Module
- Number
- 16
- Regulatory Genes
- 6
- Module Genes
- 93
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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ztf-18 | T24C4.7 | WBGene00020763 | 679 | View | |
hmg-4 | T20B12.8 | WBGene00001974 | 488 |
hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development.
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C12D12.5 | C12D12.5 | WBGene00015716 | 128 | View | |
nhr-47 | C24G6.4 | WBGene00003637 | 128 |
nhr-47 is predicted to encode a nuclear hormone receptor (NHR); gene expression of nhr-47 appears to be induced upon exposure of worm cultures to estradiol.
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B0035.1 | B0035.1 | WBGene00007105 | 122 | View | |
lin-36 | F44B9.6 | WBGene00003021 | 107 | View |
CLR Predictions
56 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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agt-2 | F09E5.13 | WBGene00000094 |
agt-2 encodes a paralog of the DNA repair enzyme O6-Alkylguanine DNA-alkyltransferase (AGT); AGT-2 has AGT biochemical activity and is expressed at all developmental stages.
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apb-3 | R11A5.1 | WBGene00000163 |
apb-3 encodes an adaptin, orthologous to the beta3 subunit of adaptor protein complex 3 (AP-3); based on structural similarity, APB-3 is predicted to be involved in the formation of intracellular transport vesicles, and genetic analyses indicate that apb-3 activity is required for biogenesis of lysosome-related gut granules.
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B0336.7 | B0336.7 | WBGene00015147 |
B0336.7 encodes, by alternative splicing, two isoforms of a protein with a THAP or THAP-like domain; other proteins with such domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1; B0336.7 is expressed in intestine and amphid neurons.
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B0564.11 | B0564.11 | WBGene00023421 | View | |
C05C8.9 | C05C8.9 | WBGene00015466 | View | |
C09G9.2 | C09G9.2 | WBGene00007493 | View | |
C13F10.5 | C13F10.5 | WBGene00015744 | View | |
cdk-7 | Y39G10AL.3 | WBGene00000408 |
The cdk-7 gene encodes a cyclin-dependent kinase orthologous to human CDK7 (OMIM:601955) that is a component of the general transcription factor IIH (TFIIH) complex; CDK-7 is required during embryogenesis for mRNA transcription and phosphorylation of RNA polymerase II on serine 2 and serine 5, as well as for cell cycle progression, maintenance of ploidy, and completion of meiosis following fertilization.
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ced-12 | Y106G6E.5 | WBGene00000426 |
ced-12 is required both for phagocytotic engulfment of dying (apoptotic) cells, and for normal migrations of healthy cells during development.
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cogc-8 | R02D3.2 | WBGene00019820 |
cogc-8 encodes an ortholog of mammalian COG-8, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-8 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-8 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
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crn-5 | C14A4.5 | WBGene00000798 | View | |
cul-2 | ZK520.4 | WBGene00000837 |
cul-2 encodes an E3 ubiquitin ligase; during development, CUL-2 functions as part of a Cul2-RING ubiquitin-ligase complex that regulates diverse biological processes, such as the initiation of meiotic anaphase II, cytokinesis and mitotic chromosome segregation, embryonic cell fate specification, and sex determination, via ubiquitin-mediated proteolysis; targets of CUL-2-mediated degradation include CYB-1/cyclin B and the zinc-finger protein TRA-1; CUL-2 is expressed in diverse cell types during embryonic and larval development and is also expressed in the adult germ line.
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cyn-15 | Y87G2A.6 | WBGene00000891 |
cyn-15 encodes a little-characterized cyclophilin homolog.
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cyn-4 | F59E10.2 | WBGene00000880 |
cyn-4 encodes a divergent member of the cyclophilin family orthologous to human hCyP-60; in the hermaphrodite germline, cyn-4 activity is required for the sperm/oocyte switch, robust germline proliferation and, redundantly with gld-3, for the mitosis/meiosis decision; in addition, maternal cyn-4 is required for embryogenesis and loss of cyn-4 via RNAi results in morphological defects at early larval stages; in vitro, CYN-4 interacts with the MEP-1 NuRD complex component, as do the MOG-1, -4, and -5 proteins; CYN-4's interaction with MEP-1 is independent of the CYN-4 CBD (central binding domain) which is also dispensable for CYN-4's role in the sperm/oocyte switch; CYN-4 is expressed in the nuclei of both germline and somatic cells; in L4 larvae, CYN-4 is ubiquitously expressed in the mitotic and meiotic regions, but absent from the proximal zone.
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D1046.1 | D1046.1 | WBGene00008362 |
D1046.1 encodes a putative cleavage and polyadenylation specificity factor, orthologous to human CPSF6 (OMIM:604979) and CPSF7, that is required for normal locomotion and fertility; D1046.1 is expressed in many, if not all, somatic tissues of larvae and adults; D1046.1(RNAi) has no obvious synthetic phenotype in dual RNAi assays with W04D2.6 (an ortholog of the splicing protein RED120).
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D2024.5 | D2024.5 | WBGene00017053 | View | |
dcr-1 | K12H4.8 | WBGene00000939 |
The dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing.
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F02E9.7 | F02E9.7 | WBGene00008531 | View | |
F08B4.5 | F08B4.5 | WBGene00017237 | View | |
F10G8.6 | F10G8.6 | WBGene00008664 |
F10G8.6 encodes an homolog of S. cerevisiae CFD1 (also known as YIL003W/DRE3), a putative P-loop ATPase conserved in eukaryotes and required in yeast for 4Fe-4S cluster assembly; F10G8.6 is also homologous to yeast NBP35/YGL091C; in C. elegans, F10G8.6 is required for normally rapid growth and maintenance of the germline; F10G8.6 protein was predicted to be mitochondrial on the basis of its phylogenetic profile.
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F25H8.2 | F25H8.2 | WBGene00009132 | View | |
F26F4.12 | F26F4.12 | WBGene00017831 | View | |
F28D1.1 | F28D1.1 | WBGene00009211 | View | |
F29B9.2 | F29B9.2 | WBGene00017920 | View | |
F29D11.2 | F29D11.2 | WBGene00009254 | View | |
F31E3.4 | F31E3.4 | WBGene00017951 | View | |
F33H2.2 | F33H2.2 | WBGene00009366 | View | |
F36A2.13 | F36A2.13 | WBGene00009460 | View | |
F39B2.5 | F39B2.5 | WBGene00009556 | View | |
F39H11.1 | F39H11.1 | WBGene00009565 | View | |
F41C3.4 | F41C3.4 | WBGene00018270 | View | |
F42G9.1 | F42G9.1 | WBGene00018362 | View | |
F43G9.10 | F43G9.10 | WBGene00009671 | View | |
F52B11.1 | F52B11.1 | WBGene00009924 | View | |
F56D12.6 | F56D12.6 | WBGene00018974 | View | |
F59A2.4 | F59A2.4 | WBGene00010304 | View | |
fis-2 | F13B9.8 | WBGene00001425 | View | |
gei-6 | C05C8.4 | WBGene00001563 | View | |
gfl-1 | M04B2.3 | WBGene00001585 |
gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.
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hmp-2 | K05C4.6 | WBGene00001979 |
hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway.
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hoe-1 | E04A4.4 | WBGene00001983 |
hoe-1 encodes, by alternative splicing, two isoforms of a putative metal-dependent hydrolase orthologous to human ELAC2 (OMIM:605367, associated with susceptibility to prostate cancer); HOE-1 is required for fertility, normal growth progression during the late larval stages and germ line proliferation; since hoe-1(RNAi) animals do not produce gametes, hoe-1 may be required for mitosis and meiosis; hoe-1 deficiency suppresses the multivulva (Muv) phenotype of activated LET-60/RAS, while having no effect on other RAS pathway members.
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hst-1 | F08B4.6 | WBGene00002028 |
hst-1 encodes the C. elegans ortholog of N-deacetylase/N-sulfotransferase (NDST), a bifunctional enzyme that catalyzes N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate; loss of hst-1 activity has been reported to result in embryonic lethality at various stages of development, defects in ventral neuroblast migrations during epidermal enclosure, and cessation of egg production in injected hermaphrodites.
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imb-1 | F28B3.8 | WBGene00002075 | View | |
lin-9 | ZK637.7 | WBGene00002998 |
lin-9 encodes two novel proteins that are conserved amongst C. elegans, Drosophila, plants, and vertebrates; lin-9 activity is required redundantly with activity of the synMuv A genes, such as lin-8, for negative regulation of the RTK/Ras-mediated signal transduction pathway that controls vulval development; in addition, lin-9 activity is required non-redundantly for hermaphrodite gonadal sheath cell development (and thus, reproduction), as well as for development of the male reproductive system including the male sensory rays and spicules.
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mvb-12 | C06A6.3 | WBGene00015508 | View | |
ngp-1 | T19A6.2 | WBGene00003596 | View | |
npp-13 | Y37E3.15 | WBGene00003799 | View | |
npp-15 | C29E4.4 | WBGene00003801 | View | |
npp-6 | F56A3.3 | WBGene00003792 |
npp-6 encodes a protein with weak similarity to mouse nuclear pore complex protein Nup160, and affects embryonic and larval viability.
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ntp-1 | C33H5.14 | WBGene00016380 | View | |
orc-2 | F59E10.1 | WBGene00003882 | View | |
pis-1 | T13F2.3 | WBGene00004031 |
pis-1 encodes an ortholog of mammalian Pax transcription activation domain interacting protein PTIP; PIS-1 has an N-terminal glutamine/asparagine-rich domain and four C-terminal BRCT domains, and is dispensable for obvious functions in mass RNAi assays; mammalian PTIP binds to the activation domain of Pax2 and other Pax proteins, and colocalizes with Pax2 to actively expressed chromatin, and appears to be required for embryonic mitosis (perhaps because of a link between BRCT domains and DNA repair).
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pqn-45 | F56F3.1 | WBGene00004132 |
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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prp-4 | C36B1.5 | WBGene00007972 | View | |
pus-1 | W06H3.2 | WBGene00004248 |
pus-1 encodes a putative tRNA pseudouridine synthase that is predicted, by phylogenetic profiling, to be mitochondrial.
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R04F11.3 | R04F11.3 | WBGene00011016 | View | |
R05D3.8 | R05D3.8 | WBGene00019881 | View | |
R05F9.9 | R05F9.9 | WBGene00019892 | View | |
R08D7.1 | R08D7.1 | WBGene00011142 | View | |
R08D7.2 | R08D7.2 | WBGene00011143 | View | |
R144.6 | R144.6 | WBGene00020096 | View | |
rnp-6 | Y47G6A.20 | WBGene00004389 |
rnp-6 encodes an ortholog of HALF-PINT in D. melanogaster and FBP Interacting Repressor (FIR)/PUF60 in mammals, predicted to be involved in mRNA splicing regulation, mRNA localization, or transcriptional regulation via TFIIH.
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rsd-6 | F16D3.2 | WBGene00004684 | View | |
rsp-8 | C18D11.4 | WBGene00004705 | View | |
set-2 | C26E6.9 | WBGene00004782 | View | |
sig-7 | F39H2.2 | WBGene00000890 |
sig-7 encodes a predicted cyclophilin; loss of sig-7 activity via large-scale RNAi screens results in embryonic and larval lethality as well as reduced brood sizes, suggesting that SIG-7 plays an essential role during C. elegans development.
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smu-1 | CC4.3 | WBGene00004895 | View | |
suf-1 | F28C6.6 | WBGene00006307 | View | |
T02C12.3 | T02C12.3 | WBGene00011368 | View | |
T07F10.3 | T07F10.3 | WBGene00011589 | View | |
T19A6.3 | T19A6.3 | WBGene00011828 | View | |
T23G5.2 | T23G5.2 | WBGene00011962 | View | |
T24G10.2 | T24G10.2 | WBGene00020779 | View | |
tag-231 | ZK430.2 | WBGene00044063 | View | |
tag-345 | F55F8.5 | WBGene00018893 | View | |
tag-72 | C25A1.3 | WBGene00006447 | View | |
tgt-2 | Y39B6A.35 | WBGene00006567 | View | |
thoc-2 | C16A3.8 | WBGene00015813 | View | |
trr-1 | C47D12.1 | WBGene00007028 |
trr-1 encodes proteins with similarity to the atypical protein kinases of the TRAAP subfamily of PIKK kinases that are found in multisubunit, chromatin-modifying histone acetyltransferase complexes; trr-1 functions as a negative regulator of let-60/Ras signaling and was initially identified in screens for synMuv genes that interact with lin-15A; trr-1 mutations were subsequently found to have weakly penetrant vulval defects on their own, as well as slow growth and sterile phenotypes; trr-1 is classified as a class C synMuv gene, as it interacts genetically with both class A and class B synMuv mutations; TRR-1 is a nuclear protein that is broadly expressed throughout development; in germ cell nuclei and cellularized oocytes, TRR-1 localizes to condensed chromosomes.
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ttll-5 | C55A6.2 | WBGene00008331 |
ttll-5 encodes a putative tubulin polyglutamylase orthologous to human TTLL5; TTLL-5 is required for embryonic development and fertility; by orthology, TTLL-5 is expected to initiate glutamyl chains rather than elongating them, to prefer alpha-tubulin over beta-tubulin as a substrate, and to have non-tubulin substrates.
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vrk-1 | F28B12.3 | WBGene00017895 | View | |
W07E6.2 | W07E6.2 | WBGene00021074 |
W07E6.2 encodes an ortholog of S. cerevisiae RSA4 that may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation; like PRO-1, -2, and -3, W07E6.2 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germ line.
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W09C5.7 | W09C5.7 | WBGene00012353 | View | |
Y110A7A.9 | Y110A7A.9 | WBGene00022459 |
Y110A7A.9 is orthologous to the human gene KIAA1351 PROTEIN (WDR11; OMIM:606417), which when mutated leads to disease.
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Y40B1B.7 | Y40B1B.7 | WBGene00012739 | View | |
Y54E10BR.3 | Y54E10BR.3 | WBGene00021842 | View | |
Y73F8A.27 | Y73F8A.27 | WBGene00013532 | View | |
Y77E11A.6 | Y77E11A.6 | WBGene00022309 | View | |
ZK353.1 | ZK353.1 | WBGene00022697 | View | |
ZK593.8 | ZK593.8 | WBGene00014004 | View | |
ZK632.2 | ZK632.2 | WBGene00014011 | View | |
ZK858.7 | ZK858.7 | WBGene00014120 | View | |
zyg-9 | F22B5.7 | WBGene00006994 |
zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1.
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