Gene: AT2G36490

General Information

Computational description demeter-like 1 (DML1); FUNCTIONS IN: protein binding, DNA N-glycosylase activity, DNA-(apurinic or apyrimidinic site) lyase activity; INVOLVED IN: DNA repair, chromatin silencing, negative regulation of chromatin silencing, DNA methylation, DNA demethylation; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: HhH-GPD base excision DNA repair family protein (TAIR:AT5G04560.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0080111	IEA	GOA Database	DNA demethylation
GO:0080111	IMP	Gene Ontology	DNA demethylation	1
GO:0080111	IEA	InterPro	DNA demethylation
GO:0006281	IEA	GOA Database	DNA repair
GO:0006281	IMP	Gene Ontology	DNA repair	2
GO:0006281	IEA	InterPro	DNA repair
GO:0006284	IEA	Gene Ontology	base-excision repair
GO:0006284	IEA	InterPro	base-excision repair
GO:0010154	ISO	PLAZA Integrative Orthology	fruit development	Solyc09g009080.4
GO:0009836	ISO	PLAZA Integrative Orthology	fruit ripening, climacteric	Solyc09g009080.4
GO:0048229	ISO	PLAZA Integrative Orthology	gametophyte development	Os01g0218032
GO:0006342	IMP	Gene Ontology	chromatin silencing	2
GO:0006306	IDA	Gene Ontology	DNA methylation	3
GO:0031936	IMP	Gene Ontology	negative regulation of chromatin silencing	1
GO:0050832	IMP	Gene Ontology	defense response to fungus	4

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0019104	IEA	GOA Database	DNA N-glycosylase activity
GO:0019104	IDA ISS TAS	Gene Ontology	DNA N-glycosylase activity	2 3 5
GO:0019104	IEA	InterPro	DNA N-glycosylase activity
GO:0051536	IEA	GOA Database	iron-sulfur cluster binding
GO:0046872	IEA	GOA Database	metal ion binding
GO:0016829	IEA	GOA Database	lyase activity
GO:0003677	IEA	GOA Database	DNA binding
GO:0003824	IEA	GOA Database	catalytic activity
GO:0003824	IEA	InterPro	catalytic activity
GO:0051539	IEA	GOA Database	4 iron, 4 sulfur cluster binding
GO:0051539	IEA	InterPro	4 iron, 4 sulfur cluster binding
GO:0035514	IEA	Gene Ontology	DNA demethylase activity
GO:0035514	IEA	InterPro	DNA demethylase activity
GO:0051747	ISO	PLAZA Integrative Orthology	cytosine C-5 DNA demethylase activity	Os05g0445900
GO:0005515	IPI	Gene Ontology	protein binding	6
GO:0140078	IEA	Gene Ontology	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0003906	IDA ISS	Gene Ontology	DNA-(apurinic or apyrimidinic site) endonuclease activity	2 3

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005634	IEA	GOA Database	nucleus
GO:0005634	IDA ISM	Gene Ontology	nucleus	2
GO:0005730	IEA	GOA Database	nucleolus

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR003265	HhH-GPD domain
IPR044811	DNA glycosylase, plant
IPR028924	Permuted single zf-CXXC unit
IPR011257	DNA glycosylase
IPR028925	Demeter, RRM-fold domain
IPR023170	Helix-hairpin-helix, base-excision DNA repair, C-terminal
IPR003651	Endonuclease III-like, iron-sulphur cluster loop motif

Mapman id	Description
12.5.3.1	Chromatin organisation.DNA methylation.ROS1-mediated DNA demethylation.methylcytosine-specific DNA glycosylase (ROS1)
14.5.4	DNA damage response.base excision repair (BER).bifunctional DNA glycosylase/lyase (ROS1)