InterPro domain: IPR013785

General Information

  • Identifier IPR013785
  • Description Aldolase-type TIM barrel
  • Number of genes 12020
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003824  

Abstract

This entry represents the TIM beta/alpha barrel found in aldolase and in related proteins. This TIM barrel usually covers the entire protein structure. Proteins containing this TIM barrel domain include class I aldolases, class I DAHP synthases, class II fructose-bisphosphate aldolases (FBP aldolases), and 5-aminolaevulinate dehydratase (a hybrid of classes I and II aldolases) [ 1 , 2 , 3 ].


1. Quaternary structure of aldolase leads to differences in its folding and unfolding intermediates. Biochemistry 42, 5713-21
2. X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase. Nat. Struct. Biol. 4, 1025-31
3. Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. J. Mol. Biol. 343, 1019-34

Species distribution

Gene table