Transcription regulatory networks in Caenorhabditis elegans
Gene
- Public Gene Name
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trr-1
- Sequence Name
- C47D12.1
- WB ID
- WBGene00007028
- Description
-
trr-1 encodes proteins with similarity to the atypical protein kinases of the TRAAP subfamily of PIKK kinases that are found in multisubunit, chromatin-modifying histone acetyltransferase complexes; trr-1 functions as a negative regulator of let-60/Ras signaling and was initially identified in screens for synMuv genes that interact with lin-15A; trr-1 mutations were subsequently found to have weakly penetrant vulval defects on their own, as well as slow growth and sterile phenotypes; trr-1 is classified as a class C synMuv gene, as it interacts genetically with both class A and class B synMuv mutations; TRR-1 is a nuclear protein that is broadly expressed throughout development; in germ cell nuclei and cellularized oocytes, TRR-1 localizes to condensed chromosomes.
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