17 5 12 16 14 24 13 14 12 12 17 16
19.2.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation) 755 54 10 0 13 15 14 9 22 26 13 20 7 10 14 16 11 11 9 8 26 10 14 10 16 13 11 16 20 15 16 7 18 16 8 10 12 19 13 15 23 19 13 19 14 16 9 13 14 12 19 11 9 8 12 15 16
19.2.2.1.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination 708 54 12 0 10 15 13 9 20 23 7 11 10 15 10 10 10 11 9 8 15 3 13 11 16 13 16 9 32 21 19 2 16 16 4 19 20 13 21 12 24 11 9 19 10 11 6 12 10 9 22 12 7 14 12 9 17
19.2.2.1.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-conjugating E2 protein (UBC) 701 54 6 0 12 14 12 8 24 25 10 14 9 16 10 12 10 9 8 11 26 7 14 9 14 10 18 8 29 19 19 6 10 19 7 9 18 8 13 14 10 11 12 16 9 16 10 11 15 10 20 13 11 8 12 11 19
19.2.2.1.5.3.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-v-class E3 ligase 688 53 11 0 18 12 13 5 26 24 10 14 12 16 11 11 10 11 12 8 20 1 13 11 17 12 12 8 33 18 17 0 18 15 1 15 10 14 12 15 15 3 10 17 10 15 8 13 14 10 14 10 13 11 12 12 15
19.2.2.8.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes 664 53 14 0 13 13 13 14 21 19 9 17 13 13 9 11 9 10 7 8 15 1 13 9 15 12 12 8 25 19 12 0 10 13 4 18 13 12 15 17 16 8 10 16 9 17 5 12 19 10 12 14 15 13 9 9 14
19.2.2.1.5.4.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.plant-specific E3 ubiquitin ligase (RSL/RFA) 570 53 7 0 10 28 20 7 19 22 5 16 4 8 9 14 5 5 10 6 9 3 27 7 15 14 15 14 14 8 12 0 12 11 2 24 6 10 8 10 19 4 12 10 7 9 5 10 11 9 5 19 5 3 5 14 7
19.2.2.8.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components 559 52 11 0 11 11 11 13 19 18 8 15 10 11 8 9 8 8 6 8 13 0 11 8 15 10 10 7 20 16 10 0 7 11 3 9 11 9 14 15 14 6 8 14 8 15 3 11 17 9 10 9 13 11 8 8 11
19.2.2.1.5.3.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (SINA) 538 52 14 0 8 19 15 5 23 22 6 11 7 6 10 9 8 6 5 6 9 0 35 7 11 6 12 8 10 13 14 0 9 9 2 21 7 7 7 9 14 4 9 14 7 13 3 9 11 6 13 17 7 5 10 11 9
19.2.2.1.5.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities.monomeric E3 ubiquitin ligase (HECT) 528 54 15 0 10 10 7 6 11 10 7 19 13 11 7 7 8 6 7 7 14 3 8 6 11 10 6 7 20 13 17 3 15 10 6 14 9 8 12 10 12 13 7 13 7 14 6 7 15 7 10 8 9 11 8 7 11
19.2.2.1.5.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.HECT-type E3 ligase activities 528 54 15 0 10 10 7 6 11 10 7 19 13 11 7 7 8 6 7 7 14 3 8 6 11 10 6 7 20 13 17 3 15 10 6 14 9 8 12 10 12 13 7 13 7 14 6 7 15 7 10 8 9 11 8 7 11
19.2.2.8.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes 506 54 8 0 8 11 9 6 13 13 10 7 7 9 6 8 6 7 7 7 16 4 11 8 11 7 10 8 23 11 13 4 8 10 6 8 7 6 7 13 11 21 9 13 8 11 7 11 5 8 10 8 9 11 8 10 13
19.2.2.5.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.conjugation E2 protein 471 54 9 0 3 8 8 6 15 14 5 11 7 8 4 7 9 7 9 5 11 2 7 8 9 8 10 7 18 18 12 2 7 13 3 6 7 8 7 13 21 7 8 11 5 12 4 7 11 9 17 8 7 6 7 11 9
19.2.2.1.5.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Ariadne) 411 54 8 0 6 13 15 2 23 19 6 8 4 3 10 6 4 3 7 6 14 2 13 4 9 4 17 9 7 7 8 1 10 10 5 8 5 9 7 11 13 6 5 7 5 6 3 12 5 5 8 7 1 3 4 8 10
19.2.2.1.6.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.ligating E3 protein (RGLG) 380 53 8 0 7 6 5 4 10 11 3 3 6 9 5 6 6 7 5 4 6 1 6 7 7 9 13 5 17 9 11 0 10 8 2 15 13 7 11 4 14 4 5 11 6 4 2 6 3 5 13 9 3 10 6 6 7
19.2.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).ubiquitin-fold protein (SUMO) 377 54 4 0 4 9 9 2 13 14 8 10 3 5 5 4 4 4 12 3 17 8 7 4 9 8 8 8 8 12 9 1 10 7 2 12 3 8 3 12 15 6 9 5 4 6 2 5 8 10 8 11 4 1 6 3 5
19.2.2.8.1.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component SKP2 363 52 12 0 7 7 6 6 14 14 5 7 5 8 5 6 6 5 5 4 10 0 8 5 8 7 4 6 15 13 8 0 7 6 6 6 9 4 18 7 9 4 5 8 5 5 3 8 5 4 8 6 4 6 2 5 7
19.2.2.1.6.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex 328 54 4 0 3 9 8 5 10 12 4 8 4 6 5 4 4 4 4 4 9 2 7 4 9 4 3 4 15 12 8 2 6 8 2 4 7 6 10 8 10 7 4 8 4 7 4 6 7 4 9 3 4 4 6 3 10
19.2.2.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-fold protein (UBQ) 313 46 6 0 4 14 9 0 8 11 3 13 2 4 7 9 0 3 8 4 6 1 9 3 0 0 6 8 10 10 6 1 0 8 5 12 0 5 28 0 6 9 6 10 0 3 10 3 6 6 5 6 4 1 3 8 4
19.2.2.5.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.MUB conjugation.ubiquitin-fold protein (MUB) 301 54 7 0 3 6 6 3 9 12 2 7 4 5 7 5 3 3 4 4 3 1 6 4 4 4 6 5 10 13 11 1 12 10 1 8 7 4 7 3 9 3 5 7 3 5 1 5 5 5 7 5 7 6 5 6 7
19.2.2.1.7 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin receptor regulatory protein (DA1) 274 54 2 0 6 7 8 2 13 9 2 7 6 6 3 4 4 4 3 3 4 1 6 4 4 8 6 6 11 3 7 1 8 5 1 5 4 4 3 7 7 9 8 7 3 5 2 5 5 4 6 5 3 5 4 4 5
19.2.2.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation 255 53 6 0 4 6 4 4 8 6 4 5 4 4 4 4 4 5 4 4 8 3 4 4 3 4 6 4 10 6 5 0 9 4 4 5 4 4 3 5 10 4 5 5 4 5 3 4 5 4 7 4 4 4 4 4 4
19.2.2.8.3.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex 246 52 4 0 4 5 4 3 6 7 5 1 3 5 4 4 3 3 4 4 10 0 5 4 7 4 5 4 12 5 6 0 5 5 2 4 2 2 3 7 5 11 5 7 4 6 3 5 4 4 5 3 4 6 4 5 4
19.2.2.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation 235 54 2 0 6 6 4 4 5 6 6 6 3 4 5 5 3 3 3 2 11 3 4 3 6 3 3 4 6 4 5 3 5 5 3 3 5 8 1 4 8 3 4 4 6 4 3 4 5 3 5 4 2 3 3 6 6
19.2.2.8.2.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BT 209 52 3 0 3 5 5 3 9 8 3 5 3 3 3 3 3 3 2 3 6 0 5 3 6 6 4 3 5 7 3 0 3 4 1 3 5 4 2 6 4 3 3 6 3 6 1 5 6 3 5 2 4 3 3 3 6
19.2.2.1.6.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Uev1 201 54 4 0 2 7 5 3 5 7 2 6 2 4 3 2 3 3 2 2 6 1 4 3 5 2 2 2 11 8 4 1 6 4 1 2 5 4 9 5 6 3 2 4 2 3 3 3 3 2 5 2 3 3 3 2 5
19.2.2.8.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.scaffold component CUL1/CUL2 194 53 6 0 4 2 3 1 7 8 2 5 3 2 2 3 2 3 4 2 4 1 2 2 4 13 4 7 6 7 7 1 2 4 1 3 3 3 0 5 5 3 4 4 2 7 1 2 5 3 3 6 2 2 2 3 2
19.2.2.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities 179 54 4 0 4 3 2 2 4 4 3 3 2 3 2 3 2 2 4 2 6 2 3 2 6 4 3 4 5 3 2 1 5 3 3 3 3 4 4 3 5 9 3 5 2 4 3 3 3 4 4 3 2 3 2 3 3
19.2.2.8.1.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EBF 172 52 4 0 3 2 2 2 3 3 2 4 3 4 2 2 4 4 2 2 4 0 2 4 3 4 3 2 7 7 4 0 5 3 1 4 4 2 2 3 5 2 2 4 2 6 2 2 8 2 6 4 3 4 2 2 4
19.2.2.3.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities 168 54 1 0 3 2 3 2 6 6 3 3 2 3 4 3 3 3 1 2 4 3 3 2 2 4 3 3 6 5 4 1 5 3 2 3 2 3 4 4 3 6 3 4 3 4 2 2 2 2 5 4 3 1 3 2 3
19.2.2.8.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component LRB 167 52 6 0 3 3 3 8 5 5 2 7 3 3 2 2 2 2 2 2 4 0 3 2 4 2 3 1 5 5 3 0 3 3 1 1 2 2 9 4 3 2 2 4 2 5 1 3 7 2 2 2 4 3 3 2 3
19.2.2.8.3.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.regulator component SPA 152 51 1 0 3 4 3 2 5 6 3 1 2 4 2 2 1 1 2 2 6 0 4 2 4 3 3 2 10 3 5 0 4 4 1 3 0 1 2 4 3 2 3 4 3 4 1 4 2 2 4 2 1 5 2 2 3
19.2.2.3.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer 146 54 3 0 2 3 3 2 7 7 2 3 1 2 2 2 3 2 2 2 4 2 3 2 3 3 2 3 4 2 3 2 3 4 2 2 3 2 3 2 3 4 2 4 2 3 2 3 2 2 3 2 2 2 2 3 3
19.2.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer 143 54 4 0 2 3 4 2 5 3 2 4 2 2 2 2 2 2 2 2 4 2 3 2 2 2 2 2 4 4 4 2 4 4 2 2 2 2 2 3 5 3 2 4 2 3 2 3 3 2 2 2 2 2 2 2 3
19.2.2.3.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB conjugation E2 protein (RCE1) 141 54 3 0 1 2 2 1 3 4 1 5 1 1 1 4 2 2 2 2 5 1 2 2 5 2 1 4 2 3 2 1 5 2 1 1 2 3 3 5 8 5 3 4 2 4 2 2 4 2 4 1 1 2 3 3 2
19.2.2.1.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-activating E1 protein (UBA) 138 54 4 0 2 3 2 1 4 4 2 3 2 2 1 2 1 1 2 2 4 1 2 1 4 2 3 2 4 5 3 1 2 3 2 2 1 4 7 3 3 4 2 3 2 2 2 2 2 2 3 4 2 2 2 2 5
19.2.2.8.1.4.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component EDL 137 51 3 0 4 3 3 2 3 3 2 3 2 3 1 2 2 2 2 1 2 0 3 2 3 3 3 2 4 4 4 0 3 3 0 2 3 4 2 4 3 1 2 2 2 3 1 3 3 2 5 2 2 3 3 3 5
19.2.2.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO conjugation E2 enzyme (SCE1) 134 54 3 0 2 1 1 1 4 4 1 6 2 1 2 2 1 1 2 2 2 3 1 1 1 2 3 2 4 5 2 3 4 2 1 2 3 3 3 3 2 2 2 4 1 6 1 2 5 2 3 2 3 2 2 2 7
19.2.2.1.6.1.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).polyubiquitination.Ubc13-Uev1 conjugating E2 complex.component Ubc13 127 52 0 0 1 2 3 2 5 5 2 2 2 2 2 2 1 1 2 2 3 1 3 1 4 2 1 2 4 4 4 1 0 4 1 2 2 2 1 3 4 4 2 4 2 4 1 3 4 2 4 1 1 1 3 1 5
19.2.2.8.1.4.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component ADO 125 50 3 0 3 3 3 2 3 3 2 3 2 3 2 2 2 2 2 1 4 0 3 1 3 2 3 1 6 4 2 0 2 2 1 2 3 3 0 2 3 0 2 4 2 2 1 1 1 2 4 2 3 2 3 3 5
19.2.2.1.5.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.RING-C2-class E3 ligase 119 51 3 0 3 3 3 2 5 4 2 2 2 1 2 1 1 1 2 2 3 0 3 1 7 2 2 2 2 2 2 0 0 2 3 2 2 2 2 3 2 4 2 2 1 2 1 3 3 2 4 2 3 2 2 2 1
19.2.2.2.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (SIZ1) 115 53 3 0 2 2 1 1 3 3 2 2 2 2 1 2 1 1 4 1 4 1 2 1 5 3 2 2 4 2 1 0 3 2 1 2 2 3 2 2 3 5 2 4 1 3 1 2 2 2 3 2 1 2 1 2 2
19.2.2.8.3.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex 112 54 1 0 2 2 2 1 2 2 2 2 2 2 2 2 1 2 1 1 2 2 2 2 2 1 2 2 6 2 2 2 1 2 2 2 2 2 2 2 3 5 2 2 2 2 2 2 1 2 2 2 2 3 2 2 5
19.2.2.8.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.scaffold component CUL3 105 51 3 0 2 2 2 1 2 1 1 2 3 2 1 2 1 2 1 0 2 1 2 1 0 2 2 1 5 3 2 0 3 2 1 9 2 3 1 2 2 2 2 2 1 2 2 1 2 1 2 5 2 2 1 1 3
19.2.2.8.1.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.UBQ-E2-recruiting component RBX1 102 51 0 0 2 1 2 1 3 3 2 2 1 2 3 2 2 2 1 1 4 1 2 1 1 3 2 1 4 3 3 1 3 2 1 2 0 2 4 2 1 3 2 3 2 2 0 1 1 1 3 3 1 1 2 1 3
19.2.2.3.5.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (RBX1) 102 51 0 0 2 1 2 1 3 3 2 2 1 2 3 2 2 2 1 1 4 1 2 1 1 3 2 1 4 3 3 1 3 2 1 2 0 2 4 2 1 3 2 3 2 2 0 1 1 1 3 3 1 1 2 1 3
19.2.2.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation 95 51 4 0 5 2 2 1 1 1 2 1 1 2 1 1 2 2 1 3 3 1 1 2 2 1 2 2 2 3 2 1 2 3 2 1 3 3 1 1 3 1 2 3 2 0 1 1 0 2 2 2 1 1 0 3 1
19.2.2.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.HUB conjugation.ubiquitin-fold protein (HUB) 95 51 4 0 5 2 2 1 1 1 2 1 1 2 1 1 2 2 1 3 3 1 1 2 2 1 2 2 2 3 2 1 2 3 2 1 3 3 1 1 3 1 2 3 2 0 1 1 0 2 2 2 1 1 0 3 1
19.2.2.8.3.4.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP1-SPA substrate adaptor subcomplex.component COP1 94 51 3 0 1 1 1 1 1 1 2 0 1 1 2 2 2 2 2 2 4 0 1 2 3 1 2 2 2 2 1 0 1 1 1 1 2 1 1 3 2 9 2 3 1 2 2 1 2 2 1 1 3 1 2 3 1
19.2.2.1.5.3.6 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RING-domain E3 ligase activities.E3 ubiquitin ligase (DA2) 88 52 1 0 1 2 2 2 4 4 1 1 1 1 1 1 1 1 1 1 2 1 2 1 2 1 1 1 2 3 2 1 2 1 0 1 4 3 2 1 2 3 1 2 1 1 1 3 0 1 3 1 1 1 1 1 6
19.2.2.1.5.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.U-Box E3 ligase activities.bifunctional co-chaperone and E3 ubiquitin ligase (CHIP) 83 53 2 0 1 1 1 2 2 2 1 1 1 2 1 1 2 1 0 1 2 1 1 1 1 1 1 1 5 2 1 1 2 2 2 1 1 2 5 2 3 2 1 1 1 1 1 1 1 1 2 1 2 1 4 1 2
19.2.2.3.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.deneddylase (DEN1) 82 53 1 0 1 2 1 1 2 2 4 3 1 1 1 1 1 1 1 0 7 1 1 1 3 1 1 3 1 1 2 1 1 2 1 1 1 3 1 1 4 1 2 1 4 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO chain-forming-ligase E4 enzyme (PIAL) 82 51 1 0 1 2 2 1 4 5 1 0 1 1 2 1 1 1 1 2 2 0 2 1 3 1 1 1 2 1 3 0 2 1 1 4 1 1 2 2 1 1 1 1 1 2 1 2 1 1 2 3 1 1 3 1 1
19.2.2.3.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH3) 82 52 0 0 3 2 1 1 2 2 1 2 1 2 3 3 1 1 1 1 2 1 1 1 2 1 1 1 3 2 2 1 1 2 1 1 1 3 0 2 3 1 1 1 1 2 1 1 2 1 1 2 1 1 1 4 2
19.2.2.3.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.small component AXR1/AXL 81 53 1 0 1 2 2 1 5 5 1 2 0 1 1 1 2 1 1 1 2 1 2 1 1 2 1 1 2 1 1 1 3 2 1 1 2 1 3 1 1 2 1 2 1 2 1 2 1 1 2 1 1 1 1 1 2
19.2.2.8.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.core adaptor component DDB1 80 52 3 0 1 3 2 1 2 2 2 3 2 1 0 1 1 1 1 1 2 1 3 1 1 1 2 1 2 1 3 1 1 1 1 1 2 1 2 3 2 2 1 2 1 1 1 2 0 1 1 2 1 1 1 1 2
19.2.2.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.small component SAE1 74 53 1 0 1 2 3 1 3 1 1 3 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 2 2 2 1 2 2 1 1 1 1 0 2 3 1 1 2 1 2 1 2 2 1 1 1 1 1 1 1 1
19.2.2.8.2.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component NPH3 73 42 1 0 2 0 0 1 2 1 1 2 2 2 1 1 2 2 1 1 2 0 0 2 2 1 2 1 5 2 2 0 0 2 0 2 1 1 2 2 4 0 1 2 1 2 0 0 2 1 0 2 3 2 0 1 1
19.2.2.6.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.ubiquitin-fold protein (UFM) 71 51 1 0 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1 2 0 1 1 0 1 2 1 4 2 2 0 3 1 1 1 1 1 1 2 4 1 1 2 1 2 1 1 2 1 2 1 1 1 1 1 1
19.2.2.3.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB maturation.ubiquitin carboxyl-terminal hydrolase (UCH1|2) 71 51 1 0 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 0 2 1 1 1 3 1 1 1 3 2 0 1 1 1 1 2 1 1 1 2 2 1 3 1 0 1 1 1 3
19.2.2.1.2.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation.ubiquitin carboxyl-terminal hydrolase (UCH) 70 51 1 0 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 0 2 1 1 1 2 1 1 1 3 2 0 1 1 1 1 2 1 1 1 2 2 1 3 1 0 1 1 1 3
19.2.2.1.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin maturation 70 51 1 0 2 2 2 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 0 2 1 1 1 2 1 1 1 3 2 0 1 1 1 1 2 1 1 1 2 2 1 3 1 0 1 1 1 3
19.2.2.8.1.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.adaptor protein exchange factor (CAND1) 69 53 1 0 2 1 1 2 2 2 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1 3 1 2 1 2 1 1 1 2 1 1 1 2 2 1 2 1 1 1 1 0 1 2 1 1 1 1 1 1
19.2.2.2.2.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO activating E1 heterodimer.large component SAE2 69 54 3 0 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 2 1 2 2 1 1 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2
19.2.2.1.5.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (ARA54) 68 51 1 0 1 0 1 2 0 1 1 3 1 1 1 2 1 1 1 2 2 1 2 1 2 1 1 1 1 1 1 1 2 1 1 1 1 6 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 0 1 2 1
19.2.2.1.5.4.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.ubiquitin conjugation (ubiquitylation).ubiquitin-ligase E3 activities.RBR-type E3 ligase activities.E3 ubiquitin ligase (RBR-Helicase) 68 48 2 0 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1 1 2 0 1 1 1 1 1 1 2 2 3 0 0 1 1 4 3 1 0 2 1 0 1 2 1 2 0 1 2 1 1 2 1 1 1 1 1
19.2.2.8.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.scaffold component CUL4 68 49 0 0 1 1 1 1 3 2 1 1 0 1 0 1 1 1 1 1 2 1 1 1 1 1 1 1 3 3 2 1 1 2 1 1 1 1 0 1 1 3 1 2 1 2 1 2 0 1 2 1 2 1 1 2 2
19.2.2.3.5.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB ligase E3 activities.RUB ligase E3 protein (DCN1) 66 48 1 0 1 1 1 1 3 3 1 1 1 1 1 1 1 1 0 1 0 2 1 1 1 1 1 2 2 2 1 0 2 1 1 1 2 1 0 2 2 3 1 1 1 2 2 1 1 1 2 1 2 0 1 1 0
19.2.2.8.3.3.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.regulator component DET1 66 53 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 2 1 1 1 1 1 1 1 5 1 1 1 1 1 1 1 1 1 2 1 2 3 1 1 1 1 1 1 1 1 1 1 1 2 1 1 4
19.2.2.3.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).RUB activating E1 heterodimer.large component ECR1 65 52 2 0 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 2 2 1 2 1 0 2 1 1 1 1 0 1 2 2 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1
19.2.2.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.RUB/NEDD8 conjugation (neddylation).ubiquitin-fold protein (RUB) 65 40 1 0 1 2 2 0 1 3 1 3 0 0 2 2 0 1 1 0 2 1 2 1 0 1 2 2 2 1 2 0 0 2 0 1 0 3 2 0 1 1 1 3 1 1 0 2 1 3 2 0 1 0 1 1 2
19.2.2.6.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-conjugation E2 protein 65 52 2 0 1 1 1 1 3 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 2 1 0 3 1 1 1 1 1 1 1 1 1 2 1 1 1 0 1 1 1 3 1 1 1 1 1 1
19.2.2.8.2.2.5 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component BPH1 64 43 0 0 2 2 2 1 2 3 1 0 1 2 1 1 1 1 1 1 0 0 2 1 2 1 0 1 4 1 1 0 0 1 0 2 2 1 0 2 1 0 1 2 1 1 0 2 1 1 2 2 2 2 1 1 1
19.2.2.2.4.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.SUMO conjugation (sumoylation).SUMO E3 ligase activities.E3 ligase (HPY2) 64 52 1 0 2 1 1 1 1 1 1 1 0 1 1 1 1 1 0 1 2 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 2 1 2 4 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1
19.2.2.6.4 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-ligase E3 protein 61 53 3 0 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 2 1 1 0 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.8.1.4.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.SKP1-CUL1-FBX (SCF) E3 ligase complexes.F-BOX substrate adaptor components.component UFO 61 49 2 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 2 0 1 1 1 1 1 3 2 1 1 0 1 1 0 1 1 1 3 1 3 0 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2
19.2.2.6.2 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.UFM conjugation.UFM-activating E1 protein 58 51 0 0 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 0 2 1 1 2 1 1 0 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.7 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation 54 49 0 0 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 0 0 1 1 1 0 1 1 1 2 1 2 0 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.7.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.URM conjugation.ubiquitin-fold protein (URM) 54 49 0 0 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 0 0 1 1 1 0 1 1 1 2 1 2 0 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1
19.2.2.8.3.3.1 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.COP10-DET1 (CDD) subcomplex.E2 conjugating component COP10 46 45 0 0 1 1 1 0 1 1 1 1 1 1 1 1 0 1 1 0 0 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 0 1 1 2 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1
19.2.2.8.2.2.3 .Protein homeostasis.ubiquitin-proteasome system.ubiquitin-fold protein conjugation.Cullin-based ubiquitylation complexes.CUL3-BTB E3 ligase complexes.BTB/POZ substrate adaptor components.component FBL 46 43 1 0 1 1 1 0 1 1 1 1 1 1 1 2 0 0 0 1 1 0 1 0 1 0 1 1 1 1 1 0 1 1 1 1 1 1 1 1 2 1 1 0 1 1 1 1 1 2 1 1 0 1 1 1 0