InterPro domain: IPR003316

General Information

  • Identifier IPR003316
  • Description E2F/DP family, winged-helix DNA-binding domain
  • Number of genes 914
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005667   GO:0006355  

Abstract

This entry represents the DNA-binding domain of the E2F and DP proteins, which have a fold related to the winged-helix DNA-binding motif [ 1 ]. The mammalian transcription factor E2F plays an important role in regulating the expression of genes that are required for passage through the cell cycle. Multiple E2F family members have been identified that bind to DNA as heterodimers, interacting with proteins known as DP - the dimerisation partners [ 2 ].


1. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev. 13, 666-74
2. In vivo association of E2F and DP family proteins. Mol. Cell. Biol. 15, 2536-46

Species distribution

Gene table