Genes

Gene

Public Gene Name: cyn-4
Sequence Name: F59E10.2
WB ID: WBGene00000880
Description: cyn-4 encodes a divergent member of the cyclophilin family orthologous to human hCyP-60; in the hermaphrodite germline, cyn-4 activity is required for the sperm/oocyte switch, robust germline proliferation and, redundantly with gld-3, for the mitosis/meiosis decision; in addition, maternal cyn-4 is required for embryogenesis and loss of cyn-4 via RNAi results in morphological defects at early larval stages; in vitro, CYN-4 interacts with the MEP-1 NuRD complex component, as do the MOG-1, -4, and -5 proteins; CYN-4's interaction with MEP-1 is independent of the CYN-4 CBD (central binding domain) which is also dispensable for CYN-4's role in the sperm/oocyte switch; CYN-4 is expressed in the nuclei of both germline and somatic cells; in L4 larvae, CYN-4 is ubiquitously expressed in the mitotic and meiotic regions, but absent from the proximal zone.