InterPro domain: IPR042176

This superfamily represents the C-terminal domain of a pantoate-beta-alanine ligase (also known as pantoate-beta-alanine synthase) which catalyses the formation of pantothenate from pantoate and alanine in the pantothenate biosynthesis pathway. Its C-terminal domain partially covers the active site cavity in the N-terminal domain and it has been proposed that a hinged movement of this domains is responsible for the opening and closing of the active site [ 1 ].

1. Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 12, 1097-108