InterPro domain: IPR028924

General Information

  • Identifier IPR028924
  • Description Permuted single zf-CXXC unit
  • Number of genes 297
  • Gene duplication stats Loading...

Abstract

This is a permuted version of a single unit of the zf-CXXC domain that is detected in the Demeter-like proteins and ROS1 (REPRESSOR OF SILENCING 1) from plants [ 1 ]. Demeter and ROS1 proteins catalyse the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism [ 2 ]. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases [ 2 ]. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.


1. DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases. Proc. Natl. Acad. Sci. U.S.A. 103, 6853-8
2. Natural history of eukaryotic DNA methylation systems. Prog Mol Biol Transl Sci 101, 25-104

Species distribution

Gene table