InterPro domain: IPR037241

The E2F transcription factors associated with the corresponding domain of the DP transcription factor forming an heterodimer fold with the N-terminal long helices of both chains forming a parallel coiled coil and their C-terminal folded beta-hairpins interlocking together in a beta-sandwich. This complex binds the C terminus of retinoblastoma protein [ 1 ].

1. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123, 1093-106