InterPro domain: IPR031925
General Information
- Identifier IPR031925
- Description Tubulin-specific chaperone C, N-terminal
- Number of genes 118
- Gene duplication stats Loading...
- Associated GO terms GO:0015631
Abstract
Tubulin binding cofactor C (TBCC) is a post-chaperonin involved in folding pathways that lead to the final release of alpha beta native heterodimers incorporated in microtubules. TBCC is organised into three different domains: N-terminal, CARP and C-terminal [ 1 ].
This entry represents the N-terminal domain of TBCC. The N-terminal comprises a structured coiled coil and a highly dynamic N-terminal region which concentrates 80% of charged and polar residues and is believed to be important in interaction with tubulin [ 2 ]. Overall, the N-terminal domain of TBCC is responsible for its interaction with components of the centrosome by its N-terminal domain.
1. The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction. PLoS ONE 6, e25912