Gene
- Public Gene Name
- pis-1
- Sequence Name
- T13F2.3
- WB ID
- WBGene00004031
- Description
- pis-1 encodes an ortholog of mammalian Pax transcription activation domain interacting protein PTIP; PIS-1 has an N-terminal glutamine/asparagine-rich domain and four C-terminal BRCT domains, and is dispensable for obvious functions in mass RNAi assays; mammalian PTIP binds to the activation domain of Pax2 and other Pax proteins, and colocalizes with Pax2 to actively expressed chromatin, and appears to be required for embryonic mitosis (perhaps because of a link between BRCT domains and DNA repair).
