Gene: Sopen01g046340

General Information

Structural Information

  • Species Solanum pennellii
  • Gene Identifier Sopen01g046340
  • Transcript Identifier Sopen01g046340.2
  • Gene Type Coding gene
  • Location Spenn-ch01 : 103035134-103047811 : negative

Gene Family Information

  • ID HOM05D005536
  • #Genes/#Species 139/97
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid Sopen01g046340.2

Descriptions

  • Description Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media. | THIAMINE REQUIRING 1 (TH1) | FUNCTIONS IN: phosphomethylpyrimidine kinase activity, thiamin-phosphate diphosphorylase activity, hydroxymethylpyrimidine kinase activity | INVOLVED IN: thiamin biosynthetic process | LOCATED IN: chloroplast | EXPRESSED IN: 22 plant structures | EXPRESSED DURING: 13 growth stages | CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase , Phosphomethylpyrimidine kinase type-2 , Aldolase-type TIM barrel , Phosphomethylpyrimidine kinase type-1
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0009228
IEA
InterProthiamine biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008972
IEA
InterProphosphomethylpyrimidine kinase activity
GO:0003824
IEA
InterProcatalytic activity
GO:0004789
IEA
InterProthiamine-phosphate diphosphorylase activity
GO:0008902
ISO
PLAZA Integrative Orthologyhydroxymethylpyrimidine kinase activity AT1G22940

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0009570
ISO
PLAZA Integrative Orthologychloroplast stroma AT1G22940
GO:0009507
ISO
PLAZA Integrative Orthologychloroplast AT1G22940

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR045029 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
IPR022998 Thiamine phosphate synthase/TenI
IPR029056 Ribokinase-like
IPR013785 Aldolase-type TIM barrel
IPR036206 Thiamin phosphate synthase superfamily
IPR004399 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase domain
IPR034291 Thiamine phosphate synthase
IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Mapman id Description
7.2.1.2 Coenzyme metabolism.thiamine pyrophosphate biosynthesis.hydroxymethylpyrimidine diphosphate biosynthesis.bifunctional hydroxymethylpyrimidine kinase and thiamine-phosphate diphosphorylase (Th1)