Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

cul-2  

Sequence Name

ZK520.4  

WB ID

WBGene00000837  

Description

cul-2 encodes an E3 ubiquitin ligase; during development, CUL-2 functions as part of a Cul2-RING ubiquitin-ligase complex that regulates diverse biological processes, such as the initiation of meiotic anaphase II, cytokinesis and mitotic chromosome segregation, embryonic cell fate specification, and sex determination, via ubiquitin-mediated proteolysis; targets of CUL-2-mediated degradation include CYB-1/cyclin B and the zinc-finger protein TRA-1; CUL-2 is expressed in diverse cell types during embryonic and larval development and is also expressed in the adult germ line.