Gene: Sopen11g027520

General Information

Description Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway. Binds DPA and RBR1 proteins. Expressed throughout the cell cycle. Abundance increased by auxin through stabilization of the protein. Elevates CDK levels and activity, even under hormone-free conditions. Promotes cell division and shortens cell doubling time, inhibits cell growth. Transgenic plants overexpressing AtE2Fa contained an increased level of AtE2Fb transcripts that is paralleled by an increase in the amount of the AtE2Fb protein, suggesting that AtE2Fb expression might actually be up-regulated by the AtE2Fa transcription factor. | E2F transcription factor 1 (E2F1) | CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding , Transcription factor E2F/dimerisation partner (TDP) , E2F Family | BEST Arabidopsis thaliana protein match is: E2F transcription factor 3

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0051301	ISO	PLAZA Integrative Orthology	cell division	AT1G47870
GO:0051446	ISO	PLAZA Integrative Orthology	positive regulation of meiotic cell cycle	AT5G22220
GO:0010767	ISO	PLAZA Integrative Orthology	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	AT1G47870
GO:0019760	ISO	PLAZA Integrative Orthology	glucosinolate metabolic process	AT1G47870
GO:0051782	ISO	PLAZA Integrative Orthology	negative regulation of cell division	AT1G47870
GO:0045893	ISO	PLAZA Integrative Orthology	positive regulation of transcription, DNA-templated	AT5G22220
GO:0051302	ISO	PLAZA Integrative Orthology	regulation of cell division	AT5G22220
GO:0009733	ISO	PLAZA Integrative Orthology	response to auxin	AT5G22220
GO:0010090	ISO	PLAZA Integrative Orthology	trichome morphogenesis	AT5G22220
GO:0042023	ISO	PLAZA Integrative Orthology	DNA endoreduplication	AT1G47870
GO:0043068	ISO	PLAZA Integrative Orthology	positive regulation of programmed cell death	AT1G47870
GO:0008284	ISO	PLAZA Integrative Orthology	positive regulation of cell population proliferation	AT5G22220
GO:0000902	ISO	PLAZA Integrative Orthology	cell morphogenesis	AT1G47870
GO:0006357	IEA	InterPro	regulation of transcription by RNA polymerase II
GO:0006355	IEA	InterPro	regulation of transcription, DNA-templated

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0046982	ISO	PLAZA Integrative Orthology	protein heterodimerization activity	AT1G47870
GO:0005515	ISO	PLAZA Integrative Orthology	protein binding	AT5G22220
GO:0003700	ISO	PLAZA Integrative Orthology	DNA-binding transcription factor activity	AT5G22220
GO:0003677	ISO	PLAZA Integrative Orthology	DNA binding	AT5G22220
GO:0000976	ISO	PLAZA Integrative Orthology	transcription cis-regulatory region binding	AT1G47870
GO:0046983	IEA	InterPro	protein dimerization activity
GO:0000978	IEA	InterPro	RNA polymerase II cis-regulatory region sequence-specific DNA binding

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005737	ISO	PLAZA Integrative Orthology	cytoplasm	AT5G22220
GO:0005634	ISO	PLAZA Integrative Orthology	nucleus	AT5G22220
GO:0005667	IEA	InterPro	transcription regulator complex
GO:0005730	ISO	PLAZA Integrative Orthology	nucleolus	AT1G47870

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR003316	E2F/DP family, winged-helix DNA-binding domain
IPR036390	Winged helix DNA-binding domain superfamily
IPR015633	E2F Family
IPR037241	E2F-DP heterodimerization region
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR032198	E2F transcription factor, CC-MB domain

Mapman id	Description
13.1.2.1.4.1	Cell cycle organisation.cell cycle control.regulation.MuvB/DREAM regulatory complexes.E2F-DP dimer.component E2F
15.5.10	RNA biosynthesis.transcriptional regulation.transcription factor (E2F)