InterPro domain: IPR037477

SCO2 (SNOWY COTYLEDON 2) is a chloroplast protein disulphide isomerase, which is thought to be involved in protein folding [ 1 ]. It interacts with LHCB1 (light-harvesting chlorophyll binding 1) and affects chloroplast biogenesis in cotyledons [ 2 ]. It has been shown to have a role in leaf variegation in both Lotus japonicus and Arabidopsis thaliana [ 3 ].

1. Snowy cotyledon 2: the identification of a zinc finger domain protein essential for chloroplast development in cotyledons but not in true leaves. Plant Mol. Biol. 66, 599-608
2. The SCO2 protein disulphide isomerase is required for thylakoid biogenesis and interacts with LHCB1 chlorophyll a/b binding proteins which affects chlorophyll biosynthesis in Arabidopsis seedlings. Plant J. 69, 743-54
3. SNOWY COTYLEDON 2 Promotes Chloroplast Development and Has a Role in Leaf Variegation in Both Lotus japonicus and Arabidopsis thaliana. Mol Plant 10, 721-734