Gene: AT3G10010

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT3G10010
  • Transcript Identifier AT3G10010.2
  • Gene Type Coding gene
  • Location Chr3 : 3081999-3088195 : negative

Gene Family Information

  • ID HOM05D001201
  • #Genes/#Species 520/96
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT3G10010.2
  • symbol DML2
  • uniprot Q9SR66

Descriptions

  • Description demeter-like 2
  • Computational description demeter-like 2 (DML2); FUNCTIONS IN: 4 iron, 4 sulfur cluster binding, catalytic activity, endonuclease activity; INVOLVED IN: DNA repair, base-excision repair; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: demeter-like 1 (TAIR:AT2G36490.1); Has 3292 Blast hits to 3211 proteins in 1332 species: Archae - 246; Bacteria - 2331; Metazoa - 80; Fungi - 82; Plants - 273; Viruses - 0; Other Eukaryotes - 280 (source: NCBI BLink).
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006281
IEA
GOA DatabaseDNA repair
GO:0006281
IEA
InterProDNA repair
GO:0048229
ISO
PLAZA Integrative Orthologygametophyte development Os01g0218032
GO:0009836
ISO
PLAZA Integrative Orthologyfruit ripening, climacteric Solyc09g009080.4
GO:0006306
ISO
PLAZA Integrative OrthologyDNA methylation Solyc09g009080.4
GO:0010154
ISO
PLAZA Integrative Orthologyfruit development Solyc09g009080.4
GO:0006284
IEA
Gene Ontologybase-excision repair
GO:0006284
IEA
InterProbase-excision repair
GO:0080111
IEA
Gene OntologyDNA demethylation
GO:0080111
IEA
InterProDNA demethylation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051747
ISO
PLAZA Integrative Orthologycytosine C-5 DNA demethylase activity Os05g0445900
GO:0051539
IEA
GOA Database4 iron, 4 sulfur cluster binding
GO:0051539
IEA
InterPro4 iron, 4 sulfur cluster binding
GO:0035514
IEA
Gene OntologyDNA demethylase activity
GO:0035514
IEA
InterProDNA demethylase activity
GO:0019104
IEA
Gene OntologyDNA N-glycosylase activity
GO:0019104
IEA
InterProDNA N-glycosylase activity
GO:0003824
IEA
GOA Databasecatalytic activity
GO:0003824
IEA
InterProcatalytic activity
GO:0016787
IEA
GOA Databasehydrolase activity
GO:0003677
IEA
GOA DatabaseDNA binding
GO:0046872
IEA
GOA Databasemetal ion binding
GO:0051536
IEA
GOA Databaseiron-sulfur cluster binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
GOA Databasenucleus
GO:0005634
ISM
Gene Ontologynucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR023170 Helix-hairpin-helix, base-excision DNA repair, C-terminal
IPR028925 Demeter, RRM-fold domain
IPR011257 DNA glycosylase
IPR028924 Permuted single zf-CXXC unit
IPR044811 DNA glycosylase, plant
IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif
IPR003265 HhH-GPD domain
Mapman id Description
12.5.3.1 Chromatin organisation.DNA methylation.ROS1-mediated DNA demethylation.methylcytosine-specific DNA glycosylase (ROS1)