InterPro domain: IPR044807

DREB2A-Interacting Proteins (DRIPs) are E3 ubiquitin-protein ligases that act as negative regulators of the response to water stress. This family includes DRIP1, DRIP2 and the DRIP homologue (DRIPH) At3g23060 from Arabidopsis, which mediate ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator Dehydration-Responsive Element-Binding Protein 2A (DREB2A) [ 1 , 2 , 3 ]. DRIP1 and DRIP2 are functionally redundant. DREB2A regulates the expression of stress-inducible genes via the dehydration-responsive elements and requires posttranslational modification for its activation. DRIPs contain a RING finger, and a RING finger- and WD40-associated ubiquitin-like (RAWUL) domain [ 4 , 4 ]. The RAWUL domain is responsible for the protein interaction with DREB2A.

1. The cowpea RING ubiquitin ligase VuDRIP interacts with transcription factor VuDREB2A for regulating abiotic stress responses. Plant Physiol Biochem 83, 51-6
2. Arabidopsis DREB2A-interacting proteins function as RING E3 ligases and negatively regulate plant drought stress-responsive gene expression. Plant Cell 20, 1693-707
3. A Canonical DREB2-Type Transcription Factor in Lily Is Post-translationally Regulated and Mediates Heat Stress Response. Front Plant Sci 9, 243